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ATP-binding cassette, sub-family B member 1B

Summary

Gene Symbol

Abcb1b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18669

PubChem

18669

Alliance of Genome Resources

MGI:97568

Annotation

Keyword

ATP-binding
Cell membrane
Cytoplasm
Glycoprotein
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B2RUR3
P06795	ATP-binding cassette sub-family B member 1B Multidrug resistance protein 1B P-glycoprotein 1 Phospholipid transporter ABCB1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
G2/M transition of mitotic cell cycle	ISO
response to xenobiotic stimulus	ISO
establishment of endothelial blood-brain barrier	ISO
phospholipid transport	IEA
lipid translocation	IEA

GO Hierarchy

biological process

cellular process [inference]

cell population proliferation [inference]

stem cell proliferation

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cell cycle G2/M phase transition [inference]

G2/M transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of endothelial blood-brain barrier

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

tissue remodeling [inference]

Sertoli cell barrier remodeling

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of endothelial blood-brain barrier

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of endothelial blood-brain barrier

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

xenobiotic transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

transepithelial transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport

phospholipid translocation

lipid translocation

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

ceramide transport [inference]

ceramide translocation

organic anion transport [inference]

carboxylic acid transport [inference]

carboxylic acid transmembrane transport

organophosphate ester transport [inference]

phospholipid transport

phospholipid translocation

organic acid transport [inference]

carboxylic acid transport [inference]

carboxylic acid transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

nitrogen compound transport [inference]

amide transport [inference]

ceramide transport [inference]

ceramide translocation

sphingolipid translocation [inference]

ceramide translocation

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transport [inference]

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of chloride transport

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of response to osmotic stress

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of molecular function [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
Golgi membrane	ISO
cytoplasm	ISO
mitochondrion	HDA	18614015
plasma membrane	ISO
cell surface	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

intercellular canaliculus

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

side of membrane [inference]

external side of plasma membrane [inference]

external side of apical plasma membrane

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
ATP binding	ISO
ATP binding	IEA
ABC-type xenobiotic transporter activity	ISO
ABC-type xenobiotic transporter activity	IEA
efflux transmembrane transporter activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

phosphatidylcholine transporter activity [inference]

phosphatidylcholine floppase activity

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

sphingolipid transporter activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	5243	ZFIN:ZDB-GENE-080204-52
Danio rerio	5244	ZFIN:ZDB-GENE-080204-52
Saccharomyces cerevisiae S288C	8647	SGD:S000001692
Danio rerio	18669	ZFIN:ZDB-GENE-080204-52
Danio rerio	18670	ZFIN:ZDB-GENE-080204-52
Danio rerio	18671	ZFIN:ZDB-GENE-080204-52
Rattus norvegicus	24646		RATNO30682
Danio rerio	24891	ZFIN:ZDB-GENE-080204-52
Saccharomyces cerevisiae S288C	27413	SGD:S000001692
Danio rerio	36428	ZFIN:ZDB-GENE-080204-52

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