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apolipoprotein E

Summary

Gene Symbol

APOE

Organism

Homo sapiens (human)

External Links

NCBI Gene

348

PubChem

348

Alliance of Genome Resources

HGNC:613

JoGo

APOE

TogoVar

APOE

Annotation

Keyword

3D-structure
Alzheimer disease
Amyloidosis
Cholesterol metabolism
Chylomicron
Coiled coil
Direct protein sequencing
Disease variant
Endosome
Extracellular matrix
Glycation
HDL
Heparin-binding
Host-virus interaction
Hyperlipidemia
Lipid transport
Lipid-binding
Lipoprotein
Neurodegeneration
Oxidation
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal
VLDL

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P02649
A0A0S2Z3D5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of **125** in total

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GO Term	Evidence Code	PMID
cholesterol catabolic process	IEA
intracellular calcium ion homeostasis	IEA
receptor-mediated endocytosis	TAS	22138302
receptor-mediated endocytosis	IDA	1917954
cytoskeleton organization	TAS	9622609

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

amyloid precursor protein metabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organonitrogen compound biosynthetic process [inference]

lipoprotein biosynthetic process

catabolic process [inference]

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organic hydroxy compound catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

alcohol catabolic process [inference]

cholesterol catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

lipoprotein biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

amyloid precursor protein metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

macromolecule biosynthetic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

amyloid precursor protein metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

amyloid precursor protein metabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organonitrogen compound biosynthetic process [inference]

lipoprotein biosynthetic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organic hydroxy compound catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

alcohol catabolic process [inference]

cholesterol catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

lipoprotein biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

organic hydroxy compound catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

alcohol catabolic process [inference]

cholesterol catabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, cholinergic

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

nitric oxide mediated signal transduction [inference]

nitric oxide-cGMP-mediated signaling pathway

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling [inference]

nitric oxide-cGMP-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

cellular localization [inference]

intracellular transport

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein import

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

maintenance of location in cell

cellular response to stimulus [inference]

cellular response to lipoprotein particle stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

vesicle organization [inference]

pigment granule organization [inference]

melanosome organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

cellular detoxification [inference]

cellular oxidant detoxification

viral process [inference]

virion assembly

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory [inference]

long-term memory

behavior [inference]

learning or memory [inference]

memory [inference]

long-term memory

locomotory behavior [inference]

locomotory exploration behavior

exploration behavior [inference]

locomotory exploration behavior

plasma lipoprotein particle clearance [inference]

triglyceride-rich lipoprotein particle clearance

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

lipid homeostasis [inference]

fatty acid homeostasis

acylglycerol homeostasis

triglyceride homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

positive regulation by host of viral process

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species

response to caloric restriction

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to chemical [inference]

response to oxygen-containing compound [inference]

response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to lipoprotein particle stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein import

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

intracellular transport

organic substance transport [inference]

lipid transport [inference]

lipid transport involved in lipid storage

fatty acid transport [inference]

long-chain fatty acid transport

phospholipid transport [inference]

phospholipid efflux

sterol transport [inference]

cholesterol transport [inference]

protein transport [inference]

protein import

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid efflux

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

nitrogen compound transport [inference]

protein transport [inference]

protein import

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

establishment of protein localization [inference]

protein transport [inference]

protein import

establishment of localization in cell [inference]

intracellular transport

maintenance of location [inference]

maintenance of location in cell

cellular localization [inference]

intracellular transport

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein import

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response [inference]

regulation of innate immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of lipid biosynthetic process

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of lipid biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

negative regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of lipid biosynthetic process

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid fibril formation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of triglyceride metabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of triglyceride metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid fibril formation

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of lipid biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid fibril formation

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of lipid biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid fibril formation

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of proteasomal protein catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of triglyceride metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

negative regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of amide metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

positive regulation of amide metabolic process [inference]

positive regulation of amyloid-beta formation

regulation of amyloid-beta formation [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid fibril formation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid fibril formation

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of protein metabolic process

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of proteasomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid fibril formation

negative regulation of protein metabolic process

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid fibril formation

regulation of amyloid precursor protein catabolic process

regulation of amyloid-beta formation [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

regulation of amyloid fibril formation

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

negative regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid fibril formation

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid fibril formation

regulation of protein metabolic process

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of proteasomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid fibril formation

negative regulation of protein metabolic process

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid fibril formation

regulation of amyloid precursor protein catabolic process

regulation of amyloid-beta formation [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

regulation of amyloid fibril formation

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of small molecule metabolic process [inference]

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of triglyceride metabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of lipid biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride metabolic process

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of protein metabolic process

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of proteasomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid fibril formation

negative regulation of protein metabolic process

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid fibril formation

regulation of amyloid precursor protein catabolic process

regulation of amyloid-beta formation [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

regulation of amyloid fibril formation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction [inference]

regulation of Cdc42 protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of long-term synaptic potentiation [inference]

negative regulation of long-term synaptic potentiation

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, cholinergic

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol efflux

negative regulation of lipid transport across blood-brain barrier

negative regulation of phospholipid transport [inference]

negative regulation of phospholipid efflux

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid transport across blood-brain barrier

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol efflux

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of lipid transport across blood-brain barrier [inference]

regulation of phospholipid transport [inference]

regulation of phospholipid efflux [inference]

negative regulation of phospholipid transport [inference]

negative regulation of phospholipid efflux

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid transport across blood-brain barrier

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

positive regulation of endocytosis

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

positive regulation of transport across blood-brain barrier [inference]

positive regulation of lipid transport across blood-brain barrier

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol efflux

negative regulation of lipid transport across blood-brain barrier

negative regulation of phospholipid transport [inference]

negative regulation of phospholipid efflux

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of transport across blood-brain barrier [inference]

negative regulation of lipid transport across blood-brain barrier

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of lipoprotein transport [inference]

positive regulation of lipoprotein transport

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of transport across blood-brain barrier [inference]

positive regulation of transport across blood-brain barrier [inference]

positive regulation of lipid transport across blood-brain barrier

negative regulation of transport across blood-brain barrier [inference]

negative regulation of lipid transport across blood-brain barrier

regulation of lipid transport across blood-brain barrier [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of lipoprotein transport [inference]

positive regulation of lipoprotein transport

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol efflux

negative regulation of lipid transport across blood-brain barrier

negative regulation of phospholipid transport [inference]

negative regulation of phospholipid efflux

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid transport across blood-brain barrier

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol efflux

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of lipid transport across blood-brain barrier [inference]

regulation of phospholipid transport [inference]

regulation of phospholipid efflux [inference]

negative regulation of phospholipid transport [inference]

negative regulation of phospholipid efflux

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol efflux

negative regulation of lipid transport across blood-brain barrier

negative regulation of phospholipid transport [inference]

negative regulation of phospholipid efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid transport across blood-brain barrier

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

regulation of growth [inference]

regulation of cell growth [inference]

regulation of extent of cell growth [inference]

regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of lipid biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid fibril formation

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of lipid biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of amyloid precursor protein catabolic process [inference]

positive regulation of amyloid-beta formation

positive regulation of amyloid fibril formation

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular component biogenesis [inference]

positive regulation of inclusion body assembly [inference]

positive regulation of neurofibrillary tangle assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of endocytosis

positive regulation of inclusion body assembly [inference]

positive regulation of neurofibrillary tangle assembly

positive regulation of presynaptic membrane organization

positive regulation of supramolecular fiber organization [inference]

positive regulation of amyloid fibril formation

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid transport across blood-brain barrier

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

positive regulation of endocytosis

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

positive regulation of transport across blood-brain barrier [inference]

positive regulation of lipid transport across blood-brain barrier

positive regulation of developmental process [inference]

positive regulation of dendritic spine development

positive regulation of multicellular organismal process [inference]

positive regulation of transport across blood-brain barrier [inference]

positive regulation of lipid transport across blood-brain barrier

positive regulation of amyloid-beta clearance

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid transport across blood-brain barrier

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid efflux

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of lipid biosynthetic process

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid fibril formation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of triglyceride metabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of triglyceride metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid fibril formation

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of triglyceride metabolic process

negative regulation of cell activation [inference]

negative regulation of platelet activation

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

negative regulation of synapse organization [inference]

negative regulation of postsynaptic membrane organization

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol efflux

negative regulation of lipid transport across blood-brain barrier

negative regulation of phospholipid transport [inference]

negative regulation of phospholipid efflux

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of transport across blood-brain barrier [inference]

negative regulation of lipid transport across blood-brain barrier

negative regulation of developmental process [inference]

negative regulation of dendritic spine development

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

negative regulation of coagulation [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

negative regulation of transport across blood-brain barrier [inference]

negative regulation of lipid transport across blood-brain barrier

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of long-term synaptic potentiation

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol efflux

negative regulation of lipid transport across blood-brain barrier

negative regulation of phospholipid transport [inference]

negative regulation of phospholipid efflux

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction [inference]

regulation of Cdc42 protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

regulation of innate immune response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

regulation of immune response [inference]

regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of innate immune response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of behavioral fear response

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

regulation of fear response [inference]

regulation of behavioral fear response

regulation of cellular response to very-low-density lipoprotein particle stimulus

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of axon extension

negative regulation of developmental process [inference]

negative regulation of dendritic spine development

positive regulation of developmental process [inference]

positive regulation of dendritic spine development

regulation of dendritic spine development [inference]

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

nitric oxide mediated signal transduction [inference]

nitric oxide-cGMP-mediated signaling pathway

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling [inference]

nitric oxide-cGMP-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction [inference]

regulation of Cdc42 protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of long-term synaptic potentiation [inference]

negative regulation of long-term synaptic potentiation

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of triglyceride metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

negative regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride metabolic process

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of inclusion body assembly [inference]

positive regulation of neurofibrillary tangle assembly

regulation of inclusion body assembly [inference]

positive regulation of inclusion body assembly [inference]

positive regulation of neurofibrillary tangle assembly

regulation of neurofibrillary tangle assembly [inference]

positive regulation of neurofibrillary tangle assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular component biogenesis [inference]

positive regulation of inclusion body assembly [inference]

positive regulation of neurofibrillary tangle assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of endocytosis

positive regulation of inclusion body assembly [inference]

positive regulation of neurofibrillary tangle assembly

positive regulation of presynaptic membrane organization

positive regulation of supramolecular fiber organization [inference]

positive regulation of amyloid fibril formation

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of triglyceride metabolic process

negative regulation of cell activation [inference]

negative regulation of platelet activation

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

negative regulation of synapse organization [inference]

negative regulation of postsynaptic membrane organization

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

regulation of cell activation [inference]

regulation of platelet activation [inference]

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

regulation of cellular component organization [inference]

regulation of cell growth [inference]

regulation of extent of cell growth [inference]

regulation of axon extension

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendritic spine maintenance [inference]

regulation of protein-containing complex assembly

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of dendritic spine maintenance [inference]

regulation of presynaptic membrane organization [inference]

positive regulation of presynaptic membrane organization

negative regulation of synapse organization [inference]

negative regulation of postsynaptic membrane organization

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

negative regulation of synapse organization [inference]

negative regulation of postsynaptic membrane organization

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of endocytosis

positive regulation of inclusion body assembly [inference]

positive regulation of neurofibrillary tangle assembly

positive regulation of presynaptic membrane organization

positive regulation of supramolecular fiber organization [inference]

positive regulation of amyloid fibril formation

regulation of inclusion body assembly [inference]

positive regulation of inclusion body assembly [inference]

positive regulation of neurofibrillary tangle assembly

regulation of neurofibrillary tangle assembly [inference]

positive regulation of neurofibrillary tangle assembly

regulation of postsynaptic membrane organization [inference]

negative regulation of postsynaptic membrane organization

regulation of supramolecular fiber organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

positive regulation of supramolecular fiber organization [inference]

positive regulation of amyloid fibril formation

regulation of amyloid fibril formation

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of lipoprotein transport [inference]

positive regulation of lipoprotein transport

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

regulation of cellular response to very-low-density lipoprotein particle stimulus

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

regulation of system process [inference]

regulation of transport across blood-brain barrier [inference]

positive regulation of transport across blood-brain barrier [inference]

positive regulation of lipid transport across blood-brain barrier

negative regulation of transport across blood-brain barrier [inference]

negative regulation of lipid transport across blood-brain barrier

regulation of lipid transport across blood-brain barrier [inference]

regulation of behavior [inference]

regulation of behavioral fear response

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of coagulation [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

regulation of cell activation [inference]

regulation of platelet activation [inference]

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of transport across blood-brain barrier [inference]

positive regulation of lipid transport across blood-brain barrier

positive regulation of amyloid-beta clearance

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of blood vessel endothelial cell migration

negative regulation of coagulation [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

negative regulation of transport across blood-brain barrier [inference]

negative regulation of lipid transport across blood-brain barrier

regulation of amyloid-beta clearance

positive regulation of amyloid-beta clearance

regulation of fear response [inference]

regulation of behavioral fear response

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of long-term synaptic potentiation [inference]

negative regulation of long-term synaptic potentiation

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

negative regulation of platelet activation

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of CoA-transferase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of CoA-transferase activity

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

positive regulation of transferase activity [inference]

positive regulation of CoA-transferase activity

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of CoA-transferase activity [inference]

positive regulation of CoA-transferase activity

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 42 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IDA	16805831 8089103
extracellular region	HDA	27068509
extracellular space	ISS
extracellular space	IDA	30333625 8340399

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle

plasma lipoprotein particle [inference]

low-density lipoprotein particle

high-density lipoprotein particle

discoidal high-density lipoprotein particle

triglyceride-rich plasma lipoprotein particle [inference]

chylomicron

chylomicron remnant

cellular anatomical entity [inference]

extracellular region

synaptic cleft

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

bounding membrane of organelle [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

pigment granule [inference]

melanosome

multivesicular body, internal vesicle

extracellular vesicle

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

pigment granule [inference]

melanosome

multivesicular body, internal vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

pigment granule [inference]

melanosome

multivesicular body, internal vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

cell body [inference]

neuronal cell body

blood microparticle

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GO Term	Evidence Code	PMID
amyloid-beta binding	IDA	11305869 25207746 8089103
amyloid-beta binding	IPI	22138302 9003062 9211985
signaling receptor binding	IPI	27477018
structural molecule activity	TAS	22138302
lipid transporter activity	IDA	17305370

GO Hierarchy

molecular function

structural molecule activity

transporter activity [inference]

lipid transporter activity

sterol transporter activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

lipid transfer activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

binding [inference]

protein binding

signaling receptor binding

receptor ligand activity

lipoprotein particle receptor binding [inference]

cytoskeletal protein binding [inference]

tau protein binding

enzyme binding

identical protein binding

protein homodimerization activity

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

protein dimerization activity

protein homodimerization activity

lipid binding

phospholipid binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

metal chelating activity

protein-containing complex binding

protein-lipid complex binding [inference]

lipoprotein particle binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

antioxidant activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatidylcholine-sterol O-acyltransferase activator activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatidylcholine-sterol O-acyltransferase activator activity

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Apolipoprotein E

Functional Category

L: Replication, recombination and repair
T: Signal transduction mechanisms

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Gene Ontology
cholesterol efflux
lipid binding
lipid transport
lipoprotein metabolic process
phosphatidylcholine binding
phosphatidylcholine metabolic process
phosphatidylcholine-sterol O-acyltransferase activator activity
phospholipid efflux
positive regulation of fatty acid biosynthetic process
positive regulation of triglyceride catabolic process

Displaying 1 entry
InterPro
Apolipoprotein A/E

Disease

Disease Ontology

Displaying entries **11 - 20** of 40 in total

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DO ID	Disease Name	Source
DOID:12365	malaria	Alliance of Genome Resources
DOID:12894	Sjogren's syndrome	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:13544	low tension glaucoma	Alliance of Genome Resources
DOID:13550	angle-closure glaucoma	Alliance of Genome Resources
DOID:13641	exfoliation syndrome	Alliance of Genome Resources
DOID:13809	familial combined hyperlipidemia	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1920	hyperuricemia	Alliance of Genome Resources
DOID:1936	atherosclerosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements