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Guidelines

MIRAGE

growth differentiation factor 3

Summary

Gene Symbol

Gdf3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14562

PubChem

14562

Alliance of Genome Resources

MGI:95686

Annotation

Keyword

Cytokine
Cytoplasm
Developmental protein
Disulfide bond
Glycoprotein
Growth factor
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07104	VG-1-related protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
skeletal system development	ISS
skeletal system development	ISO
eye development	ISS
eye development	ISO
in utero embryonic development	IMP	16368929 17936261

GO Hierarchy

biological process

cellular process [inference]

signal transduction

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

pattern specification process [inference]

axis specification [inference]

embryonic axis specification [inference]

somite rostral/caudal axis specification

anterior/posterior axis specification [inference]

somite rostral/caudal axis specification

embryonic pattern specification [inference]

embryonic axis specification [inference]

somite rostral/caudal axis specification

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

tissue development [inference]

animal organ development [inference]

sensory organ development [inference]

eye development

embryonic organ development [inference]

notochord development

system development [inference]

skeletal system development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to dietary excess

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of developmental process [inference]

regulation of cell fate commitment

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of myoblast differentiation [inference]

negative regulation of myoblast differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of myoblast differentiation [inference]

negative regulation of myoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
extracellular space	IEA
cytoplasm	ISS
cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytokine activity	IBA
cytokine activity	IEA
protein binding	IPI	16368929
growth factor activity	IEA
protein kinase binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Bone morphogenetic protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cytokine activity
growth factor activity

Displaying **all 5** entries
InterPro
Cystine-knot cytokine
TGF-beta, propeptide
Transforming growth factor beta, conserved site
Transforming growth factor-beta, C-terminal
Transforming growth factor-beta-related

Ortholog

Displaying entries **1 - 10** of 54 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	2657	Xenbase:XB-GENE-481419
Homo sapiens	9573	Xenbase:XB-GENE-487309	HUMAN10945
Xenopus tropicalis	14559	Xenbase:XB-GENE-481419
Xenopus tropicalis	14562	Xenbase:XB-GENE-481419
Xenopus tropicalis	30125	Xenbase:XB-GENE-487309
Xenopus tropicalis	179068	Xenbase:XB-GENE-487309
Xenopus tropicalis	394305	Xenbase:XB-GENE-487309
Pan troglodytes	451817		PANTR05046
Canis lupus familiaris	477702		CANLF11100
Xenopus tropicalis	493288	Xenbase:XB-GENE-487309

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Last updated: December 8, 2025