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torsin

Summary

Gene Symbol

Torsin

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

31399

PubChem

31399

Alliance of Genome Resources

FB:FBgn0025615

Annotation

Keyword

ATP-binding
Chaperone
Endoplasmic reticulum
Glycoprotein
Hydrolase
Proteomics identification
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
F6JQA6
O77277

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
lipid metabolic process	IMP	27453503
larval fat body development	IMP	27453503
eye pigment granule organization	IMP	16967506
regulation of lipid storage	IMP	27453503
positive regulation of cell growth	IMP	27453503

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process

cellular lipid metabolic process

membrane lipid metabolic process [inference]

membrane lipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

membrane lipid biosynthetic process

cellular lipid metabolic process

membrane lipid metabolic process [inference]

membrane lipid biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

membrane lipid biosynthetic process

cellular lipid metabolic process

membrane lipid metabolic process [inference]

membrane lipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process

cellular process [inference]

protein folding [inference]

'de novo' protein folding [inference]

'de novo' post-translational protein folding [inference]

chaperone cofactor-dependent protein refolding

chaperone-mediated protein folding [inference]

chaperone cofactor-dependent protein refolding

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process

cellular lipid metabolic process

membrane lipid metabolic process [inference]

membrane lipid biosynthetic process

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

nuclear envelope budding

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

pigment granule organization [inference]

eye pigment granule organization

membrane organization [inference]

membrane fission [inference]

vesicle scission

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

fat body development [inference]

larval fat body development

homeostatic process [inference]

cellular homeostasis [inference]

neuron cellular homeostasis

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

response to topologically incorrect protein [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

response to misfolded protein [inference]

cellular response to misfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

response to misfolded protein [inference]

cellular response to misfolded protein

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

nuclear envelope budding

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

nuclear envelope budding

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

nuclear envelope budding

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of primary metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of localization [inference]

regulation of lipid storage

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell growth

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

positive regulation of cellular process [inference]

positive regulation of cell growth

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nuclear envelope	IDA	16967506 23583177 34313336
endoplasmic reticulum	IDA	16967506
endoplasmic reticulum	IEA
endoplasmic reticulum lumen
nuclear membrane protein complex	IGI	34313336

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

nuclear membrane protein complex

nuclear protein-containing complex [inference]

nuclear membrane protein complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ATP binding	ISM	23583177
ATP binding	IEA
ATP hydrolysis activity	ISS
ATP hydrolysis activity	ISM	23583177
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Torsin

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
ATP binding

Displaying **all 4** entries
InterPro
ClpA/B family
P-loop containing nucleoside triphosphate hydrolase
Torsin-1A, C-terminal domain
Torsin

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
endoplasmic reticulum	PMID:16967506
nuclear envelope	PMID:16967506 PMID:23583177 PMID:34313336
perinuclear region of cytoplasm	PMID:16967506
membrane	FB:FBrf0231198

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:543	dystonia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 14 in total

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2

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Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	1861	Xenbase:XB-GENE-943837
Xenopus tropicalis	27348	Xenbase:XB-GENE-986914
Xenopus tropicalis	27433	Xenbase:XB-GENE-5806617
Xenopus tropicalis	30931	Xenbase:XB-GENE-943837
Xenopus tropicalis	30933	Xenbase:XB-GENE-5806617
Xenopus tropicalis	30934	Xenbase:XB-GENE-986914
Danio rerio	30935	ZFIN:ZDB-GENE-081104-165
Xenopus tropicalis	31399	Xenbase:XB-GENE-5806617
Danio rerio	64222	ZFIN:ZDB-GENE-081104-165
Xenopus tropicalis	174433	Xenbase:XB-GENE-5806617