Pyrophosphate hydrolysis
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Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
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- CAP-1
- CRAF1
- FIP2
- GLC1E
- HIP7
- HYPL
- IKBKE
- IKKE
- IKKI
- ITRAF
- KIAA0151
- NAK
- NRP
- OPTN
- PRVTIRB
- RPS27A
- TANK
- TBK1
- TICAM1
- TLR3
- TRAF2
- TRAF3
- TRAFAMN
- TRIF
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
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- CAP-1
- CD14
- CRAF1
- ESOP1
- FIP2
- GLC1E
- HIP7
- HYPL
- IKBKE
- IKKE
- IKKI
- ITRAF
- KIAA0151
- LY96
- MD2
- NAK
- NRP
- OPTN
- PRVTIRB
- RPS27A
- TANK
- TBK1
- TICAM1
- TICAM2
- TIRAP3
- TIRP
- TLR4
- TRAF2
- TRAF3
- TRAFAMN
- TRAM
- TRIF
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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TICAM1-dependent activation of IRF3/IRF7
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- CAP-1
- CRAF1
- FIP2
- GLC1E
- HIP7
- HYPL
- IKBKE
- IKKE
- IKKI
- IRF3
- IRF7
- ITRAF
- KIAA0151
- NAK
- NRP
- OPTN
- PRVTIRB
- RPS27A
- TANK
- TBK1
- TICAM1
- TLR3
- TRAF2
- TRAF3
- TRAFAMN
- TRIF
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
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- CAP-1
- CD14
- CRAF1
- ESOP1
- FIP2
- GLC1E
- HIP7
- HYPL
- IKBKE
- IKKE
- IKKI
- IRF3
- IRF7
- ITRAF
- KIAA0151
- LY96
- MD2
- NAK
- NRP
- OPTN
- PRVTIRB
- PTP2C
- PTPN11
- RPS27A
- SHPTP2
- TANK
- TBK1
- TICAM1
- TICAM2
- TIRAP3
- TIRP
- TLR4
- TRAF2
- TRAF3
- TRAFAMN
- TRAM
- TRIF
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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IKBKB deficiency causes SCID
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- CHUK
- FIP3
- IKBKB
- IKBKG
- IKKA
- IKKB
- NEMO
- TCF16
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IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
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- CHUK
- FIP3
- IKBKB
- IKBKG
- IKKA
- IKKB
- NEMO
- TCF16
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IkBA variant leads to EDA-ID
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- CHUK
- FIP3
- IKBA
- IKBKB
- IKBKG
- IKKA
- IKKB
- LYT10
- MAD3
- NEMO
- NFKB1
- NFKB2
- NFKB3
- NFKBI
- NFKBIA
- RELA
- TCF16
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Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria
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Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria
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Inhibition of nitric oxide production
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- KPNA1
- KPNB1
- NOS2
- NOS2A
- NTF97
- PPE2
- RCH2
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MPS II - Hunter syndrome
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Defective HPRT1 disrupts guanine and hypoxanthine salvage
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Orexin and neuropeptides FF and QRFP bind to their respective receptors
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- GPR103
- GPR147
- GPR74
- HCRT
- HCRTR1
- HCRTR2
- NPFF
- NPFF1
- NPFF2
- NPFFR1
- NPFFR2
- NPGPR
- OX
- PPORX
- PPOX
- QRFP
- QRFPR
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Hydroxycarboxylic acid-binding receptors
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- GPR104
- GPR109A
- GPR109B
- GPR81
- HCA1
- HCA2
- HCA3
- HCAR1
- HCAR2
- HCAR3
- HM74A
- HM74B
- NIACR1
- NIACR2
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MPS IX - Natowicz syndrome
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Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
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- ATOH5
- BHLHA3
- BHLHA7
- IA1
- INSM1
- NEUROD
- NEUROD1
- NEUROG3
- NGN3
- NKX2-2
- NKX2.2
- NKX2B
- PAX4
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POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
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- NANOG
- OCT3
- OCT4
- OTF3
- POU5F1
- SOX2
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Formation of the anterior neural plate
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- AN2
- EHZF
- GBX2
- KIAA0569
- LIP3
- NANOG
- OCT3
- OCT4
- OCT6
- OTF3
- OTF6
- OTX2
- PAX6
- POU3F1
- POU5F1
- SIP1
- SOX1
- SOX2
- ZEB2
- ZFHX1B
- ZFX1B
- ZIC2
- ZNF521
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NR1D1 (REV-ERBA) represses gene expression
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- EAR1
- HDAC3
- HREV
- KIAA1047
- NCOR1
- NR1D1
- THRAL
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Loss of MECP2 binding ability to 5mC-DNA
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SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
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- CBP20
- CBP80
- COD
- HBP
- KIAA1141
- LSM10
- LSM11
- NCBP
- NCBP1
- NCBP2
- PBSCF
- PBSCG
- SLBP
- SNRPB
- SNRPB1
- SNRPD3
- SNRPE
- SNRPF
- SNRPG
- ZFP100
- ZNF473
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RNA Polymerase I Promoter Opening
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- ERK1
- H2AB1
- H2AC14
- H2AC18
- H2AC19
- H2AC20
- H2AC4
- H2AC6
- H2AC7
- H2AC8
- H2AFA
- H2AFB1
- H2AFE
- H2AFG
- H2AFJ
- H2AFL
- H2AFM
- H2AFO
- H2AFQ
- H2AFV
- H2AFX
- H2AJ
- H2AV
- H2AX
- H2AZ2
- H2BC1
- H2BC10
- H2BC11
- H2BC12
- H2BC12L
- H2BC13
- H2BC14
- H2BC15
- H2BC17
- H2BC21
- H2BC26
- H2BC3
- H2BC4
- H2BC5
- H2BC6
- H2BC7
- H2BC8
- H2BC9
- H2BFA
- H2BFB
- H2BFC
- H2BFD
- H2BFE
- H2BFF
- H2BFG
- H2BFH
- H2BFJ
- H2BFK
- H2BFL
- H2BFN
- H2BFQ
- H2BFR
- H2BFS
- H2BFT
- H2BS1
- H2BU1
- H3-3A
- H3-3B
- H3.3A
- H3.3B
- H3C1
- H3C10
- H3C11
- H3C12
- H3C13
- H3C14
- H3C15
- H3C2
- H3C3
- H3C4
- H3C6
- H3C7
- H3C8
- H3F2
- H3F3
- H3F3A
- H3F3B
- H3FA
- H3FB
- H3FC HIST1H3C
- H3FD
- H3FF
- H3FH
- H3FI
- H3FJ
- H3FK
- H3FL
- H3FM
- H4-16
- H4/A
- H4/B
- H4/C
- H4/D
- H4/E
- H4/G
- H4/H
- H4/I
- H4/J
- H4/K
- H4/M
- H4/N
- H4/O
- H4C1
- H4C11
- H4C12
- H4C13
- H4C14
- H4C15
- H4C16
- H4C2
- H4C3
- H4C4
- H4C5
- H4C6
- H4C8
- H4C9
- H4F2
- H4FA
- H4FB
- H4FC
- H4FD
- H4FE
- H4FG
- H4FH
- H4FI
- H4FJ
- H4FK
- H4FM
- H4FN
- H4FO
- HIRIP1
- HIRIP2
- HIST1H2AB
- HIST1H2AC
- HIST1H2AD
- HIST1H2AE
- HIST1H2AJ
- HIST1H2BA
- HIST1H2BB
- HIST1H2BC
- HIST1H2BD
- HIST1H2BE
- HIST1H2BF
- HIST1H2BG
- HIST1H2BH
- HIST1H2BI
- HIST1H2BJ
- HIST1H2BK
- HIST1H2BL
- HIST1H2BM
- HIST1H2BN
- HIST1H2BO
- HIST1H3A
- HIST1H3B
- HIST1H3D
- HIST1H3E
- HIST1H3F
- HIST1H3G
- HIST1H3H
- HIST1H3I
- HIST1H3J
- HIST1H4A
- HIST1H4B
- HIST1H4C
- HIST1H4D
- HIST1H4E
- HIST1H4F
- HIST1H4H
- HIST1H4I
- HIST1H4J
- HIST1H4K
- HIST1H4L
- HIST2H2AA
- HIST2H2AA3
- HIST2H2AA4
- HIST2H2AC
- HIST2H2BE
- HIST2H3A
- HIST2H3C
- HIST2H3D
- HIST2H4
- HIST2H4A
- HIST2H4B
- HIST3H2BB
- HIST4H4
- MAPK3
- MBD2
- PRKM3
- TSH2B
- UBF
- UBF1
- UBTF
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Assembly of the ORC complex at the origin of replication
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- H2AB1
- H2AC14
- H2AC18
- H2AC19
- H2AC20
- H2AC4
- H2AC6
- H2AC7
- H2AC8
- H2AFA
- H2AFB1
- H2AFE
- H2AFG
- H2AFJ
- H2AFL
- H2AFM
- H2AFO
- H2AFQ
- H2AFV
- H2AFX
- H2AJ
- H2AV
- H2AX
- H2AZ2
- H2BC1
- H2BC10
- H2BC11
- H2BC12
- H2BC12L
- H2BC13
- H2BC14
- H2BC15
- H2BC17
- H2BC21
- H2BC26
- H2BC3
- H2BC4
- H2BC5
- H2BC6
- H2BC7
- H2BC8
- H2BC9
- H2BFA
- H2BFB
- H2BFC
- H2BFD
- H2BFE
- H2BFF
- H2BFG
- H2BFH
- H2BFJ
- H2BFK
- H2BFL
- H2BFN
- H2BFQ
- H2BFR
- H2BFS
- H2BFT
- H2BS1
- H2BU1
- H3-3A
- H3-3B
- H3.3A
- H3.3B
- H3C1
- H3C10
- H3C11
- H3C12
- H3C13
- H3C14
- H3C15
- H3C2
- H3C3
- H3C4
- H3C6
- H3C7
- H3C8
- H3F2
- H3F3
- H3F3A
- H3F3B
- H3FA
- H3FB
- H3FC HIST1H3C
- H3FD
- H3FF
- H3FH
- H3FI
- H3FJ
- H3FK
- H3FL
- H3FM
- H4-16
- H4/A
- H4/B
- H4/C
- H4/D
- H4/E
- H4/G
- H4/H
- H4/I
- H4/J
- H4/K
- H4/M
- H4/N
- H4/O
- H4C1
- H4C11
- H4C12
- H4C13
- H4C14
- H4C15
- H4C16
- H4C2
- H4C3
- H4C4
- H4C5
- H4C6
- H4C8
- H4C9
- H4F2
- H4FA
- H4FB
- H4FC
- H4FD
- H4FE
- H4FG
- H4FH
- H4FI
- H4FJ
- H4FK
- H4FM
- H4FN
- H4FO
- HIRIP1
- HIRIP2
- HIST1H2AB
- HIST1H2AC
- HIST1H2AD
- HIST1H2AE
- HIST1H2AJ
- HIST1H2BA
- HIST1H2BB
- HIST1H2BC
- HIST1H2BD
- HIST1H2BE
- HIST1H2BF
- HIST1H2BG
- HIST1H2BH
- HIST1H2BI
- HIST1H2BJ
- HIST1H2BK
- HIST1H2BL
- HIST1H2BM
- HIST1H2BN
- HIST1H2BO
- HIST1H3A
- HIST1H3B
- HIST1H3D
- HIST1H3E
- HIST1H3F
- HIST1H3G
- HIST1H3H
- HIST1H3I
- HIST1H3J
- HIST1H4A
- HIST1H4B
- HIST1H4C
- HIST1H4D
- HIST1H4E
- HIST1H4F
- HIST1H4H
- HIST1H4I
- HIST1H4J
- HIST1H4K
- HIST1H4L
- HIST2H2AA
- HIST2H2AA3
- HIST2H2AA4
- HIST2H2AC
- HIST2H2BE
- HIST2H3A
- HIST2H3C
- HIST2H3D
- HIST2H4
- HIST2H4A
- HIST2H4B
- HIST3H2BB
- HIST4H4
- IPOA7
- KPNA1
- KPNA6
- KPNB1
- LATHEO
- NTF97
- ORC1
- ORC1L
- ORC2
- ORC2L
- ORC3
- ORC3L
- ORC4
- ORC4L
- ORC5
- ORC5L
- ORC6
- ORC6L
- PARC1
- RCH2
- TSH2B
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SIRT1 negatively regulates rRNA expression
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- GTF2D1
- H2AB1
- H2AC14
- H2AC18
- H2AC19
- H2AC20
- H2AC4
- H2AC6
- H2AC7
- H2AC8
- H2AFA
- H2AFB1
- H2AFE
- H2AFG
- H2AFJ
- H2AFL
- H2AFM
- H2AFO
- H2AFQ
- H2AFV
- H2AFX
- H2AJ
- H2AV
- H2AX
- H2AZ2
- H2BC1
- H2BC10
- H2BC11
- H2BC12
- H2BC12L
- H2BC13
- H2BC14
- H2BC15
- H2BC17
- H2BC21
- H2BC26
- H2BC3
- H2BC4
- H2BC5
- H2BC6
- H2BC7
- H2BC8
- H2BC9
- H2BFA
- H2BFB
- H2BFC
- H2BFD
- H2BFE
- H2BFF
- H2BFG
- H2BFH
- H2BFJ
- H2BFK
- H2BFL
- H2BFN
- H2BFQ
- H2BFR
- H2BFS
- H2BFT
- H2BS1
- H2BU1
- H3-3A
- H3-3B
- H3.3A
- H3.3B
- H3C1
- H3C10
- H3C11
- H3C12
- H3C13
- H3C14
- H3C15
- H3C2
- H3C3
- H3C4
- H3C6
- H3C7
- H3C8
- H3F2
- H3F3
- H3F3A
- H3F3B
- H3FA
- H3FB
- H3FC HIST1H3C
- H3FD
- H3FF
- H3FH
- H3FI
- H3FJ
- H3FK
- H3FL
- H3FM
- H4-16
- H4/A
- H4/B
- H4/C
- H4/D
- H4/E
- H4/G
- H4/H
- H4/I
- H4/J
- H4/K
- H4/M
- H4/N
- H4/O
- H4C1
- H4C11
- H4C12
- H4C13
- H4C14
- H4C15
- H4C16
- H4C2
- H4C3
- H4C4
- H4C5
- H4C6
- H4C8
- H4C9
- H4F2
- H4FA
- H4FB
- H4FC
- H4FD
- H4FE
- H4FG
- H4FH
- H4FI
- H4FJ
- H4FK
- H4FM
- H4FN
- H4FO
- HIRIP1
- HIRIP2
- HIST1H2AB
- HIST1H2AC
- HIST1H2AD
- HIST1H2AE
- HIST1H2AJ
- HIST1H2BA
- HIST1H2BB
- HIST1H2BC
- HIST1H2BD
- HIST1H2BE
- HIST1H2BF
- HIST1H2BG
- HIST1H2BH
- HIST1H2BI
- HIST1H2BJ
- HIST1H2BK
- HIST1H2BL
- HIST1H2BM
- HIST1H2BN
- HIST1H2BO
- HIST1H3A
- HIST1H3B
- HIST1H3D
- HIST1H3E
- HIST1H3F
- HIST1H3G
- HIST1H3H
- HIST1H3I
- HIST1H3J
- HIST1H4A
- HIST1H4B
- HIST1H4C
- HIST1H4D
- HIST1H4E
- HIST1H4F
- HIST1H4H
- HIST1H4I
- HIST1H4J
- HIST1H4K
- HIST1H4L
- HIST2H2AA
- HIST2H2AA3
- HIST2H2AA4
- HIST2H2AC
- HIST2H2BE
- HIST2H3A
- HIST2H3C
- HIST2H3D
- HIST2H4
- HIST2H4A
- HIST2H4B
- HIST3H2BB
- HIST4H4
- JOSD3
- KIAA0409
- KMT1A
- NML
- RRP8
- SIR2L1
- SIRT1
- SUV39H
- SUV39H1
- TAF1A
- TAF1B
- TAF1C
- TAF1D
- TBP
- TF2D
- TFIID
- TSH2B
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