GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **551 - 575** of **1070** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲	Organism
Signaling by SCF-KIT	Chymase GRB2-associated-binding protein 2 GRB2-related adaptor protein 2 GRB2-related adaptor protein GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 10 Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 7 Kit ligand Mast/stem cell growth factor receptor Matrix metalloproteinase-9 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Protein kinase C alpha type Proto-oncogene tyrosine-protein kinase LCK Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Serine/threonine-protein kinase Chk1 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 4 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Tyrosine-protein kinase Fer Tyrosine-protein kinase Fyn Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type 11 protein-tyrosine-phosphatase	A0A0G2JX93 A0A0G2K344 A0A0G2K3H0 A0A8I6A3K6 D4A3T0 D4A584 F1LM93 P05696 P08644 P09760 P0CE43 P20171 P21581 P41499 P50282 P50339 P52631 P52632 P54100 P62994 Q01621 Q04970 Q07014 Q3KR57 Q4KM68 Q62689 Q62771 Q62844 Q63116 Q63787 Q63788 Q63789 Q6RUV5 Q91ZN7 Q9EQH1 Q9QZC5 Q9WUD9	Ash Chek1 Chk1 Cma1 Fer Fert2 Fes Flk Fyn Gab2 Grap Grap2 Grb10 Grb2 Grb7 Hras Hras1 Jak2 KIT Kit Kitl Kitlg Kras Kras2 Lck Lyn Mcpt3 Mgf Mmp9 Nras Pik3ca Pik3r1 Pik3r2 Pik3r3 Pkca Prkca Ptpn11 Ptpru Rac Rac1 Sos1 Src Stat1 Stat3 Stat4 Stat5a Stat5b Tec Vav Vav1 Yes1	Rattus norvegicus (Norway rat)
NCAM signaling for neurite out-growth	Cyclic AMP-responsive element-binding protein 1 Focal adhesion kinase 1 GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Neural cell adhesion molecule 1 Receptor-type tyrosine-protein phosphatase alpha Ribosomal protein S6 kinase SOS Ras/Rac guanine nucleotide exchange factor 1 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 2 Spectrin beta chain Spectrin beta chain Spectrin beta chain Spectrin, alpha, erythrocytic 1 Spectrin, beta, non-erythrocytic 5 Tyrosine-protein kinase Fyn	A0A0G2JY25 A0A0G2K677 A0A8I6A7D1 A0A8I6AWM3 D4A3T0 D4A678 G3V6S0 O35346 P08644 P13596 P15337 P16086 P20171 P21708 P62994 P63086 Q03348 Q04970 Q62844 Q9QWN8	Ash Creb-1 Creb1 Erk1 Erk2 Fak Fak1 Fyn Grb2 Hras Hras1 Kras Kras2 Lrp Mapk Mapk1 Mapk3 Ncam Ncam1 Nras Prkm1 Prkm3 Ptk2 Ptpra Rps6ka5 Sos1 Spna2 Spnb3 Spta1 Spta2 Sptan1 Sptb Sptbn1 Sptbn2 Sptbn4 Sptbn5	Rattus norvegicus (Norway rat)
MET activates RAP1 and RAC1	Adapter molecule crk Crk-like protein Dedicator of cytokinesis 7 GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Rap guanine nucleotide exchange factor 1 Ras-related C3 botulinum toxin substrate 1 Ras-related protein Rap-1A Ras-related protein Rap-1b	A0A0G2K3H2 D3ZAL7 F1M8L9 P17945 P62836 P62994 P97523 Q5U2U2 Q62636 Q63768 Q6RUV5	Ash Crk Crkl Crko Dock7 Gab1 Grb2 Hgf Krev1 Met Rac Rac1 Rap1a Rap1b Rapgef1	Rattus norvegicus (Norway rat)
Erythropoietin activates RAS	Crk-like protein Erythropoietin receptor Erythropoietin Growth factor receptor-bound protein 2 Insulin receptor substrate 2 Proto-oncogene vav Rap guanine nucleotide exchange factor 1 SHC-transforming protein 1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn	F1M8L9 F1MAL5 P29676 P54100 P62994 Q07014 Q07303 Q5M824 Q5U2U2 Q62689	Ash Crkl Epo Epor Grb2 Irs2 Jak2 Lyn Rapgef1 Shc1 Vav Vav1	Rattus norvegicus (Norway rat)
Interleukin receptor SHC signaling	Colony stimulating factor 2 receptor subunit beta GRB2-associated-binding protein 2 Granulocyte-macrophage colony-stimulating factor Growth factor receptor-bound protein 2 Interleukin 3 receptor subunit alpha Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 Interleukin-3 Interleukin-5 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type 6 phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A0G2K344 A0A8I5Y949 A0A8I6AM23 D4A3T0 E9PSX4 G3V608 P04823 P17108 P26896 P26897 P48750 P62994 P81718 P97573 Q08125 Q5M824 Q62689 Q63272 Q63787 Q63788 Q63789 Q9EQH1 Q9WVR3 Q9Z1L0	Ash Csf2 Csf2rb Csfgm Gab2 Grb2 Il-2 Il-3 Il-5 Il2 Il2ra Il2rb Il3 Il3ra Il5 Inpp5d Inppl1 Jak1 Jak2 Jak3 Pik3ca Pik3cb Pik3cd Pik3r1 Pik3r2 Pik3r3 Ptph6 Ptpn6 Shc1 Ship Ship1 Ship2 Sos1	Rattus norvegicus (Norway rat)
EGFR Transactivation by Gastrin	GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 Proheparin-binding EGF-like growth factor Protein kinase C alpha type Receptor protein-tyrosine kinase SOS Ras/Rac guanine nucleotide exchange factor 1 Stromelysin-1	D4A3T0 G3V6K6 P03957 P05696 P08644 P20171 P62994 Q04970 Q06175	Ash Dtr Egfr Grb2 Hbegf Hegfl Hras Hras1 Kras Kras2 Mmp3 Nras Pkca Prkca Sos1	Rattus norvegicus (Norway rat)
Signal attenuation	Growth factor receptor-bound protein 10 Growth factor receptor-bound protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin receptor Insulin-1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1	D4A3T0 F1MAL5 P01322 P0CE43 P15127 P21708 P35570 P62994 P63086 Q5M824	Ash Erk1 Erk2 Grb10 Grb2 Ins-1 Ins1 Insr Irs-1 Irs1 Irs2 Mapk Mapk1 Mapk3 Prkm1 Prkm3 Shc1 Sos1	Rattus norvegicus (Norway rat)
PI3K Cascade	Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated binding protein 1 GRB2-associated-binding protein 2 Growth factor receptor-bound protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Klotho beta Klotho Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphoinositide 3-kinase regulatory subunit 4 Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type 11 receptor protein-tyrosine kinase	A0A0G2JW59 A0A0G2K210 A0A0G2K344 A0A8I6B5D5 D3Z8T6 D3ZAL7 D4A244 F1LSG7 F1LSQ8 F1MAL5 M0RAA8 O54769 O88182 O88763 P0C0R5 P13109 P35570 P36364 P41499 P48807 P61149 P62994 P63076 P70492 Q02195 Q04589 Q498D6 Q63787 Q63788 Q8R5L5 Q8R5L9 Q8VI79 Q8VI81 Q8VI82 Q9EQH1 Q9EST9 Q9Z1L0 Q9Z2Y9	Ash FGF15 FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-7 Fgf-9 Fgf1 Fgf10 Fgf16 Fgf17 Fgf18 Fgf19 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7 Fgf7a Fgf7b Fgf8 Fgf8a Fgf9 Fgfa Fgfr1 Fgfr2 Fgfr3 Fgfr4 Flg Flt3 Frs2 Gab1 Gab2 Grb2 Irs-1 Irs1 Irs2 Kgf Kl Klb Pik3c3 Pik3ca Pik3cb Pik3r1 Pik3r2 Pik3r4 Ptpn11 Tlr9 Vps34	Rattus norvegicus (Norway rat)
FRS-mediated FGFR4 signaling	Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 Klotho beta SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type 11	A0A8I6B5D5 D3Z8T6 D4A244 D4A3T0 F1LSQ8 O54769 O88182 P08644 P13109 P20171 P36364 P41499 P61149 P62994 P63076 Q04970 Q498D6 Q52RG8 Q8R5L5 Q8VI81 Q8VI82 Q9EST9	Ash FGF15 FGF6 Fgf-1 Fgf-2 Fgf-9 Fgf1 Fgf16 Fgf17 Fgf18 Fgf19 Fgf2 Fgf20 Fgf23 Fgf4 Fgf6 Fgf7a Fgf7b Fgf8 Fgf8a Fgf9 Fgfa Fgfr4 Frs2 Frs3 Grb2 Hras Hras1 Klb Kras Kras2 Nras Ptpn11 Snt2 Sos1	Rattus norvegicus (Norway rat)
PI-3K cascade:FGFR4	Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Klotho beta Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	A0A0G2K344 A0A8I6B5D5 D3Z8T6 D3ZAL7 D4A244 F1LSQ8 O54769 O88182 P13109 P36364 P41499 P61149 P62994 P63076 Q498D6 Q63787 Q8R5L5 Q8VI81 Q8VI82 Q9EST9	Ash FGF15 FGF6 Fgf-1 Fgf-2 Fgf-9 Fgf1 Fgf16 Fgf17 Fgf18 Fgf19 Fgf2 Fgf20 Fgf23 Fgf4 Fgf6 Fgf7a Fgf7b Fgf8 Fgf8a Fgf9 Fgfa Fgfr4 Frs2 Gab1 Grb2 Klb Pik3ca Pik3r1 Ptpn11	Rattus norvegicus (Norway rat)
SHC-mediated cascade:FGFR4	Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 Klotho beta SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1	A0A8I6B5D5 D3Z8T6 D4A3T0 F1LSQ8 O54769 O88182 P08644 P13109 P20171 P36364 P61149 P62994 P63076 Q04970 Q498D6 Q5M824 Q8R5L5 Q8VI81 Q8VI82 Q9EST9	Ash FGF15 FGF6 Fgf-1 Fgf-2 Fgf-9 Fgf1 Fgf16 Fgf17 Fgf18 Fgf19 Fgf2 Fgf20 Fgf23 Fgf4 Fgf6 Fgf7a Fgf7b Fgf8 Fgf8a Fgf9 Fgfa Fgfr4 Grb2 Hras Hras1 Klb Kras Kras2 Nras Shc1 Sos1	Rattus norvegicus (Norway rat)
FRS-mediated FGFR2 signaling	Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type 11	A0A8I6B5D5 D4A244 D4A3T0 F1LSG7 F1LSQ8 O54769 O88182 P08644 P13109 P20171 P36364 P41499 P48807 P61149 P62994 P63076 P70492 Q02195 Q04970 Q52RG8 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9	Ash FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-7 Fgf-9 Fgf1 Fgf10 Fgf16 Fgf17 Fgf18 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr2 Frs2 Frs3 Grb2 Hras Hras1 Kgf Kras Kras2 Nras Ptpn11 Snt2 Sos1	Rattus norvegicus (Norway rat)
PI-3K cascade:FGFR2	Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	A0A0G2K344 A0A8I6B5D5 D3ZAL7 D4A244 F1LSG7 F1LSQ8 O54769 O88182 P13109 P36364 P41499 P48807 P61149 P62994 P63076 P70492 Q02195 Q63787 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9	Ash FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-7 Fgf-9 Fgf1 Fgf10 Fgf16 Fgf17 Fgf18 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr2 Frs2 Gab1 Grb2 Kgf Pik3ca Pik3r1 Ptpn11	Rattus norvegicus (Norway rat)
SHC-mediated cascade:FGFR2	Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1	A0A8I6B5D5 D4A3T0 F1LSG7 F1LSQ8 O54769 O88182 P08644 P13109 P20171 P36364 P48807 P61149 P62994 P63076 P70492 Q02195 Q04970 Q5M824 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9	Ash FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-7 Fgf-9 Fgf1 Fgf10 Fgf16 Fgf17 Fgf18 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr2 Grb2 Hras Hras1 Kgf Kras Kras2 Nras Shc1 Sos1	Rattus norvegicus (Norway rat)
FRS-mediated FGFR1 signaling	Fibroblast growth factor 10 Fibroblast growth factor 17 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 Klotho SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type 11	A0A8I6B5D5 D4A244 D4A3T0 F1LSQ8 P08644 P13109 P20171 P36364 P41499 P48807 P61149 P62994 P63076 P70492 Q04589 Q04970 Q52RG8 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9 Q9Z2Y9	Ash FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-9 Fgf1 Fgf10 Fgf17 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr1 Flg Frs2 Frs3 Grb2 Hras Hras1 Kl Kras Kras2 Nras Ptpn11 Snt2 Sos1	Rattus norvegicus (Norway rat)
PI-3K cascade:FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 17 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Klotho Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	A0A0G2K344 A0A8I6B5D5 D3ZAL7 D4A244 F1LSQ8 P13109 P36364 P41499 P48807 P61149 P62994 P63076 P70492 Q04589 Q63787 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9 Q9Z2Y9	Ash FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-9 Fgf1 Fgf10 Fgf17 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr1 Flg Frs2 Gab1 Grb2 Kl Pik3ca Pik3r1 Ptpn11	Rattus norvegicus (Norway rat)
SHC-mediated cascade:FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 17 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 Klotho SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1	A0A8I6B5D5 D4A3T0 F1LSQ8 P08644 P13109 P20171 P36364 P48807 P61149 P62994 P63076 P70492 Q04589 Q04970 Q5M824 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9 Q9Z2Y9	Ash FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-9 Fgf1 Fgf10 Fgf17 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr1 Flg Grb2 Hras Hras1 Kl Kras Kras2 Nras Shc1 Sos1	Rattus norvegicus (Norway rat)
FRS-mediated FGFR3 signaling	Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type 11	A0A0G2K210 A0A8I6B5D5 D4A244 D4A3T0 F1LSQ8 O54769 O88182 P08644 P13109 P20171 P36364 P41499 P48807 P61149 P62994 P63076 Q04970 Q52RG8 Q8VI82 Q9EST9	Ash Fgf-1 Fgf-2 Fgf-5 Fgf-9 Fgf1 Fgf16 Fgf17 Fgf18 Fgf2 Fgf20 Fgf23 Fgf4 Fgf5 Fgf7a Fgf8 Fgf9 Fgfa Fgfr3 Frs2 Frs3 Grb2 Hras Hras1 Kras Kras2 Nras Ptpn11 Snt2 Sos1	Rattus norvegicus (Norway rat)
PI-3K cascade:FGFR3	Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	A0A0G2K210 A0A0G2K344 A0A8I6B5D5 D3ZAL7 D4A244 F1LSQ8 O54769 O88182 P13109 P36364 P41499 P48807 P61149 P62994 P63076 Q63787 Q8VI82 Q9EST9	Ash Fgf-1 Fgf-2 Fgf-5 Fgf-9 Fgf1 Fgf16 Fgf17 Fgf18 Fgf2 Fgf20 Fgf23 Fgf4 Fgf5 Fgf7a Fgf8 Fgf9 Fgfa Fgfr3 Frs2 Gab1 Grb2 Pik3ca Pik3r1 Ptpn11	Rattus norvegicus (Norway rat)
SHC-mediated cascade:FGFR3	Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 9 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1	A0A0G2K210 A0A8I6B5D5 D4A3T0 F1LSQ8 O54769 O88182 P08644 P13109 P20171 P36364 P48807 P61149 P62994 P63076 Q04970 Q5M824 Q8VI82 Q9EST9	Ash Fgf-1 Fgf-2 Fgf-5 Fgf-9 Fgf1 Fgf16 Fgf17 Fgf18 Fgf2 Fgf20 Fgf23 Fgf4 Fgf5 Fgf7a Fgf8 Fgf9 Fgfa Fgfr3 Grb2 Hras Hras1 Kras Kras2 Nras Shc1 Sos1	Rattus norvegicus (Norway rat)
MET activates PI3K/AKT signaling	GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	A0A0G2K344 D3ZAL7 P17945 P62994 P97523 Q63787	Ash Gab1 Grb2 Hgf Met Pik3ca Pik3r1	Rattus norvegicus (Norway rat)
MET activates PTPN11	GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Tyrosine-protein phosphatase non-receptor type 11	D3ZAL7 P17945 P41499 P62994 P97523	Ash Gab1 Grb2 Hgf Met Ptpn11	Rattus norvegicus (Norway rat)
Insulin receptor signalling cascade	Growth factor receptor-bound protein 10 Growth factor receptor-bound protein 2 Insulin receptor Insulin-1 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1	D4A3T0 P01322 P0CE43 P15127 P62994 Q5M824	Ash Grb10 Grb2 Ins-1 Ins1 Insr Shc1 Sos1	Rattus norvegicus (Norway rat)
MET activates RAS signaling	GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Mucin 20, cell surface associated RAN binding protein 10 Ran-binding protein 9 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1	A0A8I5Y176 A0A8I6AAU0 D3Z7Z5 D4A3T0 P08644 P17945 P20171 P62994 P97523 Q04970 Q5M824	Ash Grb2 Hgf Hras Hras1 Kras Kras2 Met Muc20 Nras Ranbp10 Ranbp9 Shc1 Sos1	Rattus norvegicus (Norway rat)
SHC-related events triggered by IGF1R	Growth factor receptor-bound protein 2 Insulin-like growth factor 1 receptor Insulin-like growth factor I Insulin-like growth factor II SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1	D4A3T0 P01346 P08025 P24062 P62994 Q5M824	Ash Grb2 Igf-1 Igf-2 Igf1 Igf1r Igf2 Shc1 Sos1	Rattus norvegicus (Norway rat)

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