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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
tumor necrosis factor
Summary
- Gene Symbol
-
- TNF
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Cytokine
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Myristate
- Phosphoprotein
- Reference proteome
- Secreted
- Signal-anchor
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| microglial cell activation | ||
| response to L-glutamate | ||
| response to gold nanoparticle | ||
| positive regulation of amyloid-beta formation | ||
| positive regulation of leukocyte adhesion to vascular endothelial cell |
GO Hierarchy
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- regulation of membrane lipid metabolic process
- regulation of reactive oxygen species metabolic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of synaptic transmission
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of synaptic transmission
- positive regulation of action potential
- positive regulation of synaptic transmission
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of hair follicle development
- positive regulation of synaptic transmission
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- regulation of membrane lipid metabolic process
- regulation of reactive oxygen species metabolic process
- positive regulation of synaptic transmission
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of hair follicle development
biological process
immune system process [inference]
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of metabolic process
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of protein metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of nitrogen compound metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of phosphorus metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of amide metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of proteolysis [inference]
regulation of protein modification process [inference]
positive regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of RNA biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of protein metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of proteolysis [inference]
regulation of protein modification process [inference]
positive regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of lipid metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of proteolysis [inference]
regulation of protein modification process [inference]
positive regulation of protein metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
regulation of localization [inference]
regulation of transport [inference]
regulation of cellular localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of protein metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of nitrogen compound metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of protein localization [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of transport [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to external stimulus [inference]
regulation of inflammatory response [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
regulation of immune response [inference]
regulation of response to stress [inference]
regulation of defense response [inference]
regulation of developmental process [inference]
regulation of anatomical structure morphogenesis [inference]
regulation of cell differentiation [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of phosphorus metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of protein localization [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| recycling endosome | ||
| external side of plasma membrane | ||
| membrane |
|
|
| protein-containing complex |
|
|
| neuronal cell body |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| death receptor agonist activity | ||
| cytokine activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- tumor necrosis factor
- Functional Category
-
- H: Coenzyme transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| immune response |
| tumor necrosis factor receptor binding |
| InterPro |
|---|
| Tumour necrosis factor domain |
| Tumour necrosis factor-like domain superfamily |
| Tumour necrosis factor |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:9146 | visceral leishmaniasis | |
| DOID:9155 | mucocutaneous leishmaniasis | |
| DOID:9352 | type 2 diabetes mellitus | |
| DOID:9402 | epididymitis | |
| DOID:9408 | acute myocardial infarction | |
| DOID:9538 | multiple myeloma | |
| DOID:9563 | bronchiectasis | |
| DOID:9588 | encephalitis | |
| DOID:9743 | diabetic neuropathy | |
| DOID:9744 | type 1 diabetes mellitus |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 21926 | MGI:104798 | MOUSE20698 | ||
| 24835 | RGD:3876 | RATNO21568 | ||
| 397086 | PIGXX31150 | |||
| 403922 | CANLF02543 | |||
| 405785 | ZFIN:ZDB-GENE-050317-1 | |||
| 443540 | SHEEP10443 | |||
| 494186 | 9598_0:001c91 | PANTR37685 | ||
| 554167 | ZFIN:ZDB-GENE-050601-2 | |||
| 715467 | MACMU33860 | |||
| 100009088 | RABIT02187 |
