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MIRAGE
dual oxidase 2
Summary
- Gene Symbol
-
- DUOX2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Calcium
- Cell junction
- Cell membrane
- Congenital hypothyroidism
- Disease variant
- Disulfide bond
- FAD
- Glycoprotein
- Hydrogen peroxide
- Metal-binding
- NADP
- Reference proteome
- Repeat
- Signal
- Thyroid hormones biosynthesis
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9NRD8 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| superoxide anion generation | ||
| hydrogen peroxide catabolic process | ||
| hydrogen peroxide biosynthetic process | ||
| response to cAMP | ||
| response to cAMP |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| endoplasmic reticulum | ||
| cytosol | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| NAD(P)H oxidase H2O2-forming activity | ||
| superoxide-generating NAD(P)H oxidase activity | ||
| heme binding | ||
| NADH oxidase H202-forming activity | ||
| NADPH oxidase H202-forming activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- dual oxidase
- Functional Category
-
- P: Inorganic ion transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| calcium ion binding |
| cellular oxidant detoxification |
| heme binding |
| metal ion binding |
| oxidoreductase activity |
| response to oxidative stress |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050328 | congenital hypothyroidism | |
| DOID:0112189 | thyroid dyshormonogenesis 6 |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 33477 | Xenbase:XB-GENE-6047411 | ||
| 50506 | Xenbase:XB-GENE-6047411 | ||
| 53905 | Xenbase:XB-GENE-1005876 | ||
| 79107 | Xenbase:XB-GENE-6047411 | RATNO27559 | |
| 99439 | Xenbase:XB-GENE-1005876 | ||
| 171608 | Xenbase:XB-GENE-6047411 | ||
| 186188 | Xenbase:XB-GENE-6047411 | ||
| 214593 | MOUSE32874 | ||
| 266807 | Xenbase:XB-GENE-1005876 | ||
| 403719 | CANLF12476 |
