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alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Summary

Gene Symbol

MGAT2

Aliases

GNT-II

Organism

Homo sapiens (human)

External Links

NCBI Gene

4247

GGDB ID

gg126

HGNC

7045

mRNA

NM_002408

map

14q21

Protein

NP_002399

OMIM

602616

KEGG Gene ID

hsa:4247

PubChem

4247

Alliance of Genome Resources

HGNC:7045

Annotation

Keyword

3D-structure
Congenital disorder of glycosylation
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q10469	Beta-1,2-N-acetylglucosaminyltransferase II GlcNAc-T II Mannoside acetylglucosaminyltransferase 2 N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
oligosaccharide biosynthetic process	IEA
protein N-linked glycosylation	IBA
protein N-linked glycosylation via asparagine	IDA IMP	29666272 7635144 8808595
viral protein processing	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

viral process [inference]

viral protein processing

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	HDA	19946888
Golgi apparatus	IDA
Golgi membrane	IBA IDA TAS	20378551
Golgi stack	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein homodimerization activity	IDA	20378551
manganese ion binding	IDA	29666272
alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	IBA IDA IMP TAS	29666272 7635144 8808595

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000168282

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg126

Gene Symbol

MGAT2

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G61751GZ	G39213VZ	7635144

Displaying **all 3** entries
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G61751GZ	G39213VZ	7635144
UDP-GlcNAc	G07483YN	G80858MF	7635144
UDP-GlcNAc	G64272SY	G48524PJ	7635144

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Rattus norvegicus	NP_446056	NM_053604
Drosophila melanogaster	NP_651763	NM_143506
Caenorhabditis elegans	NP_505864	NM_073463
Mus musculus	NP_666147	NM_146035

KEGG BRITE Database

Orthology

K00736

Name

alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [EC:2.4.1.143]

References

2952645

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05985	2.4.1.143	G61751GZ	G39213VZ

Rhea

RHEA:12941

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.143

PMID

Disease

Disease Ontology

Displaying entries **21 - 30** of 33 in total

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DO ID	Disease Name	Source
DOID:2451	protein S deficiency	DisGeNET
DOID:3086	gingival overgrowth	DisGeNET
DOID:3265	chronic granulomatous disease	DisGeNET
DOID:3755	antithrombin III deficiency	DisGeNET
DOID:3756	protein C deficiency	DisGeNET
DOID:4480	achondroplasia	DisGeNET
DOID:5212	congenital disorder of glycosylation	DisGeNET DisGeNET
DOID:5338	gingival hypertrophy	DisGeNET
DOID:769	neuroblastoma	DisGeNET DisGeNET
DOID:9351	diabetes mellitus	DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying entries **11 - 20** of 98 in total

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HPO ID	HPO Term
HP:0000268	Dolichocephaly
HP:0000278	Retrognathia
HP:0000303	Mandibular prognathia
HP:0000316	Hypertelorism
HP:0000343	Long philtrum
HP:0000358	Posteriorly rotated ears
HP:0000363	Abnormal earlobe morphology
HP:0000368	Low-set, posteriorly rotated ears
HP:0000369	Low-set ears
HP:0000395	Prominent antihelix

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:79329	MGAT2-congenital disorder of glycosylation
OMIM:212066	MGAT2-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

MGAT2-congenital disorder of glycosylation

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIa; CDG2A

KEGG Diseases

Congenital disorders of glycosylation type II

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 61 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179562	WB:WBGene00001645
Drosophila melanogaster	43563	FB:FBgn0039738
Callorhinchus milii	103175354		CALMI07623
Latimeria chalumnae	102367380		LATCH17986
Danio rerio	100000478	ZFIN:ZDB-GENE-070410-54	DANRE20094
Astyanax mexicanus	103024773		ASTMX15110
Electrophorus electricus	113569808		ELEEL05873
Salmo salar	100195434		SALSA129248
Salmo trutta	115169272		SALTR24436
Salmo trutta	115174519		SALTR53395

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements