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Guidelines

MIRAGE

ubiquitin specific peptidase 10

Summary

Gene Symbol

Usp10

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22224

PubChem

22224

Alliance of Genome Resources

MGI:894652

Annotation

Keyword

Acetylation
Alternative splicing
Autophagy
Cytoplasm
DNA repair
Endosome
Nucleus
Phosphoprotein
Reference proteome
Thiol protease
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
P52479	Deubiquitinating enzyme 10 Ubiquitin thioesterase 10 Ubiquitin-specific-processing protease 10

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
DNA repair	IEA
proteolysis	IEA
autophagy	IEA
cellular response to DNA damage stimulus	ISS
DNA damage response	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

monoubiquitinated protein deubiquitination

catabolic process [inference]

cellular catabolic process [inference]

autophagy

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular catabolic process [inference]

autophagy

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

monoubiquitinated protein deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

monoubiquitinated protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

monoubiquitinated protein deubiquitination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

monoubiquitinated protein deubiquitination

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular catabolic process [inference]

autophagy

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle disassembly [inference]

ribosome disassembly [inference]

rescue of stalled ribosome

cellular component disassembly [inference]

organelle disassembly [inference]

ribosome disassembly [inference]

rescue of stalled ribosome

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to interleukin-1 [inference]

cellular response to interleukin-1

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of cellular component biogenesis [inference]

regulation of organelle assembly [inference]

regulation of stress granule assembly [inference]

negative regulation of stress granule assembly

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

regulation of organelle assembly [inference]

regulation of stress granule assembly [inference]

negative regulation of stress granule assembly

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

regulation of biological quality [inference]

regulation of protein stability

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	ISO
nucleus	IBA
nucleoplasm	ISO
nucleoplasm	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribosome [inference]

cytosolic ribosome

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular non-membrane-bounded organelle [inference]

ribosome [inference]

cytosolic ribosome

cytoskeleton [inference]

intermediate filament cytoskeleton

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
p53 binding	ISS
p53 binding	ISO
cysteine-type endopeptidase activity	ISS
cysteine-type endopeptidase activity	ISO
cysteine-type deubiquitinase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

binding [inference]

protein binding

molecular function regulator activity [inference]

molecular function inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquitin carboxyl-terminal hydrolase

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
hydrolase activity
proteolysis
regulation of autophagy

Displaying **all 4** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Ubiquitin specific protease domain
Ubiquitin specific protease, conserved site

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9100	Xenbase:XB-GENE-966184	HUMAN30047
Xenopus tropicalis	22224	Xenbase:XB-GENE-966184
Rattus norvegicus	307905		RATNO14498
Pan troglodytes	454287		PANTR12993
Canis lupus familiaris	479625		CANLF15893
Danio rerio	564632		DANRE39621
Xenopus tropicalis	856895	Xenbase:XB-GENE-966184
Monodelphis domestica	100023556		MONDO08920
Ornithorhynchus anatinus	100078827		ORNAN02409
Taeniopygia guttata	100231833		TAEGU03131

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Last updated: December 8, 2025