PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
Database | Last Updated |
---|---|
Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding ▲ | PubMed ID |
---|---|---|---|---|---|---|---|
Botulinum neurotoxin (type C)
|
GD1b
|
Disialoglycosphingolipids
|
Presynaptic neuronal cells
|
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
Tetanus toxin
|
GD1b
|
Disialoglycosphingolipids
|
Brain membrane
|
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
BoNT/C (located within amino acid residues 1122-1290)
|
GD1b
|
Disialoglycosphingolipids
|
Presynaptic neuronal cells
|
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
Hemagglutinin (HA)
|
GD1a
|
Disialoglycosphingolipids
|
Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas)
|
NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
Unknown
|
GD1b
|
Disialoglycosphingolipids
|
Human brain
|
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
Unknown
|
GD1b
|
Disialoglycosphingolipids
|
Brain membrane
|
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
S-fimbriae (SfaA)
|
Seminolipid (Sulfogalactosylglycerolipid)
|
Glycolipids
|
Brain endothelial cells
|
Gal(3SO4)(b1-1)-alkylacylglycerol
|
Binding
|
||
S-fimbriae
|
Sialyl galactoside units of cell surface glycoproteins
|
Glycoproteins
|
Vascular endothelial/epithelial cells of the choroid plexus, Ependyma cells lining the brain ventricles
|
NeuAc(a2-3)Gal(b1-4)Glc
|
Binding
|
||
Unknown
|
Sialylated type 2 chain conjugates (S-type 2-HSA)
|
Glycoproteins
|
Human serum albumin
|
NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD
|
Binding
|
||
Unknown
|
Sialyl Lewis x (SLex-HSA)
|
Glycoproteins
|
Human serum albumin
|
NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD
|
Binding
|
GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.
Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01