GlyCosmos Portal

Submissions

patched 2

Summary

Gene Symbol

Ptch2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

19207

PubChem

19207

Alliance of Genome Resources

MGI:1095405

Annotation

Keyword

Glycoprotein
Receptor
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O35595

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
regulation of cell growth	ISO
regulation of cell growth	IEA
cell fate determination	IGI	24492243
epidermis development	IMP	16914743
epidermal cell fate specification	IGI	24492243

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell fate specification [inference]

epidermal cell fate specification

cell fate determination

multicellular organismal process [inference]

molting cycle [inference]

hair cycle

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

animal organ development [inference]

skin development

cellular developmental process [inference]

cell fate specification [inference]

epidermal cell fate specification

cell fate determination

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of growth [inference]

regulation of cell growth

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of cellular component organization [inference]

regulation of cell growth

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
smoothened binding	ISO
smoothened binding	IBA
smoothened binding	IEA
hedgehog receptor activity	IBA
hedgehog receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

smoothened binding

hedgehog family protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

hedgehog receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

patched

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
hedgehog family protein binding
hedgehog receptor activity
smoothened binding

Displaying **all 2** entries
InterPro
Protein patched/dispatched
Sterol-sensing domain

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	5727	FB:FBgn0003892
Homo sapiens	8643	Xenbase:XB-GENE-1033868	HUMAN49521
Drosophila melanogaster	19206	FB:FBgn0003892
Xenopus tropicalis	19207	Xenbase:XB-GENE-1033868
Danio rerio	30181		DANRE29257
Xenopus tropicalis	35851	Xenbase:XB-GENE-1033868
Xenopus tropicalis	173631	Xenbase:XB-GENE-1033868
Xenopus tropicalis	174274	Xenbase:XB-GENE-1033868
Rattus norvegicus	366452		RATNO33129
Pan troglodytes	469185		PANTR20916