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Phosphoinositide 3-kinase regulatory subunit 4

Summary

UniProt ID: Q99570
Gene Symbol: PIK3R4 VPS15
Gene ID: 30849
Organism: Homo sapiens (human)

External Links

PubChem: Q99570
The Human Metabolome Database: HMDBP08851
The O-GlcNAc Database: Q99570
RaftProt: Q99570
Re-Glyco: Q99570

Annotation

Keyword: 3D-structure ATP-binding Cytoplasmic vesicle Direct protein sequencing Endosome Membrane Myristate Phosphoprotein Proteomics identification Reference proteome Repeat Serine/threonine-protein kinase WD repeat

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
pexophagy	IBA	GO_REF
protein phosphorylation	NAS	PMID
protein targeting to lysosome	NAS	PMID
protein targeting to vacuole	IBA	GO_REF
regulation of autophagy	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

catabolic process [inference]

autophagy [inference]

macroautophagy [inference]

pexophagy

autophagy of peroxisome [inference]

pexophagy

macromolecule catabolic process [inference]

receptor catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

receptor metabolic process [inference]

receptor catabolic process

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

intercellular transport [inference]

late endosome to vacuole transport

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

vesicle-mediated transport [inference]

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

late endosome to vacuole transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

vacuolar transport [inference]

protein targeting to vacuole

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

late endosome to vacuole transport

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

process utilizing autophagic mechanism [inference]

autophagy [inference]

macroautophagy [inference]

pexophagy

autophagy of peroxisome [inference]

pexophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein targeting to vacuole

protein targeting to lysosome

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

late endosome to vacuole transport

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

vesicle-mediated transport [inference]

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

late endosome to vacuole transport

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

vacuolar transport [inference]

protein targeting to vacuole

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

late endosome to vacuole transport

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole

protein targeting to lysosome

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

protein targeting to lysosome

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

vacuolar transport [inference]

protein targeting to vacuole

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

late endosome to vacuole transport

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

vacuolar transport [inference]

protein targeting to vacuole

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

late endosome to vacuole transport

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of autophagy

regulation of macroautophagy

regulation of cell division [inference]

regulation of cytokinesis

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of cytokinesis

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	Reference
late endosome	IDA	PMID
late endosome	IBA	GO_REF
late endosome	IEA	GO_REF
autophagosome	IEA	GO_REF
cytosol	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

phosphatidylinositol 3-kinase complex [inference]

phosphatidylinositol 3-kinase complex, class III

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

phosphatidylinositol 3-kinase complex [inference]

phosphatidylinositol 3-kinase complex, class III

cellular anatomical structure [inference]

microtubule organizing center [inference]

ciliary basal body

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

bounding membrane of organelle [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

autophagosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

autophagosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

organelle membrane contact site [inference]

nucleus-vacuole junction

intercellular bridge

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
protein kinase activity	NAS	PMID
protein kinase activity	IEA	GO_REF
protein serine/threonine kinase activity	IBA	GO_REF
protein serine/threonine kinase activity	IEA	GO_REF GO_REF
ATP binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICVPLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	PubMed ID	GlyTouCan ID	Source
1233	38253038	G49108TO	The O-GlcNAc Database
1238	38253038	G49108TO	The O-GlcNAc Database
1241	38253038	G49108TO	The O-GlcNAc Database
1248	38253038	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Homo sapiens
Dengue virus modulates apoptosis	Homo sapiens
Macroautophagy	Homo sapiens
PI3K Cascade	Homo sapiens
RHO GTPases Activate NADPH Oxidases	Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Homo sapiens
Synthesis of PIPs at the Golgi membrane	Homo sapiens
Synthesis of PIPs at the early endosome membrane	Homo sapiens
Synthesis of PIPs at the late endosome membrane	Homo sapiens
Toll Like Receptor 9 (TLR9) Cascade	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements