G01614ZM

Summary
GlyTouCan ID
G01614ZM
IUPAC Condensed
Neu5Ac(a2-3)Gal(b1-3)[Neu5Ac(a2-6)]GalNAc(a1-
Motifs
Di-sialyl T antigen
Subsumption Level
Fully-defined saccharide
Monoisotopic Mass
965.33
3D Structures
GlycoShape
G01614ZM
Displaying 1 entry
Archetype α β
G30110UW
G01614ZM
G04267XF
Organisms
Taxonomic Hierarchy
GlycoGene Database (GGDB)
Displaying all 5 entries
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
R
G01614ZM
R
ST6GALNAC2 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC3 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC1 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
Displaying entries 1 - 5 of 6 in total
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
R
G01614ZM
R
ST6GALNAC2 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
benzyl
G01614ZM
benzyl
ST6GALNAC3 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
KEGG BRITE Database
KEGG ID
Enzyme
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R05914
GlycoEpitope
Epitope ID
EP0023
GlycomeAtlas

Tissues in which this glycan is expressed are highlighted in yellow.

Danio rerio
Brain Gill Heart Intestine Intestine Liver Ovary Skin Testis
Literature
Tissue
  • brain
  • gill
  • heart
  • intestine
  • liver
  • skin gland
  • testis
Reference
Yamakawa N et al. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Nat Commun. 2018;9(1):4647. Published 2018 Nov 7. doi:10.1038/s41467-018-06950-3
DOI
10.1038/s41467-018-06950-3
Sequence Descriptors
GlycoCT
RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
5s:n-acetyl
6b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
7s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:3o(3+2)4d
4:4d(5+1)5n
5:1o(6+2)6d
6:6d(5+1)7n
WURCS
WURCS=2.0/3,4,3/[a2112h-1a_1-5_2*NCC/3=O][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O]/1-2-3-3/a3-b1_a6-d2_b3-c2
Literature
Displaying entries 81 - 90 of 103 in total
PubMed ID Title First Author Publication Date Source
3514617 Membrane glycophorins in Sta blood group erythrocytes Blumenfeld OO 1986 Apr 25
  • GlyGen
  • PubChem
3007481 Structures of O-linked oligosaccharides present in the proteoglycans secreted by human mammary epithelial cells Gowda DC 1986 Apr 15
  • GlyGen
3967649 Structure determination of oligosaccharides isolated from Cad erythrocyte membranes by permethylation analysis and 500-MHz 1H-NMR spectroscopy HERKT F 1985 Jan 02
  • GlyGen
  • PubChem
4091823 Comparative study of glycophorin A derived O-glycans from human Cad, Sd(a+) and Sd(a-) erythrocytes Blanchard D 1985 Dec 15
  • GlyGen
  • PubChem
3935432 Structures of the major carbohydrates of natural human interleukin-2 CONRADT HS 1985 Dec 02
  • GlyGen
  • PubChem
6436240 Purification and structures of oligosaccharide chains in swine trachea and Cowper's gland mucin glycoproteins Rana S S 1984-10-25
  • GlyGen
6327299 Structural studies on the O-linked carbohydrate chains of human platelet glycocalicin Korrel SA 1984 May 02
  • GlyGen
  • PubChem
6725284 The structure of the carbohydrate units of human plasma galactoglycoprotein determined by 500-megahertz 1H NMR spectroscopy Akiyama K 1984 Jun 10
  • GlyGen
  • PubChem
6714238 The structure of sialyl-glycopeptides of the O-glycosidic type, isolated from sialidosis (mucolipidosis I) urine Lecat D 1984 Apr 16
  • GlyGen
6619126 A carbohydrate structural variant of MM glycoprotein (glycophorin A) Adamany AM 1983 Oct 10
  • GlyGen
  • PubChem
PubAnnotation
Displaying all 4 entries
Title Authors Source Publication Date PubMed ID
Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes.
  • Fuseya S
  • Izumi H
  • Hamano A
  • Murakami Y
  • Suzuki R
  • Koiwai R
  • Hayashi T
  • Kuno A
  • Takahashi S
  • Kudo T
Sci Rep 2023 Jun 29 37386100
Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo.
  • Sim L
  • Thompson N
  • Geissner A
  • Withers SG
  • Wakarchuk WW
Glycobiology 2022 Apr 21 34939113
Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
  • Ohmi Y
  • Nishikaze T
  • Kitaura Y
  • Ito T
  • Yamamoto S
  • Sugiyama F
  • Matsuyama M
  • Takahashi Y
  • Takeda A
  • Kawahara T
  • Okajima T
  • Furukawa K
  • Furukawa K
Glycobiology 2021 Jun 3 33242079
Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro.
  • Vyas AA
  • Blixt O
  • Paulson JC
  • Schnaar RL
J Biol Chem 2005 Apr 22 15701648

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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