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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
chronic obstructive pulmonary disease
Summary
- Synonym
-
- COLD
- COPD
- chronic obstructive airway disease
- chronic obstructive lung disease
- Definition
- An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
- Super Class
- obstructive lung disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 6346 | CCL1 | C-C motif chemokine ligand 1 | |
| 6347 | CCL2 | C-C motif chemokine ligand 2 | |
| 6352 | CCL5 | C-C motif chemokine ligand 5 | |
| 6354 | CCL7 | C-C motif chemokine ligand 7 | |
| 6356 | CCL11 | C-C motif chemokine ligand 11 | |
| 6403 | SELP | selectin P | |
| 6416 | MAP2K4 | mitogen-activated protein kinase kinase 4 | |
| 6439 | SFTPB | surfactant protein B | |
| 6440 | SFTPC | surfactant protein C | |
| 6441 | SFTPD | surfactant protein D |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 11421 | Ace | angiotensin I converting enzyme | |
| 11441 | Chrna7 | cholinergic receptor, nicotinic, alpha polypeptide 7 | |
| 11450 | Adipoq | adiponectin, C1Q and collagen domain containing | |
| 11502 | Adam9 | ADAM metallopeptidase domain 9 | |
| 11554 | Adrb1 | adrenergic receptor, beta 1 | |
| 11555 | Adrb2 | adrenergic receptor, beta 2 | |
| 11596 | Ager | advanced glycosylation end product-specific receptor | |
| 12062 | Bdkrb2 | bradykinin receptor, beta 2 | |
| 12176 | Bnip3 | BCL2/adenovirus E1B interacting protein 3 | |
| 12266 | C3 | complement component 3 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 29527 | Ptgs2 | prostaglandin-endoperoxide synthase 2 | |
| 29595 | Htr2a | 5-hydroxytryptamine receptor 2A | |
| 50692 | Plaur | plasminogen activator, urokinase receptor | |
| 58959 | Crhr1 | corticotropin releasing hormone receptor 1 | |
| 59086 | Tgfb1 | transforming growth factor, beta 1 | |
| 59109 | Ntrk1 | neurotrophic receptor tyrosine kinase 1 | |
| 60582 | Il1rn | interleukin 1 receptor antagonist | |
| 78967 | Mcam | melanoma cell adhesion molecule | |
| 81687 | Mmp9 | matrix metallopeptidase 9 | |
| 81737 | Ntf3 | neurotrophin 3 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31926 | Idgf4 | Imaginal disc growth factor 4 | |
| 34091 | Spn28Dc | Serpin 28Dc | |
| 34189 | Acer | Angiotensin-converting enzyme-related | |
| 34304 | nAChRalpha6 | nicotinic Acetylcholine Receptor alpha6 | |
| 34805 | Ance | Angiotensin converting enzyme | |
| 34978 | Idgf1 | Imaginal disc growth factor 1 | |
| 34979 | Idgf2 | Imaginal disc growth factor 2 | |
| 34981 | Idgf3 | Imaginal disc growth factor 3 | |
| 36868 | Idgf6 | Imaginal disc growth factor 6 | |
| 37104 | Idgf5 | Imaginal disc growth factor 5 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 447803 | pon1 | paraoxonase 1 | |
| 554230 | kdr | kinase insert domain receptor (a type III receptor tyrosine kinase) | |
| 559080 | cftr | CF transmembrane conductance regulator | |
| 565980 | ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | |
| 791973 | cxcr3.2 | chemokine (C-X-C motif) receptor 3, tandem duplicate 2 |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373580 | crhr1.2.S | corticotropin releasing hormone receptor 1, gene 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 399298 | ntf3.L | neurotrophin 3 L homeolog | Xenopus laevis (African clawed frog) | |
| 448598 | pon2 | paraoxonase 2 | Xenopus tropicalis (tropical clawed frog) | |
| 100144634 | ace | angiotensin I converting enzyme | Xenopus tropicalis (tropical clawed frog) | |
| 108697308 | adrb1.L | adrenoceptor beta 1 L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 180628 | cht-1 | putative endochitinase | |
| 180780 | acn-1 | Inactive angiotensin-converting enzyme-related protein | |
| 180841 | gnrr-4 | G-protein coupled receptors family 1 profile domain-containing protein | |
| 180936 | acr-2 | Acetylcholine receptor subunit beta-type acr-2 | |
| 180937 | acr-3 | Acetylcholine receptor subunit beta-type acr-3 | |
| 181288 | pxn-2 | Peroxidasin homolog pxn-2 | |
| 181289 | ver-3 | Tyrosine-protein kinase receptor ver-3 | |
| 181489 | adm-2 | Disintegrin and metalloproteinase domain-containing protein adm-2 | |
| 186632 | ver-4 | Tyrosine-protein kinase receptor ver-4 | |
| 187297 | poml-1 | PON (paraoxonase) and MEC-6 Like |
