GlyCosmos Portal

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GO Term	Evidence Code	PMID
alditol:NADP+ 1-oxidoreductase activity	IBA
aldo-keto reductase (NADP) activity	TAS
steroid binding	TAS	7508385
protein binding	IPI	28514442 33961781
steroid dehydrogenase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

ketosteroid monooxygenase activity

steroid dehydrogenase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

aldo-keto reductase (NADP) activity

alcohol dehydrogenase (NADP+) activity [inference]

alditol:NADP+ 1-oxidoreductase activity

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

enone reductase activity [inference]

delta4-3-oxosteroid 5beta-reductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

ketosteroid monooxygenase activity

binding [inference]

protein binding

lipid binding [inference]

steroid binding

organic cyclic compound binding [inference]

steroid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aldo-keto

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
alditol
oxidoreductase activity

Displaying **all 4** entries
InterPro
Aldo-keto reductase
Aldo/keto reductase, conserved site
NADP-dependent oxidoreductase domain superfamily
NADP-dependent oxidoreductase domain

KEGG BRITE Database

Orthology

K00251

Name

3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3]

References

Rhea

RHEA:14037

4,5β-dihydrocortisone + NADP⁺

H⁺ + cortisone + NADPH

Enzyme

1.3.1.3

PMID

RHEA:46636

5β-dihydrotestosterone + NADP⁺

H⁺ + testosterone + NADPH

Enzyme

1.3.1.3

PMID

RHEA:11524

5β-cholestan-3-one + NADP⁺

H⁺ + cholest-4-en-3-one + NADPH

Enzyme

1.3.1.3

PMID

RHEA:54412

a 3-oxo-5β-steroid + NADP⁺

H⁺ + a 3-oxo-Δ⁴-steroid + NADPH

Enzyme

1.3.1.3

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111069	congenital bile acid synthesis defect 2	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0002014	Diarrhea
HP:0002240	Hepatomegaly
HP:0002570	Steatorrhea
HP:0002630	Fat malabsorption
HP:0002748	Rickets
HP:0002904	Hyperbilirubinemia
HP:0002908	Conjugated hyperbilirubinemia
HP:0002910	Elevated circulating hepatic transaminase concentration
HP:0003155	Elevated circulating alkaline phosphatase concentration
HP:0003256	Abnormality of the coagulation cascade

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:79303	congenital bile acid synthesis defect 2
OMIM:235555	congenital bile acid synthesis defect 2

PubChem Disease

GHR Health Conditions

Congenital bile acid synthesis defect type 2

MedGen Diseases

Congenital bile acid synthesis defect 2

OMIM Phenotypes

BILE ACID SYNTHESIS DEFECT, CONGENITAL, 2; CBAS2

KEGG Diseases

Congenital bile acid synthesis defect

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001665
Gene Name: aldo-keto reductase family 1, member D1

Ortholog

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Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	231	SGD:S000005646
Saccharomyces cerevisiae S288C	1109	SGD:S000005646
Saccharomyces cerevisiae S288C	1645	SGD:S000005646
Saccharomyces cerevisiae S288C	1646	SGD:S000005646
Xenopus tropicalis	6718	Xenbase:XB-GENE-947167
Saccharomyces cerevisiae S288C	8644	SGD:S000005646
Saccharomyces cerevisiae S288C	10327	SGD:S000005646
Saccharomyces cerevisiae S288C	11677	SGD:S000005646
Saccharomyces cerevisiae S288C	24192	SGD:S000005646
Drosophila melanogaster	39304	FB:FBgn0086254

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements