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dynein axonemal heavy chain 9

Summary

Gene Symbol

DNAH9

Organism

Homo sapiens (human)

External Links

NCBI Gene

1770

PubChem

1770

Alliance of Genome Resources

HGNC:2953

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cilium
Cilium biogenesis/degradation
Coiled coil
Cytoskeleton
Disease variant
Dynein
Kartagener syndrome
Microtubule
Motor protein
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q99499
Q9NYC9	Axonemal beta dynein heavy chain 9 Ciliary dynein heavy chain 9

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cilium movement	IMP	30471717
cell projection organization	IEA
establishment of localization in cell	IEA
cilium movement involved in cell motility	IBA
cerebrospinal fluid circulation	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement

epithelial cilium movement involved in extracellular fluid movement [inference]

cilium movement involved in cell motility

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization

multicellular organismal process [inference]

system process [inference]

respiratory system process [inference]

mucociliary clearance

nervous system process [inference]

cerebrospinal fluid circulation

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

establishment of localization in cell

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GO Term	Evidence Code	PMID
extracellular region	IEA
microtubule	IEA
axoneme	IDA	11104725 11839535 15750039 18950741 23849778 31178125
axoneme	IBA
dynein complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

dynein complex

axonemal dynein complex [inference]

outer dynein arm

catalytic complex [inference]

dynein complex

axonemal dynein complex [inference]

outer dynein arm

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

9+2 motile cilium

glial cell projection

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

9+2 motile cilium

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

distal portion of axoneme

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GO Term	Evidence Code	PMID
protein binding	IPI	30471718
ATP binding	IEA
minus-end-directed microtubule motor activity	IBA
ATP hydrolysis activity	IEA
dynein intermediate chain binding	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DYNEIN HEAVY CHAIN

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
M: Cell wall/membrane/envelope biogenesis

Displaying **all 5** entries
Gene Ontology
ATP binding
dynein intermediate chain binding
dynein light intermediate chain binding
microtubule-based movement
minus-end-directed microtubule motor activity

Displaying **all 2** entries
InterPro
Dynein heavy chain, tail
Dynein heavy chain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111853	primary ciliary dyskinesia 40	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1770	Xenbase:XB-GENE-5753499
Drosophila melanogaster	8632	FB:FBgn0013812
Drosophila melanogaster	8701	FB:FBgn0039510
Drosophila melanogaster	13411	FB:FBgn0039510
Rattus norvegicus	117251		RATNO01078
Mus musculus	237806		MOUSE04942
Pan troglodytes	455066		PANTR14757
Canis lupus familiaris	489507		CANLF15526
Macaca mulatta	722104		MACMU16265
Bos taurus	790891		BOVIN12875

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements