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keratin 2

Summary

Gene Symbol

KRT2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3849

PubChem

3849

Alliance of Genome Resources

HGNC:6439

Annotation

Keyword

Coiled coil
Cytoplasm
Disease variant
Ichthyosis
Intermediate filament
Keratin
Methylation
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P35908	Cytokeratin-2e Epithelial keratin-2e Keratin-2 epidermis Keratin-2e Type-II keratin Kb2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
keratinocyte development	IEA
intermediate filament organization	IBA
keratinization	IBA IDA	12598329
epidermis development	TAS	7524919
keratinocyte migration	IDA	15737202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

macromolecule modification [inference]

protein modification process [inference]

peptide cross-linking

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

cellular process [inference]

cell activation [inference]

keratinocyte activation

cell population proliferation [inference]

epithelial cell proliferation [inference]

keratinocyte proliferation

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

keratinocyte development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

keratinocyte migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

supramolecular fiber organization [inference]

intermediate filament organization

multicellular organismal process [inference]

cell activation [inference]

keratinocyte activation

keratinization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

cell development [inference]

epithelial cell development [inference]

keratinocyte development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

keratinocyte development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of epidermis development

regulation of developmental process [inference]

regulation of epidermis development [inference]

positive regulation of epidermis development

positive regulation of developmental process [inference]

positive regulation of epidermis development

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
intermediate filament	TAS	1380918
nucleus	HDA	21630459
intermediate filament cytoskeleton	IDA
cytoplasm	IDA	32179842
extracellular space	HDA	23580065

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane [inference]

cornified envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

keratin filament

Displaying **all 4** entries
GO Term	Evidence Code	PMID
structural constituent of skin epidermis	IBA IDA	7543090
protein binding	IPI	25416956 25910212 29892012 31515488 32296183
cytoskeletal protein binding	IEA
structural constituent of cytoskeleton	TAS	1380918

GO Hierarchy

molecular function

structural molecule activity [inference]

binding [inference]

protein binding

cytoskeletal protein binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060877	bullous congenital ichthyosiform erythroderma	Alliance of Genome Resources
DOID:1697	ichthyosis	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 58** of 58 in total

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Species	Gene ID	Orthologous MAtrix
Propithecus coquereli	105815553	PROCO09335
Microcebus murinus	105870426	MICMU13031
Dipodomys ordii	105997908	DIPOR20786
Rhinopithecus bieti	108521555	RHIBE20651
Vulpes vulpes	112921006	VULVU14036
Rhinolophus ferrumequinum	117028588	RHIFE08583
Panthera leo	122223578	PANLE16828
Ursus americanus	123794717	URSAM05825

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