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cAMP-dependent protein kinase type I-alpha regulatory subunit

Summary

UniProt ID

P10644

Gene Symbol

PRKAR1A
PKR1
PRKAR1
TSE1

Organism

Homo sapiens (human)

External Links

GlyGen: P10644
PubChem: P10644
The Human Metabolome Database: HMDBP02560
The O-GlcNAc Database: P10644
RaftProt: P10644
O-GlcNAcAtlas: P10644

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Cushing syndrome
Direct protein sequencing
Disease variant
Disulfide bond
Phosphoprotein
Reference proteome
Repeat
cAMP-binding

Gene Ontology (GO)

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GO Term
negative regulation of cAMP-dependent protein kinase activity
adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of gene expression
cellular response to glucagon stimulus
positive regulation of insulin secretion
intracellular signal transduction
sarcomere organization
cardiac muscle cell proliferation
negative regulation of activated T cell proliferation
regulation of transcription by RNA polymerase II

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GO Term
membrane
neuromuscular junction
protein-containing complex
glutamatergic synapse
nucleotide-activated protein kinase complex
cytosol
plasma membrane raft
centrosome
multivesicular body
cAMP-dependent protein kinase complex

Displaying **all 6** entries
GO Term
cAMP-dependent protein kinase inhibitor activity
cAMP-dependent protein kinase regulator activity
cAMP binding
protein kinase A catalytic subunit binding
protein domain specific binding
ubiquitin protein ligase binding

Annotation information from UniProt.

Sequence

MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
124			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
ADORA2B mediated anti-inflammatory cytokines production	Homo sapiens
ALK mutants bind TKIs	Homo sapiens
CREB1 phosphorylation through the activation of Adenylate Cyclase	Homo sapiens
DARPP-32 events	Homo sapiens
FCGR3A-mediated IL10 synthesis	Homo sapiens
Factors involved in megakaryocyte development and platelet production	Homo sapiens
GPER1 signaling	Homo sapiens
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Homo sapiens
Hedgehog 'off' state	Homo sapiens
PKA activation	Homo sapiens