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Interleukin-1 receptor-associated kinase-like 2

Summary

UniProt ID

O43187

Gene Symbol

IRAK2

Organism

Homo sapiens (human)

External Links

GlyGen: O43187
PubChem: O43187
The Human Metabolome Database: HMDBP09473
The O-GlcNAc Database: O43187

Annotation

Keyword

3D-structure
ATP-binding
Phosphoprotein
Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 10** of 14 in total

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GO Term
cellular response to lipopolysaccharide
canonical NF-kappaB signal transduction
positive regulation of NF-kappaB transcription factor activity
MyD88-dependent toll-like receptor signaling pathway
lipopolysaccharide-mediated signaling pathway
interleukin-1-mediated signaling pathway
Toll signaling pathway
negative regulation of NF-kappaB transcription factor activity
toll-like receptor 4 signaling pathway
response to interleukin-1

Displaying **all 5** entries
GO Term
nucleus
cytoplasm
plasma membrane
cytosol
endosome membrane

Displaying **all 6** entries
GO Term
protein homodimerization activity
protein heterodimerization activity
ATP binding
signaling adaptor activity
protein kinase activity
molecular adaptor activity

Annotation information from UniProt.

Sequence

MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDASSSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINEAKRKLMENILLYKEEKVDSIELFGP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 14 in total

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Pathway Name	Organism
IRAK2 mediated activation of TAK1 complex	Homo sapiens
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Homo sapiens
Interleukin-1 signaling	Homo sapiens
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	Homo sapiens
MyD88 cascade initiated on plasma membrane	Homo sapiens
MyD88 dependent cascade initiated on endosome	Homo sapiens
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Homo sapiens
NOD1/2 Signaling Pathway	Homo sapiens
SARS-CoV-1 activates/modulates innate immune responses	Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Homo sapiens