GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **476 - 499** of **499** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol	Organism	GlyTouCan ID
RAC2 GTPase cycle	Arf-GAP domain-containing protein Armadillo repeat-containing domain-containing protein CED-5 CRAL-TRIO domain-containing protein Cadherin-4 Calponin-homology (CH) domain-containing protein Caveolin-1 Caveolin-2 Cell division control protein 42 homolog Cytoplasmic FMR1-interacting protein homolog DH domain-containing protein DH domain-containing protein Ephrin receptor 1 Glutamate carboxypeptidase 2 homolog MAGUK family Membrane-associated protein gex-3 Metaxin-1 homolog N-acetylated-alpha-linked acidic dipeptidase 2 PH domain-containing protein Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Phospholipase Probable rho GDP-dissociation inhibitor Protein BRICK1 Protein let-99 Protein vav-1 Rac GTPase-activating protein 1 Ras-related protein Rab-18 Ras-related protein Rab-7a Ras-related protein ced-10 Ras-related protein rac-2 Rho GTPase-activating protein 26 Rho GTPase-activating protein 68F Rho GTPase-activating protein syd-1 Rho-GAP domain-containing protein Rho-GAP domain-containing protein SAM50-like protein gop-3 SH3 domain-containing protein Serine/threonine-protein kinase SULU Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase pak-1 Serine/threonine-protein kinase pak-2 Synaptobrevin-1 Target of ERK kinase mpk-1 Uncharacterized integrin beta-like protein C05D9.3 Vang-like protein WAPL domain-containing protein Wiskott-Aldrich syndrome protein family member	A0A0K3AR51 A0A2K5AU23 A5Z2X2 G5EDP9 G5EDU3 G5EEN3 G5EFU0 G5EGQ3 H2KY90 H2KYI7 H2KZH5 H2KZV6 O01847 O02495 O17772 O44518 O45503 O45611 O61460 O61528 P46549 P46576 P55163 P91406 Q03206 Q05062 Q10929 Q17850 Q18879 Q19319 Q19467 Q20496 Q21341 Q23130 Q23146 Q45FX5 Q7JP75 Q86NH1 Q93332 Q94051 Q94124 Q94125 Q95XW5 Q9BL44 Q9GYK2 Q9U1V2 Q9XUS9 Q9XVK6	C05D9.3 CELE_F22G12.5 CELE_T04C9.1 CELE_Y57G11C.1147 CELE_Y67A10A.7 CELE_Y71H2AM.12 PLD aap-1 abi-1 age-1 cav-1 cav-2 cdc-42 cdh-4 ced-10 ced-5 cgef-1 cyk-1 cyk-4 gcp-2.1 gcp-2.2 gex-2 gex-3 git-1 gop-3 kin-18 let-99 magu-1 max-2 mtx-1 pak-1 pak-2 pes-7 pld-1 rab-7 rac-1 rac-2 rga-1 rga-5 rga-8 rhi-1 snb-1 sulu syd-1 tiam-1 toe-2 unc-73 vab-1 vang-1 vav-1 wve-1	Caenorhabditis elegans
RAC3 GTPase cycle	Amino acid transporter Amino acid transporter Arf-GAP domain-containing protein CRAL-TRIO domain-containing protein Cadherin-4 Caveolin-1 Caveolin-2 Cell division control protein 42 homolog Cytoplasmic FMR1-interacting protein homolog DH domain-containing protein DH domain-containing protein Ephrin receptor 1 Excitatory amino acid transporter GTPase-activating protein pac-1 Glutamate carboxypeptidase 2 homolog MAGUK family Membrane-associated protein gex-3 N-acetylated-alpha-linked acidic dipeptidase 2 PH domain-containing protein Phosphoinositide 3-kinase adapter subunit Probable rho GDP-dissociation inhibitor Protein BRICK1 Protein let-99 Protein unc-112 Protein vav-1 Putative sodium-dependent excitatory amino acid transporter glt-3 Putative sodium-dependent excitatory amino acid transporter glt-4 Putative sodium-dependent excitatory amino acid transporter glt-6 Rac GTPase-activating protein 1 Rap guanine nucleotide exchange factor 1 Ras-related protein Rab-7a Ras-related protein ced-10 Rho GTPase-activating protein 26 Rho GTPase-activating protein 68F Rho GTPase-activating protein syd-1 Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein SH3 domain-containing protein Serine/threonine-protein kinase SULU Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase pak-1 Serine/threonine-protein kinase pak-2 Synaptobrevin-1 Synaptosomal-associated protein Target of ERK kinase mpk-1 Tyrosine-protein kinase abl-1 Uncharacterized integrin beta-like protein C05D9.3 Vang-like protein WAPL domain-containing protein WW domain-containing protein tag-325 Wiskott-Aldrich syndrome protein family member t-SNARE protein aex-4	A0A0K3AR51 A0A2K5AU23 A5PEW5 A5Z2X2 G5EDP9 G5EEN8 G5EFU0 G5EGQ3 H2KY90 H2KYI7 H2KZH5 H2KZV4 H2KZV6 H2KZX7 O01443 O01847 O02495 O17590 O18210 O44518 O45611 O61460 O61528 P03949 P34288 P46549 P46941 P55163 P91406 Q03206 Q05062 Q10901 Q10929 Q17850 Q18685 Q18879 Q19319 Q19370 Q19467 Q20496 Q21341 Q21353 Q21751 Q22682 Q23130 Q23146 Q45FX5 Q7JP75 Q86NH1 Q93332 Q94051 Q95XW5 Q9GYK2 Q9UAY8 Q9XUS9 Q9XVK6	C05D9.3 CELE_F22G12.5 CELE_F23H11.4 CELE_T04C9.1 CELE_Y34B4A.4 CELE_Y57G11C.1147 aap-1 abi-1 abl-1 aex-4 cav-1 cav-2 cdc-42 cdh-4 ced-10 cgef-1 cyk-1 cyk-4 gap gcp-2.1 gcp-2.2 gex-2 gex-3 git-1 glt-1 glt-3 glt-4 glt-5 glt-6 glt-7 kin-18 let-99 magu-1 max-2 ocrl-1 pac-1 pak-1 pak-2 rab-7 rac-1 rga-1 rga-5 rga-6 rga-8 rhi-1 ric-4 snb-1 srgp-1 sulu syd-1 tag-325 tag-81 tiam-1 toe-2 unc-112 unc-73 vab-1 vang-1 vav-1 wve-1	Caenorhabditis elegans
Neddylation	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein AO66 ankyrin Ankyrin repeat and KH domain-containing protein mask-1 B30.2/SPRY domain-containing protein BTB domain-containing protein BTB domain-containing protein BTB domain-containing protein BTB domain-containing protein BZIP domain-containing protein COP9 signalosome complex subunit 1 COP9 signalosome complex subunit 2 COP9 signalosome complex subunit 3 COP9 signalosome complex subunit 4 COP9 signalosome complex subunit 5 COP9 signalosome complex subunit 6 Coiled-coil domain-containing protein 22 homolog Cullin-1 Cullin-2 Cullin-3 Cullin-4 Cullin-5 Cullin-associated NEDD8-dissociated protein 1 DDB1- and CUL4-associated factor 11 homolog DDB1- and CUL4-associated factor 13 DNA damage-binding protein 1 Death domain-containing protein Defective in cullin neddylation protein 1 Elongin-C F-box domain-containing protein F-box domain-containing protein F-box domain-containing protein F-box domain-containing protein F-box protein dre-1 F-box/LRR-repeat protein fbxl-1 F-box/WD repeat-containing protein mec-15 Hypoxia-inducible factor 1 Ion transport domain-containing protein MPN domain-containing protein NEDD8-activating enzyme E1 catalytic subunit NEDD8-activating enzyme E1 regulatory subunit NEDD8 Nuclear protein localization protein 4 homolog 2 PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Probable histone-binding protein lin-53 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Protein LAZ1 Protein skinhead-1 RING-box protein 1 RING-type domain-containing protein RING-type domain-containing protein RNA polymerase II transcription factor SIII p18 subunit Retinoblastoma-binding protein homolog 5 SH2 domain-containing protein SOCS box domain-containing protein SPRY domain-containing SOCS box protein 1 Sex-determining protein fem-1 Skp1-related protein Transcription factor che-1 Transitional endoplasmic reticulum ATPase homolog 2 Tubby C-terminal domain-containing protein Ubiquitin carboxyl-terminal hydrolase Ubiquitin fusion degradation protein 1 homolog Ubiquitin-conjugating enzyme E2 2 Ubiquitin-like protease family profile domain-containing protein Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Uncharacterized WD repeat-containing protein F47D12.9 Uncharacterized protein T23G5.3 WD and tetratricopeptide repeats protein 1 WD repeat-containing protein wdr-5.1 WD repeat-containing protein wdr-5.2 WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein Zeta_toxin domain-containing protein Zinc finger protein zfp-2 von Hippel-Lindau tumor suppressor homolog	A0A0K3AQR5 A0A0M7REQ4 A0PD34 G5ECR7 G5ECU1 G5ED41 G5EFS1 G5EGD2 G5EGS4 O01422 O16368 O17071 O17324 O17586 O18152 O44156 O45323 O45498 O61742 O61792 O61795 O62102 O62200 O76371 O76577 P0CG71 P17221 P34284 P34707 P35129 P37165 P46502 P49632 P54812 P90794 P90868 P90916 P91001 P91404 P91477 Q03607 Q04908 Q09309 Q09392 Q09397 Q10920 Q17389 Q17390 Q17391 Q17392 Q17490 Q17962 Q17963 Q17971 Q18115 Q18217 Q18587 Q18787 Q18963 Q19213 Q19324 Q19360 Q19584 Q20058 Q20082 Q20183 Q20585 Q20938 Q21554 Q21920 Q21934 Q22015 Q22059 Q22071 Q22253 Q23237 Q23449 Q23457 Q23494 Q23595 Q23639 Q27488 Q4W5Q8 Q7JP60 Q86FN3 Q93349 Q93725 Q93759 Q93847 Q94251 Q95005 Q95008 Q95PZ0 Q95PZ7 Q95QZ9 Q965F9 Q965N6 Q965N7 Q965V9 Q966I8 Q966L8 Q9BKS1 Q9BL53 Q9GRV5 Q9GS00 Q9GYM5 Q9GZH5 Q9N359 Q9N425 Q9N599 Q9U3C8 Q9XTT9 Q9XUV0	3L686 C10E2.2 C14B1.3 C14C10.5 CELE_F32B4.5 CELE_F35G12.12 CELE_F39B2.5 CELE_M60.7 CELE_R08E3.3 CELE_R11D1.1 CELE_R31.2 CELE_T28D6.4 CELE_T28F2.2 CELE_VM106R.1 CELE_ZK792.4 F47D12.9 T23G5.3 adpr-1 cand-1 ccd-3 cdc-48.2 cdt-2 cfl-1 che-1 csa-1 csn-1 csn-2 csn-3 csn-4 csn-5 csn-6 cul-1 cul-2 cul-3 cul-4 cul-5 dcaf-13 dcn-1 ddb-1 div-3 dre-1 elb-1 elc-1 fbxl-1 fem-1 hif-1 ikb-1 isx-1 kel-1 kel-20 let-70 lin-19 lin-53 lsy-15 mask-1 mec-15 mfb-1 mtpn-1 ned-8 npl-4.2 par-2 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rba-2 rbbp-5 rbx-1 rbx-2 rfl-1 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 skn-1 sknr-1 skpt-1 skr-1 spsb-1 spsb-2 swah-1 swan-2 swd-3.1 swd-3.2 tag-125 tag-30 trp-4 tub-2 uba-3 ubc-2 ubh-3 ubia ubib ubl-1 ubq-1 ubq-2 ufd-1 ula-1 ulp-3 unc-44 vhl-1 wdr-23 wdr-5.1 wdr-5.2 zfp-2	Caenorhabditis elegans
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	BMP-like protein unc-129 Cell surface receptor daf-1 Cell surface receptor daf-4 DH domain-containing protein Dauer larva development regulatory growth factor daf-7 Partitioning defective protein 3 Partitioning defective protein 6 Polyubiquitin-A Protein dbl-1 Protein kinase C-like 3 Ras-like GTP-binding protein rhoA Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A0A0K3AQN0 G5EBY8 G5EEL5 P0CG71 P20792 P37165 P49632 P50488 P92172 Q17353 Q19266 Q22038 Q9NAN2	CELE_Y105E8A.25 aPKC cet-1 daf-1 daf-4 daf-7 dbl-1 par-3 par-6 pkc-3 rho-1 rhoa ubia ubib ubl-1 ubq-1 ubq-2 unc-129	Caenorhabditis elegans
RHOB GTPase cycle	Anillin-like protein 2 Armadillo repeat-containing protein wrm-1 Beta-catenin-like protein hmp-2 Beta-catenin/armadillo-related protein 1 CRAL-TRIO domain-containing protein Cadherin domain-containing protein Calponin-homology (CH) domain-containing protein Caveolin-1 Caveolin-2 DH domain-containing protein DH domain-containing protein FH2 domain-containing protein FH2 domain-containing protein Glutamate carboxypeptidase 2 homolog Guanine nucleotide exchange factor N-acetylated-alpha-linked acidic dipeptidase 2 PH domain-containing protein Phosphoinositide 3-kinase adapter subunit Probable rho GDP-dissociation inhibitor Protein ECT2 Protein kinase domain-containing protein Protein let-99 Protein vav-1 Rac GTPase-activating protein 1 Ras-like GTP-binding protein rhoA Rho GTPase-activating protein 26 Rho GTPase-activating protein 68F Rho guanine nucleotide exchange factor osg-1 Rho-GAP domain-containing protein Rho-associated protein kinase let-502 SH2 domain-containing protein START domain-containing protein Stomatin-2 Synaptobrevin-1 Synaptosomal-associated protein Target of ERK kinase mpk-1 Tight junction protein ZO-1 Unconventional myosin-IXa-like Vang-like protein WAPL domain-containing protein protein kinase C t-SNARE protein aex-4	A0A0K3AQN0 A0A4V0IKG6 A0A4V0ILM7 A5PEW5 D6VPA1 F0IWT2 G5EDP9 G5EEN8 G5EFE1 H2KY90 H2KYI7 H2KZH5 H2KZV6 O02495 O17772 O44326 O45611 O61528 P91406 P92199 Q09994 Q10953 Q17777 Q18825 Q18879 Q19479 Q19958 Q20440 Q20496 Q21341 Q21653 Q22038 Q23130 Q45FX5 Q5F4U0 Q7JP75 Q8I103 Q93332 Q94051 Q965J0 Q9U364 Q9XUS9	C07B5.4 CELE_T04C9.1 CELE_Y105E8A.25 aap-1 aex-4 ani-2 bar-1 cav-1 cav-2 cdh-10 cgef-1 cyk-1 cyk-4 daam-1 ect-2 ephx-1 gck-4 gcp-2.1 gcp-2.2 gei-1 hmp-2 hum-7 inft-2 let-502 let-99 osg-1 pes-7 pkn-1 pvl-1 rga-1 rga-5 rhgf-1 rhi-1 rho-1 rhoa ric-4 snb-1 spy-1 sto-2 tag-81 toe-2 unc-73 vang-1 vav-1 wrm-1 zoo-1	Caenorhabditis elegans
RHOA GTPase cycle	ACB domain-containing protein Anillin-like protein 2 Armadillo repeat-containing protein wrm-1 Beta-catenin-like protein hmp-2 Beta-catenin/armadillo-related protein 1 CED-5 CRAL-TRIO domain-containing protein Cadherin domain-containing protein Calponin-homology (CH) domain-containing protein Caveolin-1 Caveolin-2 Conserved regulator of innate immunity protein 3 DH domain-containing protein DH domain-containing protein DH domain-containing protein DH domain-containing protein F-BAR domain-containing protein FH2 domain-containing protein FH2 domain-containing protein Formin-homology and zinc finger domains protein 1 Glutamate carboxypeptidase 2 homolog Guanine nucleotide exchange factor Moesin/ezrin/radixin homolog 1 N-acetylated-alpha-linked acidic dipeptidase 2 PH domain-containing protein Peroxisomal Membrane Protein related Phosphoinositide 3-kinase adapter subunit Phospholipase Probable rho GDP-dissociation inhibitor Protein ECT2 Protein kinase domain-containing protein Protein let-99 Protein vav-1 Protein vav Rac GTPase-activating protein 1 Ras-like GTP-binding protein rhoA Rho GTPase-activating protein 20 Rho GTPase-activating protein 26 Rho GTPase-activating protein 68F Rho guanine nucleotide exchange factor osg-1 Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-associated protein kinase let-502 SH2 domain-containing protein SH3 domain-containing protein START domain-containing protein Sec1 family domain-containing protein 1 Stomatin-2 Synaptobrevin-1 Synaptosomal-associated protein Target of ERK kinase mpk-1 Tight junction protein ZO-1 UBX domain-containing protein Unconventional myosin-IXa-like Vang-like protein WAPL domain-containing protein WW domain-containing protein tag-325 protein kinase C t-SNARE protein aex-4	A0A0K3AQN0 A0A0K3AW57 A0A2K5AU23 A0A4V0IKG6 A0A4V0ILM7 A5PEW5 D6VPA1 F0IWT2 G5EDP9 G5EDU3 G5EEN3 G5EEN8 G5EF62 G5EF80 G5EFE1 H2KY90 H2KYI7 H2KZH5 H2KZV4 H2KZV6 O01443 O01847 O02495 O17772 O17905 O44326 O45611 O45628 O61528 P34489 P46941 P91406 P92199 Q09994 Q10953 Q17777 Q18598 Q18825 Q18879 Q19370 Q19479 Q19958 Q20364 Q20440 Q20496 Q21018 Q21341 Q21430 Q21653 Q22038 Q23130 Q45FX5 Q5F4U0 Q7JP75 Q8I103 Q93332 Q94051 Q965J0 Q9U364 Q9XTZ5 Q9XUS9 Q9XW53 S6EZU2 U4PAK0	C07B5.4 CELE_F23H11.4 CELE_H40L08.1 CELE_T04C9.1 CELE_Y105E8A.25 PLD aap-1 aex-4 ani-2 bar-1 cav-1 cav-2 cdh-10 ced-5 cgef-1 cri-3 cyk-1 cyk-4 daam-1 ect-2 ephx-1 fozi-1 frm-3 gck-4 gcp-2.1 gcp-2.2 gei-1 hmp-2 hum-7 inft-2 let-502 let-99 maa-1 osg-1 pes-7 pix-1 pkn-1 pld-1 pmp-2 pvl-1 rga-1 rga-2 rga-4 rga-5 rga-6 rga-8 rga-9 rhgf-1 rhgf-2 rhi-1 rho-1 rhoa ric-4 sly-1 snb-1 spv-1 spy-1 srgp-1 sto-2 tag-325 tag-81 tiam-1 toe-2 uig-1 unc-73 vang-1 vav-1 wrm-1 zoo-1	Caenorhabditis elegans
G alpha (12/13) signalling events	CRAL-TRIO domain-containing protein DH domain-containing protein DH domain-containing protein DH domain-containing protein DH domain-containing protein DH domain-containing protein G Protein, Alpha subunit G protein gamma domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein Guanine nucleotide exchange factor Guanine nucleotide-binding protein alpha-12 subunit Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma Intersectin-1 Plexin-2 Protein ECT2 Protein vav-1 Protein vav Ras-like GTP-binding protein rhoA Rho guanine nucleotide exchange factor osg-1 Rho-associated protein kinase let-502 SH2 domain-containing protein SH3 domain-containing GRB2-like protein SH3 domain-containing protein Son of sevenless homolog	A0A0K3AQN0 A0A0K3AS36 G5EBX8 G5ECK4 G5ECT6 G5EF62 G5EFE1 H2KYI7 O01847 O45657 O61528 P17343 P54406 P92199 Q19572 Q20636 Q21430 Q21653 Q22038 Q45FX5 Q965J0 Q9N4F4 Q9N5D3 Q9U364 S6EZU2 X5LV34	CELE_Y105E8A.25 cgef-1 dnbp-1 eat-11 ect-2 ephx-1 exc-5 gbp-2 gpa-12 gpa-17 gpb-1 gpb-2 gpc-1 gpc-2 itsn-1 let-341 let-502 osg-1 pix-1 plx-2 rhgf-1 rhgf-2 rho-1 rhoa ser-5 sos-1 tiam-1 uig-1 unc-73 vav-1	Caenorhabditis elegans
EPHB-mediated forward signaling	Actin-1 Actin-2 Actin-3 Actin-4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2/3 complex subunit Actin-related protein 2 Actin-related protein 3 CRAL-TRIO domain-containing protein Cell division control protein 42 homolog DH domain-containing protein DH domain-containing protein Inactive tyrosine-protein kinase kin-32 Intersectin-1 LITAF domain-containing protein NMDA-type ionotropic glutamate receptor NMR-2 Probable actin-related protein 2/3 complex subunit 2 Probable actin-related protein 2/3 complex subunit 3 Probable actin-related protein 2/3 complex subunit 4 Probable syndecan Ras protein let-60 Ras-like GTP-binding protein rhoA Ras-related protein ced-10 Rho-associated protein kinase let-502 Serine/threonine-protein kinase pak-1 Tyrosine protein-kinase src-1	A0A0K3AQN0 A0A0K3AS36 A0A3P6PCS5 G5EE56 G5EEH3 G5EGQ9 O01847 O61528 O61861 P0DM41 P0DM42 P10984 P10986 P22981 P50605 P53489 P58798 P92199 Q03206 Q05062 Q17850 Q22038 Q8WTM6 Q95YD4 Q9N4I0 Q9XWV3	CELE_Y105E8A.25 act-1 act-2 act-3 act-4 arp-2 arx-1 arx-2 arx-3 arx-4 arx-5 arx-6 arx-7 cdc-42 ced-10 itsn-1 kin-32 let-502 let-60 lin-34 nmr-1 nmr-2 pak-1 rac-1 rho-1 rhoa sdn-1 src-1 tiam-1 unc-73	Caenorhabditis elegans
RAC1 GTPase cycle	Amino acid transporter Amino acid transporter Arf-GAP domain-containing protein C2 DOCK-type domain-containing protein CED-5 CRAL-TRIO domain-containing protein Calponin-homology (CH) domain-containing protein Caveolin-1 Caveolin-2 Cell division control protein 42 homolog Chimerin 2 Cytoplasmic FMR1-interacting protein homolog DH domain-containing protein DH domain-containing protein DH domain-containing protein Ephrin receptor 1 Excitatory amino acid transporter F-BAR domain-containing protein FYVE, RhoGEF and PH domain-containing protein tag-77 Formin-homology and zinc finger domains protein 1 GTPase-activating protein pac-1 Glutamate carboxypeptidase 2 homolog Guanine nucleotide exchange factor Guanine nucleotide-binding protein alpha-12 subunit MAGUK family Membrane-associated protein gex-3 Moesin/ezrin/radixin homolog 1 N-acetylated-alpha-linked acidic dipeptidase 2 PH domain-containing protein Partitioning defective protein 6 Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Phospholipase Probable rho GDP-dissociation inhibitor Protein BRICK1 Protein ECT2 Protein let-99 Protein unc-112 Protein vav-1 Protein vav Putative sodium-dependent excitatory amino acid transporter glt-3 Putative sodium-dependent excitatory amino acid transporter glt-4 Putative sodium-dependent excitatory amino acid transporter glt-6 Rac GTPase-activating protein 1 Ras-related protein Rab-7a Ras-related protein ced-10 Rho GTPase-activating protein 20 Rho GTPase-activating protein 26 Rho GTPase-activating protein 68F Rho GTPase-activating protein syd-1 Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein SH2 domain-containing protein SH3 domain-containing protein SH3 domain-containing protein START domain-containing protein Serine/threonine-protein kinase SULU Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase mrck-1 Serine/threonine-protein kinase pak-1 Serine/threonine-protein kinase pak-2 Son of sevenless homolog Synaptobrevin-1 Synaptosomal-associated protein Target of ERK kinase mpk-1 Tyrosine-protein kinase abl-1 Uncharacterized integrin beta-like protein C05D9.3 Unconventional myosin-IXa-like Vang-like protein WAPL domain-containing protein WW domain-containing protein tag-325 Wiskott-Aldrich syndrome protein family member non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase protein kinase C t-SNARE protein aex-4	A0A0K3AQN0 A0A0K3AR51 A0A2K5AU23 A0A4V0ILM7 A5PEW5 A5Z2X2 F0IWT2 G5EDP9 G5EDU3 G5EEN3 G5EEN8 G5EF62 G5EF80 G5EFE1 G5EFU0 G5EGQ3 H2KY90 H2KYI7 H2KZH5 H2KZV4 H2KZV6 O01583 O01847 O02495 O17772 O17905 O18210 O44518 O45611 O61460 O61528 P03949 P34288 P34489 P46549 P46941 P55163 P91406 Q03206 Q05062 Q10901 Q10929 Q17850 Q18685 Q18879 Q19370 Q19467 Q19572 Q20440 Q20487 Q20496 Q21025 Q21341 Q21353 Q21430 Q21751 Q22682 Q23130 Q23146 Q45FX5 Q7JP75 Q86NH1 Q93332 Q94051 Q94125 Q95XW5 Q965J0 Q965N4 Q9GYK2 Q9N5D3 Q9NAN2 Q9U364 Q9UAY8 Q9XUS9 Q9XVH4 Q9XVI0 Q9XVK6 Q9XW53 U4PAK0 X5LX76	C05D9.3 CELE_F22G12.5 CELE_F23H11.4 CELE_F46H5.4 CELE_T04C9.1 CELE_Y105E8A.25 CELE_Y57G11C.1147 PLD aap-1 abi-1 abl-1 aex-4 age-1 cav-1 cav-2 cdc-42 ced-10 ced-5 cgef-1 chin-1 citk-1 citk-2 cyk-1 cyk-4 ect-2 ephx-1 fozi-1 frm-3 gap gcp-2.1 gcp-2.2 gei-1 gex-2 gex-3 git-1 glt-1 glt-3 glt-4 glt-5 glt-6 glt-7 gpa-12 hum-7 kin-18 let-341 let-99 magu-1 max-2 mrck-1 pac-1 pak-1 pak-2 par-6 pes-7 pix-1 pkn-1 pld-1 rab-7 rac-1 rga-1 rga-2 rga-5 rga-8 rga-9 rhgf-1 rhi-1 ric-4 rlbp-1 snb-1 sos-1 spv-1 srgp-1 sulu syd-1 tag-325 tag-77 tag-81 tiam-1 toe-2 uig-1 unc-112 unc-73 vab-1 vang-1 vav-1 wve-1	Caenorhabditis elegans
Inactivation, recovery and regulation of the phototransduction cascade	Beta-arrestin arr-1 Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-gated cation channel EF-hand domain-containing protein G protein-coupled receptor kinase 1 G-protein coupled receptors family 1 profile domain-containing protein Guanine nucleotide-binding protein subunit gamma Neuronal calcium sensor 2 Protein farnesyltransferase subunit beta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Receptor-type guanylate cyclase daf-11 Receptor-type guanylate cyclase gcy-10 Receptor-type guanylate cyclase gcy-11 Receptor-type guanylate cyclase gcy-12 Receptor-type guanylate cyclase gcy-13 Receptor-type guanylate cyclase gcy-14 Receptor-type guanylate cyclase gcy-15 Receptor-type guanylate cyclase gcy-17 Receptor-type guanylate cyclase gcy-18 Receptor-type guanylate cyclase gcy-19 Receptor-type guanylate cyclase gcy-1 Receptor-type guanylate cyclase gcy-20 Receptor-type guanylate cyclase gcy-21 Receptor-type guanylate cyclase gcy-22 Receptor-type guanylate cyclase gcy-23 Receptor-type guanylate cyclase gcy-25 Receptor-type guanylate cyclase gcy-27 Receptor-type guanylate cyclase gcy-29 Receptor-type guanylate cyclase gcy-2 Receptor-type guanylate cyclase gcy-3 Receptor-type guanylate cyclase gcy-4 Receptor-type guanylate cyclase gcy-5 Receptor-type guanylate cyclase gcy-6 Receptor-type guanylate cyclase gcy-7 Receptor-type guanylate cyclase gcy-8 Receptor-type guanylate cyclase gcy-9 Serine/threonine-protein phosphatase with EF-hands pef-1	A0A078BQP2 A8WI01 B1Q257 E7EAU8 G5EBX9 G5EEE2 G5EEE9 G5EFQ0 H2L002 N1NVB7 O01818 O16544 O16715 O44501 O61827 O62026 O62179 P36609 P51485 P54406 P91550 Q03611 Q09435 Q09537 Q10028 Q10029 Q18136 Q18331 Q19187 Q19752 Q19768 Q23310 Q23681 Q23682 Q7Z205 Q8I4N4 Q9GYQ4 Q9N4C1 Q9XTY1 Q9XU42 X5M8U1	CELE_F57C9.6 arr-1 cal-5 che-6 cng-1 cng-2 cng-3 daf-11 fnta-1 fntb-1 gcy-1 gcy-10 gcy-11 gcy-12 gcy-13 gcy-14 gcy-15 gcy-16 gcy-17 gcy-18 gcy-19 gcy-2 gcy-20 gcy-21 gcy-22 gcy-23 gcy-25 gcy-27 gcy-29 gcy-3 gcy-4 gcy-5 gcy-6 gcy-7 gcy-8 gcy-9 gpc-1 grk-1 ncs-2 odr-1 pef-1 tax-2 tax-4	Caenorhabditis elegans
Phase 2 - plateau phase	Guanylate kinase/L-type calcium channel beta subunit domain-containing protein SH3 domain-containing protein STarGazin (Mammalian calcium channel) homolog STarGazin (Mammalian calcium channel) homolog Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent calcium channel unc-36	A0A078BQJ0 G5EBI8 G5EDT2 O01661 P34374 Q8MQA1	STG-1 ccb-1 ccb-2 egl-19 stg-1 stg-2 unc-36 unc-72	Caenorhabditis elegans
Phase 0 - rapid depolarisation	Guanylate kinase/L-type calcium channel beta subunit domain-containing protein SH3 domain-containing protein STarGazin (Mammalian calcium channel) homolog STarGazin (Mammalian calcium channel) homolog Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent calcium channel unc-36	A0A078BQJ0 G5EBI8 G5EDT2 O01661 P34374 Q8MQA1	STG-1 ccb-1 ccb-2 egl-19 stg-1 stg-2 unc-36 unc-72	Caenorhabditis elegans
Regulation of insulin secretion	EF-hand domain-containing protein Facilitated glucose transporter homolog Facilitated glucose transporter protein 1 Guanylate kinase/L-type calcium channel beta subunit domain-containing protein MFS domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein SH3 domain-containing protein Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent calcium channel unc-36	A0A078BQJ0 A0A3B1E663 G5EC93 O01661 O16547 O44616 O44827 O45920 P34374 Q19376 Q20734 Q21381 Q21382 Q21385 Q23535 Q23626 Q5WRR9 Q8MQA1 Q95QY6 Q9GPA2 Q9GYQ1 Q9N309 Q9NEI8 Q9U2K5 Q9XU83 Q9XVL3	C03B1.13 C35A11.4 CELE_F11D5.5 CELE_F11D5.7 CELE_F13B12.2 CELE_F48E3.2 CELE_F53H8.3 CELE_K08F9.1 CELE_K08H10.6 CELE_K09C4.1 CELE_K09C4.4 CELE_K09C4.5 CELE_Y37A1A.3 CELE_Y39B6A.41 CELE_Y39E4B.5 CELE_Y61A9LA.1 CELE_ZK829.9 R09B5.11 ccb-1 ccb-2 egl-19 fdgt-2 fgt-1 slcf-2 unc-2 unc-36 unc-72	Caenorhabditis elegans	G58161NS
Presynaptic depolarization and calcium channel opening	EF-hand domain-containing protein Guanylate kinase/L-type calcium channel beta subunit domain-containing protein SH3 domain-containing protein STarGazin (Mammalian calcium channel) homolog STarGazin (Mammalian calcium channel) homolog Voltage-dependent calcium channel unc-36	A0A078BQJ0 A0A3B1E663 G5EBI8 G5EDT2 O01661 P34374	STG-1 ccb-1 ccb-2 stg-1 stg-2 unc-2 unc-36 unc-72	Caenorhabditis elegans
RHOH GTPase cycle	ANK_REP_REGION domain-containing protein Amino acid transporter Amino acid transporter Anion exchange protein Armadillo repeat-containing protein wrm-1 Beta-catenin-like protein hmp-2 Beta-catenin/armadillo-related protein 1 Caveolin-1 Caveolin-2 Excitatory amino acid transporter Glutamate carboxypeptidase 2 homolog Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial N-acetylated-alpha-linked acidic dipeptidase 2 Probable methionine synthase Probable rho GDP-dissociation inhibitor Protein FAM91A1 Protein kinase domain-containing protein Putative NipSnap protein K02D10.1 Putative sodium-dependent excitatory amino acid transporter glt-3 Putative sodium-dependent excitatory amino acid transporter glt-4 Putative sodium-dependent excitatory amino acid transporter glt-6 Rap-GAP domain-containing protein Ras-related protein Rab-18 Ras-related protein Rab-7a Ras-related protein ced-10 Ras-related protein rac-2 Rho-associated protein kinase let-502 Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase pak-1 Serine/threonine-protein kinase pak-2 Stomatin-2 Synaptobrevin-1 Transitional endoplasmic reticulum ATPase homolog 2 Tyrosine protein-kinase src-1 Tyrosine-protein kinase csk-1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase UBX domain-containing protein 2 Vang-like protein WD_REPEATS_REGION domain-containing protein	A0A061ADQ6 A0A0K3ARA3 B3WFV9 G5EBM6 G5ECJ6 G5EE56 G5EFU0 G5EGQ3 H2KY90 H2KZ40 O02495 O18210 O44326 O62219 P34492 P54812 P91406 P92199 Q03206 Q09582 Q10901 Q10953 Q17850 Q18462 Q18825 Q18879 Q19958 Q20496 Q21353 Q21751 Q22682 Q23146 Q23571 Q23595 Q93332 Q94051 Q94124 Q9BL44 Q9N2W5 Q9N4S6 Q9U3B5 Q9UAY8 Q9XW34 V6CLC2	C34F11.5 CELE_F33H2.2 CELE_K09B11.5 CELE_R151.1 CELE_T25B9.5 CELE_Y110A7A.9 CELE_Y52D5A.2 CELE_Y69E1A.3 CELE_Y71H2AM.12 CELE_ZK792.4 K02D10.1 abts-1 bar-1 cav-1 cav-2 cdc-48.2 ced-10 csk-1 dbt-1 gcp-2.1 gcp-2.2 glt-1 glt-3 glt-4 glt-5 glt-6 glt-7 hgap-1 hmp-2 kin-21 let-502 max-2 metr-1 pak-1 pak-2 pvl-1 rab-7 rac-1 rac-2 rhi-1 snb-1 spy-1 src-1 sto-2 ubxn-2 vang-1 wrm-1	Caenorhabditis elegans
Heme signaling	C-type lectin domain-containing protein C-type lectin domain-containing protein Protein vem-1 Proton-coupled folate transporter SoLute Carrier family Related SoLute Carrier family Related Solute carrier family 46 member 3	A0A061AD52 G5EFM5 H2KZC0 Q20236 Q7YZW5 Q9UAZ6 Q9XWL3	C25G4.17 clec-185 slc-46A slc-46a slcr-46.1 slcr-46.2 slcr-46.3 vem-1	Caenorhabditis elegans
Neutrophil degranulation	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 6 26S proteasome regulatory subunit 7 32 kDa beta-galactoside-binding lectin lec-3 32 kDa beta-galactoside-binding lectin ABC transporter domain-containing protein ACid Phosphatase family ACid Phosphatase family ADF-H domain-containing protein ADP-ribosylation factor-like protein 8B AMP deaminase AP-1 complex subunit mu-1-I AP-2 complex subunit alpha ATP-dependent 6-phosphofructokinase 1 ATP-dependent 6-phosphofructokinase 2 ATP-dependent DNA helicase II subunit 2 ATP-dependent RNA helicase laf-1 ATPase family AAA domain-containing protein 3 AcetylCholine Receptor AcetylCholine Receptor AcetylCholine Receptor AcetylCholine Receptor Acetylcholine receptor subunit alpha-type unc-38 Acetylcholine receptor subunit alpha-type unc-63 Acetylcholine receptor subunit beta-type acr-2 Acetylcholine receptor subunit beta-type acr-3 Acetylcholine receptor subunit beta-type lev-1 Acetylcholine receptor subunit beta-type unc-29 Acid ceramidase Actin-related protein 10 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2 Actin Adenine phosphoribosyltransferase Aldehyde dehydrogenase Alpha-galactosidase Alpha-mannosidase Aminopeptidase ltah-1.1 Aminopeptidase Amphiphysin Apple domain-containing protein Apyrase apy-1 Arginase Armadillo repeat-containing protein wrm-1 B-box type zinc finger protein ncl-1 BEACH domain-containing protein BPI1 domain-containing protein Beta-catenin-like protein hmp-2 Beta-catenin/armadillo-related protein 1 Beta-galactosidase Beta-glucuronidase Beta-hexosaminidase A Bis(5'-adenosyl)-triphosphatase C-CAP/cofactor C-like domain-containing protein C-type lectin domain-containing protein 87 C-type lectin domain-containing protein 88 C-type lectin domain-containing protein 91 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C2 domain-containing protein aex-1 CDC50 family protein chat-1 CED-5 CUE domain-containing protein Cadherin-4 Calpain catalytic domain-containing protein Calpain catalytic domain-containing protein Calpain catalytic domain-containing protein Calpain catalytic domain-containing protein Calpain catalytic domain-containing protein Calpain catalytic domain-containing protein Calpain clp-1 Calponin-homology (CH) domain-containing protein Carboxypeptidase Carboxypeptidase Carboxypeptidase Casein kinase II subunit beta Catalase Cathepsin L-like Cathepsin Z-1 Chitinase-like protein C25A8.4 Choline transporter-like protein 1 Coatomer subunit beta Collagen/olfactomedin domain containing protein 2 Cubilin homolog Cullin-associated NEDD8-dissociated protein 1 Cyclin-dependent kinase 12 Cystatin cpi-2 Cysteine-rich transmembrane CYSTM domain-containing protein Cytidine deaminase Cytoplasmic FMR1-interacting protein homolog DUF148 domain-containing protein DUF1968 domain-containing protein DYnein Light chain (Tctex type) DZF domain-containing protein Disintegrin and metalloproteinase domain-containing protein 10 homolog Disintegrin and metalloproteinase domain-containing protein adm-2 Disintegrin and metalloproteinase domain-containing protein unc-71 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Dynein heavy chain, cytoplasmic Dynein light chain 1, cytoplasmic Dynein light chain Dynein light chain Dynein light chain Dynein light chain Dynein light intermediate chain EF-hand domain-containing protein Elongation factor 1-alpha Elongation factor 2 Endocytosis protein RME-8 F-BAR domain-containing protein FERM and PDZ domain-containing protein 4 FH2 domain-containing protein Facilitated glucose transporter homolog Facilitated glucose transporter protein 1 Fatty acid-binding protein homolog 9 Ferritin Ferritin Fructose-bisphosphate aldolase 1 Fructose-bisphosphate aldolase 2 G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein GH18 domain-containing protein GPS domain-containing protein GPS domain-containing protein Galectin domain-containing protein Galectin Galectin Galectin Galectin Galectin Galectin Galectin Galectin Galectin Galectin Galectin Galectin Galectin Galectin Galectin Galectin Galectin Gelsolin-like protein 1 Glucose-6-phosphate isomerase Glutathione S-transferase P Glycogen debranching enzyme Glycogenin-1 Glycoside hydrolase 35 catalytic domain-containing protein HECT-type E3 ubiquitin transferase Heat shock protein 90 Heat shock protein hsp-1 High mobility group protein 1.2 Histidine acid phosphatase Histidine acid phosphatase Histidine phosphatase family protein IRS-type PTB domain-containing protein IST1 homolog Importin N-terminal domain-containing protein Inosine-5'-monophosphate dehydrogenase Integrin alpha pat-2 Integrin beta pat-3 Intestinal acid PHOsphatase Intestinal acid PHOsphatase Intestinal acid PHOsphatase Intestinal acid PHOsphatase Intestinal acid phosphatase Isocitrate dehydrogenase [NADP] J domain-containing protein J domain-containing protein Juxtamembrane domain-associated catenin Ku domain-containing protein L-dopachrome isomerase LAMP family protein lmp-1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Long-chain-fatty-acid--CoA ligase Long-chain-fatty-acid--CoA ligase Lysosomal acid phosphatase Lysosomal acid phosphatase Lysosomal acid phosphatase Lysosome-associated membrane glycoprotein 5 MARVEL domain-containing protein MARVEL domain-containing protein MFS domain-containing protein MMP-like protein MO25 (MOuse embryo scaffolding Protein) homolog MO25-like protein 2 MO25-like protein 3 MPN domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major sperm protein Major sperm protein Malectin domain-containing protein Matrix metalloproteinase-A Matrix metalloproteinase-B Matrix metalloproteinase-C Membrane protein BRI3 Membrane-associated protein gex-3 Methyltransferase type 11 domain-containing protein Mitogen-activated protein kinase mpk-1 Mitogen-activated protein kinase pmk-1 Mitogen-activated protein kinase pmk-2 Mitogen-activated protein kinase pmk-3 NADH dehydrogenase [ubiquinone] 1 subunit C2 NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NRAMP-like transporter smf-1 NRAMP-like transporter smf-2 NRAMP-like transporter smf-3 NTR domain-containing protein Neprilysin-11 Neprilysin-1 Neprilysin-21 Neprilysin-2 Neprilysin Neprilysin Neprilysin Neprilysin Neprilysin Neuroglian Nicastrin Nicotinate phosphoribosyltransferase Nucleoside diphosphate kinase Nucleotide-diphospho-sugar transferase O-acyltransferase Olfactomedin-like domain-containing protein Olfactomedin-like domain-containing protein Osteoclast-stimulating factor 1 P-type domain-containing protein P-type domain-containing protein PCI domain-containing protein Peptidase C1A papain C-terminal domain-containing protein Peptidase M12B domain-containing protein Peptidase M13 C-terminal domain-containing protein Peptidase M13 C-terminal domain-containing protein Peptidase M13 N-terminal domain-containing protein Peptidase M24 domain-containing protein Peptidase metallopeptidase domain-containing protein Peptidase_M13 domain-containing protein Peptidase_M13 domain-containing protein Peptidase_M13_N domain-containing protein Peptidyl-prolyl cis-trans isomerase Peroxidasin homolog pxn-1 Peroxidasin homolog pxn-2 Phosphoglucomutase-2 Phospholipase Phospholipid-transporting ATPase tat-1 Phospholipid-transporting ATPase Phosphotransferase Phosphotransferase Phosphotransferase Probable 26S proteasome regulatory subunit rpn-6.1 Probable 5-hydroxyisourate hydrolase R09H10.3 Probable 5-hydroxyisourate hydrolase ZK697.8 Probable ATP-citrate synthase Probable beta-mannosidase Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 Probable dynein light chain 2, cytoplasmic Probable endochitinase Probable galaptin lec-7 Probable galaptin lec-8 Prolyl carboxy peptidase like protein 5 Prostaglandin E synthase 2 Proteasome subunit alpha type-2 Proteasome subunit alpha type-5 Proteasome subunit beta Protein kinase C-like 1 Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein lap1 Protein lifeguard 1-like Protein lifeguard 2 Protein lin-41 Protein lon-1 Protein sdf-9 Protein vem-1 Protein-tyrosine phosphatase Protein-tyrosine phosphatase Protein-tyrosine phosphatase Protein-tyrosine phosphatase Purine nucleoside phosphorylase Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 Putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase Putative acid phosphatase 10 Putative acid phosphatase 11 Putative acid phosphatase 5 Putative alpha-L-fucosidase Putative deoxyribose-phosphate aldolase Putative metalloproteinase inhibitor tag-225 Putative protein heh-1 Putative pyridoxal kinase Putative sphingolipid delta(4)-desaturase/C4-monooxygenase Putative sphingolipid delta(4)-desaturase Pyruvate kinase Pyruvate kinase RAB family RAP homolog (Vertebrate Rap GTPase family) RING finger protein nhl-1 Rab GDP dissociation inhibitor Rab-GAP TBC domain-containing protein Rab27 Ragulator complex protein LAMTOR2 homolog Ras and EF-hand domain-containing protein homolog Ras modification protein ERF4 Ras protein let-60 Ras-like GTP-binding protein rhoA Ras-related protein Rab-10 Ras-related protein Rab-14 Ras-related protein Rab-18 Ras-related protein Rab-18 Ras-related protein Rab-3 Ras-related protein Rab-7a Ras-related protein Rap-1 Ras-related protein ced-10 Ras-related protein rab-6.2 Ras-related protein rac-2 Receptor-type tyrosine-protein phosphatase dep-1 Receptor-type tyrosine-protein phosphatase kappa Receptor-type tyrosine-protein phosphatase-like ida-1 Rho-associated protein kinase let-502 Ribonuclease T2 protein rnst-2 SCAVenger receptor (CD36 family) related SCAVenger receptor (CD36 family) related SCAVenger receptor (CD36 family) related SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SCP domain-containing protein SERPIN domain-containing protein SERPIN domain-containing protein SH3 domain-containing protein Saposin B-type domain-containing protein Saposin B-type domain-containing protein Secretory carrier-associated membrane protein Sensory neuron membrane protein 2 Serine carboxypeptidase ctsa-1.1 Serine carboxypeptidase ctsa-1.2 Serine carboxypeptidase ctsa-3.1 Serine carboxypeptidase ctsa-3.2 Serine carboxypeptidase ctsa-4.1 Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein ShKT domain-containing protein Signal recognition particle 14 kDa protein Small monomeric GTPase Soluble NSF attachment protein 29 Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Sorbin and SH3 domain-containing protein 1 homolog Spectrin alpha chain Stomatin-2 Sulfatase N-terminal domain-containing protein Sulfhydryl oxidase Surfeit locus protein 4 homolog Sushi domain-containing protein Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptogyrin homolog 1 Synaptosomal-associated protein T-complex protein 1 subunit beta T-complex protein 1 subunit theta TOM1-like protein 2 TetraSPanin family Tetraspanin-12 Tetraspanin-15 Tetraspanin Tetraspanin Tetraspanin Tetraspanin Tetraspanin Thioredoxin domain-containing protein Thioredoxin domain-containing protein Trafficking protein particle complex subunit Transitional endoplasmic reticulum ATPase homolog 2 Transmembrane BAX inhibitor motif-containing protein 4 Tubulin beta chain Tubulin beta chain Tubulin beta chain Tubulin beta-2 chain Tyrosine protein-kinase src-1 Tyrosine protein-kinase src-2 Tyrosine-protein phosphatase Lar-like Tyrosine-protein phosphatase non-receptor type eak-6 Tyrosine-protein phosphatase non-receptor type ptp-2 Tyrosine-protein phosphatase UBR-type domain-containing protein UBX domain-containing protein Ubiquitin-like modifier-activating enzyme ATG7 Uncharacterized integrin beta-like protein C05D9.3 Uncharacterized protein C03F11.3 Uncharacterized protein R07B1.3 Uncharacterized protein ZK652.6 Uncharacterized protein Uncharacterized protein Uncharacterized protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c 2 V-type proton ATPase 16 kDa proteolipid subunit c 3 V-type proton ATPase subunit D VPS35 endosomal protein sorting factor-like Vacuolar H ATPase Vinculin WAPL domain-containing protein WW domain-containing protein tag-325 Yippee domain-containing protein acylaminoacyl-peptidase glutaminyl-peptide cyclotransferase glycogenin glucosyltransferase nucleoside-diphosphate kinase phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) small monomeric GTPase t-SNARE protein aex-4	A0A061AD52 A0A0K3AST9 A0A0S4XR36 A0A131MCS3 A0A1N7SYP5 A0A1X7RC97 A0A2C9C377 A0A486WWU7 A0A4V0IJ66 A0A4V0IKG6 A0A5S9MNU9 A0AAC1 A5PEW5 A9Z1L1 B1GRL5 B2MZD0 B7WNA0 C0HLB3 C0HLB4 C4RVF6 D0PV95 D3KFV8 E5QCE7 E6N0V1 E7EM29 E7EM30 F5GU58 G4RWX0 G5EBK2 G5EBK4 G5EBM7 G5EBS5 G5EBT7 G5EBT9 G5EBU3 G5EBV4 G5EC10 G5EC24 G5EC32 G5EC63 G5EC69 G5EC93 G5EC99 G5ECC4 G5ECM9 G5ECX8 G5ECY2 G5ECZ5 G5ED34 G5ED36 G5ED41 G5ED52 G5EDC6 G5EDF1 G5EDU3 G5EDW5 G5EE40 G5EE56 G5EED5 G5EEK9 G5EEN3 G5EEN8 G5EEU3 G5EF01 G5EF50 G5EF80 G5EFA6 G5EFC7 G5EFD5 G5EFD9 G5EFH4 G5EFI4 G5EFM5 G5EFT4 G5EFV1 G5EG78 G5EGA9 G5EGJ5 G5EGJ9 G5EGM1 G5EGP1 G5EGP4 G5EGP8 G5EGU2 H2KYL1 H2KYQ5 H2KZ07 H2KZE5 H2KZY5 H2L0H3 H9G2T4 H9G2Z8 K8ERT0 K8ESM2 O01312 O01329 O01330 O01331 O01736 O01824 O02106 O02495 O16453 O16547 O16575 O16607 O16636 O16652 O16789 O16790 O16795 O16796 O16927 O17271 O17365 O17373 O17599 O17772 O17913 O17921 O18076 O18165 O18211 O44180 O44186 O44326 O44514 O44518 O44578 O44616 O44782 O44827 O44836 O44857 O44873 O45275 O45311 O45520 O45539 O45569 O45628 O45686 O45734 O45819 O45920 O45934 O61792 O61861 O61870 O61887 O61967 O62102 O62334 O62349 O62403 O62421 O62466 O62508 O76371 O76577 O76632 O76725 O76735 P09446 P10299 P19826 P22981 P28548 P29691 P30628 P34308 P34351 P34446 P34462 P34611 P34664 P34669 P34676 P34722 P35602 P36573 P39745 P45971 P46551 P46563 P46941 P47207 P48181 P48182 P49713 P52275 P52714 P52715 P52716 P52717 P53013 P53489 P53585 P54216 P54812 P55163 P83351 P90949 P91189 P91195 P91214 P91245 P91267 P91455 P91857 P92199 Q03206 Q03601 Q04908 Q09390 Q09448 Q09451 Q09566 Q09581 Q09605 Q09606 Q09610 Q09991 Q10944 Q10953 Q10956 Q11117 Q11124 Q11174 Q17441 Q17446 Q17540 Q18115 Q18136 Q18143 Q18246 Q18276 Q18279 Q18287 Q18501 Q18538 Q18539 Q18540 Q18543 Q18550 Q18625 Q18673 Q18688 Q18787 Q18813 Q18817 Q18821 Q18825 Q18849 Q18864 Q18916 Q19004 Q19020 Q19076 Q19137 Q19140 Q19175 Q19202 Q19264 Q19319 Q19324 Q19344 Q19349 Q19376 Q19390 Q19416 Q19440 Q19479 Q19651 Q19767 Q19833 Q19878 Q19930 Q19931 Q19958 Q1ENI8 Q1ZXU1 Q20026 Q20241 Q20538 Q20549 Q20585 Q20603 Q20608 Q20609 Q20628 Q20662 Q20665 Q20684 Q20707 Q20734 Q20748 Q20829 Q20911 Q20938 Q20950 Q21004 Q21146 Q21182 Q21253 Q21265 Q21267 Q21381 Q21382 Q21385 Q21408 Q21433 Q21434 Q21557 Q21643 Q21697 Q21742 Q21750 Q21801 Q21829 Q21882 Q21925 Q22038 Q22253 Q22267 Q22317 Q22421 Q22492 Q22495 Q22523 Q22525 Q22601 Q22630 Q22631 Q22763 Q22782 Q22799 Q22852 Q22908 Q23022 Q23146 Q23316 Q23355 Q23427 Q23535 Q23539 Q23626 Q27218 Q27483 Q27488 Q27526 Q27874 Q2L6V8 Q2V4S2 Q304D5 Q400M1 Q4W5T6 Q53U87 Q564S3 Q5WRR9 Q65XS9 Q7JP75 Q7K707 Q7KX00 Q7YTJ8 Q7YZW5 Q86NG3 Q8IAA5 Q8IAA9 Q8MQ55 Q8MQ79 Q8MXF0 Q8MXI4 Q8MXS1 Q8MXT1 Q8MYL7 Q8T3E3 Q8WQG5 Q93149 Q93324 Q93329 Q93344 Q93444 Q93565 Q93576 Q93746 Q93747 Q93874 Q94057 Q94124 Q94148 Q94215 Q94269 Q94417 Q94986 Q95008 Q95Q32 Q95QG1 Q95QX5 Q95QY6 Q95XG8 Q95XH1 Q95XX1 Q95YA9 Q95ZT3 Q965P2 Q965W1 Q9BIB8 Q9BL33 Q9BL40 Q9BL44 Q9BMN8 Q9GPA2 Q9GUF1 Q9GUF2 Q9GYK0 Q9GYK2 Q9GYQ1 Q9GYR2 Q9GZD8 Q9GZD9 Q9GZE0 Q9GZH3 Q9GZH5 Q9N2U6 Q9N358 Q9N384 Q9N3I3 Q9N3Y5 Q9N4A5 Q9N4B1 Q9N4B2 Q9N4M3 Q9N4W5 Q9N587 Q9N5B3 Q9N5N3 Q9N5N4 Q9N5X7 Q9NA98 Q9NCE1 Q9NEI8 Q9NLD2 Q9TYL9 Q9TYS3 Q9TYX1 Q9TZL8 Q9TZM2 Q9U204 Q9U228 Q9U280 Q9U2B2 Q9U2D2 Q9U2K5 Q9U2T0 Q9U2T1 Q9U2Z5 Q9U308 Q9U3L3 Q9U489 Q9XTT3 Q9XTY9 Q9XU14 Q9XU15 Q9XU83 Q9XUK8 Q9XVI4 Q9XVL3 Q9XVM9 Q9XVQ1 Q9XVS3 Q9XVT9 Q9XWA8 Q9XWC5 Q9XWX3 Q9XX56 Q9XX60 Q9XXC0 S6EZS3 U4PBQ7 U4PBV8 U4PBY0 U4PM93 U4PSA1 V6CJI9 W6RR46 X5LPS1 X5LV99	B0546.3 C01B10.9 C03B1.13 C03F11.3 C05D9.3 C07A12.7 C25G4.17 C27A2.12 C27C7.5 C28G1.2 C33G3.4 C35A11.4 C36E8.4 C39H7.4 C49C3.10 C53D6.7 C54G4.4 CELE_F07A5.4 CELE_F10D11.6 CELE_F11C7.2 CELE_F11D5.5 CELE_F11D5.7 CELE_F11F1.1 CELE_F11G11.5 CELE_F13B12.2 CELE_F13H10.6 CELE_F15D3.4 CELE_F20H11.4 CELE_F21F3.2 CELE_F26G1.1 CELE_F41C6.4 CELE_F43D2.6 CELE_F44E2.10 CELE_F44G3.7 CELE_F46A8.3 CELE_F46A8.4 CELE_F46A8.5 CELE_F46A8.8 CELE_F47B7.2 CELE_F47E1.2 CELE_F47E1.4 CELE_F47G9.6 CELE_F48E3.2 CELE_F49F1.10 CELE_F49F1.11 CELE_F49F1.18 CELE_F49F1.9 CELE_F52E1.2 CELE_F53B1.8 CELE_F53H8.3 CELE_F58D5.2 CELE_H20J04.9 CELE_H27A22.1 CELE_H40L08.1 CELE_K02G10.5 CELE_K03B8.6 CELE_K08F9.1 CELE_K08H10.6 CELE_K09C4.1 CELE_K09C4.4 CELE_K09C4.5 CELE_M04G7.2 CELE_M6.11 CELE_R05F9.6 CELE_R11H6.5 CELE_T10B10.8 CELE_T13H5.1 CELE_T21B6.3 CELE_T22F3.12 CELE_T28F4.3 CELE_W08E12.7 CELE_Y105E8B.9 CELE_Y106G6D.4 CELE_Y106G6E.1 CELE_Y106G6H.14 CELE_Y16B4A.2 CELE_Y32F6B.1 CELE_Y37A1A.3 CELE_Y38H6C.8 CELE_Y39B6A.41 CELE_Y39E4B.5 CELE_Y42H9AR.2 CELE_Y43F4B.5 CELE_Y48G8AL.15 CELE_Y50D7A.10 CELE_Y51B9A.9 CELE_Y57G11C.33 CELE_Y70G10A.3 CELE_Y71G12B.31 CELE_Y71H2AM.12 CELE_ZK616.65 CELE_ZK829.9 F09E5.3 F25G6.8 F33D4.4 PLD R04B3.2 R07B1.3 R09B5.11 R09H10.3 SC T19B4.3 T22D1.3 W03G11.3 ZK652.6 ZK686.3 ZK697.8 aagr-1 aagr-2 abt-1 acl-2 acly-1 acp-5 acp-6 acp-7 acr-12 acr-2 acr-3 acr-6 acr-8 acs-20 acs-22 adm-1 adm-2 aex-1 aex-4 aex-6 agl-1 aldo-1 aldo-2 alh-4 aman-1 ampd-1 amph-1 anp-1 apa-2 aph-2 apy-1 argn-1 arl-8 arp-1 arp-11 arp-2 arx-2 arx-7 asah-1 atad-3 atg-7 bar-1 ben-1 bgal-1 bgal-2 cal-5 cand-1 cas-1 cct-2 cct-8 cctb cdc-48.2 cdd-2 cdh-4 cdk-12 cdtl-7 ced-10 ced-5 cfh-1 chat-1 cht-1 cht-3 cht-4 chtl-1 cku-70 cku-80 clec-149 clec-185 clec-196 clec-199 clec-202 clec-204 clec-224 clec-266 clec-45 clec-47 clec-86 clec-87 clec-88 clec-91 clp-1 clp-3 clp-4 clp-6 clp-7 clpr-1 clpr-3 clpr-4 cof-2 copb-1 cpg-5 cpg-6 cpi-2 cpl-1 cpr-9 cpz-1 ctl-3 ctsa-1 ctsa-1.1 ctsa-1.2 ctsa-2 ctsa-3.1 ctsa-3.2 ctsa-4.1 ctsa-4.2 cubn-1 cyk-1 daf-21 deb-1 dep-1 dhc-1 dlc-1 dlc-2 dlc-3 dlc-4 dlc-5 dlc-6 dli-1 dnj-14 dnj-7 dpf-5 drd-7 dylt-1 eak-5 eak-6 eef-2 eel-1 eft-3 eft-4 erp-44.1 fdgt-2 fgt-1 frm-8 ftn-1 ftn-2 gana-1 gck-4 gdi-1 gex-2 gex-3 gie gpi-1 gska-3 gskl-2 gsnl-1 gst-1 gyg-1 gyg-2 heh-1 hex-1 hmg-1.2 hmp-2 hpo-28 hsp-1 hsp70a hxk-1 hxk-2 hxk-3 ia2 ida-1 idh-1 imb-1 inft-2 istr-1 jac-1 kin-10 kin-22 kin-5 laf-1 lbp-9 lec-1 lec-10 lec-11 lec-2 lec-3 lec-4 lec-5 lec-6 lec-7 lec-8 lec-9 let-413 let-502 let-60 lev-1 lev-7 lev-8 lin-34 lin-41 lmp-1 lmp-2 lmtr-2 lmtr-3 lon-1 ltah-1.1 lyst-1 mboa-2 mif-1 mlt-8 mop-25.1 mop-25.2 mop-25.3 mpk-1 mth-1 mth-2 ncl-1 ndk-1 nduc-2 nep-1 nep-10 nep-11 nep-12 nep-13 nep-16 nep-17 nep-18 nep-2 nep-20 nep-21 nep-22 nep-23 nep-24 nep-25 nep-26 nep-3 nep-4 nep-6 nep-8 nep-9 nhl-1 npr-14 npr-32 nprt-1 ostb-1 pas-2 pas-5 pat-2 pat-3 pbs-2 pcp-5 pdxk-1 pes-7 pfk-1.1 pfk-1.2 pges-2 phi-28 pho-1 pho-10 pho-11 pho-12 pho-13 pho-14 pho-4 pho-5 pho-6 pho-7 pho-8 pho-9 pld-1 pmk-1 pmk-2 pmk-3 pnp-1 prdx-6 ptp-2 ptp-3 pvl-1 pxn-1 pxn-2 pyk-1 pyk-2 rab-10 rab-14 rab-18 rab-3 rab-37 rab-5 rab-6.2 rab-7 rab27 rac-1 rac-2 rap-1 rap-2 rap-3 rdy-1 rho-1 rhoa ric-4 rme-8 rnst-2 rog-1 rpn-1 rpn-11 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-5 rsef-1 sax-7 scav-2 scav-3 scav-4 scav-6 scl-1 scl-10 scl-11 scl-12 scl-13 scl-14 scl-15 scl-17 scl-18 scl-2 scl-20 scl-21 scl-27 scl-3 scl-5 scl-6 scl-7 scl-8 scl-9 scm-1 sdf-9 sft-4 slcf-2 smf-1 smf-2 smf-3 snap-29 snb-1 snb-2 snb-5 snb-6 snb-7 sng-1 sorb-1 spc-1 spp-10 spp-8 spv-1 spy-1 src-1 src-2 srp-1 srp-2 srp-3 srp-6 srp-7 srp-8 sto-2 sul-3 sup-17 sur-1 surf-4 tag-120 tag-225 tag-275 tag-282 tag-312 tag-325 tag-81 tat-1 tat-2 tbb-1 tbb-2 tbb-6 tbc-10 timp-1 tli-1 tpa-1 trpp-1 tsp-12 tsp-15 tsp-19 tsp-20 tsp-4 tsp-5 tsp-6 tsp-7 ttm-5 ubr-4 unc-101 unc-122 unc-29 unc-32 unc-38 unc-63 unc-71 vamp-7 vap-1 vap-2 vem-1 vha-14 vha-2 vha-20 vha-3 vha-5 vha-6 vha-7 vpr-1 wrm-1 xbx-6 zmp-1 zmp-2 zmp-3 zmp-5 zmp-6	Caenorhabditis elegans
Downregulation of ERBB4 signaling	E3 ubiquitin-protein ligase wwp-1 E3 ubiquitin-protein ligase Polyubiquitin-A Receptor tyrosine-protein kinase let-23 Tyrosine protein-kinase src-1 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A0A061ACQ8 G5EE56 P0CG71 P24348 P37165 P49632 Q9N2Z7	CELE_Y92H12A.2 kin-7 let-23 src-1 ubia ubib ubl-1 ubq-1 ubq-2 wwp-1	Caenorhabditis elegans
Regulation of PTEN stability and activity	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Casein kinase II subunit alpha Casein kinase II subunit beta E3 ubiquitin-protein ligase CHIP E3 ubiquitin-protein ligase makorin E3 ubiquitin-protein ligase wwp-1 E3 ubiquitin-protein ligase E3 ubiquitin-protein ligase MPN domain-containing protein PCI domain-containing protein Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18 Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 RING-type domain-containing protein Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2 Tyrosine protein-kinase src-2 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein ubiquitinyl hydrolase 1	A0A061ACQ8 G5ECY6 G5EE01 O16368 O17071 O17586 O44156 O45539 O61742 O61792 O62102 O76371 O76577 P0CG71 P18334 P28548 P37165 P46502 P49632 P90868 P91477 Q04908 Q10920 Q17941 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q22253 Q23237 Q23449 Q27488 Q7JLI8 Q8WQB0 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N2Z7 Q9N373 Q9N3T6 Q9N599 Q9XTG7 Q9XTT9 Q9XUV0	1G758 C14C10.5 CELE_F35G12.12 CELE_Y105E8A.14 CELE_Y47G6A.14 CELE_Y92H12A.2 akt-1 akt-2 chn-1 daf-18 duo-1 kin-10 kin-22 kin-3 kin-5 lep-2 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 src-2 ubia ubib ubl-1 ubq-1 ubq-2 wwp-1	Caenorhabditis elegans
Downregulation of SMAD2/3:SMAD4 transcriptional activity	Dwarfin sma-4 E3 ubiquitin-protein ligase Histone deacetylase Homeobox domain-containing protein Homeobox protein ceh-60 Mitogen-activated protein kinase mpk-1 Polyubiquitin-A Probable sodium/potassium-transporting ATPase subunit beta-3 Protein phosphatase ppm-1.A Smad protein daf-8 Sodium/potassium-transporting ATPase subunit beta-1 Sodium/potassium-transporting ATPase subunit beta UBA domain-containing protein Ubiquitin-conjugating enzyme E2 2 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Uncharacterized protein T27F2.1	A0A061ACQ8 G5ECH0 G5EG81 P0CG71 P35129 P37165 P39745 P45897 P49632 Q17788 Q19775 Q21733 Q22836 Q45EK2 Q93235 Q9XUG9 Q9XUY5	CELE_T24B8.7 CELE_Y92H12A.2 T27F2.1 ceh-57 ceh-60 cem-3 daf-8 hda-3 let-70 mpk-1 nkb-1 nkb-2 nkb-3 ppm-1.A sma-4 sur-1 ubc-2 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Stimuli-sensing channels	Acid-sensing ion channel 1-like Acid-sensing ion channel 1 Amiloride-sensitive sodium channel Amiloride-sensitive sodium channel Anoctamin Band 7 domain-containing protein Cation/H+ exchanger domain-containing protein Cation/H+ exchanger domain-containing protein Cation/H+ exchanger domain-containing protein Chloride channel protein clh-3 Chloride channel protein Chloride channel protein Chloride channel protein Chloride channel protein Coelomocyte uptake defective protein 15 DEgenerin Like DEgenerin Like DEgenerin Like DEgenerin Like DEgenerin Like DEgenerin Like DEgenerin Like DEgenerin Like DEgenerin Like DEgenerin Linked to Mechanosensation DEgenerin Linked to Mechanosensation Degenerin deg-1 Degenerin del-1 Degenerin mec-10 Degenerin mec-4 Degenerin unc-8 Degenerin-like protein asic-1 Degenerin-like protein asic-2 Degenerin-like protein del-10 Degenerin-like protein unc-105 E3 ubiquitin-protein ligase wwp-1 E3 ubiquitin-protein ligase EGF-like domain-containing protein EGF-like domain-containing protein EGF-like domain-containing protein EGF-like domain-containing protein FLR-1 Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Polyubiquitin-A Protein tweety homolog 1 Raf homolog serine/threonine-protein kinase Serine/threonine-protein kinase sgk-1 Stomatin-1 Stomatin-2 Stomatin-3 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Uncharacterized transporter slc-17.2 Uncharacterized transporter slc-17.3	A0A061ACQ8 G3MU02 G5EC75 G5EFH3 G5EFS0 G5EG93 G5EGI5 G5EGT4 H2KYN8 H2KZQ1 H2L0J1 H2L2L3 O01537 O01635 O01664 O44130 O45402 P0CG71 P24585 P24612 P34272 P34886 P37165 P49632 P91100 P91102 P91103 P91835 Q03567 Q07292 Q09274 Q09322 Q10025 Q10048 Q18077 Q18651 Q19038 Q19200 Q19777 Q19958 Q20273 Q20332 Q20657 Q20852 Q21974 Q22851 Q22970 Q23514 Q23576 Q2PJ68 Q7YZV6 Q8I4F6 Q8MPW0 Q93205 Q93597 Q9BMK9 Q9N2Z7 Q9U1T8 Q9U1T9 Q9XTS9 Q9XU88	C38C10.2 CELE_F41E7.2 CELE_Y92H12A.2 acd-1 acd-2 acd-3 acd-4 acd-5 anoh-2 asic-1 asic-2 cima-1 clc-3 clh-2 clh-3 clh-4 clh-5 clh-6 cup-15 deg-1 degt-1 del-1 del-10 del-3 del-4 del-5 del-6 del-7 del-8 del-9 delm-1 delm-2 egas-1 egas-2 egas-3 egas-4 flr-1 lin-45 mec-10 mec-13 mec-4 raf-1 sgk-1 slc-17.1 slc-17.3 slc-17.4 slc-17.5 slc-17.6 slc-17.7 slc-17.8 slc-17.9 slc-9B.1 slc-9B.2 slc-9b.1 slc-9b.2 sto-1 sto-2 sto-3 sto-5 ttyh-1 ubia ubib ubl-1 ubq-1 ubq-2 unc-105 unc-8 wwp-1	Caenorhabditis elegans
ISG15 antiviral mechanism	Beclin homolog Calponin-homology (CH) domain-containing protein E1 ubiquitin-activating enzyme E3 ubiquitin-protein ligase ari-1.1 E3 ubiquitin-protein ligase Eukaryotic initiation factor 4A Eukaryotic translation initiation factor 2-alpha kinase pek-1 Eukaryotic translation initiation factor 4E-1 Eukaryotic translation initiation factor 4E-2 Eukaryotic translation initiation factor 4E-3 Eukaryotic translation initiation factor 4E-4 Eukaryotic translation initiation factor 4E-5 HECT domain-containing protein Helicase ATP-binding domain-containing protein MIF4G domain-containing protein Mitogen-activated protein kinase mpk-1 Polyubiquitin-A Protein kinase domain-containing protein Protein phosphatase ppm-1.A RNA helicase RNA helicase Signal transducer and activator of transcription 1 Signal transducer and activator of transcription b TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 UBC core domain-containing protein Ubiquitin carboxyl-terminal hydrolase usp-48 Ubiquitin-conjugating enzyme E2 13 Ubiquitin-conjugating enzyme E2 ubc-18 Ubiquitin-like domain-containing protein X-linked retinitis pigmentosa GTPase regulator homolog	A0A061ACQ8 A0A486WX07 D3YT30 G5ECC7 G5EEM6 O01965 O44820 O45551 O61955 P0CG71 P27639 P39745 P56570 Q19192 Q19775 Q20617 Q20935 Q20977 Q21633 Q21693 Q22592 Q22888 Q27481 Q5DX34 Q93413 Q95XX0 Q9BL11 Q9BL61 Q9NAD6 U4PBJ9	CELE_F52C6.3 CELE_F57B9.3 CELE_T12G3.2 CELE_Y92H12A.2 ari-1.1 atg-6 bec-1 drh-3 eif-4A3 fln-1 glo-4 herc-1 ife-1 ife-2 ife-3 ife-4 ife-5 ifg-1 inf-1 mpk-1 pek-1 ppm-1.A sta-1 sta-2 stat-b sur-1 tap-1 uba-1 ubc-13 ubc-18 ubc-24 ubia ubq-1 usp-48	Caenorhabditis elegans
Antigen processing: Ubiquitination & Proteasome degradation	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein AO66 ankyrin Abnormal embryogenesis protein 30 Aminopeptidase-like protein AC3.5 Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Ankyrin repeat and KH domain-containing protein mask-1 B30.2/SPRY domain-containing protein BTB domain-containing protein BTB domain-containing protein BTB domain-containing protein BTB domain-containing protein C3H1-type domain-containing protein Cell division cycle protein 16 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Cullin-1 Cullin-2 Cullin-3 Cullin-5 DDB1- and CUL4-associated factor homolog 1 Death domain-containing protein E1 ubiquitin-activating enzyme E2 ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E3 UFM1-protein ligase 1 homolog E3 ubiquitin-protein ligase CBL E3 ubiquitin-protein ligase CHIP E3 ubiquitin-protein ligase E3D E3 ubiquitin-protein ligase RBBP6 E3 ubiquitin-protein ligase TRIM9 E3 ubiquitin-protein ligase etc-1 E3 ubiquitin-protein ligase hecd-1 E3 ubiquitin-protein ligase hecw-1 E3 ubiquitin-protein ligase listerin E3 ubiquitin-protein ligase makorin E3 ubiquitin-protein ligase siah-1 E3 ubiquitin-protein ligase trul-1 E3 ubiquitin-protein ligase ubr-1 E3 ubiquitin-protein ligase wwp-1 E3 ubiquitin-protein ligase Elongin-C F-box domain-containing protein F-box domain-containing protein F-box domain-containing protein F-box domain-containing protein F-box protein dre-1 F-box/LRR-repeat protein fbxl-1 F-box/WD repeat-containing protein mec-15 F-box/WD repeat-containing protein sel-10 FERM domain (Protein4.1-ezrin-radixin-moesin) family HECT domain-containing protein HECT-type E3 ubiquitin transferase HECT-type E3 ubiquitin transferase Ion transport domain-containing protein K Homology domain-containing protein MPN domain-containing protein NEDD8-activating enzyme E1 catalytic subunit PCI domain-containing protein PDZ domain-containing protein PDZ domain-containing protein Peptidase_M1 domain-containing protein Polyubiquitin-A Potential E3 ubiquitin-protein ligase ariadne-2 Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Probable ubiquitin-conjugating enzyme E2 7 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Protein gfi-3 Protein kinase domain-containing protein Puromycin-sensitive aminopeptidase Putative aminopeptidase-2 RBR-type E3 ubiquitin transferase RBR-type E3 ubiquitin transferase RBR-type E3 ubiquitin transferase RING-box protein 1 RING-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RING-type domain-containing protein RING-type domain-containing protein RING-type domain-containing protein RING-type domain-containing protein RING-type domain-containing protein RING-type domain-containing protein RNA polymerase II transcription factor SIII p18 subunit SPRY domain-containing SOCS box protein 1 Skp1-related protein Transcription factor che-1 Tripeptidyl-peptidase 2 UBC core domain-containing protein UBC core domain-containing protein UBR-type domain-containing protein Ubiquitin-conjugating enzyme E2 13 Ubiquitin-conjugating enzyme E2 1 Ubiquitin-conjugating enzyme E2 25 Ubiquitin-conjugating enzyme E2 2 Ubiquitin-conjugating enzyme E2 S Ubiquitin-conjugating enzyme E2 W Ubiquitin-conjugating enzyme E2 ubc-18 Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-like modifier-activating enzyme 5 Ubiquitin-like modifier-activating enzyme ATG7 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Uncharacterized protein T23G5.3 WD repeat-containing protein fzy-1 WD repeat-containing protein wdr-5.2 X-linked retinitis pigmentosa GTPase regulator homolog Zeta_toxin domain-containing protein Zinc finger protein zfp-2 von Hippel-Lindau tumor suppressor homolog	A0A061ACQ8 A0A0S4XR36 A0A2K5ATR7 A0A4V0IJV5 A0PD34 A5A631 A8DJA6 B1Q249 G5EBK4 G5ECR7 G5ECU1 G5ECY6 G5ECZ8 G5EFS1 G5EG38 G5EGH4 G5EGS4 H2L067 H2L0M5 H8W3Y2 L8E6Y3 O16368 O17071 O17324 O17586 O17736 O18152 O18191 O44156 O45323 O45495 O61742 O61792 O61795 O62102 O62200 O62235 O76371 O76577 O76671 P0CG71 P34284 P34441 P34477 P34514 P35129 P37165 P46502 P49632 P52478 P90868 P90990 P91133 P91404 P91430 P91477 Q03607 Q04908 Q09291 Q09373 Q09397 Q09541 Q10920 Q17389 Q17390 Q17391 Q17405 Q17490 Q17750 Q17911 Q17962 Q17971 Q18115 Q18587 Q18787 Q18931 Q19019 Q19213 Q19294 Q19324 Q19360 Q20052 Q20058 Q20082 Q20183 Q20585 Q20617 Q20874 Q20938 Q21106 Q21633 Q21920 Q22015 Q22071 Q22253 Q22317 Q22431 Q22531 Q22559 Q23237 Q23449 Q23457 Q23595 Q23639 Q27481 Q27488 Q2AAC0 Q2WF61 Q4TT88 Q5DX34 Q65XX2 Q93349 Q93571 Q93794 Q93847 Q93903 Q94251 Q95005 Q95008 Q95PZ7 Q95XN7 Q95XX0 Q965N6 Q965N7 Q965X6 Q966I8 Q966L8 Q9BKS1 Q9BL11 Q9GRV5 Q9GZH5 Q9N2W9 Q9N2Z7 Q9N373 Q9N3D1 Q9N3F9 Q9N3T6 Q9N4I6 Q9N593 Q9N599 Q9NA71 Q9NAA0 Q9TZ69 Q9U1Q1 Q9U2C5 Q9U2H2 Q9UAQ3 Q9XTT9 Q9XUV0 Q9XVV9 Q9XWF6 Q9XXE6 U4PBY0 V6CLA2	1G758 3L686 AC3.5 C10E2.2 C14B1.3 C14C10.5 C17H11.6 CELE_F32B4.5 CELE_F35G12.12 CELE_F49B2.6 CELE_F56D2.2 CELE_H10E21.5 CELE_R03G8.6 CELE_R31.2 CELE_T12E12.6 CELE_T19B10.5 CELE_T28D6.4 CELE_VM106R.1 CELE_Y42A5A.1 CELE_Y47G6A.14 CELE_Y48G1C.12 CELE_Y49F6B.9 CELE_Y53F4B.20 CELE_Y53G8AR.5 CELE_Y57A10A.31 CELE_Y67D8C.9 CELE_Y71F9AL.10 CELE_Y71H2AM.3 CELE_Y92H12A.2 CELE_ZK792.4 T16G12.1 T23G5.3 Y54E10A.11 anp-1 apc-1 apc-11 apc-2 apc-3 apc-6 apc-8 ari-2 atg-7 ccd-3 cdc-23 cdc-27 cfl-1 che-1 chn-1 cul-1 cul-2 cul-3 cul-5 dcaf-1 div-3 dre-1 eel-1 egl-41 elb-1 elc-1 emb-27 emb-30 etc-1 evl-22 fbxl-1 frm-5.1 frm-5.2 fzy-1 gfi-3 glo-4 hecd-1 hecw-1 herc-1 ikb-1 kel-1 kel-20 lep-2 let-70 lin-19 madd-2 mask-1 mat-1 mat-2 mat-3 mec-15 mex-3 mfb-1 mgrn-1 mib-1 mpz-1 mtpn-1 oxi-1 pam-1 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 pod-3 pod-4 pod-5 pod-6 psmd-9 psme-3 rbpl-1 rbx-1 rbx-2 rfl-1 rnf-126 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 sel-10 siah-1 skpt-1 skr-1 sli-1 spsb-1 spsb-2 swah-1 swd-3.2 tag-30 tpp-2 trim-9 trp-4 trul-1 uba-1 uba-3 uba-5 ubc-1 ubc-13 ubc-14 ubc-16 ubc-18 ubc-2 ubc-20 ubc-24 ubc-25 ubc-26 ubc-3 ubc-6 ubc-7 ubc-8 ubia ubib ubl-1 ubq-1 ubq-2 ubr-1 ubr-4 uev-1 ufl-1 unc-44 unk-1 vex-2 vhl-1 wdr-5.2 wwp-1 zfp-2	Caenorhabditis elegans
Serine biosynthesis	D-3-phosphoglycerate dehydrogenase L-serine ammonia-lyase Phosphoserine phosphatase Probable phosphoserine aminotransferase Serine incorporator 1 Serine incorporator	A0A061ACK7 O17626 O45719 P91856 Q93968 Q95XV3	CELE_R11H6.2 CELE_Y57E12AL.1 CELE_Y62E10A.13 F26H9.5 phdh-1 serr-1	Caenorhabditis elegans

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