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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

NADPH oxidase 3

Summary

Gene Symbol

Nox3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

292279

PubChem

292279

Alliance of Genome Resources

RGD:1303190

Annotation

Keyword

Cell membrane
Glycoprotein
Heme
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q672K1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
temperature homeostasis	ISO
defense response	IBA
detection of gravity	ISO
response to gravity	ISO
superoxide anion generation	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

cellular process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

developmental process [inference]

anatomical structure development [inference]

otolith development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

response to stimulus [inference]

response to stress [inference]

defense response

response to external stimulus [inference]

detection of external stimulus [inference]

detection of gravity

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of gravity

response to gravity

detection of gravity

detection of stimulus [inference]

detection of external stimulus [inference]

detection of gravity

detection of abiotic stimulus [inference]

detection of gravity

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GO Term	Evidence Code	PMID
cytoplasm	ISO
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA
NADPH oxidase complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
superoxide-generating NAD(P)H oxidase activity	ISS
superoxide-generating NAD(P)H oxidase activity	ISO
superoxide-generating NAD(P)H oxidase activity	IBA
oxidoreductase activity	TAS	15326186
heme binding	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

superoxide-generating NAD(P)H oxidase activity

superoxide-generating NADPH oxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Respiratory burst

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 6** entries
InterPro
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Riboflavin synthase-like beta-barrel

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	50508	HGNC:7890	HUMAN87145
Mus musculus	224480	HGNC:7890	MOUSE20668
Homo sapiens	292279	HGNC:7890
Pan troglodytes	472169		PANTR39368
Canis lupus familiaris	484046		CANLF00231
Bos taurus	526999		BOVIN36026
Monodelphis domestica	100032293		MONDO11842
Equus caballus	100061382		HORSE29960
Ornithorhynchus anatinus	100090415		ORNAN15404
Taeniopygia guttata	100228883		TAEGU20196

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025