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signal-induced proliferation-associated 1 like 1

Summary

Gene Symbol

Sipa1l1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

217692

PubChem

217692

Alliance of Genome Resources

MGI:2443679

Annotation

Keyword

Alternative splicing
Coiled coil
Cytoskeleton
Direct protein sequencing
GTPase activation
Methylation
Phosphoprotein
Reference proteome
Synaptosome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8C0T5

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
actin cytoskeleton organization	ISS
actin cytoskeleton organization	ISO
regulation of GTPase activity	IMP	18094260
ephrin receptor signaling pathway	IMP	17785183 18094260
regulation of synaptic plasticity	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

regulation of organelle assembly [inference]

regulation of postsynaptic specialization assembly [inference]

regulation of postsynaptic density assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of dendritic spine morphogenesis

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of postsynaptic specialization assembly [inference]

regulation of postsynaptic density assembly

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density assembly

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

regulation of biological quality [inference]

regulation of synaptic plasticity

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity

positive regulation of GTPase activity [inference]

activation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytoplasm	IEA
plasma membrane	ISO
plasma membrane	IEA
postsynaptic density	ISS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

postsynapse

dendritic spine

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
GTPase activator activity	IBA
GTPase activator activity	IEA
protein kinase binding	ISO
ubiquitin protein ligase binding	ISO
protein-containing complex binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

ephrin receptor binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

protein-containing complex binding

actin filament binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

signal-induced proliferation-associated 1

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of small GTPase mediated signal transduction

Displaying **all 4** entries
InterPro
PDZ domain
PDZ superfamily
Rap/Ran-GAP domain
Rap/Ran-GAP superfamily

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	6494	WB:WBGene00012100
Caenorhabditis elegans	23094	WB:WBGene00012100
Homo sapiens	26037	Xenbase:XB-GENE-866790	HUMAN20080
Caenorhabditis elegans	57568	WB:WBGene00012100
Caenorhabditis elegans	74206	WB:WBGene00012100
Xenopus tropicalis	217692	Xenbase:XB-GENE-866790
Caenorhabditis elegans	244668	WB:WBGene00012100
Rattus norvegicus	246212		RATNO35410
Pan troglodytes	453008		PANTR09083
Canis lupus familiaris	480379		CANLF18051