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MIRAGE
dopamine receptor D2
Summary
- Gene Symbol
-
- DRD2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Disease variant
- Disulfide bond
- G-protein coupled receptor
- Glycoprotein
- Golgi apparatus
- Palmitate
- Reference proteome
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P14416 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| phospholipase C-activating G protein-coupled receptor signaling pathway | ||
| neuron-neuron synaptic transmission | ||
| neuroblast proliferation | ||
| axonogenesis | ||
| synapse assembly |
GO Hierarchy
- pigmentation
biological process
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
regulation of trans-synaptic signaling [inference]
regulation of localization [inference]
regulation of transport [inference]
regulation of transmembrane transport [inference]
regulation of monoatomic ion transport [inference]
regulation of secretion [inference]
negative regulation of transport [inference]
regulation of neurotransmitter transport [inference]
regulation of amine transport [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of cellular process [inference]
negative regulation of response to stimulus [inference]
negative regulation of transport [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
regulation of trans-synaptic signaling [inference]
regulation of cellular metabolic process [inference]
regulation of transmembrane transport [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of secretion by cell [inference]
regulation of multicellular organismal process [inference]
regulation of biological quality [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi membrane | ||
| acrosomal vesicle | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| dopamine neurotransmitter receptor activity, coupled via Gi/Go | ||
| dopamine neurotransmitter receptor activity, coupled via Gi/Go | ||
| G-protein alpha-subunit binding | ||
| G protein-coupled receptor activity | ||
| protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- receptor
- Functional Category
-
- E: Amino acid transport and metabolism
- I: Lipid transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| adenylate cyclase-activating adrenergic receptor signaling pathway |
| InterPro |
|---|
| G protein-coupled receptor, rhodopsin-like |
| GPCR, rhodopsin-like, 7TM |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050741 | alcohol dependence | |
| DOID:0050742 | nicotine dependence | |
| DOID:10024 | migraine with aura | |
| DOID:10763 | hypertension | |
| DOID:1596 | depressive disorder | |
| DOID:2030 | anxiety disorder | |
| DOID:251 | alcohol-induced mental disorder | |
| DOID:2559 | opiate dependence | |
| DOID:480 | movement disease | |
| DOID:783 | end stage renal disease |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 1813 | Xenbase:XB-GENE-1005779 | ||
| 1814 | FB:FBgn0053517 | ||
| 13489 | Xenbase:XB-GENE-1005779 | MOUSE60647 | |
| 13490 | FB:FBgn0053517 | ||
| 24318 | Xenbase:XB-GENE-1005779 | RATNO40292 | |
| 29238 | FB:FBgn0053517 | ||
| 33007 | Xenbase:XB-GENE-1005779 | ||
| 179347 | ZFIN:ZDB-GENE-030910-2 | ||
| 281126 | BOVIN06473 | ||
| 282557 | DANRE08232 |
