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desmoglein 4

Summary

Gene Symbol

Dsg4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

291754

PubChem

291754

Alliance of Genome Resources

RGD:735015

Annotation

Keyword

Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Disease variant
Glycoprotein
Metal-binding
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6W3B0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cell-cell adhesion	IBA ISO
hair follicle development	ISO
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
BMP signaling pathway	ISO
cell adhesion	TAS	15081105

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

multicellular organismal process [inference]

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure development [inference]

hair follicle development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
desmosome	IBA ISO
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

desmosome

Displaying 1 entry
GO Term	Evidence Code	PMID
calcium ion binding	IBA IMP	15081105

GO Hierarchy

molecular function

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

desmoglein-4

Functional Category

J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 2** entries
InterPro
Cadherin, Y-type LIR-motif
Cadherin-like

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110703	hypotrichosis 6	Alliance of Genome Resources
DOID:4535	hypotrichosis	Alliance of Genome Resources
DOID:987	alopecia	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 44 in total

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Species	Gene ID	OrthoDB
Urocitellus parryii	113191124	9999_0:002763
Marmota flaviventris	114093041	93162_0:000eb2
Grammomys surdaster	114627181	491861_0:001fa9
Peromyscus leucopus	114704999	10041_0:003dd1
Mastomys coucha	116087556	35658_0:000c03
Rattus rattus	116884674	10117_0:00488d
Arvicanthis niloticus	117719962	61156_0:00348d
Onychomys torridus	118594758	38674_0:003691
Arvicola amphibius	119815302	1047088_0:001f8e
Microtus oregoni	121441887	111838_0:005949

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements