GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **401 - 425** of **499** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol	Organism
Cell surface interactions at the vascular wall	Fibronectin type-III domain-containing protein Golgi apparatus protein 1 homolog Integrin alpha pat-2 Sushi domain-containing protein Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 Uncharacterized integrin beta-like protein C05D9.3	A0A1N7SYP5 P34446 Q18096 Q18849 Q19459 Q9GYK2	C05D9.3 C18E9.7 C54G4.4 F14E5.2 cfh-1 pat-2	Caenorhabditis elegans
Platelet degranulation	Acetylcholine regulator unc-18 Actin-1 Actin-2 Actin-3 Actin-4 Alpha-actinin, sarcomeric Amyloid-beta-like protein Anaphase-promoting complex subunit 4-like WD40 domain-containing protein BMP-like protein unc-129 CYRIA/CYRIB Rac1 binding domain-containing protein Cadherin domain-containing protein Calponin-homology (CH) domain-containing protein Cathepsin F Cdc37 Hsp90 binding domain-containing protein Chitinase domain-containing protein 1 Cysteine proteinase Cysteine proteinase Dauer larva development regulatory growth factor daf-7 EF-hand domain-containing protein EGF-like domain-containing protein EGF-like domain-containing protein ELRR (Extracellular Leucine-Rich Repeat) ONly FERM domain-containing protein Fibronectin type-III domain-containing protein Fructose-bisphosphate aldolase 1 Fructose-bisphosphate aldolase 2 Hyaluronan/mRNA-binding protein domain-containing protein ILEI/PANDER domain-containing protein Ig-like and fibronectin type-III domain-containing protein 1 Ig-like and fibronectin type-III domain-containing protein 2 Ig-like and fibronectin type-III domain-containing protein C27B7.7 Ig-like domain-containing protein Ig-like domain-containing protein Integrin alpha pat-2 Integrin beta pat-3 Kringle domain-containing protein LAMP family protein lmp-1 Lipid droplet localized protein Lysosome-associated membrane glycoprotein 5 MICOS complex subunit MIC27 Mesencephalic astrocyte-derived neurotrophic factor homolog Multidrug resistance-associated protein lethal(2)03659 NTR domain-containing protein Obg-like ATPase 1 Papain family cysteine protease Pept_C1 domain-containing protein Pept_C1 domain-containing protein Peptidase C1A papain C-terminal domain-containing protein Peptidase C1A papain C-terminal domain-containing protein Peptidase C1A papain C-terminal domain-containing protein Peptidase C1A papain C-terminal domain-containing protein Peptidase C1A papain C-terminal domain-containing protein Phosphatase and actin regulator 2 Platelet-derived growth factor (PDGF) family profile domain-containing protein Probable Hsp90 co-chaperone cdc37 Protein dbl-1 Protein lin-49 Protein unc-112 Putative metalloproteinase inhibitor tag-225 Rab27 SCAVenger receptor (CD36 family) related SCAVenger receptor (CD36 family) related SCAVenger receptor (CD36 family) related SERPIN domain-containing protein SERPIN domain-containing protein SPARC Saposin B-type domain-containing protein Saposin B-type domain-containing protein Sensory neuron membrane protein 2 Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Sulfhydryl oxidase Superoxide dismutase [Cu-Zn] Sushi domain-containing protein Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 Syntaxin-binding protein 1 Tetraspanin Tetraspanin Thioredoxin domain-containing protein Torsin-like protein Torsin Torsin Tr-type G domain-containing protein Uncharacterized integrin beta-like protein C05D9.3 Uncharacterized protein C03F11.3 Uncharacterized protein R07B1.3 Vinculin	A0A1N7SYP5 A9Z1L1 G5EBM7 G5EBS5 G5EBY8 G5ECY2 G5EE40 G5EEL5 G5EFH4 G5EFK8 G5EGK1 H2KYR1 H2KZY5 H2L0F2 O01764 O02108 O16454 O17255 O17365 O17939 O18016 O18023 O44191 O44412 O45271 O45520 P0DM41 P0DM42 P10984 P10986 P19826 P34446 P34697 P34714 P34815 P46563 P54216 P91110 P91823 P91855 P91917 P92172 Q09387 Q09606 Q10651 Q11117 Q11124 Q17526 Q18096 Q18136 Q18245 Q18276 Q18279 Q18287 Q18607 Q18685 Q18740 Q18849 Q19140 Q19344 Q19625 Q19651 Q19663 Q20318 Q21154 Q21265 Q21267 Q21810 Q22174 Q23030 Q23158 Q27874 Q2AAB9 Q5F4U0 Q688B0 Q93539 Q95NU5 Q9BL26 Q9GYK0 Q9GYK2 Q9GZE9 Q9N3B0 Q9N413 Q9N4L6 Q9U2X1 Q9XTT3 Q9XVI4 Q9XVQ1 Q9XXG5 Q9XXQ7 U4PBJ9 U4PME4	C03F11.3 C05D9.3 C18E9.7 C27B7.7 C28G1.2 C32B5.13 C32B5.7 C54G4.4 CELE_F14B4.1 CELE_F15D3.4 CELE_F21C10.7 CELE_F26H9.2 CELE_F44G3.7 CELE_F47B7.2 CELE_K02E7.10 CELE_K07E8.6 CELE_R07E3.1 CELE_R07G3.8 CELE_R09F10.1 CELE_T22A3.6 CELE_Y113G7B.15 CELE_Y51A2D.8 CELE_Y71H2AM.25 CELE_Y71H2AR.2 CELE_ZK973.11 R07B1.3 act-1 act-2 act-3 act-4 aex-6 aipl-1 aldo-1 aldo-2 apl-1 atn-1 cal-5 cdc-37 cdh-10 cet-1 cfh-1 chil-10 daf-7 dbl-1 deb-1 famp-1 fln-1 igdb-1 igdb-2 iglr-1 lan-2 ldp-1 lin-49 lmp-1 lmp-2 lron-6 manf-1 moma-1 mrp-6 ola-1 ooc-5 ost-1 pat-2 pat-3 pvf-1 rab27 rme-2 scav-2 scav-3 scav-4 scav-6 slfl-5 sod-1 sparc spp-10 spp-8 srp-1 srp-2 srp-3 srp-6 srp-7 srp-8 tag-196 tag-210 tag-225 tag-329 timp-1 tln-1 tor-1 tor-2 tsp-11 tsp-7 unc-112 unc-129 unc-18 uncp-18 vig-1	Caenorhabditis elegans
COPI-mediated anterograde transport	ADP-ribosylation factor 1-like 1 ADP-ribosylation factor 1-like 2 ADP-ribosylation factor Actin-related protein 10 Actin Alpha-soluble NSF attachment protein BET1 Coatomer subunit alpha Coatomer subunit beta Coatomer subunit epsilon Conserved oligomeric Golgi complex subunit 1 Conserved oligomeric Golgi complex subunit 2 Conserved oligomeric Golgi complex subunit 3 Conserved oligomeric Golgi complex subunit 4 Conserved oligomeric Golgi complex subunit 5 Conserved oligomeric Golgi complex subunit 6 Conserved oligomeric Golgi complex subunit 8 DUF727 domain-containing protein Dynactin subunit 1 Dynactin subunit 4 Dynactin subunit 5 Dynactin subunit 6 Dynein heavy chain, cytoplasmic Dynein light chain 1, cytoplasmic Dynein light chain Dynein light chain Dynein light chain Dynein light chain Dynein light intermediate chain E3 ubiquitin-protein ligase arc-1 ER lumen protein-retaining receptor erd-2.1 ER lumen protein-retaining receptor erd-2.2 F-actin-capping protein subunit alpha F-actin-capping protein subunit beta GOLD domain-containing protein Gamma-soluble NSF attachment protein Golgi SNAP receptor complex member 1 Golgi SNAP receptor complex member 2 homolog memb-1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog Golgin subfamily A conserved domain-containing protein PDZ GRASP-type domain-containing protein Probable coatomer subunit beta' Probable coatomer subunit delta Probable coatomer subunit gamma Probable coatomer subunit zeta Probable dynactin subunit 2 Probable dynein light chain 2, cytoplasmic Putative syntaxin-5 RAB family Spectrin alpha chain Spectrin beta chain Spectrin beta chain Suppressor/enhancer of lin-12 protein 9 Sushi domain-containing protein Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 Transmembrane emp24 domain-containing protein bai Transmembrane protein 115 Uncharacterized protein C50C3.2 Uso1_p115_head domain-containing protein Vesicle-fusing ATPase WD_REPEATS_REGION domain-containing protein YKT6 (Yeast v-SNARE) homolog	A0A1N7SYP5 A0AAC1 E0AHA7 E2JKZ0 G5ED34 G5EE66 G5EEU1 G5EFK4 G5EFW3 G5EGG0 G5EGS5 O17528 O17901 O44502 O44738 O45087 O62246 P34367 P34685 P34686 P41941 P48583 P91151 Q09236 Q09248 Q09473 Q09654 Q10943 Q18194 Q18849 Q18921 Q19020 Q19989 Q1RPT8 Q20168 Q20546 Q20797 Q21270 Q21408 Q21444 Q21557 Q22498 Q22799 Q65XS9 Q6AW08 Q7YTJ8 Q94231 Q94392 Q95XZ0 Q95ZW1 Q9GYR2 Q9N3F1 Q9N3Y1 Q9N4H7 Q9N4I1 Q9NA98 Q9NEQ8 Q9TXZ9 Q9TYL9 Q9U3K1 Q9UAQ6 Q9XWA8	C50C3.2/C50C3.3 C54G4.4 CELE_F11A10.6 CELE_Y42H9AR.1 CELE_Y59A8B.25 CELE_Y59A8B.8 arc-1 arf-1 arf-1.1 arf-1.2 arf-3 arf-5 arl-4 arl-6 arp-1 arp-11 cap-1 cap-2 cfh-1 cgo-2 cog-2 cogc-1 cogc-2 cogc-3 cogc-4 cogc-5 cogc-6 cogc-8 copa-1 copb-1 copb-2 copd-1 cope-1 copg-1 copz-1 dhc-1 dlc-1 dlc-2 dlc-3 dlc-4 dlc-5 dlc-6 dli-1 dnc-1 dnc-2 dnc-4 dnc-5 dnc-6 dyci-1 erd-2 erd-2.1 erd-2.2 gbf-1 golg-2 gos-28 gosr-1 gosr-2.1 gs28 ldlc memb-1 nbet-1 nsf-1 phi-34 rab-1 sel-9 sma-1 snap-1 spc-1 syn-3 syx-5 tmed-10 tmed-3 unc-70 uso-1 ykt-6	Caenorhabditis elegans
RHOV GTPase cycle	Arf-GAP domain-containing protein CHp/Wrch Rho-like protein homolog Calponin-homology (CH) domain-containing protein Cell division control protein 42 homolog Ephrin receptor 1 GTPase-activating protein pac-1 Microtubule-actin cross-linking factor 1 NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family PDZ domain-containing protein Partitioning defective protein 6 Phosphoinositide 3-kinase adapter subunit Probable clathrin heavy chain 1 Protein kinase domain-containing protein Protein let-99 SH2 domain-containing protein SH3 domain-containing protein Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase pak-1 Serine/threonine-protein kinase pak-2 Spectrin alpha chain Spectrin beta chain Target of ERK kinase mpk-1 Thioredoxin-like protein Tropomyosin isoforms a/b/d/f UBA domain-containing protein Uncharacterized protein C09G1.4 Unconventional myosin-IXa-like Vang-like protein WW domain-containing protein tag-325	A0A1N7SYP3 E0AHA7 F0IWT2 G5EDP9 G5EES9 G5EFU0 G5EG81 G5EGQ3 H2KY90 H2KZH5 O17772 O61460 P34288 P34574 P46941 Q05062 Q17850 Q17865 Q19467 Q19739 Q20398 Q21341 Q21408 Q21430 Q22866 Q95PX0 Q95XA9 Q9NAC7 Q9NAN2	C09G1.4 CELE_T24B8.7 CELE_Y53F4B.1 aap-1 cdc-42 chc-1 chw-1 gap gap-3 git-1 hum-7 let-99 lev-11 magu-4 max-2 nck-1 pac-1 pak-1 pak-2 par-6 pes-7 pix-1 spc-1 tag-325 tmy-1 toe-2 txl txl-1 unc-70 vab-1 vab-10 vang-1	Caenorhabditis elegans
Regulation of KIT signaling	Discoidin domain-containing receptor tyrosine kinase B E3 ubiquitin-protein ligase CBL Protein kinase C-like 2 Protein kinase domain-containing protein Protein kinase domain-containing protein Sex muscle abnormal protein 5 Son of sevenless homolog	A0A1I6CMA1 P29355 P90980 Q19019 Q21046 Q95ZV7 Q9N5D3	CELE_F59F5.3 ddr-2 kin-11 kin-36 let-341 pkc-2 sem-5 sli-1 sos-1 svh-4	Caenorhabditis elegans
FLT3 Signaling	Discoidin domain-containing receptor tyrosine kinase B Forkhead box protein O Protein kinase domain-containing protein Protein kinase domain-containing protein Ras protein let-60 Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2 Sex muscle abnormal protein 5 Son of sevenless homolog	A0A1I6CMA1 O16850 P22981 P29355 Q17941 Q21046 Q95ZV7 Q9N5D3 Q9XTG7	CELE_F59F5.3 akt-1 akt-2 daf-16 ddr-2 kin-36 let-341 let-60 lin-34 sem-5 sos-1 svh-4	Caenorhabditis elegans
Signaling by PDGF	Discoidin domain-containing receptor tyrosine kinase B Furin-like protease kpc-1 Kringle domain-containing protein Platelet-derived growth factor (PDGF) family profile domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein	A0A1I6CMA1 G5EGU7 O01545 O17798 O76836 P91823 Q18048 Q21046 Q21394 Q95ZV7 Q9GZF5 Q9N413 Q9N5F6	C16E9.1 C18H7.1 C29A12.6 CELE_F31F7.2 CELE_F59F5.3 CELE_K09E2.1 CELE_R193.2 CELE_T19D12.4 CELE_T22A3.6 ddr-2 kin-36 kpc-1 pvf-1 svh-4	Caenorhabditis elegans
Signaling by SCF-KIT	Discoidin domain-containing receptor tyrosine kinase B Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Protein kinase domain-containing protein Protein kinase domain-containing protein Protein vav-1 Ras protein let-60 Ras-related protein ced-10 Sex muscle abnormal protein 5 Son of sevenless homolog	A0A1I6CMA1 G5EDP9 P22981 P29355 Q03206 Q21046 Q45FX5 Q94125 Q95ZV7 Q9N5D3	CELE_F59F5.3 aap-1 age-1 ced-10 ddr-2 kin-36 let-341 let-60 lin-34 rac-1 sem-5 sos-1 svh-4 vav-1	Caenorhabditis elegans
RAF/MAP kinase cascade	Discoidin domain-containing receptor tyrosine kinase B EGF-like domain-containing protein EGF-like domain-containing protein EGL-17 Glycoside hydrolase family 1 protein Glycoside hydrolase family 1 protein Inactive tyrosine-protein kinase kin-32 Kringle domain-containing protein Mitogen-activated protein kinase mpk-1 Myoblast growth factor receptor egl-15 Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Platelet-derived growth factor (PDGF) family profile domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein let-756 Ral guanine nucleotide dissociation stimulator-like 1 Rap guanine nucleotide exchange factor Ras guanyl-releasing protein 3 Ras protein let-60 Ras-GEF domain-containing family member 1B Receptor tyrosine-protein kinase let-23 Sex muscle abnormal protein 5 Son of sevenless homolog Spectrin alpha chain Spectrin beta chain Spectrin beta chain Tyrosine protein-kinase src-1 Tyrosine-protein kinase receptor svh-2 Tyrosine-protein phosphatase Lar-like Uncharacterized protein C50C3.2	A0A1I6CMA1 E0AHA7 G5EDB9 G5EDP9 G5EE56 G5EEF1 G5EFK8 G5EFW3 H2KZU7 O44191 P22981 P24348 P29355 P34367 P39745 P91823 Q10656 Q11184 Q18758 Q19770 Q19852 Q21046 Q21408 Q94125 Q95YD4 Q95ZV7 Q9BMN8 Q9N413 Q9N5D3 Q9TZA0 Q9XVQ7 W6RS10	C50C3.2/C50C3.3 CELE_F11E6.8 CELE_F14B4.1 CELE_F59F5.3 CELE_R05G6.10 CELE_T22A3.6 aap-1 age-1 ddr-2 egl-15 egl-17 kin-32 kin-36 kin-7 klo-1 klo-2 let-23 let-341 let-60 let-756 lin-34 mpk-1 ptp-3 pvf-1 pxf-1 ra-gef rgef-1 rgl-1 rme-2 sem-5 sma-1 sos-1 spc-1 src-1 sur-1 svh-2 svh-4 unc-70	Caenorhabditis elegans
Downstream signal transduction	Cell death abnormality protein 2 Discoidin domain-containing receptor tyrosine kinase B NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Platelet-derived growth factor (PDGF) family profile domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Ras protein let-60 SH2 domain-containing protein Sex muscle abnormal protein 5 Signal transducer and activator of transcription 1 Signal transducer and activator of transcription b Son of sevenless homolog Tyrosine protein-kinase src-1	A0A1I6CMA1 D3YT30 G5EDP9 G5EE56 P22981 P29355 Q20977 Q21046 Q94125 Q95PX0 Q95XA9 Q95ZV7 Q9N413 Q9N5D3 Q9NAD6 Q9NHC3	CELE_F59F5.3 CELE_T12G3.2 aap-1 age-1 ced-2 ddr-2 gap-3 kin-36 let-341 let-60 lin-34 nck-1 pvf-1 sem-5 sos-1 src-1 sta-1 sta-2 stat-b svh-4	Caenorhabditis elegans
Integrin cell surface interactions	Collagen alpha-1(IV) chain Collagen alpha-2(IV) chain Contactin rig-6 Discoidin domain-containing receptor tyrosine kinase B Fibronectin type-III domain-containing protein Ig-like domain-containing protein Integrin alpha ina-1 Integrin alpha pat-2 Integrin beta pat-3 Protein kinase domain-containing protein Protein kinase domain-containing protein Titin homolog Uncharacterized integrin beta-like protein C05D9.3	A0A1I6CMA1 C6KRM7 G4SLH0 H2KZ60 P17139 P17140 P34446 Q03600 Q18096 Q21046 Q27874 Q95ZV7 Q9GYK2	C05D9.3 C18E9.7 CELE_F59F5.3 clb-1 clb-2 ddr-2 emb-9 ina-1 kin-36 let-2 pat-2 pat-3 rig-5 rig-6 svh-4 ttn-1	Caenorhabditis elegans
VEGFA-VEGFR2 Pathway	BEN domain-containing protein Cell division control protein 42 homolog Discoidin domain-containing receptor tyrosine kinase B Heat shock protein 12.6 Heat shock protein Hsp-12.2 Heat shock protein Hsp-16.1/Hsp-16.11 Heat shock protein Hsp-16.41 Heat shock protein Hsp-16.48/Hsp-16.49 Heat shock protein hsp-16.2 Heat-shock protein 12.1 Inactive tyrosine-protein kinase kin-32 Integrin alpha pat-2 Integrin beta pat-3 MAP kinase-activated protein kinase mak-1 MAP kinase-activated protein kinase mak-2 Mitogen-activated protein kinase pmk-1 Mitogen-activated protein kinase pmk-2 Mitogen-activated protein kinase pmk-3 NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein vav-1 Ras-like GTP-binding protein rhoA Ras-related protein ced-10 Rho-associated protein kinase let-502 SH2 domain-containing protein SH2 domain-containing protein SHSP domain-containing protein SHSP domain-containing protein SHSP domain-containing protein SHSP domain-containing protein SHSP domain-containing protein SHSP domain-containing protein Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase pak-1 Stress-induced protein 1 Tyrosine protein-kinase src-1 Tyrosine-protein kinase receptor svh-2 Uncharacterized integrin beta-like protein C05D9.3 cAMP-dependent protein kinase catalytic subunit	A0A1I6CMA1 B0M0L8 G5EDP9 G5EE36 G5EE56 G5EE62 G5EE65 G5EF99 G5EFV1 G5EGQ3 H2KZU7 K8ESG0 O44514 P02513 P06581 P06582 P21137 P34328 P34446 P34696 P91267 P92199 Q03206 Q05062 Q17446 Q17850 Q19227 Q19228 Q20164 Q20363 Q20660 Q21046 Q21360 Q22038 Q27874 Q45FX5 Q8MXI4 Q93344 Q94125 Q95PX0 Q95XA9 Q95YD4 Q95ZV7 Q965G5 Q9GYK2 Q9U3L3 Q9XVQ7 Q9XX60 Q9XXC0	C05D9.3 C49C3.10 CELE_F08H9.3 CELE_F08H9.4 CELE_F11E6.8 CELE_F12F6.1 CELE_F13B12.6 CELE_F21F3.2 CELE_F59F5.3 CELE_Y106G6D.4 CELE_Y106G6E.1 CELE_Y51B9A.9 CELE_ZK1128.7 aap-1 age-1 cdc-42 ced-10 ddr-2 gap-3 gska-3 gskl-2 hsp-12.1 hsp-12.2 hsp-12.3 hsp-12.6 hsp-16 hsp-16.1 hsp-16.11 hsp-16.2 hsp-16.41 hsp-16.48 hsp-16.49 hsp-17 hsp-43 hsp12-2 hsp16-1a hsp16-1b hsp16-2 hsp16-41 hsp16-48 hsp16-48a hsp16-48b hsp16-49 kin-1 kin-32 kin-36 let-502 mak-1 mak-2 max-2 nck-1 pak-1 pat-2 pat-3 pmk-1 pmk-2 pmk-3 rac-1 rho-1 rhoa sip-1 src-1 svh-2 svh-4 vav-1	Caenorhabditis elegans
PI3K/AKT Signaling	Discoidin domain-containing receptor tyrosine kinase B EGF-like domain-containing protein EGF-like domain-containing protein EGL-17 Glycoside hydrolase family 1 protein Glycoside hydrolase family 1 protein Kringle domain-containing protein Myoblast growth factor receptor egl-15 Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Platelet-derived growth factor (PDGF) family profile domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein let-756 Protein nipi-3 RICTOR_N domain-containing protein Ras-related protein Rab-18 Ras-related protein ced-10 Ras-related protein rac-2 Receptor tyrosine-protein kinase let-23 Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2 Serine/threonine-protein kinase sgk-1 Sex muscle abnormal protein 5 Stress-activated map kinase-interacting protein 1 homolog Striatin N-terminal domain-containing protein Target of rapamycin complex subunit lst8 Target of rapamycin homolog Tyrosine protein-kinase src-1 Tyrosine-protein kinase receptor svh-2 non-specific serine/threonine protein kinase	A0A1I6CMA1 A0A486WY88 G5EDP9 G5EE56 G5EED4 G5EEF1 G5EFK8 G5EFN2 H2KZU7 O44191 P24348 P29355 P91040 P91823 Q03206 Q10656 Q11184 Q17941 Q18758 Q21046 Q2PJ68 Q94124 Q94125 Q95Q95 Q95ZV7 Q9BL44 Q9N413 Q9NA80 Q9TZA0 Q9UA62 Q9XTG7 Q9XVQ7	CELE_F11E6.8 CELE_F14B4.1 CELE_F59F5.3 CELE_T22A3.6 CELE_W04B5.5 CELE_Y71H2AM.12 CeTor aap-1 age-1 akt-1 akt-2 cash-1 ced-10 ddr-2 egl-15 egl-17 kin-36 kin-7 klo-1 klo-2 let-23 let-363 let-756 mlst-8 nipi-3 pvf-1 rac-1 rac-2 rict-1 rme-2 sem-5 sgk-1 sinh-1 src-1 svh-2 svh-4	Caenorhabditis elegans
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Discoidin domain-containing receptor tyrosine kinase B EGF-like domain-containing protein EGF-like domain-containing protein EGL-17 Glycoside hydrolase family 1 protein Glycoside hydrolase family 1 protein Kringle domain-containing protein Myoblast growth factor receptor egl-15 PIPK domain-containing protein PIPK domain-containing protein Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Platelet-derived growth factor (PDGF) family profile domain-containing protein Probable serine/threonine-protein phosphatase PP2A regulatory subunit Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein let-756 Ras-related protein Rab-18 Ras-related protein ced-10 Ras-related protein rac-2 Receptor tyrosine-protein kinase let-23 Serine/threonine protein phosphatase 2A regulatory subunit Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2 Serine/threonine-protein phosphatase 2A catalytic subunit Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1 Sex muscle abnormal protein 5 Striatin N-terminal domain-containing protein Tyrosine protein-kinase src-1 Tyrosine-protein kinase receptor svh-2	A0A1I6CMA1 A0A486WY88 A9UJN4 G5EDP9 G5EE56 G5EEF1 G5EFK8 G5EGK8 H2KZU7 O01759 O18178 O44191 P24348 P29355 P91823 Q03206 Q09543 Q10656 Q11184 Q17941 Q18758 Q21046 Q94124 Q94125 Q95ZV7 Q9BL44 Q9BL73 Q9N413 Q9TZA0 Q9XTG7 Q9XVQ7	CELE_F11E6.8 CELE_F14B4.1 CELE_F59F5.3 CELE_T22A3.6 CELE_Y71H2AM.12 aap-1 age-1 akt-1 akt-2 cash-1 ced-10 ddr-2 egl-15 egl-17 kin-36 kin-7 klo-1 klo-2 let-23 let-756 let-92 paa-1 ppk-1 ppk-2 pptr-1 pptr-2 pvf-1 rac-1 rac-2 rme-2 sem-5 src-1 svh-2 svh-4	Caenorhabditis elegans
LDL clearance	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Alpha/beta hydrolase fold-3 domain-containing protein Alpha/beta hydrolase fold-3 domain-containing protein Alpha/beta hydrolase fold-3 domain-containing protein Alpha/beta hydrolase fold-3 domain-containing protein Carboxylic ester hydrolase Clathrin light chain EGF-like domain-containing protein NPC intracellular cholesterol transporter 1 homolog 2 O-acyltransferase Probable clathrin heavy chain 1 Putative protein heh-1	A0A1C3NSL8 O17271 P34389 P34574 P35603 P90961 Q17498 Q19123 Q19839 Q22601 Q7JMM5 Q7JP80 Q94187 Q9N4F3 Q9XWL5	CELE_F16F9.4 CELE_T09B9.1 ap50 apa-2 apb-1 aps-2 cest-26 chc-1 clic-1 dpy-23 gldi-2 heh-1 mboa-1 nceh-1 ncr-2 npc-2 trcs-1	Caenorhabditis elegans
Synthesis of PC	Acetylcholinesterase 1 Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Casein kinase II subunit alpha Casein kinase II subunit beta Choline O-acetyltransferase Choline kinase A2 Choline kinase B1 Choline kinase B2 Choline transporter-like protein 1 Choline/EthanolaminePhosphoTransferase Choline/ethanolamine kinase Choline/ethanolamine kinase Choline/ethanolaminephosphotransferase 1-like Gut esterase 1 LNS2/PITP domain-containing protein Protein abhd-3.2 Putative choline kinase B3 Putative choline-phosphate cytidylyltransferase START domain-containing protein START domain-containing protein Serine aminopeptidase S33 domain-containing protein choline-phosphate cytidylyltransferase	A0A1C3NSL8 G5EC09 G5EC25 G5EDJ7 H2L0K7 H9G2Y9 O01302 O17610 O18155 P18334 P28548 P32756 P38433 P46558 P46559 P46560 P49583 P92016 Q04457 Q17764 Q18610 Q20026 Q21266 Q22008 Q22942 Q23268 Q4LDP0 Q8IU09 Q8MQ23 Q9GZF3 Q9U1Z6 Q9XW75 Q9XXT5	C06H2.2 CELE_T28D6.7 CELE_Y18H1A.11 F08C6.2 abhd-3.1 abhd-3.2 ace-1 cept-1 cept-2 cest-1 cest-1.1 cest-1.2 cest-12 cest-13 cest-16 cest-17 cest-19 cest-2.1 cest-2.2 cest-2.3 cest-24 cest-26 cha-1 chtl-1 cka-1 cka-2 ckb-1 ckb-2 ckb-3 ckb-4 ges-1 kin-10 kin-3 kin-5 lpin-1	Caenorhabditis elegans
Activation of G protein gated Potassium channels	G protein gamma domain-containing protein Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2 Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma IRK_C domain-containing protein Inward rectifier potassium channel irk-1 Inward rectifier potassium channel irk-1	A0A1C3NSK2 A0A1C3NSN6 G5ECB2 G5ECT6 H2L0Q3 P17343 P52192 P54406 Q20636	eat-11 gbb-1 gbb-2 gbp-2 gpb-1 gpb-2 gpc-1 gpc-2 irk-1 irk-2 irk-3 irk-4	Caenorhabditis elegans
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	G protein gamma domain-containing protein Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2 Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma IRK_C domain-containing protein Inward rectifier potassium channel irk-1 Inward rectifier potassium channel irk-1	A0A1C3NSK2 A0A1C3NSN6 G5ECB2 G5ECT6 H2L0Q3 P17343 P52192 P54406 Q20636	eat-11 gbb-1 gbb-2 gbp-2 gpb-1 gpb-2 gpc-1 gpc-2 irk-1 irk-2 irk-3 irk-4	Caenorhabditis elegans
Phase 4 - resting membrane potential	IRK_C domain-containing protein Inward rectifier potassium channel irk-1 Inward rectifier potassium channel irk-1 Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein Potassium channel domain-containing protein TWiK family of potassium channels protein 18 Two pore potassium channel protein sup-9 Two pore potassium channel protein sup-9 Two pore potassium channel protein sup-9 Uncharacterized protein B0310.1	A0A1C3NSK2 A0A1C3NSN6 A1EHR5 F5GUD1 G5EBQ2 G5ECW6 G5EG92 G5EGD4 H2KZ66 O17185 O45422 O45891 O45894 P52192 Q10937 Q18120 Q21467 Q22042 Q22043 Q23297 Q65XY3 Q6BES3 Q6EUT8 Q9BL31 Q9NEV3 Q9XTV6 U4PFA8	B0310.1 irk-1 irk-2 irk-3 irk-4 sup-9 twk-1 twk-11 twk-14 twk-18 twk-20 twk-21 twk-22 twk-24 twk-25 twk-26 twk-31 twk-33 twk-34 twk-35 twk-36 twk-39 twk-42 twk-44 twk-45 twk-46 twk-49 twk-8	Caenorhabditis elegans
RNA Polymerase II Transcription Termination	C2H2-type domain-containing protein Chromatin target of PRMT1 protein C-terminal domain-containing protein Cleavage and polyadenylation specificity factor subunit 3 Cleavage and polyadenylation specificity factor subunit 4 Cleavage and polyadenylation specificity factor subunit 5 Cleavage stimulation factor 50 kDa subunit DUF3453 domain-containing protein Death domain-containing protein Histone RNA hairpin-binding protein Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 PWI domain-containing protein Poly(A) polymerase Polyadenylation and cleavage factor homolog 11 Pre-mRNA 3'-end-processing factor FIP1 Pre-mRNA-splicing factor SLU7 Probable cleavage and polyadenylation specificity factor subunit 1 Probable cleavage and polyadenylation specificity factor subunit 2 Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 Probable small nuclear ribonucleoprotein E Probable small nuclear ribonucleoprotein F Probable small nuclear ribonucleoprotein G Probable small nuclear ribonucleoprotein-associated protein B Probable splicing factor, arginine/serine-rich 2 Probable splicing factor, arginine/serine-rich 3 Probable splicing factor, arginine/serine-rich 4 Probable splicing factor, arginine/serine-rich 6 Probable splicing factor, arginine/serine-rich 7 Protein CASC3 Protein clpf-1 Protein mago nashi homolog RNA helicase RNA-binding protein rnp-4 RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein SAP domain-containing protein Sm domain-containing protein Sm domain-containing protein Small nuclear ribonucleoprotein Sm D3 Spliceosome RNA helicase DDX39B homolog Splicing factor U2AF 35 kDa subunit Splicing factor U2AF 65 kDa subunit Suppressor of forked domain-containing protein THO complex subunit 2 THO complex subunit 5 THO complex subunit 7 homolog UPF3 domain-containing protein WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein pre-mRNA 3' end processing protein pfs-2	A0A164D3G3 C1P629 C2BR94 G5EDE4 O01159 O01763 O16929 O17403 O18219 O44729 O45577 O62185 P34498 P34659 P49029 P52874 P90978 P91867 P91918 Q09345 Q09511 Q09599 Q17348 Q18033 Q18212 Q18409 Q19864 Q19866 Q21155 Q21278 Q21559 Q21832 Q23120 Q7YTG9 Q7YWY5 Q8WQF3 Q93233 Q93594 Q93716 Q95PY8 Q9BL61 Q9GYQ8 Q9N3G0 Q9N4C2 Q9N4G9 Q9N5E3 Q9NEW6 Q9U2P3 Q9U2U0 Q9U3S3 Q9XTU6 U4PCM1 V6CKC3	C49H3.4 CELE_K07A1.15 CELE_Y53G8AR.6 CELE_Y57G11A.5 K07C5.6 RBM8 Y14 aly-3 casc-3 cbp-20 cbp-80 cdl-1 cfim-1 cfim-2 clpf-1 cpf-1 cpf-2 cpsf-1 cpsf-2 cpsf-3 cpsf-4 eif-4A3 fipp-1 hel-1 mag-1 mog-1 ncbp-1 ncbp-2 pabp-2 pap-1 pcf-11 pfs-2 prp-17 rnp-4 rnp-5 rsp-2 rsp-3 rsp-4 rsp-6 rsp-7 rsr-1 smg-4 snr-1 snr-2 snr-5 snr-6 snr-7 srp-1 srp-2 srp-4 suf-1 symk-1 thoc-1 thoc-2 thoc-3 thoc-5 thoc-7 uaf-1 uaf-2 znf-236	Caenorhabditis elegans
Processing of Capped Intron-Containing Pre-mRNA	B30.2/SPRY domain-containing protein CSD domain-containing protein CSD domain-containing protein CSD domain-containing protein CSD domain-containing protein Cleavage and polyadenylation specificity factor subunit 3 Cleavage and polyadenylation specificity factor subunit 4 Cleavage and polyadenylation specificity factor subunit 5 Cleavage stimulation factor 50 kDa subunit DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 DUF3453 domain-containing protein General transcription factor IIF subunit 2 Heterogeneous nuclear ribonucleoprotein A1 Heterogeneous nuclear ribonucleoprotein K homolog K Homology domain-containing protein Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Poly(A) polymerase Polyadenylation and cleavage factor homolog 11 Pre-mRNA 3'-end-processing factor FIP1 Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable cleavage and polyadenylation specificity factor subunit 1 Probable cleavage and polyadenylation specificity factor subunit 2 Probable splicing factor, arginine/serine-rich 2 Probable splicing factor, arginine/serine-rich 3 Probable splicing factor, arginine/serine-rich 4 Probable splicing factor, arginine/serine-rich 6 Probable splicing factor, arginine/serine-rich 7 Protein clpf-1 Putative RNA-binding protein PTB-1a Putative RNA-binding protein R05D3.8 RNA polymerase Rpb4/RPC9 core domain-containing protein RNA-binding protein 5 RNA-binding protein FUS RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein Schlafen-like protein 2 Suppressor of forked domain-containing protein Transcription initiation factor IIF subunit alpha pre-mRNA 3' end processing protein pfs-2	A0A164D3G3 B9WRU1 C1P629 D0G911 G5EDV3 O01159 O01763 O02092 O16929 O17403 O18219 O45577 O62213 P16356 P34541 P52874 P91277 P91306 P91398 Q09345 Q09511 Q10578 Q17558 Q17684 Q18265 Q18409 Q18999 Q19614 Q19826 Q19864 Q19866 Q22037 Q23120 Q4W5P0 Q7YTG9 Q8MXR2 Q8MYM8 Q93233 Q93338 Q93594 Q93716 Q95PY8 Q95QR5 Q95Y67 Q965S0 Q9BIB7 Q9BIC2 Q9GR61 Q9N3C9 Q9N4C2 Q9N5K2 Q9NEW6 Q9NLD1 Q9U2P3 Q9U3I0 Q9XTZ2 Q9XVH6 U4PCM1	CELE_Y57G11A.5 CELE_ZK616.1 R05D3.8 ama-1 cbp-20 cbp-80 cey-1 cey-2 cey-3 cey-4 cfim-1 cfim-2 clpf-1 cpf-1 cpf-2 cpsf-1 cpsf-2 cpsf-3 cpsf-4 fipp-1 fust-1 gtf-2F1 gtf-2F2 gtf-2f1 gtf-2f2 hrp-1 hrp-2 hrpf-1 hrpf-2 hrpk-1 hrpl-1 hrpr-1 hrpu-1 ncbp-1 ncbp-2 pabp-2 pap-1 pcf-11 pes-4 pfs-2 ptb-1 rbm-5 rbp-1 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 rsp-2 rsp-3 rsp-4 rsp-6 rsp-7 rsp-8 sqd-1 srp-1 srp-2 srp-4 suf-1 symk-1 tofu-2	Caenorhabditis elegans
CDK-mediated phosphorylation and removal of Cdc6	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 BRCT domain-containing protein Cell division control protein Cyclin-dependent kinase 2 G1/S-specific cyclin-E G2/mitotic-specific cyclin-A1 GNAT family N-acetyltransferase MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A0A131MD44 O01501 O16368 O17071 O17586 O44156 O61742 O61792 O61847 O62102 O76371 O76577 P0CG71 P34638 P37165 P46502 P49632 P90868 P91155 P91477 Q04908 Q10920 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q22253 Q22319 Q23237 Q23449 Q27488 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N599 Q9XTT9 Q9XUV0	C14C10.5 CELE_F35G12.12 CELE_T07F10.5 CELE_T24A6.1 cdc-6 cdk-2 cya-1 cye-1 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Cyclin A:Cdk2-associated events at S phase entry	BRCT domain-containing protein Cyclin-dependent kinase 2 Cyclin-dependent kinase inhibitor G2/mitotic-specific cyclin-A1 GNAT family N-acetyltransferase M-phase inducer phosphatase cdc-25.1 M-phase inducer phosphatase cdc-25.2 M-phase inducer phosphatase cdc-25.3 M-phase inducer phosphatase Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2	A0A131MD44 G5EEJ2 O44552 O44628 O61847 P30634 P34638 Q17941 Q21762 Q22319 Q9XTG7	CELE_T07F10.5 CELE_T24A6.1 akt-1 akt-2 cdc-25.1 cdc-25.2 cdc-25.3 cdc-25.4 cdk-2 cki-2 cya-1	Caenorhabditis elegans
p53-Dependent G1 DNA Damage Response	BRCT domain-containing protein Cyclin-dependent kinase 2 Cyclin-dependent kinase inhibitor G1/S-specific cyclin-E G2/mitotic-specific cyclin-A1 GNAT family N-acetyltransferase	A0A131MD44 G5EEJ2 O01501 O61847 P34638 Q22319	CELE_T07F10.5 CELE_T24A6.1 cdk-2 cki-2 cya-1 cye-1	Caenorhabditis elegans
DNA Damage/Telomere Stress Induced Senescence	BRCT domain-containing protein Cyclin-dependent kinase 2 Cyclin-dependent kinase inhibitor G1/S-specific cyclin-E G2/mitotic-specific cyclin-A1 GNAT family N-acetyltransferase	A0A131MD44 G5EEJ2 O01501 O61847 P34638 Q22319	CELE_T07F10.5 CELE_T24A6.1 cdk-2 cki-2 cya-1 cye-1	Caenorhabditis elegans

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