chronic obstructive pulmonary disease

Summary
Synonym
  • COLD
  • COPD
  • chronic obstructive airway disease
  • chronic obstructive lung disease
Definition
An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
Super Class
obstructive lung disease
Disease Ontology
DOID:3083
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
Related Genes
Displaying entries 1 - 10 of 126 in total
Gene ID Gene Symbol Description Source
12 SERPINA3 serpin family A member 3
153 ADRB1 adrenoceptor beta 1
154 ADRB2 adrenoceptor beta 2
177 AGER advanced glycosylation end-product specific receptor
355 FAS Fas cell surface death receptor
356 FASLG Fas ligand
624 BDKRB2 bradykinin receptor B2
718 C3 complement C3
727 C5 complement C5
728 C5AR1 complement C5a receptor 1
Displaying entries 111 - 120 of 123 in total
Gene ID Gene Symbol Description Source
72393 Faim2 Fas apoptotic inhibitory molecule 2
74069 Serpina3a serine (or cysteine) peptidase inhibitor, clade A, member 3A
74180 Muc5b mucin 5, subtype B, tracheobronchial
83995 Mmp1a matrix metallopeptidase 1a (interstitial collagenase)
84004 Mcam melanoma cell adhesion molecule
94217 Lrp1b low density lipoprotein-related protein 1B
110751 Adam33 a disintegrin and metallopeptidase domain 33
110834 Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3
110835 Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5
238393 Serpina3f serine (or cysteine) peptidase inhibitor, clade A, member 3F
Displaying entries 51 - 60 of 68 in total
Gene ID Gene Symbol Description Source
83516 Ppargc1a PPARG coactivator 1 alpha
83619 Nfe2l2 NFE2 like bZIP transcription factor 2
83785 Vegfa vascular endothelial growth factor A
83837 Bambi BMP and activin membrane-bound inhibitor
84024 Pon1 paraoxonase 1
84475 Cxcr3 C-X-C motif chemokine receptor 3
89824 Chi3l1 chitinase 3 like 1
113959 C5ar1 complement C5a receptor 1
116510 Timp1 TIMP metallopeptidase inhibitor 1
116553 Il13 interleukin 13
Displaying entries 1 - 10 of 21 in total
Gene ID Gene Symbol Description Source
31926 Idgf4 Imaginal disc growth factor 4
34091 Spn28Dc Serpin 28Dc
34189 Acer Angiotensin-converting enzyme-related
34304 nAChRalpha6 nicotinic Acetylcholine Receptor alpha6
34805 Ance Angiotensin converting enzyme
34978 Idgf1 Imaginal disc growth factor 1
34979 Idgf2 Imaginal disc growth factor 2
34981 Idgf3 Imaginal disc growth factor 3
36868 Idgf6 Imaginal disc growth factor 6
37104 Idgf5 Imaginal disc growth factor 5
Displaying all 6 entries
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa
447803 pon1 paraoxonase 1
554230 kdr kinase insert domain receptor (a type III receptor tyrosine kinase)
559080 cftr CF transmembrane conductance regulator
565980 ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
791973 cxcr3.2 chemokine (C-X-C motif) receptor 3, tandem duplicate 2
Displaying all 6 entries
Gene ID Gene Symbol Description Source Organism
373580 crhr1.2.S corticotropin releasing hormone receptor 1, gene 2 S homeolog Xenopus laevis (African clawed frog)
397778 tgfb1.L transforming growth factor beta 1 L homeolog Xenopus laevis (African clawed frog)
399298 ntf3.L neurotrophin 3 L homeolog Xenopus laevis (African clawed frog)
448598 pon2 paraoxonase 2 Xenopus tropicalis (tropical clawed frog)
100144634 ace angiotensin I converting enzyme Xenopus tropicalis (tropical clawed frog)
108697308 adrb1.L adrenoceptor beta 1 L homeolog Xenopus laevis (African clawed frog)
Displaying entries 31 - 33 of 33 in total
Gene ID Gene Symbol Description Source
188252 lev-9 Protein lev-9
191484 pxn-1 Peroxidasin homolog pxn-1
191602 acr-15 Acetylcholine receptor subunit alpha-type acr-15
Displaying all 3 entries
Gene ID Gene Symbol Description Source
851977 CTS2 putative chitinase
853313 PBS2 mitogen-activated protein kinase kinase PBS2
853978 NFT1 putative multidrug transporter NFT1

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