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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
major depressive disorder
Summary
- Synonym
-
- clinical depression
- major depression
- recurrent major depression
- single major depressive episode
- unipolar depression
- Definition
- A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.
- Super Class
- depressive disorder
External Links
- Disease Ontology
- DOID:1470
- Mondo Disease Ontology
- UMLS
- NCI Thesaurus
- OMIM
- MGI genotype (from TogoID)
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 4157 | MC1R | melanocortin 1 receptor | |
| 4842 | NOS1 | nitric oxide synthase 1 | |
| 4915 | NTRK2 | neurotrophic receptor tyrosine kinase 2 | |
| 5074 | PAWR | pro-apoptotic WT1 regulator | |
| 5728 | PTEN | phosphatase and tensin homolog | |
| 6532 | SLC6A4 | solute carrier family 6 member 4 | |
| 6853 | SYN1 | synapsin I | |
| 9968 | MED12 | mediator complex subunit 12 | |
| 23373 | CRTC1 | CREB regulated transcription coactivator 1 | |
| 26047 | CNTNAP2 | contactin associated protein 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 12064 | Bdnf | brain derived neurotrophic factor | |
| 14815 | Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | |
| 15482 | Hspa1l | heat shock protein 1-like | |
| 15551 | Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B | |
| 15558 | Htr2a | 5-hydroxytryptamine (serotonin) receptor 2A | |
| 15560 | Htr2c | 5-hydroxytryptamine (serotonin) receptor 2C | |
| 15567 | Slc6a4 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | |
| 16153 | Il10 | interleukin 10 | |
| 16187 | Il3 | interleukin 3 | |
| 16191 | Il5 | interleukin 5 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24225 | Bdnf | brain-derived neurotrophic factor | |
| 24598 | Nos1 | nitric oxide synthase 1 | |
| 24949 | Syn1 | synapsin I | |
| 25054 | Ntrk2 | neurotrophic receptor tyrosine kinase 2 | |
| 25075 | Htr1b | 5-hydroxytryptamine receptor 1B | |
| 25187 | Htr2c | 5-hydroxytryptamine receptor 2C | |
| 25325 | Il10 | interleukin 10 | |
| 25553 | Slc6a4 | solute carrier family 6 member 4 | |
| 29595 | Htr2a | 5-hydroxytryptamine receptor 2A | |
| 64508 | Adcy3 | adenylate cyclase 3 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 37191 | 5-HT1B | 5-hydroxytryptamine (serotonin) receptor 1B | |
| 37196 | 5-HT1A | 5-hydroxytryptamine (serotonin) receptor 1A | |
| 37892 | mAChR-A | muscarinic Acetylcholine Receptor, A-type | |
| 37895 | SerT | Serotonin transporter | |
| 38545 | nAChRbeta1 | nicotinic Acetylcholine Receptor beta1 | |
| 38657 | vn | vein | |
| 39387 | Nrx-IV | Neurexin IV | |
| 41247 | Syn | Synapsin | |
| 42245 | ChT | Choline transporter | |
| 42918 | nAChRalpha1 | nicotinic Acetylcholine Receptor alpha1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 172105 | unc-38 | Acetylcholine receptor subunit alpha-type unc-38 | |
| 172150 | unc-63 | Acetylcholine receptor subunit alpha-type unc-63 | |
| 178167 | nlr-1 | Neurexin like receptor 1 | |
| 178274 | cho-1 | High-affinity choline transporter 1 | |
| 179962 | gar-3 | Muscarinic acetylcholine receptor gar-3 | |
| 180937 | acr-3 | Acetylcholine receptor subunit beta-type acr-3 |
