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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
type 2 diabetes mellitus
Summary
- Synonym
-
- NIDDM
- insulin resistance
- non-insulin-dependent diabetes mellitus
- type 2 diabetes
- type II diabetes mellitus
- Definition
- A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
- Super Class
- diabetes mellitus
External Links
- Disease Ontology
- DOID:9352
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- OMIM
- MGI genotype (from TogoID)
-
- 5504442
- 3760281
- 3766122
- 3789135
- 3842791
- 3847120
- 4361710
- 4429442
- 5294956
- 5301577
- 5428893
- 5435319
- 5502687
- 3721145
- 5620891
- 5637560
- 5638149
- 5695740
- 5766495
- 5789257
- 5804115
- 5804125
- 6111393
- 6160731
- 7314952
- 7622052
- 3531404
- 2175101
- 2177705
- 2385750
- 2385751
- 2653988
- 2654708
- 3028851
- 3029380
- 3051529
- 3052685
- 3510669
- 3510670
- 2174965
- 3531409
- 3582680
- 3583344
- 3583687
- 3583763
- 3583951
- 3583952
- 3586490
- 3590085
- 3623394
- 3629188
- 3694548
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 19 | ABCA1 | ATP binding cassette subfamily A member 1 | |
| 111 | ADCY5 | adenylate cyclase 5 | |
| 133 | ADM | adrenomedullin | |
| 142 | PARP1 | poly(ADP-ribose) polymerase 1 | |
| 150 | ADRA2A | adrenoceptor alpha 2A | |
| 154 | ADRB2 | adrenoceptor beta 2 | |
| 155 | ADRB3 | adrenoceptor beta 3 | |
| 177 | AGER | advanced glycosylation end-product specific receptor | |
| 183 | AGT | angiotensinogen | |
| 186 | AGTR2 | angiotensin II receptor type 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 11303 | Abca1 | ATP-binding cassette, sub-family A member 1 | |
| 11421 | Ace | angiotensin I converting enzyme | |
| 11450 | Adipoq | adiponectin, C1Q and collagen domain containing | |
| 11491 | Adam17 | a disintegrin and metallopeptidase domain 17 | |
| 11551 | Adra2a | adrenergic receptor, alpha 2a | |
| 11556 | Adrb3 | adrenergic receptor, beta 3 | |
| 11596 | Ager | advanced glycosylation end product-specific receptor | |
| 11601 | Angpt2 | angiopoietin 2 | |
| 11609 | Agtr2 | angiotensin II receptor, type 2 | |
| 11625 | Ahsg | alpha-2-HS-glycoprotein |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24476 | Iapp | islet amyloid polypeptide | |
| 24483 | Igf2 | insulin-like growth factor 2 | |
| 24484 | Igfbp3 | insulin-like growth factor binding protein 3 | |
| 24505 | Ins1 | insulin 1 | |
| 24506 | Ins2 | insulin 2 | |
| 24536 | Lepr | leptin receptor | |
| 24539 | Lpl | lipoprotein lipase | |
| 24598 | Nos1 | nitric oxide synthase 1 | |
| 24600 | Nos3 | nitric oxide synthase 3 | |
| 24617 | Serpine1 | serpin family E member 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 41549 | Octbeta2R | Octopamine beta2 receptor | |
| 41573 | Ugt37A2 | UDP-glycosyltransferase family 37 member A2 | |
| 41574 | Ugt37A3 | UDP-glycosyltransferase family 37 member A3 | |
| 41625 | Ace | Acetylcholine esterase | |
| 42514 | Snmp1 | Sensory neuron membrane protein 1 | |
| 42518 | Oga | O-GlcNAcase | |
| 42538 | Ugt49B2 | UDP-glycosyltransferase family 49 member B2 | |
| 42549 | InR | Insulin-like receptor | |
| 42620 | PyK | Pyruvate kinase | |
| 42652 | Octbeta1R | Octopamine beta1 receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30173 | nog3 | noggin 3 | |
| 30174 | nog1 | noggin 1 | |
| 30262 | ins | preproinsulin | |
| 30667 | mtnr1aa | melatonin receptor 1A a | |
| 30668 | mtnr1bb | melatonin receptor 1Bb | |
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 266751 | adra2b | adrenoceptor alpha 2B | |
| 321664 | aldob | aldolase b, fructose-bisphosphate | |
| 337685 | ogt.1 | O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1 | |
| 393807 | ppp1r3cb | protein phosphatase 1, regulatory subunit 3Cb |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373759 | cnr1.S | cannabinoid receptor 1 (brain) S homeolog | Xenopus laevis (African clawed frog) | |
| 378584 | drd2.L | dopamine receptor D2 L homeolog | Xenopus laevis (African clawed frog) | |
| 378695 | ins.L | insulin L homeolog | Xenopus laevis (African clawed frog) | |
| 378696 | ins.S | insulin S homeolog | Xenopus laevis (African clawed frog) | |
| 379783 | akt2.L | v-akt murine thymoma viral oncogene homolog 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 380341 | pon2.L | paraoxonase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 394283 | sdc2.S | syndecan 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397750 | hmgcr.L | 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog | Xenopus laevis (African clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 398006 | insr.L | insulin receptor L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 175383 | zmp-2 | Matrix metalloproteinase-B | |
| 175410 | daf-2 | Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase | |
| 175591 | ugt-62 | UDP-glucuronosyltransferase | |
| 175781 | daf-4 | Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase | |
| 176000 | ogt-1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase;protein O-GlcNAc transferase | |
| 176076 | fbn-1 | EGF-like domain-containing protein | |
| 176673 | scav-3 | Sensory neuron membrane protein 2 | |
| 176787 | scav-2 | SCAVenger receptor (CD36 family) related | |
| 176788 | aldo-1 | Fructose-bisphosphate aldolase 1 | |
| 177343 | skn-1 | BZIP domain-containing protein;Protein skinhead-1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850317 | GLK1 | glucokinase | |
| 850369 | ADP1 | putative ATP-dependent permease ADP1 | |
| 850391 | NPP1 | nucleotide diphosphatase/phosphodiesterase NPP1 | |
| 850614 | HXK1 | hexokinase 1 | |
| 850645 | BPT1 | ATP-binding cassette bilirubin transporter BPT1 | |
| 850678 | YBT1 | bile acid-transporting ATPase YBT1 | |
| 850886 | ATG26 | sterol 3-beta-glucosyltransferase | |
| 850979 | PIG1 | protein phosphatase regulator PIG1 | |
| 851006 | ECM38 | gamma-glutamyltransferase | |
| 851171 | HMG2 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000855 | Insulin resistance |
| HP:0005978 | Type II diabetes mellitus |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0003584 | Late onset |
| Gene ID | Gene Symbol | Description |
|---|---|---|
| 2645 | GCK | glucokinase |
| 2820 | GPD2 | glycerol-3-phosphate dehydrogenase 2 |
| 3990 | LIPC | lipase C, hepatic type |
| 5167 | ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| 5506 | PPP1R3A | protein phosphatase 1 regulatory subunit 3A |
| 6514 | SLC2A2 | solute carrier family 2 member 2 |
