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histone deacetylase 4
Summary
- Gene Symbol
-
- HDAC4
- Aliases
-
- HA6116
- HD4
- HDAC-4
- HDAC-A
- HDACA
- KIAA0288
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Chromatin regulator
- Coiled coil
- Cytoplasm
- Disease variant
- Epilepsy
- Hydrolase
- Intellectual disability
- Isopeptide bond
- Metal-binding
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repressor
- Transcription regulation
- Ubl conjugation
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A7I2SVS4 |
|
| P56524 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| negative regulation of transcription by RNA polymerase II | ||
| negative regulation of transcription by RNA polymerase II | ||
| chromatin remodeling | ||
| protein deacetylation |
GO Hierarchy
biological process
metabolic process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
negative regulation of cellular process [inference]
GO Hierarchy
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- histone deacetylase
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| histone deacetylase activity |
| InterPro |
|---|
| Histone deacetylase domain superfamily |
| Histone deacetylase domain |
| Histone deacetylase family |
| Ureohydrolase domain superfamily |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12704 | ataxia telangiectasia | |
| DOID:8466 | retinal degeneration | |
| DOID:8670 | eating disorder |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000003 | Multicystic kidney dysplasia |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000028 | Cryptorchidism |
| HP:0000126 | Hydronephrosis |
| HP:0000179 | Thick lower lip vermilion |
| HP:0000233 | Thin vermilion border |
| HP:0000248 | Brachycephaly |
| HP:0000252 | Microcephaly |
| HP:0000256 | Macrocephaly |
| HP:0000272 | Malar flattening |
| Disease ID | Disease Name |
|---|---|
| OMIM:619797 |
|
| ORPHA:1001 |
|
| OMIM:600430 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 9734 | FB:FBgn0041210 | ||
| 9759 | Xenbase:XB-GENE-488767 | ||
| 51564 | FB:FBgn0041210 | ||
| 181723 | Xenbase:XB-GENE-488767 | ||
| 208727 | Xenbase:XB-GENE-488767 | MOUSE29475 | |
| 363287 | RATNO42707 | ||
| 460060 | PANTR30176 | ||
| 517559 | BOVIN27448 | ||
| 607662 | CANLF10145 | ||
| 710797 | MACMU06288 |
ChIP-Atlas
- Target Genes
-
Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for HDAC4
Distance from TSS: ± 10 kb
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| abhydrolase domain containing 16B |
|
|
| fucosyltransferase 10 |
|
|
| solute carrier family 35 member B1 |
|
|
| mannosyl-oligosaccharide glucosidase |
|
|
| RAB11A, member RAS oncogene family |
|
|
| ectonucleotide pyrophosphatase/phosphodiesterase 3 |
|
|
| insulin receptor |
|
|
| decapping mRNA 1A |
|
|
| large 60S subunit nuclear export GTPase 1 |
|
|
| histone deacetylase 7 |
|
- Colocalization
-
Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for HDAC4
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| INO80 complex ATPase subunit |
|
|
| methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 |
|
|
| histone deacetylase 2 |
|
|
| decapping mRNA 1A |
|
|
| histone deacetylase 3 |
|
|
| MORC family CW-type zinc finger 2 |
|
|
| WRN helicase interacting protein 1 |
|
|
| histone deacetylase 4 |
|
|
| histone deacetylase 9 |
|
