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MIRAGE
sonic hedgehog signaling molecule
Summary
- Gene Symbol
-
- Shh
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Autocatalytic cleavage
- Calcium
- Cell membrane
- Developmental protein
- Endoplasmic reticulum
- Glycoprotein
- Golgi apparatus
- Metal-binding
- Palmitate
- Protease
- Reference proteome
- Signal
- Transferase
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q63673 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| negative regulation of transcription by RNA polymerase II | ||
| angiogenesis | ||
| branching involved in blood vessel morphogenesis | ||
| branching involved in blood vessel morphogenesis |
GO Hierarchy
- positive regulation of cell division
- regulation of epithelial cell differentiation
- regulation of epithelial cell differentiation
- positive regulation of cell division
biological process
metabolic process [inference]
cellular process [inference]
reproductive process [inference]
multicellular organismal process [inference]
developmental process [inference]
developmental process involved in reproduction [inference]
anatomical structure morphogenesis [inference]
anatomical structure development [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of neuron differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of cell population proliferation
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of neuron differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of cell activation [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| presynapse | ||
| postsynapse | ||
| glutamatergic synapse |
| GO Term | Evidence Code | PMID |
|---|---|---|
| glycosaminoglycan binding | ||
| peptidase activity | ||
| peptidase activity | ||
| peptidase activity | ||
| zinc ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- hedgehog
- Functional Category
-
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
- X: Mobilome: prophages, transposons
| Gene Ontology |
|---|
| calcium ion binding |
| cell fate specification |
| cell-cell signaling |
| hydrolase activity |
| intein-mediated protein splicing |
| metal ion binding |
| patched binding |
| protein autoprocessing |
| proteolysis |
| regulation of gene expression |
| InterPro |
|---|
| Hedgehog protein, Hint domain |
| Hedgehog protein |
| Hedgehog, N-terminal signalling domain |
| Hint domain C-terminal |
| Hint domain N-terminal |
| Hint domain superfamily |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080855 | Parkinsonism | |
| DOID:5844 | myocardial infarction |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3549 | FB:FBgn0004644 | ||
| 6469 | Xenbase:XB-GENE-488039 | HUMAN92227 | |
| 16147 | FB:FBgn0004644 | ||
| 20423 | Xenbase:XB-GENE-488039 | MOUSE45693 | |
| 29499 | Xenbase:XB-GENE-488039 | ||
| 30269 | DANRE40080 | ||
| 180349 | HGNC:10848 | ||
| 180638 | HGNC:10848 | ||
| 181300 | FB:FBgn0004644 | ||
| 445636 | CIOIN09955 |
