GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **301 - 325** of **1070** in total

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Pathway Name	Protein Name ▼	UniProt ID	Gene Symbol	Organism
NOTCH3 Activation and Transmission of Signal to the Nucleus	Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 E3 ubiquitin-protein ligase Gamma-secretase subunit APH-1 Gamma-secretase subunit PEN-2 Neurogenic locus notch homolog protein 3 Nicastrin Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Pro-epidermal growth factor Protein jagged-1 Protein jagged-2 (Fragment) Receptor protein-tyrosine kinase Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein	A0A8I6A5Y3 B4F767 D3ZHH1 F7EYZ3 G3V6K6 O88777 P07522 P0CG51 P62982 P97607 P97677 P97887 Q10743 Q63429 Q63722 Q6QI68 Q8CGU6 Q9R172	Adam10 Aph1a Dll1 Dll4 Egf Egfr Jag1 Jag2 LOC100360645 Madm Ncstn Notch3 Ps2 Psen1 Psen2 Psenen Psnl1 Psnl2 Rps27a Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Wwp2	Rattus norvegicus (Norway rat)
FGFR2 alternative splicing	DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase subunit beta DNA-directed RNA polymerase subunit DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 Heterogeneous nuclear ribonucleoprotein A1 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Polypyrimidine tract-binding protein 1 RNA polymerase II subunit C RNA polymerase II subunit D RNA polymerase II subunit I RNA polymerase II subunit J	A0A8I6A2X2 A0A8I6AXL7 B0BNE2 B1WC40 D3ZQI0 D4A5A6 G3V8Y5 M0RBH0 M0RCG9 O88828 P04256 P62489 Q00438 Q01750 Q56A27 Q5EB90 Q6AY96	AC109542.1 Cbp20 Cbp80 Gtf2f1 Gtf2f2 Hnrnpa1 Hnrpa1 LOC120098305 Ncbp1 Ncbp2 Polr2a Polr2b Polr2c Polr2d Polr2e Polr2f Polr2g Polr2i Polr2j Ptb Ptbp1 Pybp Rap30 Tbfii	Rattus norvegicus (Norway rat)
Translesion Synthesis by POLH	DNA polymerase eta DNA-dependent metalloprotease SPRTN Nuclear protein localization protein 4 homolog Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 32 kDa subunit Replication protein A subunit Replication protein A3 Transitional endoplasmic reticulum ATPase Ubiquitin B-like Ubiquitin recognition factor in ER-associated degradation protein 1 Ubiquitin-ribosomal protein eS31 fusion protein	A0A8I6A5Y3 B4F778 B5DF29 D3ZFT1 D3ZVU1 D4A845 D4ADZ0 P04961 P0CG51 P46462 P62982 Q5M830 Q63429 Q63528 Q641W4 Q7TP21 Q9ES53 Q9ES54	LOC100360645 Npl4 Nploc4 Pcna Polh Rfc1 Rfc2 Rfc3 Rfc4 Rfc5 Rpa1 Rpa2 Rpa3 Rps27a Sprtn Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Ufd1 Ufd1l Vcp	Rattus norvegicus (Norway rat)
Regulation of PTEN gene transcription	DNA helicase DNA helicase GATA zinc finger domain containing 2A GATA zinc finger domain containing 2B GTP-binding protein Rheb Histone deacetylase 1 Histone deacetylase 2 Histone-binding protein RBBP7 Metastasis associated 1 family, member 2 Metastasis associated 1 family, member 3 Metastasis-associated protein MTA1 Methyl-CpG binding domain protein 3 Neutral amino acid transporter 9 RB binding protein 4, chromatin remodeling factor Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein Ras-related GTP-binding protein Regulatory associated protein of MTOR, complex 1 Repressor of RNA polymerase III transcription MAF1 homolog Roadblock/LAMTOR2 domain-containing protein Serine/threonine-protein kinase mTOR Spalt-like transcription factor 4 Target of rapamycin complex subunit LST8	A0A8I5ZYK6 A0A8I6ADH7 A0A8I6AFB3 A0A8I6AQI0 A0A8I6GIY0 B2RZ38 D3ZDU2 D3ZF11 D4AD29 E9PU01 F7ENH8 F7EY92 F7F888 G3V8R7 M0RDM1 P42346 Q0D2L6 Q3B8Q3 Q4QQW4 Q5U204 Q5XIH0 Q62599 Q62639 Q63486 Q63487 Q6P791 Q71UF4 Q9Z2K5	Chd3 Chd4 ENSRNOG00000066475 Frap1 Gatad2a Gatad2b Gbl Hdac1 Hdac2 LOC686412 Lamtor1 Lamtor3 Lamtor4 Lamtor5 Lst8 Maf1 Map2k1ip1 Mbd3 Mlst8 Mta1 Mta2 Mta3 Mtor Raft1 Rbbp4 Rbbp7 Rheb Rptor RragB Rraga Rragc Rragc_predicted Rragd Sall4 Slc38a9 Zg29	Rattus norvegicus (Norway rat)
Regulation of lipid metabolism by PPARalpha	DNA helicase Fatty acid-binding protein, liver Histone deacetylase 3 Histone lysine acetyltransferase CREBBP Histone-arginine methyltransferase CARM1 Mediator of RNA polymerase II transcription subunit 1 Nuclear receptor co-repressor 2 Nuclear receptor coactivator 2 Nuclear receptor coactivator Peroxisome proliferator-activated receptor alpha Retinoic acid receptor RXR-alpha SIN3 transcription regulator family member A SIN3 transcription regulator family member B SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 TBL1X/Y related 1 Transducin (beta)-like 1 X-linked Trimethylguanosine synthase	A0A096MJV7 A0A0G2JU91 A0A0G2JY80 A0A8I5ZQQ2 A0A8I6AC46 A0A8I6APA0 A0A8I6G8L9 D3ZBP2 D3ZNF4 P02692 P37230 P85107 Q05343 Q4AE70 Q6JHU9 Q6P6W3 Q9WUI9	Carm1 Cbp Chd9 Crebbp Fabp1 Hdac3 Med1 Ncoa1 Ncoa2 Ncoa6ip Ncor2 Nr1c1 Nr2b1 Pimt Ppar Ppara Prmt4 Rxra Sin3a Sin3b Smarcd3 Tbl1x Tbl1xr1 Tgs1 Tif2	Rattus norvegicus (Norway rat)
RHOJ GTPase cycle	DEP domain containing 1B Dedicator of cytokinesis 8 Inositol polyphosphate 5-phosphatase OCRL Oligophrenin-1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 Ras homolog family member J Rho GTPase activating protein 1 Rho GTPase activating protein 21 Rho GTPase activating protein 32 Rho GTPase activating protein 5 Rho GTPase-activating protein 26 Rho GTPase-activating protein 35 Rho GTPase-activating protein SYDE1 Triple functional domain protein	A0A0G2JYR5 A0A0G2K7N9 A0A8I6A829 A0A8I6APL5 A0A8I6GDA1 A0A8I6GLR6 D3ZGS3 D3ZZN9 D4AA32 F1M0Z1 F1MAK3 P0CAX5 P81128 Q5RJS2 Q63787 Q63788	Arhgap1 Arhgap21 Arhgap26 Arhgap32 Arhgap35 Arhgap5 Depdc1b Dock8 Grlf1 Ocrl Ophn1 P190A Pik3r1 Pik3r2 Prex1 Rhoj Syde1 Trio p190ARHOGAP	Rattus norvegicus (Norway rat)
Serine biosynthesis	D-3-phosphoglycerate dehydrogenase Phosphoserine aminotransferase Phosphoserine phosphatase Serine incorporator 1 Serine incorporator 2 Serine incorporator 3 Serine incorporator 4 Serine incorporator 5 Serine racemase	A0A0G2K931 A0A8I6ADL4 A0A8I6AVM7 A8WCG0 O08651 Q5M819 Q63175 Q76EQ0 Q7TNK0	Phgdh Psat1 Psph Serinc1 Serinc2 Serinc3 Serinc4 Serinc5 Srr Tde1l Tde2 Tpo1	Rattus norvegicus (Norway rat)
Dopamine receptors	D(1B) dopamine receptor D(2) dopamine receptor D(3) dopamine receptor D(4) dopamine receptor	P19020 P25115 P30729 P61169	Drd2 Drd3 Drd4 Drd5	Rattus norvegicus (Norway rat)
phospho-PLA2 pathway	Cytosolic phospholipase A2 Mitogen-activated protein kinase 1	P50393 P63086	Cpla2 Erk2 Mapk Mapk1 Pla2g4 Pla2g4a Prkm1	Rattus norvegicus (Norway rat)
Hydrolysis of LPC	Cytosolic phospholipase A2 Lysosomal phospholipase A and acyltransferase Phospholipase A2 group IVC Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase B-like 1	D3Z9B7 D3ZQH6 D4A1I6 F1LMQ4 F1LPY6 P50393 Q5U2V4 Q675A5	Cpla2 Lypla3 Pla2g15 Pla2g4 Pla2g4a Pla2g4b Pla2g4c Pla2g4d Pla2g4e Pla2g4f Plbd1	Rattus norvegicus (Norway rat)
Acyl chain remodeling of CL	Cytosolic phospholipase A2 Lysocardiolipin acyltransferase 1 Tafazzin family protein Trifunctional enzyme subunit alpha, mitochondrial Trifunctional enzyme subunit beta, mitochondrial	A0A0G2K0X0 A0A8I6AFV0 P50393 Q60587 Q64428	Cpla2 Hadha Hadhb Lclat1 Pla2g4 Pla2g4a TAZ Tafazzin	Rattus norvegicus (Norway rat)
ADP signalling through P2Y purinoceptor 1	Cytosolic phospholipase A2 Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit alpha-15 Guanine nucleotide-binding protein subunit alpha Mitogen-activated protein kinase 14 P2Y purinoceptor 1 Proto-oncogene tyrosine-protein kinase Src	A0A8J8XRQ3 O88302 P49651 P50393 P70618 P82471 Q9JID2 Q9WUD9	Cpla2 Csbp1 Csbp2 Gna11 Gna14 Gna15 Gnaq Mapk14 P2ry1 Pla2g4 Pla2g4a Src	Rattus norvegicus (Norway rat)
Acyl chain remodelling of PI	Cytosolic phospholipase A2 Group 10 secretory phospholipase A2 Phospholipase A and acyltransferase 3 Phospholipase A2 group IVC Phospholipase A2 group V Phospholipase A2, group XIIA Phospholipase A2, membrane associated Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase B-like 1 Secretory phospholipase A2 receptor	B0K018 D3Z9B7 D3ZLB5 D3ZQH6 F1LMQ4 F1LPY6 F1M495 F7F420 P04055 P14423 P50393 P51433 P53817 Q5U2V4 Q9QZT3	Cpla2 H-rev107 Hrasls3 Hrev107 Pla2g10 Pla2g12a Pla2g16 Pla2g1b Pla2g2a Pla2g2d Pla2g2f Pla2g4 Pla2g4a Pla2g4c Pla2g4d Pla2g4e Pla2g4f Pla2g5 Pla2r1 Plaat3 Plbd1 Rlp-3	Rattus norvegicus (Norway rat)
Acyl chain remodelling of PS	Cytosolic phospholipase A2 Group 10 secretory phospholipase A2 Lysophosphatidylcholine acyltransferase 4 Lysophospholipid acyltransferase 5 Membrane bound O-acyltransferase domain containing 1 Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Phospholipase A and acyltransferase 3 Phospholipase A1 member A Phospholipase A2 group V Phospholipase A2, group XIIA Phospholipase A2, membrane associated Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Secretory phospholipase A2 receptor	A0A0G2JXN8 A0A8I5ZU98 B0K018 D3Z9B7 D3ZLB5 D3ZQH6 D3ZR52 D4A1I6 F1LPY6 F1LV18 F1LWM8 F1M495 F7F420 P04055 P14423 P50393 P51433 P53817 P97535 Q5FVN0 Q9QZT3	Cpla2 Grcc3f H-rev107 Hrasls3 Hrev107 Lpcat3 Lpcat4 Mboat1 Mboat5 Oact5 Osbpl10 Osbpl5 Osbpl8 Pla1a Pla2g10 Pla2g12a Pla2g16 Pla2g1b Pla2g2a Pla2g2d Pla2g2f Pla2g4 Pla2g4a Pla2g4b Pla2g4d Pla2g4e Pla2g4f Pla2g5 Pla2r1 Plaat3 Pspla1 Rlp-3	Rattus norvegicus (Norway rat)
Nephrin family interactions	Cytoplasmic protein Cytoplasmic protein IQ motif containing GTPase activating protein 1 Kin of IRRE-like protein 1 Kirre like nephrin family adhesion molecule 2 Kirre like nephrin family adhesion molecule 3 Nephrin Tyrosine-protein kinase Fyn	A0A8I5ZQV3 B2RZ33 D4A3M8 D4A934 G3V7Q7 Q62844 Q6X936 Q9R044	Fyn Iqgap1 Kirrel Kirrel1 Kirrel2 Kirrel3 Nck1 Nck2 Neph1 Nphn Nphs1	Rattus norvegicus (Norway rat)
Intracellular oxygen transport	Cytoglobin Myoglobin Neuroglobin	Q921A4 Q99JA8 Q9QZ76	Cygb Mb Ngb Stap	Rattus norvegicus (Norway rat)
Transcriptional activation of mitochondrial biogenesis	Cytochrome c domain-containing protein Cytochrome c, somatic GA binding protein transcription factor subunit alpha GA binding protein transcription factor subunit beta 1 Glutamate dehydrogenase 1, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial NAD-dependent protein deacylase sirtuin-5, mitochondrial NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Propionate--CoA ligase Similar to Cytochrome c, somatic Sirtuin 3 Superoxide dismutase [Mn], mitochondrial	A0A0G2K6D8 A0A8I5XWT5 A0A8I5ZWD2 A0A8I6GJ11 D3ZXV2 D4A5L9 D4ACQ9 P07895 P10860 P56574 P62898 Q68FX9	AC128290.1 Acss2 Cycs Cycsl2 Cycsl3 Gabpa Gabpb1 Glud Glud1 Idh2 LOC690675 RGD1562558 SIRT4 Sirt3 Sirt4 Sirt5 Sod2	Rattus norvegicus (Norway rat)
Vitamin C (ascorbate) metabolism	Cytochrome b5 Glutathione S-transferase omega-1 Glutathione S-transferase omega-2 NADH-cytochrome b5 reductase 3 Solute carrier family 2, facilitated glucose transporter member 1 Solute carrier family 2, facilitated glucose transporter member 3 Solute carrier family 23 member 1 Solute carrier family 23 member 2	P00173 P11167 P20070 Q07647 Q6AXV9 Q9WTW7 Q9WTW8 Q9Z339	Cyb5 Cyb5a Cyb5r3 Dia1 Glut1 Glut3 Gsto1 Gsto2 Slc23a1 Slc23a2 Slc2a1 Slc2a3 Svct1 Svct2	Rattus norvegicus (Norway rat)
RHO GTPases Activate NADPH Oxidases	Cytochrome b-245 heavy chain Cytochrome b-245 light chain Mapk11 protein Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 NADPH oxidase 1 NADPH oxidase 3 NADPH oxidase activator 1 NADPH oxidase organizer 1 Neutrophil cytosol factor 2 Neutrophil cytosolic factor 1 Neutrophil cytosolic factor 4 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 Protein S100-A8 Protein S100-A9 Protein kinase C alpha type Protein kinase C beta type Protein kinase C delta type Protein kinase C zeta type Rac family small GTPase 2 Ras-related C3 botulinum toxin substrate 1 peptidylprolyl isomerase	A0A8I5ZNF3 A0A8I6A1P8 A0A8I6GJ67 A7E3N2 A7E3N7 D4A3U7 D4ACU5 F1M707 O88763 P05696 P09215 P09217 P0C0R5 P21708 P50115 P50116 P63086 P68403 P70618 Q62737 Q672K1 Q6RUV5 Q9ERL1 Q9WV87	Csbp1 Csbp2 Cyba Cybb Erk1 Erk2 Mapk Mapk1 Mapk11 Mapk14 Mapk3 Mox1 Mrp14 Mrp8 Ncf1 Ncf2 Ncf4 Noh1 Nox1 Nox3 Noxa1 Noxo1 Pik3c3 Pik3r4 Pin1 Pkca Pkcb Pkcd Pkcz Prkca Prkcb Prkcb1 Prkcd Prkcz Prkm1 Prkm3 Rac Rac1 Rac2 S100a8 S100a9 Vps34	Rattus norvegicus (Norway rat)
Cross-presentation of particulate exogenous antigens (phagosomes)	Cytochrome b-245 heavy chain Cytochrome b-245 light chain Integrin beta Integrin subunit alpha V Neutrophil cytosol factor 2 Neutrophil cytosolic factor 1 Neutrophil cytosolic factor 4 Platelet glycoprotein 4	A0A8I5ZNF3 A0A8I6AQL1 A7E3N2 F1LZX9 F1M707 Q07969 Q62737 Q9ERL1	Cd36 Cyba Cybb Fat Itgav Itgb5 Ncf1 Ncf2 Ncf4	Rattus norvegicus (Norway rat)
The canonical retinoid cycle in rods (twilight vision)	Cytochrome P450 4V2 LRRGT00111 Lecithin retinol acyltransferase Myosin VIIA Receptor for retinol uptake STRA6 Retinaldehyde binding protein 1 Retinoid isomerohydrolase Retinol binding protein 3 Retinol dehydrogenase 10 Retinol dehydrogenase 12 Retinol-binding protein 1 Retinol-binding protein 4 Rhodopsin Transthyretin	A0A8I5ZWB0 A2RRT9 D3Z956 D3ZEP9 G3V8Q4 O70276 P02696 P02767 P04916 P51489 Q4QR83 Q6TUD3 Q80ZF7 Q9JI61	Cyp4v2 Cyp4v3 Lrat Myo7a Rbp-1 Rbp1 Rbp3 Rbp4 Rdh10 Rdh11 Rdh12 Rho Rlbp1 Rpe65 Stra6 Tt Ttr	Rattus norvegicus (Norway rat)
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	Cytochrome P450 1A2	P04799	Cyp1a-2 Cyp1a2	Rattus norvegicus (Norway rat)
Biosynthesis of maresin-like SPMs	Cytochrome P450 1A2 Cytochrome P450 2C26-like Cytochrome P450 2D4 Cytochrome P450 2E1 Cytochrome P450 3A18 Cytochrome P450 3A1 Cytochrome P450 3A2 Cytochrome P450 3A9 Cytochrome P450 3A	A0A0G2K5K4 A0A8I6AFV7 P04799 P04800 P05182 P05183 P51538 Q64581 Q64680	Cyp1a-2 Cyp1a2 Cyp2c66 Cyp2d-18 Cyp2d-4 Cyp2d18 Cyp2d4 Cyp2e Cyp2e-1 Cyp2e1 Cyp3a-1 Cyp3a-2 Cyp3a1 Cyp3a11 Cyp3a13 Cyp3a18 Cyp3a2 Cyp3a62 Cyp3a9 LOC100912265	Rattus norvegicus (Norway rat)
Biosynthesis of protectins	Cytochrome P450 1A1 Cytochrome P450 1A2 Leukotriene A-4 hydrolase Polyunsaturated fatty acid lipoxygenase ALOX15	P00185 P04799 P30349 Q02759	Alox12l Alox15 Cyp1a-1 Cyp1a-2 Cyp1a1 Cyp1a2 Lta4h	Rattus norvegicus (Norway rat)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	Cytochrome P450 1A1 Cytochrome P450 1A2 Cytochrome P450 1B1 Cytochrome P450 2C26-like Cytochrome P450 2U1 Cytochrome P450 4A12 Cytochrome P450 4F4	A0A8I6AFV7 P00185 P04799 P24464 P51869 Q4V8D1 Q64678	Cyp1a-1 Cyp1a-2 Cyp1a1 Cyp1a2 Cyp1b1 Cyp2c66 Cyp2u1 Cyp4a-8 Cyp4a12 Cyp4a8 Cyp4f4 LOC100912265	Rattus norvegicus (Norway rat)

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