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Guidelines

MIRAGE

myosin heavy chain 1

Summary

Gene Symbol

MYH1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4619

PubChem

4619

Alliance of Genome Resources

HGNC:7567

Annotation

Keyword

ATP-binding
Actin-binding
Calmodulin-binding
Coiled coil
Cytoplasm
Methylation
Myosin
Phosphoprotein
Reference proteome
Thick filament

Proteins

Displaying 1 entry
UniProt	Protein Name
P12882	Myosin heavy chain 1 Myosin heavy chain 2x Myosin heavy chain IIx/d Myosin heavy chain, skeletal muscle, adult 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
muscle contraction	IBA

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
muscle myosin complex	IDA	18310078
intercalated disc	IEA
myosin II complex	IBA
A band	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin complex [inference]

myosin II complex

muscle myosin complex

cellular anatomical entity [inference]

cytoplasm

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

A band

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular polymer [inference]

supramolecular fiber [inference]

myosin filament

Displaying **all 5** entries
GO Term	Evidence Code	PMID
microfilament motor activity	IBA
protein binding	IPI	25416956 32296183
calmodulin binding	IEA
ATP binding	IEA
actin filament binding	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microfilament motor activity

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
actin binding
actin filament binding
cytoskeletal motor activity
nucleotide binding

Displaying **all 7** entries
InterPro
IQ motif, EF-hand binding site
Kinesin motor domain superfamily
Myosin S1 fragment, N-terminal
Myosin head, motor domain
Myosin tail
Myosin, N-terminal, SH3-like
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **1 - 10** of **262** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4619	Xenbase:XB-GENE-989283
Saccharomyces cerevisiae S288C	4625	SGD:S000001065
Saccharomyces cerevisiae S288C	4627	SGD:S000001065
Saccharomyces cerevisiae S288C	4628	SGD:S000001065
Saccharomyces cerevisiae S288C	4629	SGD:S000001065
Danio rerio	8735	ZFIN:ZDB-GENE-081124-1
Mus musculus	17879	Xenbase:XB-GENE-989283	MOUSE05041
Xenopus tropicalis	17882	Xenbase:XB-GENE-989276
Danio rerio	17883	ZFIN:ZDB-GENE-081124-1
Xenopus tropicalis	17884	Xenbase:XB-GENE-989276

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Last updated: December 8, 2025