G01614ZM

Summary
GlyTouCan ID
G01614ZM
IUPAC Condensed
Neu5Ac(a2-3)Gal(b1-3)[Neu5Ac(a2-6)]GalNAc(a1-
Motifs
Di-sialyl T antigen
Subsumption Level
Fully-defined saccharide
Monoisotopic Mass
965.33
3D Structures
GlycoShape
G01614ZM
Displaying 1 entry
Archetype α β
G30110UW
G01614ZM
G04267XF
Organisms
Taxonomic Hierarchy
GlycoGene Database (GGDB)
Displaying all 5 entries
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
R
G01614ZM
R
ST6GALNAC2 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC3 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC1 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
Displaying entry 6 - 6 of 6 in total
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
ST6GALNAC1 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
KEGG BRITE Database
KEGG ID
Enzyme
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R05914
GlycoEpitope
Epitope ID
EP0023
GlycomeAtlas

Tissues in which this glycan is expressed are highlighted in yellow.

Danio rerio
Brain Gill Heart Intestine Intestine Liver Ovary Skin Testis
Literature
Tissue
  • brain
  • gill
  • heart
  • intestine
  • liver
  • skin gland
  • testis
Reference
Yamakawa N et al. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Nat Commun. 2018;9(1):4647. Published 2018 Nov 7. doi:10.1038/s41467-018-06950-3
DOI
10.1038/s41467-018-06950-3
Sequence Descriptors
GlycoCT
RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
5s:n-acetyl
6b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
7s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:3o(3+2)4d
4:4d(5+1)5n
5:1o(6+2)6d
6:6d(5+1)7n
WURCS
WURCS=2.0/3,4,3/[a2112h-1a_1-5_2*NCC/3=O][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O]/1-2-3-3/a3-b1_a6-d2_b3-c2
Literature
Displaying entries 21 - 30 of 103 in total
PubMed ID Title First Author Publication Date Source
10742600 Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells Samyn-Petit B 2000 Apr 06
  • PubChem
10536037 Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens Ikehara Y 1999 Nov 01
  • PubChem
10381349 Impaired galactosylation of core 2 O-glycans in erythrocytes of beta1,4-galactosyltransferase knockout mice Kotani N 1999 Jun 24
  • GlyGen
10406848 Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and 'brain-type' neutral N-glycans Zamze S 1999 Aug
  • GlyGen
  • PubChem
9442070 The Glycosylation and Structure of Human Serum IgA1, Fab, and Fc Regions and the Role of N-Glycosylation on Fcα Receptor Interactions Mattu TS 1998 Jan 23
  • GlyGen
  • PubChem
9492296 Structural study of the O-linked sugar chains of human leukocyte tyrosine phosphatase CD45 Furukawa K 1998 Jan 15
  • GlyGen
  • PubChem
9852066 Phosphorylation and O-Glycosylation Sites of Human Chromogranin A (CGA79–439) from Urine of Patients with Carcinoid Tumors Gadroy P 1998 Dec 18
  • GlyGen
  • PubChem
9654101 Structural characterisation of N-linked and O-linked oligosaccharides derived from interferon-alpha2b and interferon-alpha14c produced by Sendai-virus-induced human peripheral blood leukocytes Nyman TA 1998 Apr 15
  • GlyGen
  • PubChem
9250810 Expression of sialosyl-T and disialosyl-T antigens in erythroid cells Muroi K 1997 May
  • GlyGen
  • GlycoEpitope
9118998 Glycosylation analysis and protein structure determination of murine fetal antigen 1 (mFA1)--the circulating gene product of the delta-like protein (dlk), preadipocyte factor 1 (Pref-1) and stromal-cell-derived protein 1 (SCP-1) cDNAs Krogh TN 1997 Mar 01
  • GlyGen
  • PubChem
PubAnnotation
Displaying all 4 entries
Title Authors Source Publication Date PubMed ID
Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes.
  • Fuseya S
  • Izumi H
  • Hamano A
  • Murakami Y
  • Suzuki R
  • Koiwai R
  • Hayashi T
  • Kuno A
  • Takahashi S
  • Kudo T
Sci Rep 2023 Jun 29 37386100
Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo.
  • Sim L
  • Thompson N
  • Geissner A
  • Withers SG
  • Wakarchuk WW
Glycobiology 2022 Apr 21 34939113
Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
  • Ohmi Y
  • Nishikaze T
  • Kitaura Y
  • Ito T
  • Yamamoto S
  • Sugiyama F
  • Matsuyama M
  • Takahashi Y
  • Takeda A
  • Kawahara T
  • Okajima T
  • Furukawa K
  • Furukawa K
Glycobiology 2021 Jun 3 33242079
Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro.
  • Vyas AA
  • Blixt O
  • Paulson JC
  • Schnaar RL
J Biol Chem 2005 Apr 22 15701648

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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