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Standards Ontologies Notations
type 2 diabetes mellitus

Summary
Synonym
  • NIDDM
  • insulin resistance
  • non-insulin-dependent diabetes mellitus
  • type 2 diabetes
  • type II diabetes mellitus
Definition
A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
Super Class
diabetes mellitus
Disease Ontology
DOID:9352
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 1 - 10 of 325 in total
Gene ID Gene Symbol Description Source
19 ABCA1 ATP binding cassette subfamily A member 1
111 ADCY5 adenylate cyclase 5
133 ADM adrenomedullin
142 PARP1 poly(ADP-ribose) polymerase 1
150 ADRA2A adrenoceptor alpha 2A
154 ADRB2 adrenoceptor beta 2
155 ADRB3 adrenoceptor beta 3
177 AGER advanced glycosylation end-product specific receptor
183 AGT angiotensinogen
186 AGTR2 angiotensin II receptor type 2
Displaying entries 1 - 10 of 249 in total
Gene ID Gene Symbol Description Source
11303 Abca1 ATP-binding cassette, sub-family A member 1
11421 Ace angiotensin I converting enzyme
11450 Adipoq adiponectin, C1Q and collagen domain containing
11491 Adam17 a disintegrin and metallopeptidase domain 17
11551 Adra2a adrenergic receptor, alpha 2a
11556 Adrb3 adrenergic receptor, beta 3
11596 Ager advanced glycosylation end product-specific receptor
11601 Angpt2 angiopoietin 2
11609 Agtr2 angiotensin II receptor, type 2
11625 Ahsg alpha-2-HS-glycoprotein
Displaying entries 101 - 110 of 166 in total
Gene ID Gene Symbol Description Source
29527 Ptgs2 prostaglandin-endoperoxide synthase 2
29535 Pdx1 pancreatic and duodenal homeobox 1
29539 Aldh2 aldehyde dehydrogenase 2 family member
29686 Scn1b sodium voltage-gated channel beta subunit 1
29747 Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1
50672 Ednrb endothelin receptor type B
50692 Plaur plasminogen activator, urokinase receptor
54225 Apob apolipoprotein B
54315 Ucp2 uncoupling protein 2
57027 Adam17 ADAM metallopeptidase domain 17
Displaying entries 21 - 30 of 80 in total
Gene ID Gene Symbol Description Source
35259 Lar Leukocyte-antigen-related-like
35486 sxc super sex combs
36232 Sod3 Superoxide dismutase 3
36411 sca scabrous
36428 Mdr49 Multi drug resistance 49
36546 CtsL1 Cathepsin L1
36692 scb scab
36773 Dg Dystroglycan
36868 Idgf6 Imaginal disc growth factor 6
37104 Idgf5 Imaginal disc growth factor 5
Displaying entries 11 - 18 of 18 in total
Gene ID Gene Symbol Description Source
403310 cacna1da calcium channel, voltage-dependent, L type, alpha 1D subunit, a
406731 ugt1ab UDP glucuronosyltransferase 1 family a, b
447803 pon1 paraoxonase 1
554230 kdr kinase insert domain receptor (a type III receptor tyrosine kinase)
560788 parp1 poly (ADP-ribose) polymerase 1
565980 ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
100004455 epoa erythropoietin a
100384891 ugt1a7 UDP glucuronosyltransferase 1 family, polypeptide A7
Displaying entries 1 - 10 of 20 in total
Gene ID Gene Symbol Description Source Organism
373759 cnr1.S cannabinoid receptor 1 (brain) S homeolog Xenopus laevis (African clawed frog)
378584 drd2.L dopamine receptor D2 L homeolog Xenopus laevis (African clawed frog)
378695 ins.L insulin L homeolog Xenopus laevis (African clawed frog)
378696 ins.S insulin S homeolog Xenopus laevis (African clawed frog)
379783 akt2.L v-akt murine thymoma viral oncogene homolog 2 L homeolog Xenopus laevis (African clawed frog)
380341 pon2.L paraoxonase 2 L homeolog Xenopus laevis (African clawed frog)
394283 sdc2.S syndecan 2 S homeolog Xenopus laevis (African clawed frog)
397750 hmgcr.L 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog Xenopus laevis (African clawed frog)
397778 tgfb1.L transforming growth factor beta 1 L homeolog Xenopus laevis (African clawed frog)
398006 insr.L insulin receptor L homeolog Xenopus laevis (African clawed frog)
Displaying entries 1 - 10 of 69 in total
Gene ID Gene Symbol Description Source
171619 C53D5.5 Gamma-glutamyltranspeptidase 1
171782 abt-2 ABC transporter domain-containing protein
171905 ace-2 Carboxylic ester hydrolase
171999 poml-2 Arylesterase
172085 ugt-26 UDP-glucuronosyltransferase
172509 gpdh-3 putative glycerol-3-phosphate dehydrogenase, mitochondrial
173297 F49B2.6 Aminopeptidase
174685 ptp-3 Protein-tyrosine-phosphatase;Tyrosine-protein phosphatase Lar-like;protein-tyrosine-phosphatase
175076 ace-3 Carboxylic ester hydrolase
175182 ver-1 Protein ver-1
Displaying entries 1 - 10 of 32 in total
Gene ID Gene Symbol Description Source
850317 GLK1 glucokinase
850369 ADP1 putative ATP-dependent permease ADP1
850391 NPP1 nucleotide diphosphatase/phosphodiesterase NPP1
850614 HXK1 hexokinase 1
850645 BPT1 ATP-binding cassette bilirubin transporter BPT1
850678 YBT1 bile acid-transporting ATPase YBT1
850886 ATG26 sterol 3-beta-glucosyltransferase
850979 PIG1 protein phosphatase regulator PIG1
851006 ECM38 gamma-glutamyltransferase
851171 HMG2 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
The Human Phenotype Ontology
Displaying all 4 entries
HPO ID HPO Term
HP:0000855 Insulin resistance
HP:0005978 Type II diabetes mellitus
HP:0000006 Autosomal dominant inheritance
HP:0003584 Late onset
Displaying all 6 entries
Gene ID Gene Symbol Description
2645 GCK glucokinase
2820 GPD2 glycerol-3-phosphate dehydrogenase 2
3990 LIPC lipase C, hepatic type
5167 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
5506 PPP1R3A protein phosphatase 1 regulatory subunit 3A
6514 SLC2A2 solute carrier family 2 member 2
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024