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cAMP-dependent protein kinase type I-alpha regulatory subunit

Summary

UniProt ID

P10644

Gene Symbol

PRKAR1A
PKR1
PRKAR1
TSE1

Organism

Homo sapiens (human)

External Links

GlyGen: P10644
PubChem: P10644
The Human Metabolome Database: HMDBP02560
The O-GlcNAc Database: P10644
RaftProt: P10644
O-GlcNAcAtlas: P10644

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Cushing syndrome
Direct protein sequencing
Disease variant
Disulfide bond
Phosphoprotein
Reference proteome
Repeat
cAMP-binding

Gene Ontology (GO)

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GO Term
negative regulation of gene expression
cellular response to glucagon stimulus
positive regulation of insulin secretion
intracellular signal transduction
sarcomere organization
cardiac muscle cell proliferation
negative regulation of activated T cell proliferation
regulation of transcription by RNA polymerase II
negative regulation of cAMP-dependent protein kinase activity
adenylate cyclase-activating G protein-coupled receptor signaling pathway

Displaying entries **11 - 13** of 13 in total

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GO Term
nucleotide-activated protein kinase complex
cytosol
plasma membrane raft

Displaying **all 6** entries
GO Term
protein domain specific binding
ubiquitin protein ligase binding
cAMP-dependent protein kinase inhibitor activity
cAMP-dependent protein kinase regulator activity
cAMP binding
protein kinase A catalytic subunit binding

Annotation information from UniProt.

Sequence

MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
124			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 13 in total

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Pathway Name	Organism
ADORA2B mediated anti-inflammatory cytokines production	Homo sapiens
ALK mutants bind TKIs	Homo sapiens
CREB1 phosphorylation through the activation of Adenylate Cyclase	Homo sapiens
DARPP-32 events	Homo sapiens
FCGR3A-mediated IL10 synthesis	Homo sapiens
Factors involved in megakaryocyte development and platelet production	Homo sapiens
GPER1 signaling	Homo sapiens
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Homo sapiens
Hedgehog 'off' state	Homo sapiens
PKA activation	Homo sapiens