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cholesterol 25-hydroxylase

Summary

Gene Symbol

CH25H

Organism

Homo sapiens (human)

External Links

NCBI Gene

9023

HGNC

1907

KEGG Gene ID

hsa:9023

PubChem

9023

Alliance of Genome Resources

HGNC:1907

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Monooxygenase
Reference proteome
Sterol biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O95992	Cholesterol 25-monooxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cholesterol metabolic process	IBA IDA	33239446
negative regulation of fusion of virus membrane with host plasma membrane	IDA	32944968 33239446
sterol biosynthetic process	IBA
response to type I interferon	IDA	33239446
B cell chemotaxis	ISS

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

cellular process [inference]

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to type I interferon

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of small molecule metabolic process [inference]

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

negative regulation of viral process [inference]

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of viral process [inference]

negative regulation of viral process [inference]

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
cholesterol 25-hydroxylase activity	IDA ISS	32944968
C-4 methylsterol oxidase activity	IBA
iron ion binding	IEA
steroid hydroxylase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity

cholesterol 25-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

cholesterol 25-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

methylsterol

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 10** entries
Gene Ontology
C-4 methylsterol oxidase activity
C-5 sterol desaturase activity
cholesterol biosynthetic process via lathosterol
ergosterol biosynthetic process
iron ion binding
lipid biosynthetic process
oxidoreductase activity
sphingolipid biosynthetic process
sphingolipid delta-4 desaturase activity
sphingosine hydroxylase activity

Displaying 1 entry
InterPro
Fatty acid hydroxylase

KEGG BRITE Database

Orthology

K10223

Name

cholesterol 25-hydroxylase [EC:1.14.99.38]

References

9852097

Rhea

RHEA:21104

O₂ + cholesterol + AH₂

A + H₂O + 25-hydroxycholesterol

Enzyme

1.14.99.38

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001605
Gene Name: cholesterol 25-hydroxylase

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12642		MGI:1333869	MOUSE25396
Caenorhabditis elegans	185268		WB:WBGene00018036
Rattus norvegicus	309527		RGD:1310575	RATNO15977
Pan troglodytes	450584	9598_0:002ca2		PANTR01109
Danio rerio	494109		ZFIN:ZDB-GENE-041212-81	DANRE03735
Macaca mulatta	694532			MACMU46413
Saccharomyces cerevisiae S288C	851891		SGD:S000002705
Xenopus laevis	100037239		Xenbase:XB-GENE-961014
Equus caballus	100062138			HORSE15939
Ornithorhynchus anatinus	100078582			ORNAN17525