glioblastoma

Summary
Synonym
  • GBM
  • adult glioblastoma multiforme
  • glioblastoma multiforme
  • grade IV adult Astrocytic tumor
  • primary glioblastoma multiforme
  • spongioblastoma multiforme
Definition
A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.
Super Class
malignant astrocytoma
Disease Ontology
DOID:3068
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 31 - 40 of 54 in total
Gene ID Gene Symbol Description Source
5293 PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5426 POLE DNA polymerase epsilon, catalytic subunit
5605 MAP2K2 mitogen-activated protein kinase kinase 2
5606 MAP2K3 mitogen-activated protein kinase kinase 3
5742 PTGS1 prostaglandin-endoperoxide synthase 1
5743 PTGS2 prostaglandin-endoperoxide synthase 2
5787 PTPRB protein tyrosine phosphatase receptor type B
5925 RB1 RB transcriptional corepressor 1
6165 RPL35A ribosomal protein L35a
6774 STAT3 signal transducer and activator of transcription 3
Displaying entries 1 - 10 of 38 in total
Gene ID Gene Symbol Description Source
12258 Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1
12654 Chi3l1 chitinase 3 like 1
12876 Cpe carboxypeptidase E
12945 Dmbt1 deleted in malignant brain tumors 1
13030 Ctsb cathepsin B
13036 Ctsh cathepsin H
13645 Egf epidermal growth factor
14056 Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit
14256 Flt3l FMS-like tyrosine kinase 3 ligand
14726 Pdpn podoplanin
Displaying entries 1 - 10 of 24 in total
Gene ID Gene Symbol Description Source
24479 Idh1 isocitrate dehydrogenase (NADP(+)) 1
24628 Pdgfb platelet derived growth factor subunit B
24629 Pdgfrb platelet derived growth factor receptor beta
24842 Tp53 tumor protein p53
25313 Egf epidermal growth factor
25425 Ctsh cathepsin H
25589 Kdr kinase insert domain receptor
25669 Cpe carboxypeptidase E
29414 Akt3 AKT serine/threonine kinase 3
29527 Ptgs2 prostaglandin-endoperoxide synthase 2
Displaying entries 11 - 13 of 13 in total
Gene ID Gene Symbol Description Source
36868 Idgf6 Imaginal disc growth factor 6
37104 Idgf5 Imaginal disc growth factor 5
42850 Atg6 Autophagy-related 6
Displaying 1 entry
Gene ID Gene Symbol Description Source
554230 kdr kinase insert domain receptor (a type III receptor tyrosine kinase)
Displaying entries 11 - 14 of 14 in total
Gene ID Gene Symbol Description Source
180628 cht-1 putative endochitinase
180931 cpr-6 Cathepsin B-like cysteine proteinase 6
181684 cpd-2 Peptidase M14 carboxypeptidase A domain-containing protein
186632 ver-4 Tyrosine-protein kinase receptor ver-4
Displaying all 7 entries
Gene ID Gene Symbol Description Source
850391 NPP1 nucleotide diphosphatase/phosphodiesterase NPP1
850871 IDP2 isocitrate dehydrogenase (NADP(+)) IDP2
851493 IDP1 isocitrate dehydrogenase (NADP(+)) IDP1
851977 CTS2 putative chitinase
853313 PBS2 mitogen-activated protein kinase kinase PBS2
855723 IDP3 isocitrate dehydrogenase (NADP(+)) IDP3
856699 NPP2 nucleotide diphosphatase/phosphodiesterase NPP2

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