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acetylcholinesterase (Yt blood group)

Summary

Gene Symbol

ACHE

Aliases

Yt blood group

Organism

Homo sapiens (human)

External Links

NCBI Gene

HGNC

108

KEGG Gene ID

hsa:43

PubChem

Alliance of Genome Resources

HGNC:108

Annotation

Keyword

3D-structure
Alternative splicing
Blood group antigen
Cell membrane
Direct protein sequencing
Disulfide bond
GPI-anchor
Neurotransmitter degradation
Nucleus
Reference proteome
Secreted
Serine esterase
Signal
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
P22303

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
acetylcholine receptor signaling pathway	IEA
synapse assembly	TAS	11283752
positive regulation of protein secretion	TAS	11283752
acetylcholine catabolic process in synaptic cleft	NAS	1517212
receptor internalization	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

protein metabolic process [inference]

amyloid precursor protein metabolic process

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

catabolic process [inference]

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

primary metabolic process [inference]

protein metabolic process [inference]

amyloid precursor protein metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

amyloid precursor protein metabolic process

acetate ester metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

protein metabolic process [inference]

amyloid precursor protein metabolic process

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

acetylcholine catabolic process in synaptic cleft

cellular process [inference]

cell adhesion

signal transduction [inference]

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular developmental process [inference]

cell development [inference]

osteoblast development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

osteoblast development

system development [inference]

nervous system development

retina development in camera-type eye

cellular developmental process [inference]

cell development [inference]

osteoblast development

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of receptor recycling

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

negative regulation of synaptic transmission, cholinergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of cellular process [inference]

signal transduction [inference]

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

negative regulation of synaptic transmission, cholinergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
membrane	IDA	16262697
Golgi apparatus	IDA	15454088
plasma membrane	TAS
neuromuscular junction	IEA
basement membrane	NAS	16289501

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

synaptic cleft

membrane

plasma membrane

cell junction [inference]

synapse

neuromuscular junction

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10800960 15526038 18194455
hydrolase activity	IDA	1517212
cholinesterase activity	IDA	1517212
serine hydrolase activity	IDA	3954986
collagen binding	IDA	12524166

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

cholinesterase activity

acetylcholinesterase activity

serine hydrolase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

laminin binding

protein dimerization activity [inference]

protein homodimerization activity

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

ion binding [inference]

cation binding [inference]

acetylcholine binding

protein-containing complex binding [inference]

collagen binding

extracellular matrix binding [inference]

laminin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

acetylcholinesterase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
acetylcholine catabolic process
acetylcholinesterase activity
choline metabolic process
cholinesterase activity
hydrolase activity

Displaying **all 5** entries
InterPro
Alpha/Beta hydrolase fold
Carboxylesterase type B, active site
Carboxylesterase type B, conserved site
Carboxylesterase, type B
Cholinesterase

KEGG BRITE Database

Orthology

K01049

Name

acetylcholinesterase [EC:3.1.1.7]

References

Rhea

RHEA:17561

acetylcholine + H₂O

choline + H⁺ + acetate

Enzyme

3.1.1.7

PMID

Disease

PubChem Disease

MedGen Diseases

Antigen in Cartwright blood group system

OMIM Phenotypes

YT BLOOD GROUP ANTIGEN

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001073
Gene Name: acetylcholinesterase (Yt blood group)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11423	MGI:87876	MOUSE47297
Drosophila melanogaster	41625	FB:FBgn0000024
Rattus norvegicus	83817	RGD:69313	RATNO05102
Danio rerio	114549	ZFIN:ZDB-GENE-010906-1	DANRE41472
Caenorhabditis elegans	175074	WB:WBGene00000038
Caenorhabditis elegans	175076	WB:WBGene00000037
Caenorhabditis elegans	181706	WB:WBGene00000035
Canis lupus familiaris	489828		CANLF16192
Felis catus	493674		FELCA35129
Bos taurus	540446		BOVIN20838

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements