metabolic dysfunction-associated steatohepatitis

Summary
Synonym
  • MASH
  • NASH
  • non-alcoholic steatohepatitis
  • nonalcoholic steatohepatitis
Definition
A metabolic dysfunction-associated steatotic liver disease characterized by the presence of inflammation with hepatocyte injury such as ballooning, with or without fibrosis.
Super Class
metabolic dysfunction-associated steatotic liver disease
Disease Ontology
DOID:0080547
MGI genotype (from TogoID)
Related Genes
Displaying entries 11 - 20 of 39 in total
Gene ID Gene Symbol Description Source
3357 HTR2B 5-hydroxytryptamine receptor 2B
3383 ICAM1 intercellular adhesion molecule 1
3569 IL6 interleukin 6
3586 IL10 interleukin 10
3663 IRF5 interferon regulatory factor 5
3875 KRT18 keratin 18
3953 LEPR leptin receptor
4089 SMAD4 SMAD family member 4
4160 MC4R melanocortin 4 receptor
4780 NFE2L2 NFE2 like bZIP transcription factor 2
Displaying entries 1 - 10 of 31 in total
Gene ID Gene Symbol Description Source
11551 Adra2a adrenergic receptor, alpha 2a
12007 Azgp1 alpha-2-glycoprotein 1, zinc
12514 Cd68 CD68 antigen
12842 Col1a1 collagen, type I, alpha 1
12894 Cpt1a carnitine palmitoyltransferase 1a, liver
14828 Hspa5 heat shock protein 5
15559 Htr2b 5-hydroxytryptamine (serotonin) receptor 2B
15894 Icam1 intercellular adhesion molecule 1
16153 Il10 interleukin 10
16668 Krt18 keratin 18
Displaying entries 1 - 10 of 19 in total
Gene ID Gene Symbol Description Source
24536 Lepr leptin receptor
24629 Pdgfrb platelet derived growth factor receptor beta
24770 Ccl2 C-C motif chemokine ligand 2
24787 Sod2 superoxide dismutase 2
24835 Tnf tumor necrosis factor
25083 Adra2a adrenoceptor alpha 2A
25325 Il10 interleukin 10
25464 Icam1 intercellular adhesion molecule 1
25635 Mc4r melanocortin 4 receptor
25757 Cpt1a carnitine palmitoyltransferase 1A
Displaying all 3 entries
Gene ID Gene Symbol Description Source
35717 tor torso
36232 Sod3 Superoxide dismutase 3
37131 Pepck1 Phosphoenolpyruvate carboxykinase 1
Displaying 1 entry
Gene ID Gene Symbol Description Source
286833 mc4r melanocortin 4 receptor
Displaying all 3 entries
Gene ID Gene Symbol Description Source
175182 ver-1 Protein ver-1
177343 skn-1 BZIP domain-containing protein;Protein skinhead-1
179197 cri-2 Putative metalloproteinase inhibitor tag-225
Displaying all 4 entries
Gene ID Gene Symbol Description Source
852481 YPC1 phytoceramidase
853418 KAR2 Hsp70 family ATPase KAR2
855247 HFA1 acetyl-CoA carboxylase HFA1
856018 YDC1 alkaline dihydroceramidase

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024