GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **426 - 450** of **499** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol	Organism
Orc1 removal from chromatin	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 BRCT domain-containing protein CDT1 Geminin-binding domain-containing protein Cell division control protein Cullin-1 Cyclin-dependent kinase 2 DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM7 DNA replication licensing factor mcm-4 DNA replication licensing factor mcm-5 DNA replication licensing factor mcm-6 F-box domain-containing protein G2/mitotic-specific cyclin-A1 GNAT family N-acetyltransferase MPN domain-containing protein ORC (Origin Recognition Complex) subunit Origin recognition complex subunit 1 Origin recognition complex subunit 2 Origin recognition complex subunit 5 C-terminal domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 RING-box protein 1 Skp1-related protein Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A0A131MD44 G5ECU1 O16297 O16368 O17071 O17586 O44156 O61742 O61792 O61847 O62102 O76371 O76577 P0CG71 P34638 P34647 P37165 P46502 P49632 P90868 P91155 P91477 Q04908 Q09397 Q10920 Q17389 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q21037 Q21902 Q22253 Q22319 Q23237 Q23249 Q23449 Q23457 Q27488 Q86S68 Q95005 Q95008 Q95PZ7 Q95XQ8 Q966I8 Q9GZH5 Q9N599 Q9XTT9 Q9XUV0 Q9XVR7 Q9XX16 Q9XX17 Q9XXI9	C14C10.5 CELE_F35G12.12 CELE_T07F10.5 CELE_T24A6.1 MCM7 cdc-6 cdk-2 cdt-1 cul-1 cya-1 let-358 lin-19 lin-6 mcm-2 mcm-3 mcm-4 mcm-5 mcm-6 mcm-7 orc-1 orc-2 orc-4 orc-5 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rbx-1 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 skpt-1 skr-1 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
SCF(Skp2)-mediated degradation of p27/p21	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 BRCT domain-containing protein Cullin-1 Cyclin-dependent kinase 2 Cyclin-dependent kinase inhibitor Cyclin-dependent kinases regulatory subunit F-box domain-containing protein G1/S-specific cyclin-E G2/mitotic-specific cyclin-A1 GNAT family N-acetyltransferase MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Skp1-related protein Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A0A131MD44 G5ECU1 G5EEJ2 O01501 O16368 O17071 O17586 O44156 O61742 O61792 O61847 O62102 O76371 O76577 P0CG71 P34638 P37165 P46502 P49632 P90868 P91477 Q04908 Q09397 Q10920 Q17389 Q17868 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q22253 Q22319 Q23237 Q23449 Q27488 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N599 Q9XTT9 Q9XUV0	CELE_F35G12.12 CELE_T07F10.5 CELE_T24A6.1 cdk-2 cki-2 cks-1 cul-1 cya-1 cye-1 dom-6 lin-19 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 skpt-1 skr-1 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Ub-specific processing proteases	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 BRCT domain-containing protein CAAX prenyl protease 2 homolog Dicer-related helicase Dwarfin sma-2 Dwarfin sma-3 Dwarfin sma-4 Forkhead box protein O G2/mitotic-specific cyclin-A1 GNAT family N-acetyltransferase Helicase ATP-binding domain-containing protein Histone H2A Histone H2A Histone H2A Hypoxia-inducible factor 1 Insulin-degrading enzyme M-phase inducer phosphatase cdc-25.1 M-phase inducer phosphatase cdc-25.2 M-phase inducer phosphatase cdc-25.3 M-phase inducer phosphatase MPN domain-containing protein Mitochondrial Rho GTPase 1 Mitochondrial import receptor subunit TOM20 homolog Mitochondrial import receptor subunit tomm-70 PCI domain-containing protein Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18 Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Probable peptidyl-tRNA hydrolase 2 Probable ubiquitin carboxyl-terminal hydrolase K02C4.3 Probable voltage-dependent anion-selective channel Proteasomal ubiquitin receptor ADRM1 homolog Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Protein kinase domain-containing protein RING-type domain-containing protein RuvB-like 1 Smad protein daf-8 Smad-related protein daf-14 UBA domain-containing protein USP domain-containing protein Ubiquitin carboxyl-terminal hydrolase 14 Ubiquitin carboxyl-terminal hydrolase 36 Ubiquitin carboxyl-terminal hydrolase 46 Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein WD repeat-containing protein 20 homolog WD repeat-containing protein 48 homolog WD repeat-containing protein fzy-1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A131MD44 A0A4V0IKF7 D9N129 F5GUE5 G5EBW2 G5EDI8 G5EE01 G5EEP3 G5EG81 G5EGD2 H2L010 O01467 O16249 O16368 O16850 O17071 O17586 O17607 O44156 O44552 O44624 O44628 O61742 O61792 O62102 O76371 O76387 O76577 P09588 P0CG71 P30634 P34547 P34638 P37165 P45896 P45897 P46502 P49632 P90868 P91477 Q02330 Q02335 Q04908 Q09289 Q09373 Q09931 Q10920 Q17361 Q17971 Q18115 Q18787 Q19132 Q19324 Q19766 Q20058 Q20059 Q20585 Q20938 Q21733 Q21752 Q21762 Q22253 Q22319 Q23237 Q23429 Q23449 Q27485 Q27488 Q7JKC3 Q7JMS4 Q93413 Q93875 Q94263 Q95005 Q95008 Q95PZ7 Q966I8 Q9BKQ6 Q9GRV2 Q9GZH5 Q9N599 Q9NAC7 Q9XTT9 Q9XUV0 V6CJY2	C04E6.5 C14C10.5 C24G6.8 CELE_F07A11.4 CELE_F35B3.3 CELE_F35G12.12 CELE_F44E7.4 CELE_T07F10.5 CELE_T22F3.2 CELE_T24A6.1 CELE_T24B8.7 CELE_Y53F4B.1 CELE_Y67D2.2 K02C4.3 cdc-25.1 cdc-25.2 cdc-25.3 cdc-25.4 cem-1 cem-2 cem-3 cya-1 cyld-1 daf-14 daf-16 daf-18 daf-8 drh-1 drh-3 exc-14 fce-2 fzy-1 hif-1 his-12 his-16 his-19 his-21 his-3 his-30 his-33 his-35 his-43 his-47 his-51 his-53 his-57 his-61 his-65 his-68 his-7 htas-1 math-33 miro-1 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rpn-1 rpn-10 rpn-11 rpn-12 rpn-13 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 ruvb-1 sma-2 sma-3 sma-4 tgt-1 tomm-20 tomm-70 ubia ubib ubl-1 ubq-1 ubq-2 usp-14 usp-3 usp-33 usp-4 usp-46 usp-50 usp-7 vdac-1 wdr-20 wdr-48	Caenorhabditis elegans
Physiological factors	Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Gut esterase 1 NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family Neprilysin-11 Neprilysin-1 Neprilysin-21 Neprilysin-2 Neprilysin Neprilysin Neprilysin Neprilysin Neprilysin Peptidase M13 C-terminal domain-containing protein Peptidase M13 C-terminal domain-containing protein Peptidase M13 N-terminal domain-containing protein Peptidase_M13 domain-containing protein Peptidase_M13 domain-containing protein Peptidase_M13_N domain-containing protein	A0A131MCS3 A0A1C3NSL8 A0A5S9MNU9 G5ED52 G5EDJ7 H2KYL1 H2KZE5 H2L0K7 H9G2Y9 O01302 O16607 O16636 O16652 O16789 O16790 O16795 O16796 O44857 O45311 O45569 P92016 Q04457 Q18673 Q21266 Q22008 Q22523 Q22763 Q23268 Q23427 Q400M1 Q4LDP0 Q8MQ23 Q9U2T0 Q9U2T1 Q9XW75	CELE_F41C6.4 cest-1 cest-1.1 cest-1.2 cest-12 cest-13 cest-16 cest-17 cest-19 cest-2.1 cest-2.2 cest-2.3 cest-24 cest-26 ges-1 nep-1 nep-10 nep-11 nep-12 nep-13 nep-16 nep-17 nep-18 nep-2 nep-20 nep-21 nep-22 nep-23 nep-24 nep-25 nep-26 nep-3 nep-4 nep-6 nep-8 nep-9	Caenorhabditis elegans
Metabolism of Angiotensinogen to Angiotensins	Aminopeptidase-like protein AC3.5 Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Aspartic protease 10 Aspartic protease 17 Aspartic protease 1 Aspartic protease 3 Aspartic protease 4 Aspartic protease 6 Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Cathepsin Z-1 Gut esterase 1 Inactive angiotensin-converting enzyme-related protein NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family Neprilysin-11 Neprilysin-1 Neprilysin-21 Neprilysin-2 Neprilysin Neprilysin Neprilysin Neprilysin Neprilysin Peptidase A1 domain-containing protein Peptidase A1 domain-containing protein Peptidase A1 domain-containing protein Peptidase A1 domain-containing protein Peptidase A1 domain-containing protein Peptidase A1 domain-containing protein Peptidase A1 domain-containing protein Peptidase A1 domain-containing protein Peptidase A1 domain-containing protein Peptidase A1 domain-containing protein Peptidase A1 domain-containing protein Peptidase A1 domain-containing protein Peptidase M13 C-terminal domain-containing protein Peptidase M13 C-terminal domain-containing protein Peptidase M13 N-terminal domain-containing protein Peptidase M14 carboxypeptidase A domain-containing protein Peptidase M14 carboxypeptidase A domain-containing protein Peptidase M14 carboxypeptidase A domain-containing protein Peptidase M14 carboxypeptidase A domain-containing protein Peptidase_M1 domain-containing protein Peptidase_M13 domain-containing protein Peptidase_M13 domain-containing protein Peptidase_M13_N domain-containing protein Puromycin-sensitive aminopeptidase Putative aminopeptidase-2 Putative carboxypeptidase suro-1 SERPIN domain-containing protein SERPIN domain-containing protein Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein ShKT domain-containing protein ShKT domain-containing protein ShKT domain-containing protein Vacuolar H ATPase	A0A131MCS3 A0A1C3NSL8 A0A5S9MNU9 A5A631 A9Z1L1 G3MU29 G5EC01 G5EC13 G5EC96 G5ECY2 G5ED52 G5EDJ7 G5EE40 G5EEI4 G5EFH4 G5EGH4 G5EGP8 H2KYL1 H2KZE5 H2L0K5 H2L0K7 H2L0M5 H9G2Y9 O01302 O01530 O01531 O01532 O16338 O16339 O16607 O16636 O16652 O16789 O16790 O16795 O16796 O17365 O44857 O45072 O45311 O45520 O45569 P55956 P92016 Q04457 Q17405 Q18020 Q18287 Q18581 Q18673 Q19651 Q21266 Q21966 Q22008 Q22317 Q22523 Q22531 Q22763 Q22972 Q23268 Q23427 Q400M1 Q4LDP0 Q4TT88 Q6A577 Q7JKL9 Q86NE0 Q8MQ23 Q8MYN5 Q8MYN6 Q8MYN7 Q94271 Q9BL88 Q9NAA0 Q9TZC6 Q9U2H2 Q9U2T0 Q9U2T1 Q9XTY9 Q9XU75 Q9XVQ1 Q9XVV9 Q9XW75	AC3.5 C28G1.2 CELE_F02D8.4 CELE_F15D3.4 CELE_F41C6.4 CELE_F44G3.7 CELE_F49B2.6 CELE_R03G8.6 CELE_T06A4.1 CELE_T06A4.3 CELE_T12E12.6 CELE_W01A8.6 CELE_Y18H1A.9 CELE_Y42A5A.1 CELE_Y53F4B.20 CELE_Y59C2A.1 CELE_Y67D8C.9 CELE_ZC434.9 T16G12.1 acn-1 anp-1 asp-1 asp-10 asp-12 asp-13 asp-14 asp-15 asp-16 asp-17 asp-18 asp-19 asp-2 asp-3 asp-4 asp-5 asp-6 asp-7 asp-8 asp-9 cest-1 cest-1.1 cest-1.2 cest-12 cest-13 cest-16 cest-17 cest-19 cest-2.1 cest-2.2 cest-2.3 cest-24 cest-26 cpz-1 ges-1 hrg-7 nep-1 nep-10 nep-11 nep-12 nep-13 nep-16 nep-17 nep-18 nep-2 nep-20 nep-21 nep-22 nep-23 nep-24 nep-25 nep-26 nep-3 nep-4 nep-6 nep-8 nep-9 pam-1 srp-1 srp-2 srp-3 srp-6 srp-7 srp-8 suro-1 vha-20	Caenorhabditis elegans
Azathioprine ADME	Equilibrative nucleoside transporter 3 Hypoxanthine phosphoribosyltransferase Inosine-5'-monophosphate dehydrogenase Multidrug resistance-associated protein 5 Multidrug resistance-associated protein lethal(2)03659 Nucleoside diphosphate kinase Probable GMP synthase [glutamine-hydrolyzing] Protein vav-1 Ras-related protein ced-10 Sodium/nucleoside cotransporter Sodium/nucleoside cotransporter guanylate kinase nucleoside-diphosphate kinase xanthine dehydrogenase	A0A131MBV2 G5EE72 G5EE77 O17892 P91425 Q03206 Q09580 Q19625 Q45FX5 Q7KX00 Q93576 Q93690 Q9GZH3 Q9NF11	CELE_Y48G8AL.15 CNT1 T22D1.3 ced-10 ent-6 ent-7 gmps-1 guk-1 hprt-1 mrp-5 mrp-6 ndk-1 rac-1 slc-28.1 slc-28.2 vav-1 xdh-1 xhd-1	Caenorhabditis elegans
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	14-3-3-like protein 1 14-3-3-like protein 2 5'-3' exoribonuclease 1 C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein CCCH-type zinc finger protein moe-3 CCCH-type zinc finger protein oma-1 CCCH-type zinc finger protein oma-2 Exoribonuclease phosphorolytic domain-containing protein Exosome complex component CSL4 homolog Exosome complex component RRP4 homolog Exosome complex component RRP45 Exosome complex component RRP46 homolog Importin N-terminal domain-containing protein MAP kinase-activated protein kinase mak-1 MAP kinase-activated protein kinase mak-2 Pharynx and intestine in excess protein 1 Probable exosome complex exonuclease RRP44 Putative exosome complex component RRP41 RNA-binding protein pos-1 Ribosomal RNA-processing protein 40 Ribosomal RNA-processing protein 42 Ribosomal RNA-processing protein 43 Zinc finger protein mex-5 Zinc finger protein mex-6 m7GpppN-mRNA hydrolase dcap-2 mRNA-decapping enzyme 1	A0A131MBF9 G5EC86 G5ECB9 G5EDS8 G5EF15 G5EG59 O18251 O45289 O45491 O45493 O62255 P41932 Q09436 Q17533 Q17632 Q20128 Q20155 Q20655 Q21360 Q23359 Q93830 Q94131 Q95QG7 Q95XD0 Q965G5 Q9BHK7 Q9N363 Q9N4P9 Q9U1Y2 Q9U2V1 Q9U2V2 Q9U2V4 Q9XUB2 Q9XV46 Q9XXD2	C35D6.4 CELE_F38C2.7 CELE_Y116A8C.19 CELE_Y116A8C.20 CELE_Y60A9.3 ccch-1 ccch-2 ccch-5 crn-5 dcap-1 dcap-2 dcp-2 dct-13 dis-3 exos-1 exos-2 exos-3 exos-4.1 exos-4.2 exos-7 exos-8 exos-9 ftt-1 ftt-2 imb-2 mak-1 mak-2 mex-1 mex-5 mex-6 moe-1 moe-2 moe-3 ndx-5 oma-1 oma-2 par-5 pic-1 pie-1 pos-1 xrn-1	Caenorhabditis elegans
SUMOylation of DNA damage response and repair proteins	BRCT domain-containing protein Breast cancer type 1 susceptibility protein homolog Cohesin subunit scc-3 E3 SUMO-protein ligase NSE2 E3 SUMO-protein ligase gei-17 Histone deacetylase 4 Meiotic recombination protein rec-8 Non-structural maintenance of chromosomes element 4 Phorbol-ester/DAG-type domain-containing protein RING-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RING-type domain-containing protein RING-type domain-containing protein Rad21_Rec8 domain-containing protein SUMO-conjugating enzyme UBC9 Sister chromatid cohesion protein 1 Small ubiquitin-related modifier Structural maintenance of chromosomes protein 1 Structural maintenance of chromosomes protein 3 Structural maintenance of chromosomes protein 5 Structural maintenance of chromosomes protein 6 homolog smc-6 XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog	A0A131MBD0 B2FDA8 B6VQ60 G5ED20 G5EG17 H2L0K3 O01789 O17323 P55853 P91501 Q18237 Q19325 Q19555 Q19818 Q23420 Q7YWU1 Q94361 Q95017 Q9N4C3 Q9U370 Q9XTV3 Q9XUB3	CELE_T02C1.2 CELE_ZK1248.11 brc-1 coh-1 coh-2 gei-17 hda-4 hda-7 him-1 nhl-2 nhl-3 nse-1 nse-4 pis-1 rad-21.1 rec-8 scc-1 scc-3 smc-1 smc-3 smc-5 smc-6 smo-1 smt3 sumo tam-1 ubc-9 xpc-1	Caenorhabditis elegans
Aflatoxin activation and detoxification	3-ketosteroid oxygenase CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family Gamma-glutamyltransferase Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 N-acyl-aliphatic-L-amino acid amidohydrolase Probable cytochrome P450 CYP36A1 Probable cytochrome P450 cyp-35D1	A0A0M7RF98 A0A486WVP7 B5BM47 G5ECD0 G5EE22 H2KY69 H2KYS3 H2L030 H2L0B7 O02627 O02628 O02641 O16220 O16362 O16482 O16670 O16671 O16673 O18256 O44649 O44650 O44651 O44652 O44655 O44656 O44657 O44658 O44704 O44706 O45364 O45659 O61204 O61935 O62377 O62378 P90771 Q20315 Q27465 Q27470 Q27471 Q27482 Q27499 Q5WRS4 Q965T7 Q9N4Q4 Q9N5I1 Q9N5V4	C06A6.4 C53D5.5 CELE_H14N18.4 CELE_T03D8.6 CELE_T19H12.6 CELE_Y7A9A.1 CELE_Y97E10AR.2 cyp-23A1 cyp-23a1 cyp-33A1 cyp-33B1 cyp-33C1 cyp-33C11 cyp-33C12 cyp-33C2 cyp-33C3 cyp-33C4 cyp-33C5 cyp-33C6 cyp-33C7 cyp-33C8 cyp-33C9 cyp-33D1 cyp-33D3 cyp-33E1 cyp-33E2 cyp-33E3 cyp-33a1 cyp-33b1 cyp-33c1 cyp-33c11 cyp-33c12 cyp-33c2 cyp-33c3 cyp-33c4 cyp-33c5 cyp-33c6 cyp-33c7 cyp-33c8 cyp-33c9 cyp-33d1 cyp-33d3 cyp-33e1 cyp-33e2 cyp-33e3 cyp-34A1 cyp-34A10 cyp-34A2 cyp-34A5 cyp-34A6 cyp-34A7 cyp-34A8 cyp-34A9 cyp-34a1 cyp-34a10 cyp-34a2 cyp-34a4 cyp-34a5 cyp-34a6 cyp-34a7 cyp-34a8 cyp-34a9 cyp-35A1 cyp-35A2 cyp-35A3 cyp-35A4 cyp-35A5 cyp-35B1 cyp-35B2 cyp-35B3 cyp-35C1 cyp-35a1 cyp-35a2 cyp-35a3 cyp-35a4 cyp-35a5 cyp-35b1 cyp-35b2 cyp-35b3 cyp-35c1 cyp-35d1 cyp-36A1 cyp36a1 dach-1 daf-9	Caenorhabditis elegans
APAP ADME	3-ketosteroid oxygenase ABC transmembrane type-1 domain-containing protein ABC transporter domain-containing protein ABC transporter family G domain-containing protein CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family Gamma-glutamyltransferase Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Glucuronosyltransferase Glutathione S-transferase P Multidrug resistance protein mrp-7 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 5 Multidrug resistance-associated protein lethal(2)03659 N-acyl-aliphatic-L-amino acid amidohydrolase Peptidase M20 dimerisation domain-containing protein Probable cytochrome P450 CYP36A1 Probable cytochrome P450 cyp-35D1	A0A0M7RF98 A0A486WVP7 B5BM47 D7SFK1 G5ECD0 G5EE22 G5EE72 G5EFP3 H2KY69 H2KYS3 H2L030 H2L0B7 O02627 O02628 O02641 O16220 O16362 O16482 O16670 O16671 O16673 O18000 O18256 O44649 O44650 O44651 O44652 O44655 O44656 O44657 O44658 O44704 O44706 O45364 O45659 O61204 O61935 O62377 O62378 P10299 P90771 Q19048 Q19082 Q19585 Q19625 Q20315 Q20943 Q27465 Q27470 Q27471 Q27482 Q27499 Q3S1M2 Q5WRS4 Q965T7 Q9N4Q4 Q9N5I1 Q9N5V4 Q9U2G5 Q9XW61	C06A6.4 C53D5.5 CELE_H14N18.4 CELE_T03D8.6 CELE_T19H12.6 CELE_Y7A9A.1 CELE_Y97E10AR.2 abcx-1 cyp-23A1 cyp-23a1 cyp-33A1 cyp-33B1 cyp-33C1 cyp-33C11 cyp-33C12 cyp-33C2 cyp-33C3 cyp-33C4 cyp-33C5 cyp-33C6 cyp-33C7 cyp-33C8 cyp-33C9 cyp-33D1 cyp-33D3 cyp-33E1 cyp-33E2 cyp-33E3 cyp-33a1 cyp-33b1 cyp-33c1 cyp-33c11 cyp-33c12 cyp-33c2 cyp-33c3 cyp-33c4 cyp-33c5 cyp-33c6 cyp-33c7 cyp-33c8 cyp-33c9 cyp-33d1 cyp-33d3 cyp-33e1 cyp-33e2 cyp-33e3 cyp-34A1 cyp-34A10 cyp-34A2 cyp-34A5 cyp-34A6 cyp-34A7 cyp-34A8 cyp-34A9 cyp-34a1 cyp-34a10 cyp-34a2 cyp-34a4 cyp-34a5 cyp-34a6 cyp-34a7 cyp-34a8 cyp-34a9 cyp-35A1 cyp-35A2 cyp-35A3 cyp-35A4 cyp-35A5 cyp-35B1 cyp-35B2 cyp-35B3 cyp-35C1 cyp-35a1 cyp-35a2 cyp-35a3 cyp-35a4 cyp-35a5 cyp-35b1 cyp-35b2 cyp-35b3 cyp-35c1 cyp-35d1 cyp-36A1 cyp36a1 dach-1 daf-9 gst-1 mrp-1 mrp-2 mrp-3 mrp-4 mrp-5 mrp-6 mrp-7 mrp-8 pes-9 ugt-57 wht-5	Caenorhabditis elegans
Phase I - Functionalization of compounds	3-ketosteroid oxygenase AB hydrolase-1 domain-containing protein Aldehyde dehydrogenase Aldehyde dehydrogenase Alpha/beta hydrolase fold-3 domain-containing protein CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Cytochrome b5 heme-binding domain-containing protein Cytochrome b5 heme-binding domain-containing protein Epoxide hydrolase Epoxide hydrolase Gut esterase 1 MOSC domain-containing protein MOSC domain-containing protein MOSC domain-containing protein Probable cytochrome P450 CYP36A1 Probable cytochrome P450 cyp-35D1	A0A0M7RF98 A0A1C3NSL8 A0A486WWU7 A4UVK7 G5ECD0 G5EDJ7 G5EE22 H2KY69 H2KYS3 H2L0K7 H9G2Y9 O01302 O02627 O02628 O02641 O16220 O16362 O16482 O16670 O16671 O16673 O44555 O44649 O44650 O44651 O44652 O44655 O44656 O44657 O44658 O44704 O44706 O45364 O45394 O45659 O61204 O61935 O62377 O62378 P90771 P91321 P92016 Q04457 Q19839 Q20315 Q20976 Q21266 Q22008 Q23068 Q23268 Q27465 Q27470 Q27471 Q27482 Q27499 Q4LDP0 Q8MQ23 Q93315 Q965T7 Q9N4Q4 Q9N5I1 Q9TZ58 Q9XW75 U4PC34	C45B11.6 CELE_F22B8.7 CELE_F53E10.1 CELE_F56A11.5 CELE_F58B4.2 CELE_K01A2.5 CELE_W01A11.1 alh-4 alh-5 cest-1 cest-1.1 cest-1.2 cest-12 cest-13 cest-16 cest-17 cest-19 cest-2.1 cest-2.2 cest-2.3 cest-24 cest-26 cyp-23A1 cyp-23a1 cyp-33A1 cyp-33B1 cyp-33C1 cyp-33C11 cyp-33C12 cyp-33C2 cyp-33C3 cyp-33C4 cyp-33C5 cyp-33C6 cyp-33C7 cyp-33C8 cyp-33C9 cyp-33D1 cyp-33D3 cyp-33E1 cyp-33E2 cyp-33E3 cyp-33a1 cyp-33b1 cyp-33c1 cyp-33c11 cyp-33c12 cyp-33c2 cyp-33c3 cyp-33c4 cyp-33c5 cyp-33c6 cyp-33c7 cyp-33c8 cyp-33c9 cyp-33d1 cyp-33d3 cyp-33e1 cyp-33e2 cyp-33e3 cyp-34A1 cyp-34A10 cyp-34A2 cyp-34A5 cyp-34A6 cyp-34A7 cyp-34A8 cyp-34A9 cyp-34a1 cyp-34a10 cyp-34a2 cyp-34a4 cyp-34a5 cyp-34a6 cyp-34a7 cyp-34a8 cyp-34a9 cyp-35A1 cyp-35A2 cyp-35A3 cyp-35A4 cyp-35A5 cyp-35B1 cyp-35B2 cyp-35B3 cyp-35C1 cyp-35a1 cyp-35a2 cyp-35a3 cyp-35a4 cyp-35a5 cyp-35b1 cyp-35b2 cyp-35b3 cyp-35c1 cyp-35d1 cyp-36A1 cyp36a1 cytb-5.1 dach-1 daf-9 ges-1 trcs-1	Caenorhabditis elegans
Nuclear events mediated by NFE2L2	5'-AMP-activated protein kinase catalytic subunit alpha-2 BZIP domain-containing protein Protein cbp-1 Protein skinhead-1	A0A0M7REQ4 P34545 P34707 Q95ZQ4	aak-2 cbp-1 skn-1 sknr-1	Caenorhabditis elegans
KEAP1-NFE2L2 pathway	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 BZIP domain-containing protein Cullin-3 MPN domain-containing protein Nuclear protein localization protein 4 homolog 2 PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Protein kinase C-like 3 Protein lgg-2 Protein skinhead-1 RING-box protein 1 RING-type domain-containing protein Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2 Sestrin homolog Transitional endoplasmic reticulum ATPase homolog 2 Ubiquitin fusion degradation protein 1 homolog Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein ZZ-type domain-containing protein	A0A0M7REQ4 O16368 O17071 O17586 O44156 O61742 O61792 O62102 O76371 O76577 P0CG71 P34707 P37165 P46502 P49632 P54812 P90868 P91477 Q04908 Q10920 Q17391 Q17746 Q17941 Q17971 Q18115 Q18787 Q19266 Q19324 Q19584 Q20058 Q20585 Q20938 Q22253 Q23237 Q23449 Q23457 Q23536 Q27488 Q95005 Q95008 Q95PZ7 Q95QZ9 Q966I8 Q9GZH5 Q9N3T6 Q9N4D6 Q9N599 Q9XTG7 Q9XTT9 Q9XUV0	C14C10.5 CELE_F35G12.12 CELE_Y47G6A.14 aPKC akt-1 akt-2 cdc-48.2 cul-3 gldi-4 lgg-2 npl-4.2 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 pkc-3 psmd-9 psme-3 rbx-1 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 sesn-1 skn-1 sknr-1 ubia ubib ubl-1 ubq-1 ubq-2 ufd-1	Caenorhabditis elegans
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 BZIP domain-containing protein Cullin-1 Glycogen synthase kinase-3 MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Protein kinase domain-containing protein Protein skinhead-1 Putative serine/threonine-protein kinase R03D7.5 RING-box protein 1 Skp1-related protein Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A0A0M7REQ4 G5ECU1 O16368 O17071 O17586 O44156 O61742 O61792 O62102 O76371 O76577 P0CG71 P34707 P37165 P46502 P49632 P90868 P91477 Q04908 Q09595 Q10920 Q17389 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q22253 Q23237 Q23449 Q23457 Q27488 Q93372 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N599 Q9U2Q9 Q9XTT9 Q9XUV0	C44H4.6 CELE_F35G12.12 R03D7.5 cul-1 gsk-3 lin-19 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rbx-1 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 sgg-1 skn-1 sknr-1 skr-1 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Prostanoid ligand receptors	G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein Neuropeptide receptor 18 Probable G-protein coupled receptor C06G4.5	A0A0K3AXD3 A0A3B1DQQ4 P34311 Q09502 Q20841 Q23033 Q9N452	C06G4.5 npr-16 npr-18 npr-23 npr-24 npr-26 npr-28	Caenorhabditis elegans
BBSome-mediated cargo-targeting to cilium	ADP-ribosylation factor-like protein 6 Bardet-Biedl syndrome 1 protein homolog Bardet-Biedl syndrome 2 protein homolog Bardet-Biedl syndrome 4 protein homolog Bardet-Biedl syndrome 5 protein homolog Bardet-Biedl syndrome 7 protein homolog G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein GDP/GTP exchange factor Sec2 N-terminal domain-containing protein Neuropeptide receptor 18 Probable G-protein coupled receptor C06G4.5 Protein pthb1 homolog Tetratricopeptide repeat protein 8	A0A0K3AXD3 A0A3B1DQQ4 O01514 P34311 Q09502 Q18510 Q19640 Q20759 Q20841 Q21626 Q23033 Q23049 Q5CZ52 Q9N452 Q9NEZ7 Q9XW70	C06G4.5 CELE_F54C9.11 arl-6 bbs-1 bbs-2 bbs-4 bbs-5 bbs-7 bbs-8 bbs-9 npr-16 npr-18 npr-23 npr-24 npr-26 npr-28 osm-12	Caenorhabditis elegans
G-protein activation	G protein gamma domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma Neuropeptide receptor 18 Probable G-protein coupled receptor C06G4.5	A0A0K3AXD3 A0A3B1DQQ4 G5ECT6 G5EGU1 P17343 P34311 P54406 Q09502 Q20636 Q20841 Q23033 Q9N452	C06G4.5 eat-11 egl-30 gbp-2 gpb-1 gpb-2 gpc-1 gpc-2 npr-16 npr-18 npr-23 npr-24 npr-26 npr-28	Caenorhabditis elegans
G alpha (i) signalling events	CELF35-1 Dopamine receptor 2 Dopamine receptor 3 G protein gamma domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 3 profile domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2 Guanine nucleotide-binding protein alpha-16 subunit Guanine nucleotide-binding protein alpha-4 subunit Guanine nucleotide-binding protein alpha-6 subunit Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma Muscarinic acetylcholine receptor gar-3 Neuropeptide receptor 18 Probable G-protein coupled receptor C06G4.5 Probable metabotropic glutamate receptor mgl-1 RGS domain-containing protein RGS domain-containing protein Regulator of G-protein signaling 7 Regulator of G-protein signaling egl-10 Regulator of G-protein signaling rgs-10 Regulator of G-protein signaling rgs-11 Regulator of G-protein signaling rgs-1 Regulator of G-protein signaling rgs-2 Regulator of G-protein signaling rgs-3 Regulator of G-protein signaling rgs-6 Regulator of G-protein signaling rgs-7 Regulator of G-protein signaling rgs-9 SERPIN domain-containing protein SERPIN domain-containing protein Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Tetratricopeptide repeat protein 28 Tyramine receptor Ser-2 Tyramine receptor tyra-2 Tyrosine protein-kinase src-1	A0A0K3AXD3 A0A3B1DQQ4 A0A5S9MNH1 A1IMB8 A9Z1L1 E7EM37 G5ECB2 G5ECK9 G5ECT6 G5ECY2 G5ECZ3 G5EE40 G5EE56 G5EFH4 G5EGH0 H2KZ99 H2L0Q3 O01818 O02213 O17365 O17589 O18014 O45520 O45523 O45524 P17343 P34295 P34311 P49808 P49809 P54406 Q09502 Q09630 Q18287 Q18312 Q18563 Q19084 Q19651 Q19779 Q19955 Q1ZXT2 Q20636 Q20827 Q20841 Q23033 Q23376 Q6RYS9 Q7JP61 Q8MPR3 Q8WQC0 Q93743 Q9BIG5 Q9N2V6 Q9N452 Q9U7D5 Q9XVQ1	C06G4.5 C28G1.2 CELE_F15D3.4 CELE_F35H10.10 CELE_F44G3.7 CELE_F55D10.4 CELE_F57C9.6 CELE_ZK813.5 ador-1 ags-3 dop-2 dop-2L dop-3 eat-11 eat-16 egl-10 gar-3 gbb-1 gbb-2 gbp-2 gnrr-4 gpa-16 gpa-4 gpa-6 gpb-1 gpb-2 gpc-1 gpc-2 gtr-1 mgl-1 mgl-3 npr-16 npr-18 npr-23 npr-24 npr-25 npr-26 npr-28 octr-1 rgs-1 rgs-10 rgs-11 rgs-2 rgs-3 rgs-4 rgs-6 rgs-7 rgs-8.1 rgs-8.2 rgs-9 ser-2 ser-4 spn-1 src-1 srp-1 srp-2 srp-3 srp-6 srp-7 srp-8 tyra-2	Caenorhabditis elegans
G alpha (q) signalling events	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 Amyloid-beta-like protein Annexin Annexin CRAL-TRIO domain-containing protein G protein gamma domain-containing protein G protein-coupled receptor kinase 2 G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 3 profile domain-containing protein Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma Muscarinic acetylcholine receptor gar-3 Neuromedin U receptor homolog nmur-2 Neuropeptide receptor 18 Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Probable G-protein coupled receptor C06G4.5 Probable G-protein coupled receptor tkr-1 RGS domain-containing protein RGS domain-containing protein Regulator of G-protein signaling rgs-10 Regulator of G-protein signaling rgs-11 Regulator of G-protein signaling rgs-1 Regulator of G-protein signaling rgs-2 Regulator of G-protein signaling rgs-3 Regulator of G-protein signaling rgs-6 Regulator of G-protein signaling rgs-7 Regulator of G-protein signaling rgs-9 SERPIN domain-containing protein SERPIN domain-containing protein Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Thyrotropin-releasing hormone receptor	A0A0K3AXD3 A0A131MBL3 A0A3B1DQQ4 A0A5S9MNH1 A9Z1L1 G5EBH0 G5EBX8 G5ECK9 G5ECT6 G5ECY2 G5EDI0 G5EDP9 G5EE40 G5EFH4 G5EFT1 G5EG10 G5EGU1 H2KZ99 O17239 O17365 O17899 O18014 O44731 O45520 O45523 O45524 O45601 O61528 O62403 P17343 P34295 P34311 P49808 P54406 P91096 Q03566 Q09502 Q09639 Q10651 Q18130 Q18287 Q18312 Q18563 Q18701 Q18929 Q19125 Q19651 Q20636 Q20841 Q23033 Q23376 Q27473 Q8WQC0 Q94125 Q95YD7 Q9N452 Q9U7D5 Q9XUK8 Q9XVQ1	C06G4.5 C24B5.1 C28G1.2 CELE_F15D3.4 CELE_F44G3.7 aap-1 age-1 apl-1 dcar-1 dop-6 eat-11 egl-30 egl-8 gar-3 gbp-2 gnrr-1 gnrr-4 gpb-1 gpb-2 gpc-1 gpc-2 grk-2 mgl-2 nex-3 nex-4 nmur-1 nmur-2 nmur-3 nmur-4 npr-14 npr-16 npr-18 npr-20 npr-23 npr-24 npr-25 npr-26 npr-28 npr-32 pcdr-1 rgs-1 rgs-10 rgs-11 rgs-2 rgs-3 rgs-4 rgs-6 rgs-7 rgs-8.1 rgs-8.2 rgs-9 ser-5 sro-1 srp-1 srp-2 srp-3 srp-6 srp-7 srp-8 tag-89 tkr-1 trhr-1 unc-73	Caenorhabditis elegans
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Clathrin light chain Frizzled-2 Probable clathrin heavy chain 1 Protein Wnt-2 Protein mom-5 Tyrosine-protein kinase receptor cam-1	A0A0K3AWM6 G5ECQ2 G5EGK5 P34574 P34889 P35603 P90961 Q19123 Q22601 Q9N4F3	ap50 apa-2 apb-1 aps-2 cam-1 cfz-2 chc-1 clic-1 cwn-2 dpy-23 kin-8 mom-5 wnt-2	Caenorhabditis elegans
Asymmetric localization of PCP proteins	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Frizzled-2 Frizzled-4 LIM zinc-binding domain-containing protein MPN domain-containing protein PCI domain-containing protein Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Protein Wnt-2 Protein mom-5	A0A0K3AWM6 G5ECQ2 G5EDV1 H2KYA1 O16368 O17071 O17586 O44156 O61742 O61792 O62102 O76371 O76577 P34889 P46502 P90868 P91477 Q04908 Q10920 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q22253 Q23237 Q23449 Q27488 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N599 Q9XTT9 Q9XUV0	C14C10.5 CELE_F35G12.12 cfz-2 cwn-2 lin-17 mom-5 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 prkl-1 psmd-9 psme-3 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 wnt-2	Caenorhabditis elegans
Regulation of FZD by ubiquitination	EGF-like domain-containing protein EGF-like domain-containing protein Frizzled-2 Frizzled-4 Polyubiquitin-A Probable E3 ubiquitin-protein ligase plr-1 Protein mom-5 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A0A0K3AWM6 G5ECQ2 G5EDV1 G5EFK8 O44191 P0CG71 P37165 P49632 Q9U2B7	CELE_F14B4.1 cfz-2 lin-17 mom-5 plr-1 rme-2 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Ca2+ pathway	Abnormal cell lineage protein 44 Beta-catenin-like protein hmp-2 Calcium/calmodulin-dependent protein kinase type II EF-hand domain-containing protein Frizzled-2 Frizzled-4 G protein gamma domain-containing protein Guanine nucleotide-binding protein G(o) subunit alpha Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma Protein Wnt-2 Protein mom-2 Protein mom-5 Protein phosphatase 2B regulatory subunit cnb-1 Protein pop-1 Ras protein let-60 Serine/threonine kinase NLK Serine/threonine-protein phosphatase 2B catalytic subunit	A0A0K3AWM6 G5ECQ2 G5ECT6 G5EDN6 G5EDV1 O44326 O62305 P17343 P22981 P34889 P51875 P54406 Q0G819 Q10459 Q10666 Q18136 Q20636 Q27886 Q9U9Y8	cal-5 cfz-2 cna-1 cnb-1 cwn-2 eat-11 gbp-2 goa-1 gpb-1 gpb-2 gpc-1 gpc-2 hmp-2 let-60 lin-17 lin-34 lin-44 lit-1 mom-2 mom-5 nlk pop-1 tax-6 unc-43 wnt-2	Caenorhabditis elegans
Abacavir transmembrane transport	Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Organic cation transporter 1 Putative transporter B0252.3 Putative transporter B0361.11 Uncharacterized protein F23F12.3	A0A0K3AVV4 A0A0K3AWD3 A0A238UKL7 G5EDA7 G5EEI9 G5EGL6 O18247 P46499 Q09617 Q10917 Q18613 Q18655 Q18795 Q19442 Q22686 Q23501 Q4PIX1 Q7Z118 Q9BKR9 Q9U539 Q9UAW9	B0252.3 B0361.11 C06H5.6 C44C10.3 C46C2.2 CELE_F23F12.13 CELE_F45E10.2 CELE_K05F1.6 CELE_K09E9.1 CELE_K11D9.3 CELE_T08B1.1 CELE_T12B3.2 CELE_T22F7.1 CELE_Y57G11C.23 CELE_Y82E9BR.16 CELE_ZK892.3 F23F12.3/F23F12.1 oct-1 oct-2 pes-23 suex-2	Caenorhabditis elegans
Organic anion transport	Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Organic cation transporter 1 Putative transporter B0252.3 Putative transporter B0361.11 Uncharacterized protein F23F12.3	A0A0K3AVV4 A0A0K3AWD3 A0A238UKL7 G5EDA7 G5EEI9 G5EGL6 O18247 P46499 Q09617 Q10917 Q18613 Q18655 Q18795 Q19442 Q22686 Q23501 Q4PIX1 Q7Z118 Q9BKR9 Q9U539 Q9UAW9	B0252.3 B0361.11 C06H5.6 C44C10.3 C46C2.2 CELE_F23F12.13 CELE_F45E10.2 CELE_K05F1.6 CELE_K09E9.1 CELE_K11D9.3 CELE_T08B1.1 CELE_T12B3.2 CELE_T22F7.1 CELE_Y57G11C.23 CELE_Y82E9BR.16 CELE_ZK892.3 F23F12.3/F23F12.1 oct-1 oct-2 pes-23 suex-2	Caenorhabditis elegans

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