GlyCosmos Portal

Submissions

cholesterol 25-hydroxylase

Summary

Gene Symbol

CH25H

Organism

Homo sapiens (human)

External Links

NCBI Gene

9023

HGNC

1907

KEGG Gene ID

hsa:9023

PubChem

9023

Alliance of Genome Resources

HGNC:1907

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Monooxygenase
Reference proteome
Sterol biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O95992	Cholesterol 25-monooxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
lipid metabolic process	TAS	9852097
cholesterol metabolic process	IDA	33239446
cholesterol metabolic process	IBA
sterol biosynthetic process	IBA
response to type I interferon	IDA	33239446

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

cellular process [inference]

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to type I interferon

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of small molecule metabolic process [inference]

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

negative regulation of viral process [inference]

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of viral process [inference]

negative regulation of viral process [inference]

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
C-4 methylsterol oxidase activity	IBA
cholesterol 25-hydroxylase activity	ISS
cholesterol 25-hydroxylase activity	IDA	32944968
iron ion binding	IEA
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity

cholesterol 25-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

cholesterol 25-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cholesterol 25-hydroxylase

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 10** entries
Gene Ontology
C-4 methylsterol oxidase activity
C-5 sterol desaturase activity
cholesterol biosynthetic process via lathosterol
ergosterol biosynthetic process
iron ion binding
lipid biosynthetic process
oxidoreductase activity
sphingolipid biosynthetic process
sphingolipid delta-4 desaturase activity
sphingosine hydroxylase activity

Displaying 1 entry
InterPro
Fatty acid hydroxylase

KEGG BRITE Database

Orthology

K10223

Name

cholesterol 25-hydroxylase [EC:1.14.99.38]

References

9852097

Rhea

RHEA:21104

O₂ + cholesterol + AH₂

A + H₂O + 25-hydroxycholesterol

Enzyme

1.14.99.38

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001605
Gene Name: cholesterol 25-hydroxylase

Ortholog

Displaying entries **1 - 10** of 72 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9023	Xenbase:XB-GENE-961011
Mus musculus	12642	Xenbase:XB-GENE-961011	MOUSE25396
Xenopus tropicalis	185268	Xenbase:XB-GENE-961011
Rattus norvegicus	309527	Xenbase:XB-GENE-961011	RATNO15977
Saccharomyces cerevisiae S288C	336673	SGD:S000002705
Pan troglodytes	450584		PANTR01109
Danio rerio	494109		DANRE03735
Macaca mulatta	694532		MACMU46413
Saccharomyces cerevisiae S288C	798384	SGD:S000002705
Equus caballus	100062138		HORSE15939