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Guidelines

MIRAGE

myosin heavy chain 1

Summary

Gene Symbol

MYH1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4619

PubChem

4619

Alliance of Genome Resources

HGNC:7567

Annotation

Keyword

ATP-binding
Actin-binding
Calmodulin-binding
Coiled coil
Cytoplasm
Methylation
Myosin
Phosphoprotein
Reference proteome
Thick filament

Proteins

Displaying 1 entry
UniProt	Protein Name
P12882	Myosin heavy chain 1 Myosin heavy chain 2x Myosin heavy chain IIx/d Myosin heavy chain, skeletal muscle, adult 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
muscle contraction	IBA

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
A band	IEA
muscle myosin complex	IDA	18310078
cytoplasm	IBA
intercalated disc	IEA
myosin II complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin complex [inference]

myosin II complex

muscle myosin complex

cellular anatomical entity [inference]

cytoplasm

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

A band

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular polymer [inference]

supramolecular fiber [inference]

myosin filament

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ATP binding	IEA
protein binding	IPI	25416956 32296183
calmodulin binding	IEA
actin filament binding	IBA
microfilament motor activity	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microfilament motor activity

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0050646	distal arthrogryposis	Alliance of Genome Resources
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0080326	familial hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:0080719	congenital myopathy 6	Alliance of Genome Resources
DOID:0110454	dilated cardiomyopathy 1S	Alliance of Genome Resources
DOID:0111269	autosomal dominant hyaline body myopathy	Alliance of Genome Resources
DOID:0111596	distal arthrogryposis type 1	Alliance of Genome Resources
DOID:0111602	distal arthrogryposis type 2B3	Alliance of Genome Resources
DOID:0111605	distal arthrogryposis type 2A	Alliance of Genome Resources
DOID:11720	distal myopathy	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.1

Last updated: February 17, 2025