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myelofibrosis
Summary
- Synonym
-
- Agnogenic myeloid metaplasia
- Aleukemic myelosis
- Megakaryocytic myelosclerosis
- bone Marrow Fibrosis
- myelosclerosis
- primary myelofibrosis
- Definition
- A myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.
- Super Class
- myeloid neoplasm
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 811 | CALR | calreticulin | |
| 998 | CDC42 | cell division cycle 42 | |
| 2146 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | |
| 2322 | FLT3 | fms related receptor tyrosine kinase 3 | |
| 2323 | FLT3LG | fms related receptor tyrosine kinase 3 ligand | |
| 3077 | HFE | homeostatic iron regulator | |
| 4297 | KMT2A | lysine methyltransferase 2A | |
| 4352 | MPL | MPL proto-oncogene, thrombopoietin receptor | |
| 7040 | TGFB1 | transforming growth factor beta 1 | |
| 7157 | TP53 | tumor protein p53 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0003593 | Infantile onset |
| HP:0011974 | Myelofibrosis |
| HP:0005547 | Myeloproliferative disorder |
| HP:0012156 | Hemophagocytosis |
| HP:0001442 | Typified by somatic mosaicism |
