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nicastrin

Summary

Gene Symbol

Ncstn

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

289231

PubChem

289231

Alliance of Genome Resources

RGD:631418

Annotation

Keyword

Alternative splicing
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Glycoprotein
Notch signaling pathway
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A0G2K9X9
A0A8I6G5D3
Q8CGU6
A6JG19
B3DM90

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	PMID
myeloid cell homeostasis	ISO
membrane protein ectodomain proteolysis	ISS
membrane protein ectodomain proteolysis	ISO
dopamine receptor signaling pathway	ISO
glutamate receptor signaling pathway	ISO

GO Hierarchy

biological process

immune system process [inference]

myeloid cell homeostasis

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

amyloid-beta formation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

amyloid-beta formation

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

Notch receptor processing

amyloid precursor protein metabolic process

amyloid precursor protein biosynthetic process

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

organonitrogen compound biosynthetic process [inference]

amyloid precursor protein biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amyloid precursor protein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amyloid precursor protein biosynthetic process

organonitrogen compound biosynthetic process [inference]

amyloid precursor protein biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amyloid precursor protein biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

Notch receptor processing

amyloid precursor protein metabolic process

amyloid precursor protein biosynthetic process

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

amyloid precursor protein biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

Notch receptor processing

amyloid precursor protein metabolic process

amyloid precursor protein biosynthetic process

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

amyloid-beta formation

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

Notch receptor processing

amyloid precursor protein metabolic process

amyloid precursor protein biosynthetic process

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

organonitrogen compound biosynthetic process [inference]

amyloid precursor protein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amyloid precursor protein biosynthetic process

organonitrogen compound biosynthetic process [inference]

amyloid precursor protein biosynthetic process

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

dopamine receptor signaling pathway

ensheathment of neurons [inference]

axon ensheathment [inference]

axon ensheathment in central nervous system [inference]

central nervous system myelination

myelination [inference]

central nervous system myelination

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cell population proliferation [inference]

epithelial cell proliferation

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

T cell proliferation

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amyloid precursor protein biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

myeloid cell homeostasis

developmental process [inference]

anatomical structure development [inference]

cerebellum development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

myeloid cell homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to calcium ion [inference]

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

response to salt [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

dopamine receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
lysosome	ISO
lysosomal membrane	IDA	12736250
early endosome	IDA	20126630
endoplasmic reticulum	ISS
endoplasmic reticulum	ISO

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

gamma-secretase complex

catalytic complex [inference]

gamma-secretase complex

cellular anatomical entity [inference]

membrane

plasma membrane

sarcolemma

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

plasma membrane region [inference]

synaptic membrane

presynaptic membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

pigment granule [inference]

melanosome

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

pigment granule [inference]

melanosome

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

pigment granule [inference]

melanosome

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	ISO
protein binding	IPI	15456764 22535952
peptidase activity	IDA	12736250
protein-macromolecule adaptor activity	ISO
aspartic endopeptidase activity, intramembrane cleaving	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

binding [inference]

protein binding

signaling receptor binding [inference]

growth factor receptor binding

enzyme binding [inference]

ATPase binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

peptidase regulator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

endopeptidase regulator activity [inference]

endopeptidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
lysosomal membrane	PMID:12736250
sarcolemma	PMID:16595164
early endosome	PMID:20126630
protein-containing complex	PMID:15456764
synaptic membrane	PMID:20126630
synaptic vesicle	PMID:20126630

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements