GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **376 - 400** of **499** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Aurora/IPL1-related protein kinase 2 Cullin-1 MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 RING-box protein 1 Skp1-related protein Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	G5ECU1 O01427 O16368 O17071 O17586 O44156 O61742 O61792 O62102 O76371 O76577 P0CG71 P37165 P46502 P49632 P90868 P91477 Q04908 Q10920 Q17389 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q22253 Q23237 Q23449 Q23457 Q27488 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N599 Q9XTT9 Q9XUV0	C14C10.5 CELE_F35G12.12 air-2 cul-1 lin-19 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rbx-1 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 skr-1 stu-7 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Extra-nuclear estrogen signaling	EF-hand domain-containing protein EGF-like domain-containing protein EGF-like domain-containing protein Heat shock protein 90 Inactive tyrosine-protein kinase kin-32 Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Receptor tyrosine-protein kinase let-23 Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2 Sphingosine kinase 1 Striatin N-terminal domain-containing protein Tyrosine protein-kinase src-1	A0A486WY88 G5EDP9 G5EE56 G5EFK8 O44191 P24348 Q17941 Q18136 Q18425 Q18688 Q94125 Q95YD4 Q9XTG7	CELE_F14B4.1 aap-1 age-1 akt-1 akt-2 cal-5 cash-1 daf-21 kin-32 kin-7 let-23 rme-2 sphk-1 src-1 tag-274	Caenorhabditis elegans
Events associated with phagocytolytic activity of PMN cells	Peroxidasin homolog pxn-1 Peroxidasin homolog pxn-2	G5EG78 Q1ENI8	pxn-1 pxn-2	Caenorhabditis elegans
Estrogen-dependent gene expression	Cyclin-T1.1 Cyclin-T1.2 DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription factor IIF subunit 2 Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable cyclin-dependent kinase 9 RNA polymerase Rpb4/RPC9 core domain-containing protein Transcription initiation factor IIF subunit alpha	O02092 P16356 P34424 P34425 Q10578 Q17558 Q17684 Q19826 Q8MYM8 Q93338 Q965S0 Q9GR61 Q9N3C9 Q9N5K2 Q9TVL3 Q9U3I0 Q9XVH6	ama-1 cdk-9 cit-1.1 cit-1.2 gtf-2F1 gtf-2F2 gtf-2f1 gtf-2f2 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9	Caenorhabditis elegans
Erythrocytes take up oxygen and release carbon dioxide	Ammonium transporter AmtB-like domain-containing protein Anion exchange protein Carbonic anhydrase Putative carbonic anhydrase 3 Putative carbonic anhydrase 5	O02637 Q10462 Q22947 Q27504 Q58QG8	abts-4 cah-3 cah-5 cah-6 rhr-1	Caenorhabditis elegans
Erythrocytes take up carbon dioxide and release oxygen	Ammonium transporter AmtB-like domain-containing protein Anion exchange protein Carbonic anhydrase Putative carbonic anhydrase 3 Putative carbonic anhydrase 5	O02637 Q10462 Q22947 Q27504 Q58QG8	abts-4 cah-3 cah-5 cah-6 rhr-1	Caenorhabditis elegans
Ephrin signaling	Arf-GAP domain-containing protein Ephrin RBD domain-containing protein Ephrin RBD domain-containing protein Ephrin RBD domain-containing protein Ephrin receptor 1 Ephrin-4 Myosin regulatory light chain NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family Ras-related protein ced-10 SH2 domain-containing protein SH3 domain-containing protein Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase pak-1 Tyrosine protein-kinase src-1	G5EE56 G5EEE7 G5EGQ3 O44516 O61460 Q03206 Q09510 Q17850 Q19467 Q19475 Q21430 Q95PX0 Q95XA9 Q9U3M2	ced-10 efn-2 efn-3 efn-4 gap-3 git-1 mab-26 max-2 mlc-4 nck-1 pak-1 pix-1 rac-1 src-1 vab-1 vab-2	Caenorhabditis elegans
Energy dependent regulation of mTOR by LKB1-AMPK	5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 Association with the SNF1 complex (ASC) domain-containing protein Association with the SNF1 complex (ASC) domain-containing protein CBS domain-containing protein CBS domain-containing protein CBS domain-containing protein CBS domain-containing protein CBS domain-containing protein DAF-15 GTP-binding protein Rheb homolog 1 GTP-binding protein Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Protein phosphatase ppm-1.A Ragulator complex protein LAMTOR2 homolog Ras-related GTP-binding protein C Sodium-coupled neutral amino acid transporter 9 homolog Target of rapamycin complex subunit lst8 Target of rapamycin homolog	A0A1T5HUK9 G5EGB3 H2L0K0 O02168 O17268 P34443 P45894 P91040 Q19425 Q19775 Q22743 Q68TI8 Q8I112 Q8WQG5 Q95Q95 Q95ZQ4 Q9N2U6 Q9N501 Q9NAH7 Q9XUY2	CeTor F13H10.3 aak-1 aak-2 aakb-1 aakb-2 aakg-1 aakg-2 aakg-3 aakg-4 aakg-5 daf-15 let-363 lmtr-2 lmtr-3 lmtr-5 mlst-8 ppm-1.A raga-1 ragc-1 rheb-1	Caenorhabditis elegans
Endosomal Sorting Complex Required For Transport (ESCRT)	Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4b Charged multivesicular body protein 4b Charged multivesicular body protein 6 Charged multivesicular body protein 7 Hepatocyte growth factor-regulated tyrosine kinase substrate Multivesicular body subunit 12A Polyubiquitin-A Signal transducing adapter molecule 1 Tumor susceptibility gene 101 protein UBA domain-containing protein Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein VPS37 C-terminal domain-containing protein Vacuolar protein sorting-associated protein 28 homolog Vacuolar protein-sorting-associated protein 25 Vacuolar protein-sorting-associated protein 36 Vacuolar-sorting protein SNF8	O01498 O02208 O44158 O76258 P0CG71 P37165 P49632 Q17687 Q17796 Q18258 Q18886 Q19519 Q21959 Q22718 Q8WTK0 Q9BL60 Q9GYK4 Q9NA26 Q9U2F6 Q9U354	C01A2.4 CELE_R12C12.5 chmp-7 hgrs-1 mvb-12 pqn-19 spe-48 stam-1 tsg-101 ubia ubib ubl-1 ubq-1 ubq-2 vps-2 vps-20 vps-22 vps-24 vps-25 vps-28 vps-32.1 vps-36 vps-37	Caenorhabditis elegans
ERK/MAPK targets	Mitogen-activated protein kinase mpk-1 Mitogen-activated protein kinase pmk-1 Mitogen-activated protein kinase pmk-2 Mitogen-activated protein kinase pmk-3 Mitogen-activated protein kinase Probable serine/threonine-protein phosphatase PP2A regulatory subunit Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Putative ribosomal protein S6 kinase alpha-1 Putative ribosomal protein S6 kinase alpha-2 Serine/threonine protein phosphatase 2A regulatory subunit Serine/threonine-protein phosphatase 2A catalytic subunit	A9UJN4 G5EFV1 G5EGK8 H2KYF8 O44514 P39745 P91267 Q09543 Q17446 Q18846 Q21734 Q8MXI4 Q93344 Q9U3L3 Q9XX60 Q9XXC0	C49C3.10 CELE_F21F3.2 CELE_Y106G6D.4 CELE_Y106G6E.1 CELE_Y51B9A.9 gska-3 gskl-2 let-92 mpk-1 mpk-2 paa-1 pmk-1 pmk-2 pmk-3 pptr-2 rskn-1 rskn-2 sur-1	Caenorhabditis elegans
ERBB2 Regulates Cell Motility	EGF-like domain-containing protein EGF-like domain-containing protein FH2 domain-containing protein Protein memo-1 homolog Ras-like GTP-binding protein rhoA Receptor tyrosine-protein kinase let-23 WAPL domain-containing protein	G5EFK8 O44191 P24348 Q19479 Q22038 Q22915 Q7JP75	CELE_F14B4.1 cyk-1 inft-2 kin-7 let-23 memo-1 rho-1 rhoa rme-2 tag-253	Caenorhabditis elegans
ERBB2 Activates PTK6 Signaling	EGF-like domain-containing protein EGF-like domain-containing protein Protein kinase domain-containing protein Protein nipi-4 Receptor tyrosine-protein kinase let-23 Tyrosine-protein kinase	A0A4V0IL59 G5EFK8 O16262 O44191 P24348 Q9N3S5	CELE_F14B4.1 CELE_Y47G6A.5 kin-7 let-23 nipi-4 rme-2 trk-1	Caenorhabditis elegans
EPHB-mediated forward signaling	Actin-1 Actin-2 Actin-3 Actin-4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2/3 complex subunit Actin-related protein 2 Actin-related protein 3 CRAL-TRIO domain-containing protein Cell division control protein 42 homolog DH domain-containing protein DH domain-containing protein Inactive tyrosine-protein kinase kin-32 Intersectin-1 LITAF domain-containing protein NMDA-type ionotropic glutamate receptor NMR-2 Probable actin-related protein 2/3 complex subunit 2 Probable actin-related protein 2/3 complex subunit 3 Probable actin-related protein 2/3 complex subunit 4 Probable syndecan Ras protein let-60 Ras-like GTP-binding protein rhoA Ras-related protein ced-10 Rho-associated protein kinase let-502 Serine/threonine-protein kinase pak-1 Tyrosine protein-kinase src-1	A0A0K3AQN0 A0A0K3AS36 A0A3P6PCS5 G5EE56 G5EEH3 G5EGQ9 O01847 O61528 O61861 P0DM41 P0DM42 P10984 P10986 P22981 P50605 P53489 P58798 P92199 Q03206 Q05062 Q17850 Q22038 Q8WTM6 Q95YD4 Q9N4I0 Q9XWV3	CELE_Y105E8A.25 act-1 act-2 act-3 act-4 arp-2 arx-1 arx-2 arx-3 arx-4 arx-5 arx-6 arx-7 cdc-42 ced-10 itsn-1 kin-32 let-502 let-60 lin-34 nmr-1 nmr-2 pak-1 rac-1 rho-1 rhoa sdn-1 src-1 tiam-1 unc-73	Caenorhabditis elegans
EPH-ephrin mediated repulsion of cells	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Clathrin light chain DH domain-containing protein Dynamin Ephrin RBD domain-containing protein Ephrin RBD domain-containing protein Ephrin RBD domain-containing protein Ephrin receptor 1 Ephrin-4 Gamma-secretase subunit aph-1 Gamma-secretase subunit pen-2 MMP-like protein Matrix metalloproteinase-A Matrix metalloproteinase-B Matrix metalloproteinase-C Nicastrin Peptidase metallopeptidase domain-containing protein Presenilin sel-12 Probable clathrin heavy chain 1 Protein vav-1 Ras-related protein ced-10 Tyrosine protein-kinase src-1 Uncharacterized protein	G5EBU3 G5ECC4 G5EE56 G5EEE7 G5EGM1 O01847 O17913 O44516 O44836 O45876 O61460 P34574 P35603 P39055 P52166 P90961 Q03206 Q19123 Q19475 Q21182 Q22601 Q23316 Q45FX5 Q9N4F3 Q9U357 Q9U3M2	CELE_K03B8.6 ap50 apa-2 apb-1 aph-1 aph-2 aps-2 ced-10 chc-1 clic-1 dpy-23 dyn-1 efn-2 efn-3 efn-4 mab-26 pen-1 pen-2 rac-1 sel-12 src-1 tiam-1 vab-1 vab-2 vav-1 zmp-1 zmp-2 zmp-3 zmp-5 zmp-6	Caenorhabditis elegans
EPH-Ephrin signaling	Ephrin RBD domain-containing protein Ephrin RBD domain-containing protein Ephrin RBD domain-containing protein Ephrin receptor 1 Ephrin-4	G5EEE7 O44516 O61460 Q19475 Q9U3M2	efn-2 efn-3 efn-4 mab-26 vab-1 vab-2	Caenorhabditis elegans
EGFR downregulation	Cell division control protein 42 homolog E3 ubiquitin-protein ligase CBL EGF-like domain-containing protein EGF-like domain-containing protein EHS-1 ENTH domain-containing protein Endophilin-A homolog Hepatocyte growth factor-regulated tyrosine kinase substrate Polyubiquitin-A Receptor tyrosine-protein kinase let-23 SH3 domain-containing protein SH3 domain-containing protein Sex muscle abnormal protein 5 Signal transducing adapter molecule 1 Tyrosine-protein phosphatase 1 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	B1V8A0 G5EFK8 O01498 O44191 P0CG71 P24348 P28191 P29355 P37165 P49632 Q05062 Q17796 Q19019 Q21430 Q6A573 Q9BI71 Q9BIF4	CELE_F14B4.1 cdap-2 cdc-42 ehs-1 epn-1 hgrs-1 kin-7 let-23 pix-1 pqn-19 ptp-1 rme-2 sem-5 sli-1 stam-1 ubia ubib ubl-1 ubq-1 ubq-2 unc-57	Caenorhabditis elegans
EGFR Transactivation by Gastrin	MMP-like protein Matrix metalloproteinase-A Matrix metalloproteinase-B Matrix metalloproteinase-C Peptidase metallopeptidase domain-containing protein Protein kinase C-like 2 Ras protein let-60 Receptor tyrosine-protein kinase let-23 Sex muscle abnormal protein 5 Son of sevenless homolog Uncharacterized protein	G5EBU3 G5ECC4 G5EGM1 O17913 O44836 P22981 P24348 P29355 P90980 Q21182 Q9N5D3	CELE_K03B8.6 kin-11 kin-7 let-23 let-341 let-60 lin-34 pkc-2 sem-5 sos-1 zmp-1 zmp-2 zmp-3 zmp-5 zmp-6	Caenorhabditis elegans
ECM proteoglycans	Dystroglycan 1 Fibrinogen C-terminal domain-containing protein Fibrinogen C-terminal domain-containing protein Fibrinogen C-terminal domain-containing protein Fibronectin type-III domain-containing protein Ig-like domain-containing protein InTestinal NeureXin-like Integrin alpha ina-1 Integrin alpha pat-2 Integrin beta pat-3 Laminin G domain-containing protein SPARC Titin homolog Uncharacterized integrin beta-like protein C05D9.3	C6KRM7 G4SLH0 O45000 P34446 P34714 Q03600 Q18096 Q18705 Q22574 Q22629 Q27874 Q5ZR75 Q9GYK2 Q9XXE9	C05D9.3 C18E9.7 C49C8.5 CELE_T15B7.1 CELE_T19D12.6 CELE_Y43C5A.2 dgn-1 ina-1 itx-1 ost-1 pat-2 pat-3 rig-5 sparc ttn-1	Caenorhabditis elegans
Dual incision in TC-NER	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cullin-4 Cyclin-dependent kinase 7 DNA damage-binding protein 1 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 3 DNA polymerase epsilon catalytic subunit DNA polymerase epsilon subunit 3 DNA polymerase kappa DNA repair and recombination protein RAD54-like DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 ERCC1-like central domain-containing protein ERCC4 domain-containing protein General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 Intron-binding protein aquarius Polyubiquitin-A Pre-mRNA-processing factor 19 Pre-mRNA-splicing factor SYF1 Probable DNA polymerase delta small subunit Probable DNA polymerase epsilon subunit 2 Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable replication factor A 73 kDa subunit Probable replication factor C subunit 5 Proliferating cell nuclear antigen Protein isy-1 Putative transcription elongation factor S-II RING-box protein 1 RNA polymerase Rpb4/RPC9 core domain-containing protein RPA_C domain-containing protein Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 UV-stimulated scaffold protein A homolog Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein WD_REPEATS_REGION domain-containing protein XPA C-terminal domain-containing protein Zinc finger protein 830	G5EBZ1 G5EFV5 K8F7X5 O02092 O02115 O17245 O44175 O44499 O62218 P0CG71 P16356 P34409 P34429 P34567 P37165 P49632 P52652 P53016 P90829 P91175 P91356 Q09645 Q10051 Q10578 Q17392 Q17684 Q18547 Q18841 Q18963 Q19196 Q19366 Q19537 Q19826 Q20716 Q21302 Q21554 Q21730 Q22139 Q22798 Q23088 Q23457 Q7JKC3 Q86D18 Q93338 Q93456 Q95PZ4 Q965S0 Q9GR61 Q9N390 Q9N3C9 Q9N3L2 Q9N5K2 Q9U1Q7 Q9U3I0 Q9XVH6	CELE_F53H4.6 CELE_R04F11.3 CELE_T26A5.8 F10C2.4 F12F6.7 F44B9.8 T24H10.1 ama-1 cdk-7 csa-1 cul-4 ddb-1 emb-4 ercc-1 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2h1 gtf-2h3 isy-1 math-33 mnat-1 pcn-1 pole-1 pole-2 polk-1 prp-19 rbx-1 rfc-1 rfc-2 rfc-3 rfc-4 rpa-1 rpa-4 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 sel-13 syf-1 ubia ubib ubl-1 ubq-1 ubq-2 usp-7 uvs-1 xpa-1 xpb-1 xpd-1 xpf-1	Caenorhabditis elegans
Drug-mediated inhibition of MET activation	Kringle domain-containing protein Protein kinase domain-containing protein Tyrosine-protein kinase receptor svh-2	H2KZU7 P91823 Q9XVQ7	CELE_F11E6.8 CELE_T22A3.6 svh-2	Caenorhabditis elegans
Drug-mediated inhibition of ERBB2 signaling	Heat shock protein 90 Probable Hsp90 co-chaperone cdc37 Receptor tyrosine-protein kinase let-23	O02108 P24348 Q18688	cdc-37 daf-21 kin-7 let-23	Caenorhabditis elegans
Downstream signal transduction	Cell death abnormality protein 2 Discoidin domain-containing receptor tyrosine kinase B NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Platelet-derived growth factor (PDGF) family profile domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Ras protein let-60 SH2 domain-containing protein Sex muscle abnormal protein 5 Signal transducer and activator of transcription 1 Signal transducer and activator of transcription b Son of sevenless homolog Tyrosine protein-kinase src-1	A0A1I6CMA1 D3YT30 G5EDP9 G5EE56 P22981 P29355 Q20977 Q21046 Q94125 Q95PX0 Q95XA9 Q95ZV7 Q9N413 Q9N5D3 Q9NAD6 Q9NHC3	CELE_F59F5.3 CELE_T12G3.2 aap-1 age-1 ced-2 ddr-2 gap-3 kin-36 let-341 let-60 lin-34 nck-1 pvf-1 sem-5 sos-1 src-1 sta-1 sta-2 stat-b svh-4	Caenorhabditis elegans
Downregulation of TGF-beta receptor signaling	BMP-like protein unc-129 Cell surface receptor daf-1 Cell surface receptor daf-4 Dauer larva development regulatory growth factor daf-7 E3 ubiquitin-protein ligase CHIP Mothers against decapentaplegic homolog Polyubiquitin-A Protein dbl-1 Smad protein daf-8 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	G5EBY8 G5ECY6 G5EDS9 G5EEL5 P0CG71 P20792 P37165 P49632 P50488 P92172 Q21733	1G758 cet-1 chn-1 daf-1 daf-4 daf-7 daf-8 dbl-1 tag-68 ubia ubib ubl-1 ubq-1 ubq-2 unc-129	Caenorhabditis elegans
Downregulation of SMAD2/3:SMAD4 transcriptional activity	Dwarfin sma-4 E3 ubiquitin-protein ligase Histone deacetylase Homeobox domain-containing protein Homeobox protein ceh-60 Mitogen-activated protein kinase mpk-1 Polyubiquitin-A Probable sodium/potassium-transporting ATPase subunit beta-3 Protein phosphatase ppm-1.A Smad protein daf-8 Sodium/potassium-transporting ATPase subunit beta-1 Sodium/potassium-transporting ATPase subunit beta UBA domain-containing protein Ubiquitin-conjugating enzyme E2 2 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Uncharacterized protein T27F2.1	A0A061ACQ8 G5ECH0 G5EG81 P0CG71 P35129 P37165 P39745 P45897 P49632 Q17788 Q19775 Q21733 Q22836 Q45EK2 Q93235 Q9XUG9 Q9XUY5	CELE_T24B8.7 CELE_Y92H12A.2 T27F2.1 ceh-57 ceh-60 cem-3 daf-8 hda-3 let-70 mpk-1 nkb-1 nkb-2 nkb-3 ppm-1.A sma-4 sur-1 ubc-2 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Downregulation of ERBB4 signaling	E3 ubiquitin-protein ligase wwp-1 E3 ubiquitin-protein ligase Polyubiquitin-A Receptor tyrosine-protein kinase let-23 Tyrosine protein-kinase src-1 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A0A061ACQ8 G5EE56 P0CG71 P24348 P37165 P49632 Q9N2Z7	CELE_Y92H12A.2 kin-7 let-23 src-1 ubia ubib ubl-1 ubq-1 ubq-2 wwp-1	Caenorhabditis elegans

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