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desmoglein 4

Summary

Gene Symbol

Dsg4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

291754

PubChem

291754

Alliance of Genome Resources

RGD:735015

Annotation

Keyword

Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Disease variant
Glycoprotein
Metal-binding
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6W3B0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cell-cell adhesion	IBA ISO
hair follicle development	ISO
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
BMP signaling pathway	ISO
cell adhesion	TAS	15081105

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

multicellular organismal process [inference]

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure development [inference]

hair follicle development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
desmosome	IBA ISO
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

desmosome

Displaying 1 entry
GO Term	Evidence Code	PMID
calcium ion binding	IBA IMP	15081105

GO Hierarchy

molecular function

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

desmoglein-4

Functional Category

J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 2** entries
InterPro
Cadherin, Y-type LIR-motif
Cadherin-like

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110703	hypotrichosis 6	Alliance of Genome Resources
DOID:4535	hypotrichosis	Alliance of Genome Resources
DOID:987	alopecia	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 44 in total

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Species	Gene ID	OrthoDB
Microtus oregoni	121453648	111838_0:001de3
Dipodomys spectabilis	122104254	105255_0:000ba9
Marmota monax	124082000	9995_0:00416d
Sciurus carolinensis	124965679	30640_0:0042e2
Perognathus longimembris pacificus	125363923	214514_0:003609
Myodes glareolus	125405735	447135_0:001bad
Microtus fortis	126497060	100897_0:0009ca
Acomys russatus	127204509	60746_0:0035ce
Phodopus roborovskii	127234929	109678_0:003f43
Apodemus sylvaticus	127663676	10129_0:003b3f

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements