GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1 - 25** of **499** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism
trans-Golgi Network Vesicle Budding	ADP-ribosylation factor 1-like 1 ADP-ribosylation factor 1-like 2 E3 ubiquitin-protein ligase arc-1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog Putative syntaxin-2 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptosomal-associated protein Syntaxin-1A homolog V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein t-SNARE protein aex-4	A5PEW5 G5EBK2 G5EEN8 G5EGS5 O02495 O16000 P34351 Q09654 Q10943 Q19767 Q20574 Q94057 Q94231 Q95XH1	aex-4 arc-1 arf-1 arf-1.1 arf-1.2 arl-4 arl-6 gbf-1 phi-34 ric-4 snb-1 snb-2 snb-5 snb-6 snb-7 syn-2 syx-2 tag-81 unc-64 vamp-7	Caenorhabditis elegans
pre-mRNA splicing	ATP-dependent RNA helicase B30.2/SPRY domain-containing protein Beta-catenin-like protein 1 N-terminal domain-containing protein CBF1-interacting co-repressor CIR N-terminal domain-containing protein CID domain-containing protein CSD domain-containing protein CSD domain-containing protein CSD domain-containing protein CSD domain-containing protein Cell division cycle 5-like protein Chromatin target of PRMT1 protein C-terminal domain-containing protein Coiled-coil domain-containing protein 12 DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 G patch domain-containing protein 1 homolog Gastrulation defective protein 1 General transcription factor IIF subunit 2 Heat shock protein hsp-1 Hepatocellular carcinoma-associated antigen 59 Heterogeneous nuclear ribonucleoprotein A1 Heterogeneous nuclear ribonucleoprotein K homolog Intron-binding protein aquarius K Homology domain-containing protein NF-kappa-B-activating protein C-terminal domain-containing protein Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Nuclear speckle splicing regulatory protein 1 homolog PHD finger-like domain-containing protein 5A PPIase cyclophilin-type domain-containing protein PWI domain-containing protein Peptidyl-prolyl cis-trans isomerase 10 Peptidyl-prolyl cis-trans isomerase 4 Peptidyl-prolyl cis-trans isomerase sig-7 Peptidyl-prolyl cis-trans isomerase Pinin/SDK/MemA protein domain-containing protein Poly(U)-binding-splicing factor rnp-6 Pre-mRNA-processing factor 19 Pre-mRNA-splicing factor 18 Pre-mRNA-splicing factor 8 homolog Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15 Pre-mRNA-splicing factor CWC22 homolog Pre-mRNA-splicing factor CWC25 homolog Pre-mRNA-splicing factor RBM22 Pre-mRNA-splicing factor SLU7 Pre-mRNA-splicing factor SPF27 Pre-mRNA-splicing factor SYF1 Pre-mRNA-splicing factor syf-2 Probable ATP-dependent RNA helicase DHX35 homolog Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable U2 small nuclear ribonucleoprotein A' Probable histone deacetylase complex subunit SAP18 Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5 Probable small nuclear ribonucleoprotein E Probable small nuclear ribonucleoprotein F Probable small nuclear ribonucleoprotein G Probable small nuclear ribonucleoprotein Sm D1 Probable small nuclear ribonucleoprotein Sm D2 Probable small nuclear ribonucleoprotein-associated protein B Probable splicing factor, arginine/serine-rich 2 Probable splicing factor, arginine/serine-rich 3 Probable splicing factor, arginine/serine-rich 4 Probable splicing factor, arginine/serine-rich 6 Probable splicing factor, arginine/serine-rich 7 Proline-rich protein PRCC Protein BUD31 homolog Protein CASC3 Protein FAM32A Protein FAM50 homolog Protein isy-1 Protein mago nashi homolog Putative RNA-binding protein PTB-1a Putative RNA-binding protein R05D3.8 RNA helicase RNA helicase RNA helicase RNA polymerase Rpb4/RPC9 core domain-containing protein RNA-binding protein 5 RNA-binding protein FUS RNA-binding protein rnp-4 RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein Replication stress response regulator SDE2 SAP domain-containing protein STING ER exit protein Schlafen-like protein 2 Serrate RNA effector molecule homolog Small nuclear ribonucleoprotein Sm D3 Spliceosome RNA helicase DDX39B homolog Spliceosome-associated protein CWC15 homolog Splicing factor 45 Splicing factor Cactin Splicing factor YJU2 TPR_REGION domain-containing protein Tr-type G domain-containing protein Transcription initiation factor IIF subunit alpha U2 snRNP-associated SURP motif-containing protein U5 small nuclear ribonucleoprotein 200 kDa helicase UPF3 domain-containing protein Uncharacterized protein F37A4.2 Uncharacterized protein T27F2.1 WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein WW domain-containing protein Zinc finger protein 830 mRNA transport homolog 4	A0A3P6MY32 A9D4S6 B9WRU1 D0G911 G5EBT5 G5EBY6 G5EC45 G5ED97 G5EDE4 G5EDH3 G5EDV3 G5EEL2 G5EEW6 G5EFC4 G5EG14 O01159 O01763 O02092 O02097 O16519 O16786 O18219 O44729 O45431 O45766 O62185 O62213 P09446 P16356 P34313 P34369 P34498 P34541 P34659 P41880 P49029 P52012 P52017 P91156 P91175 P91277 P91306 P91398 P91401 P91918 Q09250 Q09252 Q09385 Q09511 Q09530 Q10013 Q10051 Q10578 Q17336 Q17348 Q17558 Q17684 Q18212 Q18265 Q18409 Q18445 Q18535 Q18691 Q18786 Q18999 Q19211 Q19614 Q19826 Q20124 Q20716 Q20875 Q20966 Q21155 Q21278 Q21322 Q21559 Q21827 Q21832 Q22037 Q22139 Q22412 Q22417 Q22836 Q23120 Q23223 Q23463 Q4W5P0 Q8MXR2 Q8MYM8 Q8WQF3 Q93338 Q93594 Q95Q06 Q95QR5 Q95XJ1 Q95Y67 Q95YF1 Q95ZQ5 Q965K2 Q965S0 Q966L5 Q966L6 Q9BIB7 Q9BIC2 Q9BKQ8 Q9BL61 Q9BLB6 Q9GR61 Q9N3C9 Q9N3S4 Q9N4G9 Q9N5K1 Q9N5K2 Q9NEW6 Q9NLD1 Q9U1Q3 Q9U1Q7 Q9U2G0 Q9U3I0 Q9XTU6 Q9XTZ2 Q9XUW5 Q9XVH6 Q9XVH9	C16C10.4 C47E8.4 CELE_K01G5.8 CELE_T23G11.4 CELE_Y18H1A.2 CELE_Y57G11A.5 CELE_Y66D12A.8 CELE_ZK616.1 E01A2.2 F37A4.2 K07C5.6 R05D3.8 R07E5.1 RBM8 T27F2.1 Y14 acin-1 aly-3 ama-1 bcas-2 bud-31 cacn-1 casc-3 cbp-20 cbp-80 ccdc-12 ccdc-55 cdc-5L cdc-5l cey-1 cey-2 cey-3 cey-4 ctnb-1 cwc-15 cyn-10 cyn-12 cyn-15 cyn-4 cyp-10 cyp-4 ddx-15 ddx-17 ddx-35 ddx-46 eftu-2 eif-4A3 emb-4 fust-1 gad-1 gtf-2F1 gtf-2F2 gtf-2f1 gtf-2f2 hel-1 hrp-1 hrp-2 hrpf-1 hrpf-2 hrpk-1 hrpl-1 hrpr-1 hrpu-1 hsp-1 hsp70a isy-1 let-504 let-858 mag-1 mog-1 mog-2 mog-3 mog-5 mog-6 mtr-4 ncbp-1 ncbp-2 pes-4 phf-5 plrg-1 pnn-1 pqbp-1.1 prcc-1 prp-17 prp-18 prp-19 prp-8 ptb-1 rbm-17 rbm-22 rbm-5 rbp-1 rnp-2 rnp-4 rnp-5 rnp-6 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 rsp-2 rsp-3 rsp-4 rsp-6 rsp-7 rsp-8 rsr-1 sacy-1 sap-1 sap-140 scaf-6 sde-2 sel-13 sig-7 smg-4 snr-1 snr-2 snr-3 snr-4 snr-5 snr-6 snr-7 snrp-200 snrp-40.1 snrp-40.2 sqd-1 srp-1 srp-2 srp-4 syf-1 syf-2 syf-3 tag-65 tofu-2 yju-2	Caenorhabditis elegans
p53-Dependent G1 DNA Damage Response	BRCT domain-containing protein Cyclin-dependent kinase 2 Cyclin-dependent kinase inhibitor G1/S-specific cyclin-E G2/mitotic-specific cyclin-A1 GNAT family N-acetyltransferase	A0A131MD44 G5EEJ2 O01501 O61847 P34638 Q22319	CELE_T07F10.5 CELE_T24A6.1 cdk-2 cki-2 cya-1 cye-1	Caenorhabditis elegans
mTORC1-mediated signalling	14-3-3-like protein 1 14-3-3-like protein 2 DAF-15 Eukaryotic elongation factor 2 kinase GTP-binding protein Rheb homolog 1 GTP-binding protein Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 MIF4G domain-containing protein Ragulator complex protein LAMTOR2 homolog Ras-related GTP-binding protein C Ribosomal protein S6 kinase beta Small ribosomal subunit protein eS6 Sodium-coupled neutral amino acid transporter 9 homolog Target of rapamycin complex subunit lst8 Target of rapamycin homolog peptidylprolyl isomerase peptidylprolyl isomerase	A0A486WX07 G5EGB3 O01991 O17268 P34443 P41932 P91040 Q19425 Q20655 Q22743 Q68TI8 Q8I4E5 Q8WQG5 Q95Q95 Q9N2U6 Q9NAH6 Q9NEN6 Q9U2Q8	CeTor F13H10.3 daf-15 efk-1 fkb-2 fkb-8 ftt-1 ftt-2 ifg-1 let-363 lmtr-2 lmtr-3 lmtr-5 mlst-8 par-5 raga-1 ragc-1 rheb-1 rps-6 rsks-1	Caenorhabditis elegans
mRNA Capping	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cyclin-dependent kinase 7 DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIF subunit 2 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 RNA polymerase Rpb4/RPC9 core domain-containing protein Transcription elongation factor SPT5 Transcription initiation factor IIF subunit alpha mRNA cap guanine-N7 methyltransferase mRNA-capping enzyme	G5EFV5 K8F7X5 O01763 O02092 O17245 O44499 P16356 P34567 Q09645 Q10578 Q17558 Q17607 Q17684 Q19826 Q21338 Q8MYM8 Q93338 Q93594 Q95PZ4 Q965S0 Q9GR61 Q9N390 Q9N3C9 Q9N3L2 Q9N5K2 Q9U3I0 Q9XVH6 Q9XVS1	ama-1 cbp-20 cbp-80 cdk-7 cel-1 gtf-2F1 gtf-2F2 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2f1 gtf-2f2 gtf-2h1 gtf-2h3 mnat-1 ncbp-1 ncbp-2 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 spt-5 tag-72 xpb-1 xpd-1	Caenorhabditis elegans
eNOS activation	EF-hand domain-containing protein Globin family profile domain-containing protein Heat shock protein 90 Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2	O17824 Q17941 Q18136 Q18688 Q9XTG7	akt-1 akt-2 cal-5 daf-21 glb-14	Caenorhabditis elegans
betaKlotho-mediated ligand binding	EGL-17 Glycoside hydrolase family 1 protein Glycoside hydrolase family 1 protein Myoblast growth factor receptor egl-15	G5EEF1 Q10656 Q18758 Q9TZA0	egl-15 egl-17 klo-1 klo-2	Caenorhabditis elegans
alpha-linolenic acid (ALA) metabolism	ABC transporter domain-containing protein Acyl-coenzyme A oxidase acox-1.3 Delta(5) fatty acid desaturase fat-4 Delta(6)-fatty-acid desaturase fat-3 Elongation of very long chain fatty acids protein Elongation of very long chain fatty acids protein Elongation of very long chain fatty acids protein Long chain fatty acid elongase 1 Long chain fatty acid elongase 2 Long chain fatty acid elongase 5 Long chain fatty acid elongase 6 MaoC-like domain-containing protein Putative fatty acid elongase 3 Putative fatty acid elongase 4 palmitoyl-CoA hydrolase	F3Y5R4 G5EEE5 G5EG11 O45730 O62138 P49191 Q03574 Q19058 Q20300 Q20303 Q20904 Q23221 Q9BIA9 Q9NAC6 Q9XVQ9	C17C3.1 acox-1.3 acox-3 des-5 elo-1 elo-2 elo-3 elo-4 elo-5 elo-6 elo-7 elo-8 elo-9 fat-3 fat-4 maoc-1 pmp-4	Caenorhabditis elegans
Zinc influx into cells by the SLC39 gene family	Zinc transporter ZIP3 Zinc transporter ZIP8 Zinc transporter zipt-7.2 Zrt (ZRT), Irt- (IRT-) like Protein Transporter Zrt (ZRT), Irt- (IRT-) like Protein Transporter	O62192 P91348 Q22395 Q9XTQ7 U4PS08	hke-4.2 tag-140 zipt-1 zipt-15 zipt-16 zipt-2.4 zipt-7.2	Caenorhabditis elegans
WNT5A-dependent internalization of FZD4	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Beta-arrestin arr-1 Clathrin light chain DiSHevelled related DiSHevelled related Frizzled-4 Probable clathrin heavy chain 1 Protein Wnt-2 Protein kinase C-like 2 Segment polarity protein dishevelled homolog mig-5	A0A0K3AUI8 G5EDV1 P34574 P34889 P35603 P51485 P90961 P90980 Q18239 Q19123 Q22227 Q22601 Q9N4F3	ap50 apa-2 apb-1 aps-2 arr-1 chc-1 clic-1 cwn-2 dpy-23 dsh-1 dsh-2 kin-11 lin-17 mig-5 pkc-2 wnt-2	Caenorhabditis elegans
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Clathrin light chain Frizzled-2 Probable clathrin heavy chain 1 Protein Wnt-2 Protein mom-5 Tyrosine-protein kinase receptor cam-1	A0A0K3AWM6 G5ECQ2 G5EGK5 P34574 P34889 P35603 P90961 Q19123 Q22601 Q9N4F3	ap50 apa-2 apb-1 aps-2 cam-1 cfz-2 chc-1 clic-1 cwn-2 dpy-23 kin-8 mom-5 wnt-2	Caenorhabditis elegans
WNT ligand biogenesis and trafficking	Abnormal cell lineage protein 44 GOLD domain-containing protein PX domain-containing protein Protein Wnt-1 Protein Wnt-2 Protein Wnt Protein mom-2 Protein wntless homolog Vacuolar protein sorting-associated protein 26 Vacuolar protein sorting-associated protein 29 Vacuolar protein sorting-associated protein 35	G5EG05 O01258 P34888 P34889 Q10459 Q21053 Q21336 Q27886 Q7YWX7 Q86D99 Q9XW41	cwn-1 cwn-2 egl-20 let-553 lin-44 mig-14 mom-2 mom-3 pvl-2 snx-3 tmed-1 vps-26 vps-29 vps-35 wnt-1 wnt-2	Caenorhabditis elegans
VxPx cargo-targeting to cilium	Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-gated cation channel Exocyst complex component 1 Exocyst complex component 2 Exocyst complex component 3 Exocyst complex component 4 Exocyst complex component 5 Exocyst complex component 6 Exocyst complex component 7 Exocyst component Exo84 C-terminal domain-containing protein FIP-RBD domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein GDP/GTP exchange factor Sec2 N-terminal domain-containing protein Polycystin-2 RAB family Rab8 Ras-related protein rab-11.1	A8WI01 G5EEE2 G5EFC1 O01803 O01818 O61827 P91149 Q03611 Q18286 Q18406 Q19262 Q20678 Q20759 Q21137 Q22706 Q7Z205 Q95Q35 Q95ZS6 Q9N4C1 Q9U1S7 Q9XWS2	CELE_F54C9.11 CELE_F57C9.6 che-6 cng-1 cng-2 cng-3 exoc-7 exoc-8 pdk-2 pkd-2 rab-11.1 rab-8 rab8 rabr-1 rfip-1 sec-10 sec-15 sec-3 sec-5 sec-6 sec-8 tax-2 tax-4	Caenorhabditis elegans
Vitamin D (calciferol) metabolism	3-ketosteroid oxygenase Nuclear hormone receptor family member daf-12 Nuclear hormone receptor family member nhr-48 Nuclear hormone receptor family member nhr-8 Suppressor of lurcher protein 1	G5EFF5 H2KYS3 Q93212 Q94407 Q9XYB7	XL285 daf-12 daf-20 daf-9 mig-7 nhr-48 nhr-8 sol-1	Caenorhabditis elegans
Vitamin C (ascorbate) metabolism	Cytochrome b5 heme-binding domain-containing protein Facilitated glucose transporter homolog Facilitated glucose transporter protein 1 Glutathione S-transferase omega Glutathione S-transferase omega Glutathione S-transferase Glutathione transferase omega-1 MFS domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Probable glutathione transferase omega-2 Solute carrier family 23 member 2 Solute carrier family 23 member 2 Solute carrier family 23 member 2 Solute carrier family 23 member 2 Solute carrier family 23 member 2 Solute carrier family 23 member 2	D6RYE3 D7SFI3 G5EC93 G8JZM6 O16547 O17234 O18057 O18061 O44616 O44827 O45352 O45920 P34277 P34345 Q18771 Q19376 Q20734 Q21381 Q21382 Q21385 Q23535 Q23626 Q5WRR9 Q93315 Q95QY6 Q9GPA2 Q9GYQ1 Q9NEI8 Q9TYX7 Q9U2K5 Q9XU83 Q9XVL3	C02D5.4 C03B1.13 C35A11.4 C51E3.6 CELE_F11D5.5 CELE_F11D5.7 CELE_F13B12.2 CELE_F48E3.2 CELE_F53H8.3 CELE_K08F9.1 CELE_K08H10.6 CELE_K09C4.1 CELE_K09C4.4 CELE_K09C4.5 CELE_R11E3.2 CELE_T07G12.2 CELE_T07G12.4 CELE_T07G12.5 CELE_Y37A1A.3 CELE_Y39B6A.41 CELE_Y39E4B.5 CELE_Y59E9AL.4 CELE_ZK829.9 R09B5.11 cytb-5.1 fdgt-2 fgt-1 gst-44 gsto-1 gsto-2 gsto-3 slcf-2	Caenorhabditis elegans
Vitamin B2 (riboflavin) metabolism	Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 Probable FAD synthase Riboflavin transporter rft-1 Riboflavin transporter rft-2 Tartrate-resistant acid phosphatase type 5 riboflavin kinase	G4SDH4 O01320 P90754 P90755 Q21918 Q22017 Q3LFN0	C27A7.1 C27A7.3 CELE_F02E9.7 flad-1 rfk-1 rft-1 rft-2	Caenorhabditis elegans
Vitamin B1 (thiamin) metabolism	Folate transporter 1 Folate-like transporter 2 Folate-like transporter 3 Mitochondrial thiamine pyrophosphate carrier Thiamin pyrophosphokinase 1	A3QMB9 O45166 P30636 Q17766 Q22931	folt-1 folt-2 folt-3 hpo-12 tag-330 tpk-1	Caenorhabditis elegans
VLDLR internalisation and degradation	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Clathrin light chain EGF-like domain-containing protein Probable clathrin heavy chain 1	P34574 P35603 P90961 Q19123 Q22601 Q7JP80 Q9N4F3	ap50 apa-2 apb-1 aps-2 chc-1 clic-1 dpy-23 gldi-2	Caenorhabditis elegans
VEGFR2 mediated vascular permeability	Alpha-catenin-like protein hmp-1 Armadillo repeat-containing protein wrm-1 Beta-catenin-like protein hmp-2 Beta-catenin/armadillo-related protein 1 EF-hand domain-containing protein Heat shock protein 90 Juxtamembrane domain-associated catenin Protein nipi-3 Protein vav-1 RICTOR_N domain-containing protein Ras-related protein ced-10 Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2 Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase pak-1 Stress-activated map kinase-interacting protein 1 homolog Target of rapamycin complex subunit lst8 Target of rapamycin homolog non-specific serine/threonine protein kinase	G5EED4 G5EFN2 G5EGQ3 O44326 P90947 P91040 Q03206 Q10953 Q17850 Q17941 Q18136 Q18688 Q18825 Q45FX5 Q95Q95 Q9NA80 Q9U308 Q9UA62 Q9XTG7	CELE_W04B5.5 CeTor akt-1 akt-2 bar-1 cal-5 ced-10 daf-21 hmp-1 hmp-2 jac-1 let-363 max-2 mlst-8 nipi-3 pak-1 pvl-1 rac-1 rict-1 sinh-1 spy-1 vav-1 wrm-1	Caenorhabditis elegans
VEGFR2 mediated cell proliferation	Protein kinase C-like 1 Protein kinase C-like 2 Protein kinase C-like 3 Sphingosine kinase 1 non-specific serine/threonine protein kinase	P34722 P90980 Q18425 Q19266 Q9UA62	CELE_W04B5.5 aPKC kin-11 pkc-2 pkc-3 sphk-1 tag-274 tpa-1	Caenorhabditis elegans
VEGFA-VEGFR2 Pathway	BEN domain-containing protein Cell division control protein 42 homolog Discoidin domain-containing receptor tyrosine kinase B Heat shock protein 12.6 Heat shock protein Hsp-12.2 Heat shock protein Hsp-16.1/Hsp-16.11 Heat shock protein Hsp-16.41 Heat shock protein Hsp-16.48/Hsp-16.49 Heat shock protein hsp-16.2 Heat-shock protein 12.1 Inactive tyrosine-protein kinase kin-32 Integrin alpha pat-2 Integrin beta pat-3 MAP kinase-activated protein kinase mak-1 MAP kinase-activated protein kinase mak-2 Mitogen-activated protein kinase pmk-1 Mitogen-activated protein kinase pmk-2 Mitogen-activated protein kinase pmk-3 NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein vav-1 Ras-like GTP-binding protein rhoA Ras-related protein ced-10 Rho-associated protein kinase let-502 SH2 domain-containing protein SH2 domain-containing protein SHSP domain-containing protein SHSP domain-containing protein SHSP domain-containing protein SHSP domain-containing protein SHSP domain-containing protein SHSP domain-containing protein Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase pak-1 Stress-induced protein 1 Tyrosine protein-kinase src-1 Tyrosine-protein kinase receptor svh-2 Uncharacterized integrin beta-like protein C05D9.3 cAMP-dependent protein kinase catalytic subunit	A0A1I6CMA1 B0M0L8 G5EDP9 G5EE36 G5EE56 G5EE62 G5EE65 G5EF99 G5EFV1 G5EGQ3 H2KZU7 K8ESG0 O44514 P02513 P06581 P06582 P21137 P34328 P34446 P34696 P91267 P92199 Q03206 Q05062 Q17446 Q17850 Q19227 Q19228 Q20164 Q20363 Q20660 Q21046 Q21360 Q22038 Q27874 Q45FX5 Q8MXI4 Q93344 Q94125 Q95PX0 Q95XA9 Q95YD4 Q95ZV7 Q965G5 Q9GYK2 Q9U3L3 Q9XVQ7 Q9XX60 Q9XXC0	C05D9.3 C49C3.10 CELE_F08H9.3 CELE_F08H9.4 CELE_F11E6.8 CELE_F12F6.1 CELE_F13B12.6 CELE_F21F3.2 CELE_F59F5.3 CELE_Y106G6D.4 CELE_Y106G6E.1 CELE_Y51B9A.9 CELE_ZK1128.7 aap-1 age-1 cdc-42 ced-10 ddr-2 gap-3 gska-3 gskl-2 hsp-12.1 hsp-12.2 hsp-12.3 hsp-12.6 hsp-16 hsp-16.1 hsp-16.11 hsp-16.2 hsp-16.41 hsp-16.48 hsp-16.49 hsp-17 hsp-43 hsp12-2 hsp16-1a hsp16-1b hsp16-2 hsp16-41 hsp16-48 hsp16-48a hsp16-48b hsp16-49 kin-1 kin-32 kin-36 let-502 mak-1 mak-2 max-2 nck-1 pak-1 pat-2 pat-3 pmk-1 pmk-2 pmk-3 rac-1 rho-1 rhoa sip-1 src-1 svh-2 svh-4 vav-1	Caenorhabditis elegans
Unblocking of NMDA receptors, glutamate binding and activation	Alpha-actinin, sarcomeric Calcium/calmodulin-dependent protein kinase type II Disks large homolog 1 EF-hand domain-containing protein GLutamate Receptor family (AMPA) GLutamate Receptor family (AMPA) GLutamate Receptor family (AMPA) Glutamate receptor 1 Glutamate receptor 2 Glutamate receptor ionotropic, kainate 2 Glutamate receptor ionotropic, kainate glr-3 LITAF domain-containing protein NMDA-type ionotropic glutamate receptor NMR-2 Protein lap1	A0A1T5HUM0 G5ECY0 G5EEH3 G5EGQ9 O01623 O61967 O62305 P34299 Q10914 Q17697 Q18136 Q21415 Q23158 Q8MXV8	atn-1 cal-5 dlg-1 glr-1 glr-2 glr-3 glr-4 glr-5 glr-6 glr-7 let-413 nmr-1 nmr-2 unc-43	Caenorhabditis elegans
Ubiquitin-dependent degradation of Cyclin D	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 G1/S-specific cyclin-D MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	O16368 O17071 O17586 O44156 O61742 O61792 O62102 O76371 O76577 P0CG71 P37165 P46502 P49632 P90868 P91477 Q04908 Q10920 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q22253 Q23237 Q23449 Q27488 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N599 Q9U2M5 Q9XTT9 Q9XUV0	C14C10.5 CELE_F35G12.12 cyd-1 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 CHeckpoint Kinase Related M-phase inducer phosphatase cdc-25.1 M-phase inducer phosphatase cdc-25.2 M-phase inducer phosphatase cdc-25.3 M-phase inducer phosphatase MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Serine/threonine-protein kinase chk-1 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A4F324 O16368 O17071 O17586 O44156 O44552 O44628 O61742 O61792 O62102 O76371 O76577 P0CG71 P30634 P37165 P46502 P49632 P90868 P91477 Q04908 Q10920 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q21762 Q22253 Q23237 Q23449 Q27488 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N3Z3 Q9N599 Q9XTT9 Q9XUV0	C14C10.5 CELE_F35G12.12 cdc-25.1 cdc-25.2 cdc-25.3 cdc-25.4 chk-1 chkr-1 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Ub-specific processing proteases	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 BRCT domain-containing protein CAAX prenyl protease 2 homolog Dicer-related helicase Dwarfin sma-2 Dwarfin sma-3 Dwarfin sma-4 Forkhead box protein O G2/mitotic-specific cyclin-A1 GNAT family N-acetyltransferase Helicase ATP-binding domain-containing protein Histone H2A Histone H2A Histone H2A Hypoxia-inducible factor 1 Insulin-degrading enzyme M-phase inducer phosphatase cdc-25.1 M-phase inducer phosphatase cdc-25.2 M-phase inducer phosphatase cdc-25.3 M-phase inducer phosphatase MPN domain-containing protein Mitochondrial Rho GTPase 1 Mitochondrial import receptor subunit TOM20 homolog Mitochondrial import receptor subunit tomm-70 PCI domain-containing protein Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18 Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Probable peptidyl-tRNA hydrolase 2 Probable ubiquitin carboxyl-terminal hydrolase K02C4.3 Probable voltage-dependent anion-selective channel Proteasomal ubiquitin receptor ADRM1 homolog Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Protein kinase domain-containing protein RING-type domain-containing protein RuvB-like 1 Smad protein daf-8 Smad-related protein daf-14 UBA domain-containing protein USP domain-containing protein Ubiquitin carboxyl-terminal hydrolase 14 Ubiquitin carboxyl-terminal hydrolase 36 Ubiquitin carboxyl-terminal hydrolase 46 Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein WD repeat-containing protein 20 homolog WD repeat-containing protein 48 homolog WD repeat-containing protein fzy-1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A131MD44 A0A4V0IKF7 D9N129 F5GUE5 G5EBW2 G5EDI8 G5EE01 G5EEP3 G5EG81 G5EGD2 H2L010 O01467 O16249 O16368 O16850 O17071 O17586 O17607 O44156 O44552 O44624 O44628 O61742 O61792 O62102 O76371 O76387 O76577 P09588 P0CG71 P30634 P34547 P34638 P37165 P45896 P45897 P46502 P49632 P90868 P91477 Q02330 Q02335 Q04908 Q09289 Q09373 Q09931 Q10920 Q17361 Q17971 Q18115 Q18787 Q19132 Q19324 Q19766 Q20058 Q20059 Q20585 Q20938 Q21733 Q21752 Q21762 Q22253 Q22319 Q23237 Q23429 Q23449 Q27485 Q27488 Q7JKC3 Q7JMS4 Q93413 Q93875 Q94263 Q95005 Q95008 Q95PZ7 Q966I8 Q9BKQ6 Q9GRV2 Q9GZH5 Q9N599 Q9NAC7 Q9XTT9 Q9XUV0 V6CJY2	C04E6.5 C14C10.5 C24G6.8 CELE_F07A11.4 CELE_F35B3.3 CELE_F35G12.12 CELE_F44E7.4 CELE_T07F10.5 CELE_T22F3.2 CELE_T24A6.1 CELE_T24B8.7 CELE_Y53F4B.1 CELE_Y67D2.2 K02C4.3 cdc-25.1 cdc-25.2 cdc-25.3 cdc-25.4 cem-1 cem-2 cem-3 cya-1 cyld-1 daf-14 daf-16 daf-18 daf-8 drh-1 drh-3 exc-14 fce-2 fzy-1 hif-1 his-12 his-16 his-19 his-21 his-3 his-30 his-33 his-35 his-43 his-47 his-51 his-53 his-57 his-61 his-65 his-68 his-7 htas-1 math-33 miro-1 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rpn-1 rpn-10 rpn-11 rpn-12 rpn-13 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 ruvb-1 sma-2 sma-3 sma-4 tgt-1 tomm-20 tomm-70 ubia ubib ubl-1 ubq-1 ubq-2 usp-14 usp-3 usp-33 usp-4 usp-46 usp-50 usp-7 vdac-1 wdr-20 wdr-48	Caenorhabditis elegans

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