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chronic obstructive pulmonary disease
Summary
- Synonym
-
- COLD
- COPD
- chronic obstructive airway disease
- chronic obstructive lung disease
- Definition
- An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
- Super Class
- obstructive lung disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 2006 | ELN | elastin | |
| 2150 | F2RL1 | F2R like trypsin receptor 1 | |
| 2638 | GC | GC vitamin D binding protein | |
| 2901 | GRIK5 | glutamate ionotropic receptor kainate type subunit 5 | |
| 2904 | GRIN2B | glutamate ionotropic receptor NMDA type subunit 2B | |
| 2908 | NR3C1 | nuclear receptor subfamily 3 group C member 1 | |
| 3115 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | |
| 3356 | HTR2A | 5-hydroxytryptamine receptor 2A | |
| 3557 | IL1RN | interleukin 1 receptor antagonist | |
| 3593 | IL12B | interleukin 12B |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P05177 | Cytochrome P450 1A2 | |
| P05305 | Endothelin-1 | |
| P07550 | Beta-2 adrenergic receptor | |
| P07988 | Pulmonary surfactant-associated protein B | |
| P08294 | Extracellular superoxide dismutase [Cu-Zn] | |
| P08588 | Beta-1 adrenergic receptor | |
| P11226 | Mannose-binding protein C | |
| P11245 | Arylamine N-acetyltransferase 2 | |
| P12821 | Angiotensin-converting enzyme | |
| P13010 | X-ray repair cross-complementing protein 5 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P17246 | Transforming growth factor beta-1 proprotein |
