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MIRAGE
Platelet glycoprotein Ib alpha chain

Summary
UniProt ID
P07359
Gene Symbol
  • GP1BA
Gene ID
2811
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P07359
PubChem
P07359
The O-GlcNAc Database
P07359
RaftProt
P07359
Re-Glyco
P07359
Annotation
Keyword
  • 3D-structure
  • Bernard Soulier syndrome
  • Cell adhesion
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Leucine-rich repeat
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Signal
  • Sulfation
  • Transmembrane helix
  • von Willebrand disease
Gene Ontology (GO)
Displaying all 8 entries
GO Term
extracellular space
plasma membrane
membrane
extracellular matrix
external side of plasma membrane
cell surface
extracellular exosome
glycoprotein Ib-IX-V complex
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying 1 entry
GO Term
thrombin-activated receptor activity
Annotation information from UniProt.
Sequence
MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQTTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLSTVSIRYSGHSL
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 52 in total
Position Description PubMed ID GlyTouCan ID Source
37 N-linked (GlcNAc...) asparagine
129
130
175 N-linked (GlcNAc...) asparagine
308 O-linked (GalNAc...) threonine
316 O-linked (GalNAc...) threonine
320 O-linked (GalNAc...) threonine
321 O-linked (GalNAc...) threonine
328 O-linked (GalNAc...) serine
331 O-linked (GalNAc...) threonine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 8 entries
Pathway Name Organism
Defective F9 activation Homo sapiens
Defective binding of VWF variant to GPIb:IX:V Homo sapiens
Enhanced binding of GP1BA variant to VWF multimer:collagen Homo sapiens
GP1b-IX-V activation signalling Homo sapiens
Intrinsic Pathway of Fibrin Clot Formation Homo sapiens
Platelet Adhesion to exposed collagen Homo sapiens
Platelet Aggregation (Plug Formation) Homo sapiens
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Homo sapiens
Disease
Displaying all 5 entries
DO ID Disease Name Source
DOID:0050864 non-arteritic anterior ischemic optic neuropathy
DOID:0111056 platelet-type bleeding disorder 3
DOID:0111059 Bernard-Soulier syndrome type A2
DOID:2217 Bernard-Soulier syndrome
DOID:5844 myocardial infarction
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025