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Standards Ontologies Notations
type 2 diabetes mellitus

Summary
Synonym
  • NIDDM
  • insulin resistance
  • non-insulin-dependent diabetes mellitus
  • type 2 diabetes
  • type II diabetes mellitus
Definition
A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
Super Class
diabetes mellitus
Disease Ontology
DOID:9352
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 121 - 130 of 325 in total
Gene ID Gene Symbol Description Source
3250 HPR haptoglobin-related protein
3283 HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
3290 HSD11B1 hydroxysteroid 11-beta dehydrogenase 1
3291 HSD11B2 hydroxysteroid 11-beta dehydrogenase 2
3293 HSD17B3 hydroxysteroid 17-beta dehydrogenase 3
3304 HSPA1B heat shock protein family A (Hsp70) member 1B
3308 HSPA4 heat shock protein family A (Hsp70) member 4
3358 HTR2C 5-hydroxytryptamine receptor 2C
3383 ICAM1 intercellular adhesion molecule 1
3458 IFNG interferon gamma
Displaying entries 1 - 10 of 249 in total
Gene ID Gene Symbol Description Source
11303 Abca1 ATP-binding cassette, sub-family A member 1
11421 Ace angiotensin I converting enzyme
11450 Adipoq adiponectin, C1Q and collagen domain containing
11491 Adam17 a disintegrin and metallopeptidase domain 17
11551 Adra2a adrenergic receptor, alpha 2a
11556 Adrb3 adrenergic receptor, beta 3
11596 Ager advanced glycosylation end product-specific receptor
11601 Angpt2 angiopoietin 2
11609 Agtr2 angiotensin II receptor, type 2
11625 Ahsg alpha-2-HS-glycoprotein
Displaying entries 121 - 130 of 166 in total
Gene ID Gene Symbol Description Source
66015 Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
81528 Ogg1 8-oxoguanine DNA glycosylase
81686 Mmp2 matrix metallopeptidase 2
81687 Mmp9 matrix metallopeptidase 9
81810 Tgfbr2 transforming growth factor, beta receptor 2
83504 Kl Klotho
83516 Ppargc1a PPARG coactivator 1 alpha
83535 Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11
83619 Nfe2l2 NFE2 like bZIP transcription factor 2
83785 Vegfa vascular endothelial growth factor A
Displaying entries 61 - 70 of 80 in total
Gene ID Gene Symbol Description Source
44058 Ugt36A1 UDP-glycosyltransferase family 36 member A1
45815 Spn27A Serpin 27A
49804 Spn88Ea Serpin 88Ea
49808 Spn42Dd Serpin 42Dd
53501 Ugt304A1 UDP-glycosyltransferase family 304 member A1
53502 Ugt302K1 UDP-glycosyltransferase family 302 member K1
53503 Ugt303A1 UDP-glycosyltransferase family 303 member A1
53504 Ugt35E1 UDP-glycosyltransferase family 35 member E1
53506 Ugt35E2 UDP-glycosyltransferase family 35 member E2
53507 Ugt35C1 UDP-glycosyltransferase family 35 member C1
Displaying entries 1 - 10 of 18 in total
Gene ID Gene Symbol Description Source
30173 nog3 noggin 3
30174 nog1 noggin 1
30262 ins preproinsulin
30667 mtnr1aa melatonin receptor 1A a
30668 mtnr1bb melatonin receptor 1Bb
30682 vegfaa vascular endothelial growth factor Aa
266751 adra2b adrenoceptor alpha 2B
321664 aldob aldolase b, fructose-bisphosphate
337685 ogt.1 O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1
393807 ppp1r3cb protein phosphatase 1, regulatory subunit 3Cb
Displaying entries 1 - 10 of 20 in total
Gene ID Gene Symbol Description Source Organism
373759 cnr1.S cannabinoid receptor 1 (brain) S homeolog Xenopus laevis (African clawed frog)
378584 drd2.L dopamine receptor D2 L homeolog Xenopus laevis (African clawed frog)
378695 ins.L insulin L homeolog Xenopus laevis (African clawed frog)
378696 ins.S insulin S homeolog Xenopus laevis (African clawed frog)
379783 akt2.L v-akt murine thymoma viral oncogene homolog 2 L homeolog Xenopus laevis (African clawed frog)
380341 pon2.L paraoxonase 2 L homeolog Xenopus laevis (African clawed frog)
394283 sdc2.S syndecan 2 S homeolog Xenopus laevis (African clawed frog)
397750 hmgcr.L 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog Xenopus laevis (African clawed frog)
397778 tgfb1.L transforming growth factor beta 1 L homeolog Xenopus laevis (African clawed frog)
398006 insr.L insulin receptor L homeolog Xenopus laevis (African clawed frog)
Displaying entries 1 - 10 of 69 in total
Gene ID Gene Symbol Description Source
171619 C53D5.5 Gamma-glutamyltranspeptidase 1
171782 abt-2 ABC transporter domain-containing protein
171905 ace-2 Carboxylic ester hydrolase
171999 poml-2 Arylesterase
172085 ugt-26 UDP-glucuronosyltransferase
172509 gpdh-3 putative glycerol-3-phosphate dehydrogenase, mitochondrial
173297 F49B2.6 Aminopeptidase
174685 ptp-3 Protein-tyrosine-phosphatase;Tyrosine-protein phosphatase Lar-like;protein-tyrosine-phosphatase
175076 ace-3 Carboxylic ester hydrolase
175182 ver-1 Protein ver-1
Displaying entries 1 - 10 of 32 in total
Gene ID Gene Symbol Description Source
850317 GLK1 glucokinase
850369 ADP1 putative ATP-dependent permease ADP1
850391 NPP1 nucleotide diphosphatase/phosphodiesterase NPP1
850614 HXK1 hexokinase 1
850645 BPT1 ATP-binding cassette bilirubin transporter BPT1
850678 YBT1 bile acid-transporting ATPase YBT1
850886 ATG26 sterol 3-beta-glucosyltransferase
850979 PIG1 protein phosphatase regulator PIG1
851006 ECM38 gamma-glutamyltransferase
851171 HMG2 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
The Human Phenotype Ontology
Displaying all 4 entries
HPO ID HPO Term
HP:0000855 Insulin resistance
HP:0005978 Type II diabetes mellitus
HP:0000006 Autosomal dominant inheritance
HP:0003584 Late onset
Displaying all 6 entries
Gene ID Gene Symbol Description
2645 GCK glucokinase
2820 GPD2 glycerol-3-phosphate dehydrogenase 2
3990 LIPC lipase C, hepatic type
5167 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
5506 PPP1R3A protein phosphatase 1 regulatory subunit 3A
6514 SLC2A2 solute carrier family 2 member 2
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024