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MIRAGE

peptidylglycine alpha-amidating monooxygenase

Summary

Gene Symbol

pam

Organism

Pygocentrus nattereri (red-bellied piranha)

External Links

NCBI Gene: 108427288
PubChem: 108427288

Annotation

Keyword

Calcium
Copper
Disulfide bond
Glycoprotein
Lyase
Metal-binding
Monooxygenase
Multifunctional enzyme
Repeat
Signal
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A3B4CRU0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
peptide metabolic process	IEA	22301074

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

organic substance metabolic process [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	30032202
membrane	IEA	22301074

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peptidylglycine monooxygenase activity	IEA	30032202
peptidylamidoglycolate lyase activity
copper ion binding	IEA	22301074
protein binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

peptidylglycine monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

peptidylglycine monooxygenase activity

lyase activity [inference]

carbon-nitrogen lyase activity [inference]

amidine-lyase activity [inference]

peptidylamidoglycolate lyase activity

catalytic activity, acting on a protein [inference]

peptidylamidoglycolate lyase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Peptidyl-glycine alpha-amidating monooxygenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
catalytic activity
copper ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
peptide metabolic process
peptidylglycine monooxygenase activity

Displaying **all 8** entries
InterPro
Copper type II ascorbate-dependent monooxygenase, C-terminal
Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Copper type II, ascorbate-dependent monooxygenase, N-terminal
Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
NHL repeat
PHM/PNGase F domain superfamily
Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
Six-bladed beta-propeller, TolB-like

Ortholog

Displaying entries **1 - 10** of 81 in total

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5066		HUMAN80199
Mus musculus	18484		MOUSE30132
Rattus norvegicus	25508		RATNO43121
Bos taurus	280890		BOVIN34034
Pan troglodytes	461974		PANTR35852
Danio rerio	570822		DANRE00295
Macaca mulatta	707733		MACMU39189
Monodelphis domestica	100030601		MONDO16536
Ornithorhynchus anatinus	100073355		ORNAN01447
Oryctolagus cuniculus	100352005		RABIT01820

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025